MycoData

Mesima · 2008 · Research Support, Non U.S. Gov'T · Biological & pharmaceutical bulletin

Blockade of the Aryl Hydrocarbon Receptor Pathway Triggered by Dioxin, Polycyclic Aromatic Hydrocarbons and Cigarette Smoke by Phellinus linteus

Environmental pollutants including halogenated and polycyclic aromatic hydrocarbons activate the aryl hydrocarbon receptor (AhR) and thereby cause a wide range of pathological changes. Development of AhR antagonists will be useful for prevention and treatment of diseases related to AhR activation..

OncologyImmune supportCognition & nerves

Lion's Mane · 2008 · Patent · journal metadata

HERICIUM ERINACEUS MYCELIUM COMPRISING RICE BRAN AND GINSENG STEAMED RED AND CULTIVATION METHOD THEREOF

The present invention relates to a production method of Hericium erinaceus mycelium using rice bran or ginseng steamed red as a substrate and Hericium erinaceus mycelium containing active ingredients of rice bran or ginseng steamed red prepared by the same, aiming at the increase of production of mycelium by using….

Lion's Mane · 2008 · Research Support, Non U.S. Gov'T · Biological & pharmaceutical bulletin

Nerve Growth Factor-Inducing Activity of Hericium erinaceus in 1321N1 Human Astrocytoma Cells

Neurotrophic factors are essential to maintain and organize neurons functionally; thereby neurotrophic factor-like substances or their inducers are expected to be applied to the treatment of neurodegenerative diseases such as Alzheimer's disease..

Snow Fungus · 2007 · Patent · journal metadata

Health Functional Food Composition for Promoting Neuronal Cell Differentiation Comprising Mixed Mycelium Extract of Tremella Fuciformis and Hypoxylon sp. or Extract of Mixed Mycelium Culture

A mixture mycelium extract of Tremella Fuciformis and Hypoxylon sp. is provided to promote the differentiation of neuronal cell by acting like a nerve growth factor, thereby being applied to develop health functional foods and medicines..

Reishi · 2026 · Journal Article · BMC complementary medicine and therapies

Acute neurotoxicity in a child following multi-component medicinal fungi supplementation: a case report.

BACKGROUND: Medicinal fungi supplements have gained widespread recognition, increasing off-label use in pediatric populations. However, their safety profile remains inadequately characterized, and the potential for toxic effects, including neurotoxicity, is underrecognized in clinical practice..

Reishi · 2019 · Review · Advances in experimental medicine and biology

Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Brain Injury.

Neurological dysfunction and death are common events leading to acute and chronic neurodegenerative diseases. Neurodegenerative disorders such as Alzheimer's and Parkinson's disease account for a significant and increasing proportion of morbidity and mortality in the developed world.

OncologyImmune supportCognition & nervesLiver support

Maitake · 2002 · Review · Alternative medicine review: a journal of clinical therapeutic

Can maitake MD-fraction aid cancer patients?

Maitake mushroom (Grifola frondosa) MD-fraction containing beta-1,6 glucan with beta-1,3 branched chains has previously exhibited strong anticancer activity by increasing immune-competent cell activity.1,2 In this non-random case series, a combination of MD-fraction and whole maitake powder was investigated to….

Lion's Mane · 2026 · Published Erratum · International journal of biological macromolecules

Corrigendum to "Effect of ultrasound synergistic pH shift modification treatment on Hericium erinaceus protein structure and its application in 3D printing" [International Journal of Biological Macromolecules, 295 (2025) 139562].

Metadata-grounded summary: This published erratum indexes research on Hericium erinaceus in International journal of biological macromolecules in 2026. MycoData maps the paper to cognition & nerves based on its title, species context, article metadata, and study classification..

Immune supportCognition & nerves

Niu-Chang-Chih · 2024 · Published Erratum · Brain and behavior

Correction to "Antrodia camphorata polysaccharide resists 6-OHDA-induced dopaminergic neuronal damage by inhibiting ROS-NLRP3 activation".

Metadata-grounded summary: This published erratum indexes research on Antrodia camphorata in Brain and behavior in 2024. MycoData maps the paper to immune support, cognition & nerves based on its title, species context, article metadata, and study classification..

OncologyImmune supportCognition & nerves

Niu-Chang-Chih · 2023 · Research Article · Molecules (Basel, Switzerland)

Ergosterol Isolated from Antrodia camphorata Suppresses LPS-Induced Neuroinflammatory Responses in Microglia Cells and ICR Mice.

Inflammation caused by microglial activation is important in neurodegenerative diseases. In this research, we tried to identify safe and effective anti-neuroinflammatory agents by screening a natural compounds library and found that Ergosterol can inhibit the nuclear factor kappa-light-chain enhancer of the activated….

Cognition & nervesGut & microbiome

Lion's Mane · 2023 · Journal Article · Brain research

Retraction notice to "Improvement of extraction from Hericium erinaceus on the gut-brain axis in AD-like mice" [Brain Res. 1793 (2022) 148038].

Metadata-grounded summary: This journal article indexes research on Hericium erinaceus in Brain research in 2023. MycoData maps the paper to cognition & nerves, gut & microbiome based on its title, species context, article metadata, and study classification..

Lion's Mane · 2023 · Journal Article · Annual Meeting of the Japanese Society of Toxicology

The development of medicinal fungi Cordyceps sobolifera and Hericium erinaceus in the therapeutic application of retinopathies

Metadata-grounded summary: This journal article indexes research on Hericium erinaceus in Annual Meeting of the Japanese Society of Toxicology in 2023. MycoData maps the paper to cognition & nerves based on its title, species context, article metadata, and study classification..

Immune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2021 · Research Article · International journal of molecular sciences

Neuroprotective Metabolites of Hericium erinaceus Promote Neuro-Healthy Aging.

Frailty is a geriatric syndrome associated with both locomotor and cognitive decline, typically linked to chronic systemic inflammation, i.e., inflammaging. In the current study, we investigated the effect of a two-month oral supplementation with standardized extracts of H..

Immune supportCognition & nervesGut & microbiome

Maitake · 2020 · Research Support, Non U.S. Gov'T · Journal of natural products

A (1→6)-Branched (1→4)-β-d-Glucan from Grifola frondosa Inhibits Lipopolysaccharide-Induced Cytokine Production in RAW264.7 Macrophages by Binding to TLR2 Rather than Dectin-1 or CR3 Receptors.

Mushroom polysaccharides including β-glucans possess various health-promoting properties and are known to be the major bioactive constituents of Grifola frondosa (GF), which is a popular edible and medicinal mushroom. Dectin-1, a pattern-recognition receptor, is responsible for recognizing β-glucans..

OncologyImmune supportCognition & nervesEnergy & fatigue

Niu-Chang-Chih · 2020 · Research Support, Non U.S. Gov'T · Brain and behavior

Antrodia camphorata polysaccharide resists 6-OHDA-induced dopaminergic neuronal damage by inhibiting ROS-NLRP3 activation.

INTRODUCTION: Parkinson's disease (PD) is a common degenerative disease of the central nervous system (CNS). The main pathological change is the apoptosis of dopaminergic neurons in the substantia nigra pars compacta (SNPc), thereby leading to dopamine reduction in nigral striatum..

Chaga · 2020 · Research Support, Non U.S. Gov'T · Bioorganic chemistry

Flavan derivative enantiomers and drimane sesquiterpene lactones from the Inonotus obliquus with neuroprotective effects.

A pair of new flavan derivative enantiomers (1a and 1b), four new drimane sesquiterpene lactones (2-5) and a known compound (6) were isolated from Inonotus obliquus. Their structures were determined by comprehensive spectroscopic analyses.

Lion's Mane · 2020 · Research Support, Non U.S. Gov'T · Scientific reports

Hericium erinaceus potentially rescues behavioural motor deficits through ERK-CREB-PSD95 neuroprotective mechanisms in rat model of 3-acetylpyridine-induced cerebellar ataxia.

Cerebellar ataxia is a neurodegenerative disorder with no definitive treatment. Although several studies have demonstrated the neuroprotective effects of Hericium erinaceus (H.E.), its mechanisms in cerebellar ataxia remain largely unknown.

Chaga · 2020 · Research Support, Non U.S. Gov'T · Organic & biomolecular chemistry

Highly modified steroids from Inonotus obliquus.

Six undescribed steroids were isolated from the fungus Inonotus obliquus. Notably, compounds 1 and 2 represented the first example of 8,14-seco-4-methylpregnane.

Shiitake · 2020 · Research Support, Non U.S. Gov'T · Genes

Investigation of Mating Pheromone-Pheromone Receptor Specificity in Lentinula edodes.

The B mating-type locus of Lentinula edodes, a representative edible mushroom, is highly complex because of allelic variations in the mating pheromone receptors (RCBs) and the mating pheromones (PHBs) in both the Bα and Bβ subloci..

OncologyCognition & nerves

Chaga · 2020 · Research Support, Non U.S. Gov'T · Bioorganic chemistry

Modified lanostane-type triterpenoids with neuroprotective effects from the fungus Inonotus obliquus.

Six undescribed lanostane triterpenoids (1-6), together with three known compounds (7-9) were isolated from Inonotus obliquus. Compounds 3-5 are the rare natural compounds featuring a 4,5-seco-lanostane core with a 5,7,9-trien-21,24-cyclopentane moiety..

Shiitake · 2019 · Research Support, Non U.S. Gov'T · Genes

Effects of Medium Composition and Genetic Background on Agrobacterium-Mediated Transformation Efficiency of Lentinula edodes.

The establishment of genetic transformation method is crucial for the functional genomics research in filamentous fungi. Although the transformation method has been developed in several types of fungi, a highly efficient and convenient transformation system is desperately needed in Lentinula edodes..

Lion's Mane · 2019 · Comparative Study · Neurological research

Regenerative activity of Hericium erinaceus on axonal injury model using in vitro laser microdissection technique.

OBJECTIVE: Peripheral nerve injury (PNI) is an important global health problem. Nerve Growth Factor (NGF) plays crucial role in the survival, growth, and maintenance of various neurons in the mammalian nervous system, human included..

Immune supportCognition & nervesMetabolic health

Almond Mushroom · 2018 · Research Support, Non U.S. Gov'T · Journal of food and drug analysis

Characteristics of fucose-containing polysaccharides from submerged fermentation of Agaricus blazei Murill.

Fucose is one of important residues of recognition pattern for many immune cells. In this study, we characterized bioactive fucose-containing acidic polysaccharides from submerged fermentation of Agaricus blazei Murill..

Turkey Tail · 2018 · Research Support, Non U.S. Gov'T · Scientific reports

Molecular recognition of wood polyphenols by phase II detoxification enzymes of the white rot Trametes versicolor.

Wood decay fungi have complex detoxification systems that enable them to cope with secondary metabolites produced by plants. Although the number of genes encoding for glutathione transferases is especially expanded in lignolytic fungi, little is known about their target molecules..

Lion's Mane · 2016 · Research Support, Non U.S. Gov'T · Journal of natural products

Erinacine S, a Rare Sesterterpene from the Mycelia of Hericium erinaceus.

A new sesterterpene, erinacine S, and one cyathane diterpene xyloside, erinacine A, were isolated from the ethanol extract of the mycelia of Hericium erinaceus. Their structures were elucidated by spectroscopic and X-ray analysis..

OncologyImmune supportCognition & nerves

Lion's Mane · 2016 · Retracted Publication · Journal of translational medicine

Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade.

BACKGROUND: Hericium erinaceus is an edible mushroom; its various pharmacological effects which have been investigated. This study aimed to demonstrate whether efficacy of oral administration of H..

OncologyCognition & nervesEnergy & fatigue

Enoki · 2016 · Research Support, Non U.S. Gov'T · Food chemistry

Identification of flavonoids from Flammulina velutipes and its neuroprotective effect on pheochromocytoma-12 cells.

The flavonoids from Flammulina velutipes (FVF) were isolated and the chemical composition of FVF was identified by high-performance liquid chromatography/mass spectrometry (HPLC/MS)..

OncologyCognition & nervesEnergy & fatigue

Mesima · 2016 · Research Support, Non U.S. Gov'T · Nutrition research (New York, N.Y.)

Neuroprotective effects of the Phellinus linteus ethyl acetate extract against H2O2-induced apoptotic cell death of SK-N-MC cells.

Numerous studies have suggested that neuronal cells are protected against oxidative stress-induced cell damage by antioxidants, such as polyphenolic compounds. Phellinus linteus (PL) has traditionally been used to treat various symptoms in East Asian countries..

OncologyCognition & nervesEnergy & fatigueLiver support

Niu-Chang-Chih · 2015 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Antrodia camphorata Potentiates Neuroprotection against Cerebral Ischemia in Rats via Downregulation of iNOS/HO-1/Bax and Activated Caspase-3 and Inhibition of Hydroxyl Radical Formation.

Antrodia camphorata (A. camphorata) is a fungus generally used in Chinese folk medicine for treatment of viral hepatitis and cancer.

Lion's Mane · 2015 · Journal Article · Archives of physiology and biochemistry

Enhancement of the neuroprotective activity of Hericium erinaceus mycelium co-cultivated with Allium sativum extract.

This study investigated the neuroprotective effects of Hericium erinaceus mycelium enriched with garlic extract (HGE) on rat pheochromocytoma nerve cells (PC12). The survival rates of the PC12 nerve cells and the neurite-bearing cells after the addition of HGE were estimated as 3.5 × 10(3) viable cells/ml and 2.3 ×….

OncologyCognition & nervesLiver supportRespiratory

Mesima · 2015 · Research Article · Journal of clinical medicine research

Potent Anticancer Effects of Bioactive Mushroom Extracts (Phellinus linteus) on a Variety of Human Cancer Cells.

BACKGROUND: Although several therapeutic options are currently available for patients with various cancers, the outcomes are often disappointing and a more effective modality needs to be promptly established..

Lion's Mane · 2015 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced Diabetic Neuropathic Pain in Rats.

We investigated the effects of Hericium erinaceus (HEE) on alloxan induced diabetic neuropathic pain in laboratory rats. Alloxan induced diabetic rats were administered orally HEE..

Lion's Mane · 2014 · Journal Article · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association

Evaluation of the toxicological safety of erinacine A-enriched Hericium erinaceus in a 28-day oral feeding study in Sprague-Dawley rats.

Natural products have attained great importance as they are believed to be the new alternative medicines for conventional therapy. As numerous studies have proved the tremendous medicinal values of Hericium erinaceus, it is necessary to take into account its safety as well as its risk for the recipient..

Cognition & nervesGut & microbiome

Lion's Mane · 2014 · Research Article · Toxicology reports

Genotoxicity profile of erinacine A-enriched Hericium erinaceus mycelium.

Hericium erinaceus (H. erinaceus) has a long history of usage in traditional Chinese medicine for the treatment of gastric disorders.

Immune supportCognition & nerves

Snow Fungus · 2013 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Long-Term Regeneration and Functional Recovery of a 15 mm Critical Nerve Gap Bridged by Tremella fuciformis Polysaccharide-Immobilized Polylactide Conduits.

Novel peripheral nerve conduits containing the negatively charged Tremella fuciformis polysaccharide (TF) were prepared, and their efficacy in bridging a critical nerve gap was evaluated. The conduits were made of poly(D,L-lactide) (PLA) with asymmetric microporous structure..

OncologyImmune supportCognition & nervesSkin & hydration

Enoki · 2012 · Journal Article · Carbohydrate polymers

Purification, characterization and anti-proliferation activity of polysaccharides from Flammulina velutipes

A polysaccharide was isolated from Flammulina velutipes (FVP) using ultrasonic-assisted extraction, and then further purified by DEAE cellulose-52 chromatography and Sephadex G-100 size-exclusion chromatography to afford FVP-1 and FVP-2..

Cognition & nervesEnergy & fatigue

Maitake · 2011 · Journal Article · World journal of microbiology & biotechnology

On the role of carbohydrate-protein highly selective interactions in the biological activity of glycoconjugates: Grifola frondosa (Fr.) S.F. Gray lectin binding to specific and non-specific antibodies

Both quantitative and qualitative estimations of the basidiomycete Grifola frondosa lectin binding to the specific and non-specific polyclonal rabbit antibodies were attempted..

Immune supportCognition & nerves

Enoki · 2011 · Journal Article · Food research international (Ottawa, Ont.)

Optimization of ultrasonic extraction of Flammulina velutipes polysaccharides and evaluation of its acetylcholinesterase inhibitory activity

Polysaccharide was testified to be the main component of Flammulina velutipes for inhibiting AChE activity in our preliminary study. Therefore, response surface methodology, based on Box–Behnken design, was used to optimize the ultrasonic extraction conditions of F.

Snow Fungus · 2007 · Research Article · Mycobiology

The Neuroprotective and Neurotrophic Effects of Tremella fuciformis in PC12h Cells.

We examined the neuroprotective and neurotrophic effects of Tremella fuciformis. The neurotrophic effects of the hot water extract of T.

OncologyCognition & nervesEnergy & fatigueSkin & hydration

Maitake · 2006 · Journal Article · Journal of lipid research

Lysophosphatidylethanolamine in Grifola frondosa as a neurotrophic activator via activation of MAPK.

We found that Grifola frondosa extracts induced the activation of mitogen-activated protein kinase (MAPK) in cultured PC12 cells, a line of rat pheochromocytoma cells..

King Oyster · 1992 · Research Support, Non U.S. Gov'T · European journal of biochemistry

Substrate specificity and properties of the aryl-alcohol oxidase from the ligninolytic fungus Pleurotus eryngii.

The production in a 5-1 fermenter of the extracellular enzymes laccase and aryl-alcohol oxidase by the fungus Pleurotus eryngii was studied. The latter enzyme has been purified 50-fold by Sephacryl S-200 and Mono Q chromatography..

OncologyCognition & nerves

Almond Mushroom · 2026 · Clinical Trial Protocol · JMIR research protocols

Digital Attention Bias in Cancer Survivors Intervention for Adolescent and Young Adult Cancer Survivors: Protocol for a Pilot Randomized Controlled Trial.

BACKGROUND: Adolescent and young adult cancer survivors face a high burden of psychological late effects, with cancer-related anxiety being a prevalent mental health concern..

Immune supportCognition & nervesEnergy & fatigueRespiratory

Reishi · 2026 · Clinical Trial Protocol · JMIR research protocols

Effectiveness and Safety of a Supplement Containing a Pharmacologically Active Basidiomycete Mushroom for Chronic Fatigue and Post-COVID-19 Fatigue Syndrome: Protocol for a Randomized Controlled Trial.

BACKGROUND: Chronic fatigue syndrome, or myalgic encephalomyelitis, is characterized by persistent, unexplained exhaustion unalleviated by rest, with a pathophysiology distinct from underlying medical conditions..

Cognition & nervesEnergy & fatigue

Lion's Mane · 2026 · Review · International journal of molecular sciences

Phytochemical and Fungal Bioactive Compounds in the "Brain Health Triad": A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy.

This narrative review proposes the 'Brain Health Triad' as a novel integrative framework for neurorehabilitation and cognitive enhancement, built upon three interdependent biological pillars: neurostimulation, neurotrophy, and neuroprotection..

Immune supportCognition & nervesSkin & hydration

Shiitake · 2025 · Case Reports · Skin health and disease

An unusually severe case of shiitake mushroom dermatitis with features of drug reaction with eosinophilia and systemic symptoms.

Shiitake mushroom dermatitis is a well-documented phenomenon in the literature seen after consuming raw or undercooked shiitake mushrooms (Lentinus edodes). However, systemic features resembling a drug reaction with eosinophilia and systemic symptoms (DRESS) are rare..

Almond Mushroom · 2025 · Clinical Trial Protocol · Contemporary clinical trials

Efficacy of traditional and gamified attention bias modification for depression: Study protocol for a randomized controlled trial.

Cognitive models posit that negatively biased attention toward dysphoric information has a causal role in the maintenance of depression-related psychopathology. Attention bias modification (ABM) tests this idea by altering an attentional bias and examining subsequent effects on depression..

OncologyImmune supportCognition & nervesLiver support

Reishi · 2025 · Review · Journal of ethnopharmacology

Ganoderic acid A: an in-depth review of pharmacological effects and molecular docking analysis.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderic acid A (GAA, C30H44O7) is one of the most abundant and active components of Ganoderic acids (GAs). GAs are highly oxidized tetracyclic triterpenoid compounds mainly derived from Ganoderma lucidum (Curtis) P.

Immune supportCognition & nervesMetabolic healthGut & microbiome

Lion's Mane · 2025 · Review · Molecules (Basel, Switzerland)

Macromycete Edible Fungi as a Functional Poultry Feed Additive: Influence on Health, Welfare, Eggs, and Meat Quality-Review.

Over the years, macromycete fungi have been used as a source of food, part of religious rites and rituals, and as a medicinal remedy. Species with strong health-promoting potential include Hericium erinaceus, Cordyceps militaris, Ganoderma lucidum, Pleurotus ostreatus, Flammulina velutipes, and Inonotus obliquus..