MycoData

Laccase (oxygen oxidoreductase, EC 1.10.3.2) from Trametes versicolor was thoroughly characterized in terms of its catalytic stability and its effectiveness as a biocatalyst under various reaction conditions when using phenol as a model substrate..

Energy & fatigue

Medium relevance

Niu-Chang-Chih · 2008 · Research Support, Non U.S. Gov'T · Natural product research

Chemical constituents of Antrodia camphorata submerged whole broth.

One new compound, 10-hydroxy-gamma-dodecalactone (1) and three natural new compounds, 11-hydroxy-gamma-dodecalactone (2), 2-(2-hydroxyethyl)phenol (3) and 12-hydroxydodecanoic acid methyl ester (4), together with eight known compounds, ergostatrien-3beta-ol, ergosterol peroxide, methyl (4-hydroxyphenyl)acetate,….

Medium relevance

Turkey Tail · 2008 · Comparative Study · Archives of biochemistry and biophysics

Comparative characterization of four laccases from Trametes versicolor concerning phenolic C-C coupling and oxidation of PAHs.

The laccase genes lccalpha, lccbeta, lccgamma and lccdelta encoding four isoenzymes from Trametes versicolor have been cloned and expressed in Pichia pastoris. Biochemical characterization allowed classification of these laccases into two distinct groups: Lccalpha and Lccbeta possessed higher thermal stability, but….

Medium relevance

Niu-Chang-Chih · 2008 · Patent · journal metadata

Cyclohexenone compounds from Antrodia Camphorata for use in the treatment of liver disease

A compound of formula (I) as defined therein can be obtained from Antrodia camphorata and finds use in liver protection, in particular 4-hydroxy-2,3-dimethoxy-6-methyl- 5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone..

Liver support

Medium relevance

Niu-Chang-Chih · 2008 · Patent · journal metadata

Cyclohexenones from Antrodia Camphorata for use in the treatment of autoimmune disease

A compound of formula (1) as defined therein is obtained from Antrodia camphorata and may be used to treat autoimmune disease, in particular 4-hydroxy-2,3-dimethoxy-6- methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone..

Immune support

Medium relevance

Niu-Chang-Chih · 2008 · Research Support, Non U.S. Gov'T · The Chinese journal of physiology

Effects of antrodia camphorata on viability, apoptosis, and [Ca2+]i in PC3 human prostate cancer cells.

Antrodia camphorata (AC) has been used as a health supplement in Asia to control different cancers; however, the cellular mechanisms of its effects are unclear. The effect of AC on cultured human prostate cancer cells (PC3) has not been explored..

OncologyImmune support

Medium relevance

Turkey Tail · 2008 · Research Support, Non U.S. Gov'T · Journal of microbiology (Seoul, Korea)

Enhanced expression of laccase during the degradation of endocrine disrupting chemicals in Trametes versicolor.

A putative laccase cDNA from a white-rot basidiomycete, Trametes versicolor, that consisted of 1,769 nucleotides was cloned using the rapid amplification of cDNA ends (RACE)-PCR method. The deduced amino acid sequence had 4 putative copper binding regions, which are common to fungal laccases..

Medium relevance

Maitake · 2008 · Patent · journal metadata

Grifola frondosa beta-dextran freeze-dried powder for injection

The invention relates to a freeze-dried powder for injection which is prepared by Beta-glucan that is extracted and separated by using Grifola frondosa mycelium and has the structure shown in the attached figure I and a preparation method thereof, which pertains to the technical field of medical preparations..

OncologyImmune supportMetabolic health

Medium relevance

Maitake · 2008 · Patent · journal metadata

GRIFOLA FRONDOSA-ORIGIN SUBSTANCE HAVING ANTIINFLUENZA VIRUS ACTIVITY AND METHOD OF PRODUCING THE SAME

It has been found out that a fraction having a potent antiinfluenza virus activity via microphage activation or an active substance is distributed in low-molecular weight fractions of a Grifola frondosa extract..

Respiratory

Medium relevance

Snow Fungus · 2008 · Research Support, Non U.S. Gov'T · Science in China. Series C, Life sciences

Highly efficient transformation of intact yeast-like conidium cells of Tremella fuciformis by electroporation.

Tremella fuciformis is one of higher basidiomycetes. Its basidiospore can reproduce yeast-like conidia, also called the blastospore by budding.

Gut & microbiome

Medium relevance

Chaga · 2008 · Research Support, Non U.S. Gov'T · Current microbiology

Identification of Inonotus obliquus and analysis of antioxidation and antitumor activities of polysaccharides.

Inonotus obliquus, a wild wood-decay fungus which grows on Betula trees in cool climates, has a variety of biological activities that the scientific community is paying more and more attention to. However, the research work is moving at a snail's pace..

OncologyImmune supportEnergy & fatigueLiver support

Medium relevance

Turkey Tail · 2008 · Research Support, Non U.S. Gov'T · Journal of hazardous materials

Impact assessment of bisphenol A on lignin-modifying enzymes by basidiomycete Trametes versicolor.

The impact of different concentrations of bisphenol A (BPA) was evaluated on growth of the white-rot basidiomycete, Trametes versicolor, and on the expression of genes encoding lignin-modifying enzyme (LME) activities..

Medium relevance

Yellow Morel · 2008 · Research Support, Non U.S. Gov'T · Journal of industrial microbiology & biotechnology

Influence of the carbon source on the growth and lignocellulolytic enzyme production by Morchella esculenta strains.

Growth and lignocellulolytic enzymes production by two Morchella esculenta strains (BAFC 1728 and BEL 124) growing in solid state fermentation using different lignocellulosic materials along 58 days was characterized..

Medium relevance

Snow Fungus · 2008 · Research Support, Non U.S. Gov'T · Current microbiology

Inhibition of bacterial quorum sensing-regulated behaviors by Tremella fuciformis extract.

Quorum sensing (QS), or the control of gene expression in response to cell density, is used by both gram-negative and gram-positive bacteria to regulate a variety of physiological functions. Increasing evidence implies that certain eukaryotes produce QS-inhibitory compounds..

Medium relevance

Mesima · 2008 · Research Support, Non U.S. Gov'T · Biological & pharmaceutical bulletin

Inhibitory Constituents of Aldose Reductase in the Fruiting Body of Phellinus linteus

In an effort to characterize active principles for diabetic complication from medicinal mushroom, aldose reductase inhibitors were isolated from the fruiting body of Phellinus linteus and identified as hispidin (5), phelligridimer A (6), davallialactone (7), methyldavallialactone (8), hypholomine B (9), interfungins A….

Metabolic health

Medium relevance

Maitake · 2008 · Research Support, Non U.S. Gov'T · The American journal of Chinese medicine

Inhibitory Effect of TNF-alpha Produced by Macrophages Stimulated with Grifola frondosa Extract (ME) on the Growth of Influenza A/Aichi/2/68 Virus in MDCK Cells.

We investigated the inhibitory effect of the conditioned medium (CM) from P338D1 (D1) cells, a murine macrophage cell line, stimulated for 10 hours with a fixed dose (100 mug/ml) of the extracts from the fruit bodies of Grifola frondosa (ME) or its ultra filtration-based fractions (MFs), on the growth of influenza….

Immune supportRespiratory

Medium relevance

Enoki · 2008 · Research Support, Non U.S. Gov'T · FEMS microbiology letters

Isolation and characterization of a gene coding for chitin deacetylase specifically expressed during fruiting body development in the basidiomycete Flammulina velutipes and its expression in the yeast Pichia pastoris.

Fv-pda, a gene coding for chitin deacetylase (CDA), was isolated from the basidiomycete Flammulina velutipes by differential display targeted for genes specifically expressed during fruiting body development. The fv-pda ORF comprises 250 amino acid residues and is interrupted by 10 introns..

Medium relevance

Chaga · 2008 · Research Support, Non U.S. Gov'T · European journal of medicinal chemistry

Lanostane-type triterpenoids from the sclerotia of Inonotus obliquus possessing anti-tumor promoting activity.

Two new lanostane-type triterpenoids, 1 and 2 besides two known lanostane-type triterpenoids, 3 and 4 were isolated from the sclerotia of Inonotus obliquus. Their structures were determined to be lanosta-8,23E-diene-3beta,22R,25-triol (1) and lanosta-7:9(11),23E-triene-3beta,22R,25-triol (2) by spectral data..

OncologySkin & hydration

Medium relevance

Niu-Chang-Chih · 2008 · Patent · journal metadata

LIVER PROTECTION COMPOUNDS OF THE CYCLOHEXENONE TYPE FROM ANTRODIA CAMPHORATA

The present invention relates to a compound of Antrodia camphorata used for liver protection, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone which is isolated from Antrodia camphorate..

Liver support

Medium relevance

Turkey Tail · 2008 · Research Support, Non U.S. Gov'T · Chemosphere

Mechanistics of trichloroethylene mineralization by the white-rot fungus Trametes versicolor.

The white-rot fungus Trametes versicolor degraded trichloroethylene (TCE), a highly oxidized chloroethene, and produced 2,2,2-trichloroethanol and carbon dioxide as the main products of degradation, based on the results obtained using [13C]-TCE as the substrate..

Medium relevance

Zhu Ling · 2008 · Research Support, Non U.S. Gov'T · Bioorganic & medicinal chemistry letters

New anti-inflammatory ergostane-type ecdysteroids from the sclerotium of Polyporus umbellatus.

Bioassay-guided fractionation of the ethyl acetate extract from the sclerotium of Polyporus umbellatus resulted in the isolation of three new ergostane-type ecdysteroids, named polyporoid A (1), B (2), and C (3), together with five known ecdysteroids..

Immune support

Medium relevance

Niu-Chang-Chih · 2008 · Patent · journal metadata

NOVEL ANTI-FATIGUE CYCLOHEXENONE COMPOUNDS FROM ANTRODIA CAMPHORATA

The present invention relates to a compound of Antrodia camphorata used to delay physiological fatigue, in particular to a extract isolated from Antrodia camphorata4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone, and its use in delaying fatigue..

Energy & fatigue

Medium relevance

Niu-Chang-Chih · 2008 · Patent · journal metadata

NOVEL CYCLOHEXENONE COMPOUNDS FROM ANTRODIA CAMPHORATA AND APPLICATION THEREOF

A cyclohexenone compound is provided to suppress the growth of cancer cells such as breast cancer, liver cancer, and prostatic cancer, and to ensure antioxidant activities..

OncologyEnergy & fatigueLiver support

Medium relevance

Niu-Chang-Chih · 2008 · Patent · journal metadata

Novel diterpenes from the fruiting body of Antrodia camphorata and pharmaceutical compositions thereof

The present invention relates to novel diterpene compounds isolated from the fruiting body of Antrodia camphorata, especially to the new compounds of following structural formula: and pharmaceutically acceptable salt, solvate, hydrate or biologically active equivalent thereof..

Cognition & nerves

Medium relevance

Niu-Chang-Chih · 2008 · Research Support, Non U.S. Gov'T · International immunopharmacology

Polysaccharides from Antrodia camphorata mycelia extracts possess immunomodulatory activity and inhibits infection of Schistosoma mansoni.

Antrodia camphorata (AC) is a commonly used fungus in folk medicine for the treatment of viral hepatitis and cancer. AC polysaccharides (AC-PS) are reported to possess anti-inflammatory, anti-hepatitis B virus, and anticancer activities..

OncologyImmune supportLiver supportRespiratory

Medium relevance

Turkey Tail · 2008 · Research Support, Non U.S. Gov'T · Bulletin of environmental contamination and toxicology

Prediction of biodegradation rate constants of hydroxylated polychlorinated biphenyls by fungal laccases from Trametes versicolor and Pleurotus ostreatus.

Quantitative structure-activity relationship (QSAR) models for fungal laccase-catalyzed degradation of different hydroxylated polychlorinated biphenyls (OH-PCBs) were developed using some fundamental quantum chemical descriptors..

Energy & fatigue

Medium relevance

Mesima · 2008 · Research Support, Non U.S. Gov'T · Biological & pharmaceutical bulletin

Protein Glycation Inhibitors from the Fruiting Body of Phellinus linteus

To characterize active principles for prevention and treatment of diabetic complications, the isolation of protein glycation inhibitors from the fruiting body of Phellinus linteus was conducted in vitro using the model systems of hemoglobin-delta-gluconolactone (early stage), bovine serum albumin-methylglyoxal (middle….

Metabolic health

Medium relevance

Maitake · 2008 · Research Support, Non U.S. Gov'T · Microbiology (Reading, England)

Protein HGFI from the edible mushroom Grifola frondosa is a novel 8 kDa class I hydrophobin that forms rodlets in compressed monolayers.

Hydrophobins are a group of low-molecular-mass, cysteine-rich proteins that have unusual biophysical properties. They are highly surface-active and can self-assemble at hydrophobic-hydrophilic interfaces, forming surface layers that are able to reverse the hydropathy of surfaces..

Medium relevance

Turkey Tail · 2008 · Research Support, Non U.S. Gov'T · Biotechnology letters

Purification of recombinant laccase from Trametes versicolor in Pichia methanolica and its use for the decolorization of anthraquinone dye.

A recombinant laccase from Trametes versicolor in Pichia methanolica was produced constitutively in a defined medium. The recombinant laccase was purified using ultrafiltration, anion-exchange chromatography, and gel filtration.

Medium relevance

Wood Ear · 2008 · Research Support, Non U.S. Gov'T · Biopolymers

Structure and chain conformation of beta-glucan isolated from Auricularia auricula-judae.

From Auricularia auricula-judae, a water soluble beta-D-glucan, named as AAG, was isolated by extraction with 70% ethanol/water solution. Its chemical structure was analyzed by gas chromatography (GC), gas chromatography-mass spectrometry (GC-MS), matrix-assisted laser desorption /ionization (MALDI)-time of flight….

Immune support

Medium relevance

Maitake · 2008 · Research Support, Non U.S. Gov'T · Bioresource technology

Study of mycelial growth and bioactive polysaccharide production in batch and fed-batch culture of Grifola frondosa.

The fermentation of Grifola frondosa was investigated in the shake flasks and a 5-L jar fermenter in batch and fed-batch modes. In the shake-flask experiments, the preferable mycelial growth and exopolysaccharide (EPS) production was observed at relatively low pH; maltose and glucose were preferred carbon sources for….

Immune supportMetabolic health

Medium relevance

Mesima · 2008 · Patent · journal metadata

THE METHOD FOR MAKING AGING MEAT USING PHELLINUS LINTEUS AND PRODUCT THEREOF

All kinds of meats which are ripened with the Phellinus yucatensis are provided to remove bad smell of meats and improve all kinds of the minerals and amino acid and reduce the cholesterol of the meat and help the prevention of adult chronic disease by the active ingredient of the phellinus yucatensis, fomes….

Metabolic health

Medium relevance

Turkey Tail · 2008 · Research Support, Non U.S. Gov'T · Journal of the Society for Integrative Oncology

Trametes versicolor mushroom immune therapy in breast cancer.

Data from multiple epidemiologic and clinical studies on immune effects of conventional cancer treatment and the clinical benefits of polysaccharide immune therapy suggest that immune function has a role in breast cancer prevention..

OncologyImmune support

Medium relevance

Enoki · 2008 · Research Support, Non U.S. Gov'T · Journal of applied genetics

Use of inter-simple sequence repeat markers to develop strain-specific SCAR markers for Flammulina velutipes.

In this paper, we report for the first time on authentication of Flammulina velutipes cultivars by using strain-specific sequence-characterized amplified region (SCAR) markers developed from inter-simple sequence repeat (ISSR) markers. The genomic DNA polymorphism was analyzed by the ISSR technique in 7 strains of F..

Medium relevance

Maitake · 2007 · Research Support, Non U.S. Gov'T · Mikrobiologiia

[Isolation and characterization of lectin from the surface of Grifola frondosa (FR.) S.F. Gray mycelium].

For the first time, from the surface of the dikaryotic mycelium of the xylotrophic basidiomycete Grifola frondosa 0917 a lectin has been isolated with a molecular mass of 68 +/- 1 kDa, consisting of two subunits of 33-34 kDa each. The lectin is a hydrophilic glycoprotein with the protein: glycan ratio of 3: 1..

Immune supportMetabolic health

Medium relevance

Zhu Ling · 2007 · English Abstract · Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

[The extraction and sulfation of polysaccharide from Polyporus umbellatus].

OBJECTIVE: To prepare and sulfate of polysaccharide from Polyporus umbellatus, and to compare the results of joined dispersant or not. METHODS: After purified, SEC-LLS was used to determine the molecular weight of polysaccharide.

Immune support

Medium relevance

Niu-Chang-Chih · 2007 · Research Support, Non U.S. Gov'T · Journal of biotechnology

A highly stable cambialistic-superoxide dismutase from Antrodia camphorata: expression in yeast and enzyme properties.

A cDNA encoding a putative superoxide dismutase (SOD) was identified in expressed sequence tags of Antrodia camphorata, a medicinal mushroom found only in Taiwan. The deduced protein was aligned with Mn-SODs and Fe-SODs from other organisms, this SOD showed greater homology to Mn-SOD.

Immune supportSkin & hydration

Medium relevance

Niu-Chang-Chih · 2007 · Research Support, Non U.S. Gov'T · Planta medica

A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata.

Antroquinonol ( 1), an ubiquinone derivative, was isolated from the solid-state fermented mycelium of Antrodia camphorata (Polyporaceae, Aphyllophorales), a parasitic fungus indigenous to Taiwan. The structure of compound 1 was elucidated by the analysis of their spectroscopic data..

OncologyLiver support

Medium relevance

Niu-Chang-Chih · 2007 · Research Support, Non U.S. Gov'T · Journal of natural products

Anti-inflammatory benzenoids from Antrodia camphorata.

Four new compounds, including three new benzenoids, antrocamphin A (1), antrocamphin B (2), and 2,3,4,5-tetramethoxybenzoyl chloride (3), and a new 1,3-dioxolan-2-one derivative, antrodioxolanone (4), together with 13 known compounds have been isolated from the fruiting body of Antrodia camphorata..

Immune support

Medium relevance

Niu-Chang-Chih · 2007 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Antrodia camphorata extract induces replicative senescence in superficial TCC, and inhibits the absolute migration capability in invasive bladder carcinoma cells.

The Antrodia camphorata crude extract (ACCE), an extract obtained from a precious traditional Chinese folkloric herbal medicine Zhan-Ku (a camphor tree mushroom) since the 18th century, has showed rather significant inhibitory effects on the growth and proliferation of the transitional cell carcinomas (TCC) cell lines….

Oncology

Medium relevance

Niu-Chang-Chih · 2007 · Research Support, Non U.S. Gov'T · Applied microbiology and biotechnology

Biochemical characterization of a novel 2-Cys peroxiredoxin from Antrodia camphorata.

Peroxiredoxins (Prxs) play important roles in antioxidation and cell signaling. A gene encoding a novel 2-Cys Prx was identified based on sequence homology in an expressed sequence tag database of the Antrodia camphorata, a medicinal mushroom found only in Taiwan..

Gut & microbiome

Medium relevance

Maitake · 2007 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Chemical characteristics and immuno-modulating activities of exo-biopolymers produced by Grifola frondosa during submerged fermentation process.

The immuno-modulating activities and chemical characteristics of exo-biopolymer (EX-GF) produced by a submerged mycelial culture of Grifola frondosa were studied. The EX-GF was fractionated into EX-GF-Fr.I, II, and III by Sephadex G-100 gel chromatography..

Immune support

Medium relevance

Niu-Chang-Chih · 2007 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Chemical characterization and anti-inflammatory effect of polysaccharides fractionated from submerge-cultured Antrodia camphorata mycelia.

Five polysaccharide fractions (AC-1, AC-2, AC-3, AC-4, and AC-5) were obtained after systemic solvent extractions and precipitations from Antrodia camphorata mycelia with yields of 2.92, 10.38, 1.65, 0.34, and 1.64%, respectively..

Immune supportMetabolic health

Medium relevance

Turkey Tail · 2007 · Research Support, Non U.S. Gov'T · Canadian journal of microbiology

Decoloration of Amaranth by the white-rot fungus Trametes versicolor. Part II. Verification study.

The involvement of lignin peroxidase (LiP) in the decoloration of the mono-azo substituted napthalenic dye Amaranth was investigated with pure enzymes and whole cultures of Trametes versicolor..

Energy & fatigue

Medium relevance

Snow Fungus · 2007 · Research Support, Non U.S. Gov'T · Biological & pharmaceutical bulletin

Effect of Tremella fuciformis on the Neurite Outgrowth of PC12h Cells and the Improvement of Memory in Rats

We investigated the neuritogenic effects of Tremella fuciformis (TF), which has been valued in traditional Chinese medicine as a remedy with nutritive and tonic actions, on PC12h cells..

Immune supportCognition & nervesEnergy & fatigue

Medium relevance

Chaga · 2007 · Research Support, Non U.S. Gov'T · Journal of medicinal food

Ethanol extract of Inonotus obliquus inhibits lipopolysaccharide-induced inflammation in RAW 264.7 macrophage cells.

Inonotus obliquus (Pers.:Fr.) Pil. is a white rot fungus that belongs to the family Hymenochaetaceae of Basidiomycetes.

OncologyImmune supportEnergy & fatigue

Medium relevance

Niu-Chang-Chih · 2007 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Evaluation of the anti-inflammatory and anti-proliferation tumoral cells activities of Antrodia camphorata, Cordyceps sinensis, and Cinnamomum osmophloeum bark extracts.

The extracts of chloroform (1) and methanol (2) from Antrodia camphorata (AC), and chloroform (3) and n-butanol (4) fractions of methanol extract from Cordyceps sinensis (CS), and hexane (5), ethyl acetate (6), and methanol (7) from Cinnamomum osmophloeum bark (CO) were evaluated for their anti-inflammatory as well as….

OncologyImmune supportGut & microbiome

Medium relevance

Turkey Tail · 2007 · Research Support, Non U.S. Gov'T · Chemosphere

Exoenzymes of Trametes versicolor can metabolize coplanar PCB congeners and hydroxy PCB.

Two fractions containing the oxidase activity toward 2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonate) (ABTS) were obtained using ion-exchange DEAE-Sepharose column chromatography of the culture fluid of white-rot fungus, Trametes versicolor..

Medium relevance

Turkey Tail · 2007 · Research Support, Non U.S. Gov'T · Journal of microbiology (Seoul, Korea)

Generation of a transformant showing higher manganese peroxidase (Mnp) activity by overexpression of Mnp gene in Trametes versicolor.

Trametes versicolor has a lignin degrading enzyme system, which is also involved in the degradation of diverse recalcitrant compounds. Manganese-dependent peroxidase (MnP) is one of the lignin degrading enzymes in T.

Medium relevance

Lion's Mane · 2007 · Patent · journal metadata

Hericium erinaceus tea and its preparation method

A health-care hericium erinaceus tea for improving immunity, regulating the action of immune globulin, and preventing and treating the diseases in digestive tract is prepared from hedgehog hydnum, tea, ganoderma, champignon, edible fungus and liquiorice root through immersing, decocting, filtering, concentrating,….

Immune supportGut & microbiome