MycoData

BACKGROUND/AIM: Flammulina velutipes (FV), also known as the golden needle mushroom, is an edible and medicinal fungus that contains bioactive substances regulating various physiological functions..

OncologyImmune support

High relevance

Reishi · 2023 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Inhibitory effects of Ganoderma lucidum spore oil on rheumatoid arthritis in a collagen-induced arthritis mouse model.

Holistic healthcare practitioners have now started to focus on specific traditional medicinal mushrooms to treat rheumatoid arthritis (RA). Ganoderma lucidum (GL) is one of the oldest mushrooms that have been used in ancient Chinese medicine to treat inflammatory ailments, including autoimmune diseases such as RA..

OncologyImmune supportSkin & hydration

High relevance

Reishi · 2023 · Journal Article · American journal of translational research

Inhibitory effects of Ganoderma lucidum triterpenoid on the growth and metastasis of hepatocellular carcinoma.

OBJECTIVE: To investigate the inhibitory effects and mechanisms of triterpenoids from Ganoderma lucidum (G. lucidum triterpenoids) on the growth and metastasis of hepatocellular carcinoma (HCC) both in vitro and in vivo.

OncologyImmune supportLiver support

High relevance

Shiitake · 2023 · Research Article · BMC complementary medicine and therapies

Lentinula Edodes Mycelia extract regulates the function of antigen-presenting cells to activate immune cells and prevent tumor-induced deterioration of immune function.

Immune cell activation is essential for cancer rejection; however, the tumor microenvironment leads to deterioration of immune function, which enables cancer cells to survive and proliferate..

OncologyImmune support

High relevance

Chaga · 2023 · Research Article · AMB Express

Lignin-degrading enzymes from a pathogenic canker-rot fungus Inonotus obliquus strain IO-B2.

Inonotus obliquus is a pathogenic fungus found in living trees and has been widely used as a traditional medicine for cancer therapy. Although lignocellulose-degrading enzymes are involved in the early stages of host infection, the parasitic life cycle of this fungus has not been fully understood..

Oncology

High relevance

Lion's Mane · 2023 · Journal Article · Natural product research

New benzaldehyde derivatives from the fruiting bodies of Hericium erinaceus with cytotoxic activity.

Four new natural compounds named hericenone O (1), hericenone P (2), hericenone Q (3), and hericenone R (4), two of them were reported synthetically (3-4), together with eleven known compounds were isolated from the fruiting bodies of Hericium erinaceus..

OncologyCognition & nerves

High relevance

Reishi · 2023 · Journal Article · Natural product research

Nor-triterpenoids from the fruiting bodies of Ganoderma lucidum and their inhibitory activity against FAAH.

Two new nor-triterpenoids ganodrenol A (1), B (2), and a new natural product ganodrenol C (3), along with three known nor-triterpenoids (4-6) were isolated from the fruiting bodies of Ganoderma lucidum..

Oncology

High relevance

Reishi · 2023 · Research Article · Frontiers in microbiology

Optimization of chemical conditions for metabolites production by Ganoderma lucidum using response surface methodology and investigation of antimicrobial as well as anticancer activities.

Ganoderma lucidum (G. lucidum) is a medicinal mushroom that is known for its ability to produce compounds with physiological effects on human health.

OncologyImmune supportMetabolic health

High relevance

Snow Fungus · 2023 · Research Article · International journal of oncology

Overcharged lipid metabolism in mechanisms of antitumor by Tremella fuciformis‑derived polysaccharide.

Tremella fuciformis‑derived polysaccharide (TFP) is a natural macromolecular compound that is well known for whitening skin, as well as for its ability to regulate lipids and immunity. However, its mechanism of action is not clear..

OncologyImmune supportMetabolic healthSkin & hydration

High relevance

Almond Mushroom · 2023 · Journal Article · International journal of biological macromolecules

Pentacyclic triterpene-loaded emulsion stabilized by Agaricus blazei Murill polysaccharides: Factorial design and cytoprotection study.

In this study, pentacyclic triterpene-loaded emulsions were stabilized by polysaccharides from Agaricus blazei Murill mushroom (PAb). The drug-excipient compatibility results by Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) showed the absence of physicochemical….

OncologyImmune supportEnergy & fatigue

High relevance

Chaga · 2023 · Journal Article · Microbial pathogenesis

Polysaccharide from fermented mycelium of Inonotus obliquus attenuates the ulcerative colitis and adjusts the gut microbiota in mice.

Ulcerative colitis (UC) is a disease characterized by chronic inflammation of the colon. Polysaccharides not only have biological activities but also can regulate gut microbiota to alleviate the symptoms of UC..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Enoki · 2023 · Journal Article · International journal of biological macromolecules

Polysaccharide from Flammulina velutipes residues protects mice from Pb poisoning by activating Akt/GSK3β/Nrf-2/HO-1 signaling pathway and modulating gut microbiota.

Lead (Pb) can cause damages to the brain, liver, kidney, endocrine and other systems. Flammulina velutipes residues polysaccharide (FVRP) has been reported to exhibit anti-heavy metal toxicity on yeast, but its regulating mechanism is unclear..

OncologyImmune supportCognition & nervesGut & microbiome

High relevance

Cordyceps · 2023 · Research Article · Frontiers in immunology

Potential bioactivities via anticancer, antioxidant, and immunomodulatory properties of cultured mycelial enriched β-D-glucan polysaccharides from a novel fungus Ophiocordyceps sinensis OS8.

BACKGROUND: Ophiocordyceps sinensis is well-known worldwide as a traditional medicine. An alternative natural source of O.

OncologyImmune supportGut & microbiome

High relevance

Shiitake · 2023 · Journal Article · Journal of the science of food and agriculture

Preventive and synbiotic effects of the soluble dietary fiber obtained from Lentinula edodes byproducts and Lactobacillus plantarum LP90 against dextran sulfate sodium-induced colitis in mice.

BACKGROUND: Soluble dietary fiber (SDF) obtained from Lentinula edodes byproducts has beneficial effects on human intestinal health. This study aimed to examine the combined preventive and ameliorative effects of a kind of synbiotic (SDF with a molecular weight of 1.58 × 102 kDa and Lactobacillus plantarum LP90 (LP)….

OncologyImmune supportGut & microbiome

High relevance

Reishi · 2023 · Journal Article · Frontiers in bioscience (Landmark edition)

Protective Effect of Ganoderma lucidum Spore Powder on Acute Liver Injury in Mice and its Regulation of Gut Microbiota.

BACKGROUND: Ganoderma lucidum spore powder (GLSP) has abundant pharmacological activities. However, the difference in the hepatoprotective function of sporoderm-broken and sporoderm-unbroken Ganoderma spore powder has not been studied..

OncologyImmune supportGut & microbiomeLiver support

High relevance

Shiitake · 2023 · Research Article · RSC advances

Pyrrole alkaloids from the fruiting bodies of edible mushroom Lentinula edodes.

Nine pyrrole alkaloid derivatives, including four new ones (1-4), were isolated from the wild mushroom Lentinula edodes for the first time. Their chemical structures were determined using UV-Vis spectroscopy, IR spectroscopy, MS, NMR spectroscopy, and single-crystal X-ray diffraction techniques..

OncologyImmune supportLiver support

High relevance

Reishi · 2023 · Journal Article · International journal of biological macromolecules

Significance of culture period on the physiochemistry and anti-cancer potentials of polysaccharides from mycelia of Ganoderma lucidum.

Ganoderma lucidum polysaccharides (GPS) have many functions. Polysaccharides are abundant in G.

OncologyImmune supportMetabolic healthSkin & hydration

High relevance

Reishi · 2023 · Journal Article · International journal of biological macromolecules

The role of post-transcriptional modification on a new tRNAIle(GAU) identified from Ganoderma lucidum in its fragments' cytotoxicity on cancer cells.

Ganoderma lucidum (Ganoderma) is a famous Chinese herbal medicine which has been used clinically for thousands of years in China. Despite numerous studies on triterpenes and polysaccharides, the bioactivity of RNAs abundant in Ganoderma remains unknown..

OncologyImmune support

High relevance

Reishi · 2023 · Journal Article · Journal of ethnopharmacology

Toxicogenic effects of the mushroom Ganoderma lucidum on human liver and kidney tumor cells and peripheral blood lymphocytes.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (Curtis) P. Karst., a bioactive mushroom with medicinal properties, is known to exert immunomodulatory, anti-inflammatory, hypocholesterolemic, hypoglycemic, and hepatoprotective effects.

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Snow Fungus · 2023 · Research Article · Molecules (Basel, Switzerland)

Tremella fuciformis Polysaccharide Induces Apoptosis of B16 Melanoma Cells via Promoting the M1 Polarization of Macrophages.

Anti-tumor activity of Tremella fuciformis polysaccharides (TFPS) has been widely reported, but its mechanism remains poorly understood. In this study, we established an in vitro co-culture system (B16 melanoma cells and RAW 264.7 macrophage-like cells) to explore the potential anti-tumor mechanism of TFPS..

OncologyImmune support

High relevance

Snow Fungus · 2023 · Journal Article · Photochemical & photobiological sciences: Official journal of the European Photochemistry Association and the European Society for Photobiology

Tremella fuciformis polysaccharides alleviates UV-provoked skin cell damage via regulation of thioredoxin interacting protein and thioredoxin reductase 2.

INTRODUCTION: Skin is exposed to a wide range of environmental risk factors including ultraviolet (UV) and all kinds of pollutants. Excessive UV exposure contributes to many disorders, such as photoaging, skin inflammation, and carcinogenesis..

OncologyImmune supportEnergy & fatigueSkin & hydration

High relevance

Reishi · 2023 · Journal Article · Heliyon

Triterpenoids of Ganoderma lucidum inhibited S180 sarcoma and H22 hepatoma in mice by regulating gut microbiota

In order to explore effect of natural plant extracts on anti-tumor and prevent tumor development. The study assessed the antitumor effect of triterpenoids of Ganoderma lucidum (TGL) on S180 and H22 tumor bearing mice..

OncologyGut & microbiomeLiver support

High relevance

Reishi · 2023 · Research Article · Heliyon

Triterpenoids of Ganoderma lucidum inhibited S180 sarcoma and H22 hepatoma in mice by regulating gut microbiota.

OncologyGut & microbiomeLiver support

High relevance

Niu-Chang-Chih · 2023 · Research Article · Frontiers in pharmacology

Turicibacter fermentation enhances the inhibitory effects of Antrodia camphorata supplementation on tumorigenic serotonin and Wnt pathways and promotes ROS-mediated apoptosis of Caco-2 cells.

Introduction: Diet-induced obesity has been shown to decrease the abundance of Turicibacter, a genus known to play a role in the serotonin signaling system, which is associated with colorectal tumorigenesis, making the presence of Turicibacter potentially influential in the protection of intestinal tumorigenesis..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Enoki · 2023 · Journal Article · Journal of Asian natural products research

Two new sesquiterpenoids from plant endophytic fungus Flammulina velutipes.

Two new sesquiterpenoids, flammupin A (1) and flammupin B (2), along with two known compounds, enokipodin C (3) and 5,5'-dibuthoxy-2,2'-bifuran (4) were obtained from Flammulina velutipes, an endophytic fungus isolated from the roots of Caulophyllum robustum Maxim..

Oncology

High relevance

Reishi · 2023 · Research Article · Journal of fungi (Basel, Switzerland)

Unraveling the Polysaccharide Biosynthesis Potential of Ganoderma lucidum: A Chromosome-Level Assembly Using Hi-C Sequencing.

Ganoderma lucidum exhibits the ability to synthesize a diverse range of biologically active molecules with significant pharmaceutical potential, including xylomannan and fucogalactan, which have demonstrated antitumor activity..

OncologyImmune support

High relevance

Enoki · 2023 · Research Article · International journal of molecular sciences

Water Extract from Brown Strain of Flammulina velutipes Alleviates Cisplatin-Induced Acute Kidney Injury by Attenuating Oxidative Stress, Inflammation, and Autophagy via PI3K/AKT Pathway Regulation.

One of the most popular edible mushrooms in the world, Flammulina velutipes, has been shown to possess pharmacological properties such as anti-inflammatory and antioxidant properties. However, the potential activity of the brown strain of F..

OncologyImmune support

High relevance

Maitake · 2022 · Journal Article · International journal of biological macromolecules

A cold-water polysaccharide-protein complex from Grifola frondosa exhibited antiproliferative activity via mitochondrial apoptotic and Fas/FasL pathways in HepG2 cells.

Grifola frondosa (G. frondosa) is widely known for its anti-tumor potential, which has been demonstrated by numerous scientific researches.

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Lion's Mane · 2022 · Research Article · Oxidative medicine and cellular longevity

A Mixture of Ginkgo biloba L. Leaf and Hericium erinaceus (Bull.) Pers. Fruit Extract Attenuates Scopolamine-Induced Memory Impairments in Mice.

Alzheimer's disease (AD) is a neurodegenerative disease that is characterized by loss of memory and cognitive impairment via dysfunction of the cholinergic nervous system..

OncologyCognition & nerves

High relevance

Oyster Mushroom · 2022 · Journal Article · International journal of biological macromolecules

A natural selenium polysaccharide from Pleurotus ostreatus: Structural elucidation, anti-gastric cancer and anti-colon cancer activity in vitro.

The development and application of new natural selenium polysaccharides with relatively clear structure and excellent activity have become hot and difficult issues..

OncologyImmune supportGut & microbiome

High relevance

Niu-Chang-Chih · 2022 · Research Article · Molecules (Basel, Switzerland)

Anti-Inflammatory Constituents of Antrodia camphorata on RAW 264.7 Cells Induced by Polyinosinic-Polycytidylic Acid.

Antrodia camphorata is an endemic mushroom in Taiwan. This study was designed to screen anti-inflammatory compounds from the methanolic extract of the mycelium of A..

OncologyImmune supportRespiratory

High relevance

Reishi · 2022 · Research Article · International journal of molecular sciences

Anticancer and Antioxidant Activities in Ganoderma lucidum Wild Mushrooms in Poland, as Well as Their Phenolic and Triterpenoid Compounds.

The goal of this study was to the assess anti-cancer and antioxidant properties of the Ganoderma lucidum fruiting body, and to identify bioactive compounds found in their extracts. Significant antiproliferative activity was observed against MCF-7, MCF-7/DX, LOVO, LOVO/DX, MDA-MB 231, SW 620, and NHDF cell lines..

Oncology

High relevance

Oyster Mushroom · 2022 · Journal Article · International journal of medicinal mushrooms

Anticancer Properties of Selenium-Enriched Oyster Culinary-Medicinal Mushroom, Pleurotus ostreatus (Agaricomycetes), in Colon Cancer In Vitro.

Mushrooms have become an important way to safely supply the body with the daily needs of organic selenium and they also possess remarkable medicinal properties. In this study, we examined the ability of the Pleurotus ostreatus mushroom to grow in selenium (Se) and its ability to accumulate and convert Se from….

OncologyImmune supportGut & microbiome

High relevance

Reishi · 2022 · Journal Article · Carbohydrate polymers

Antimelanoma effect of a fucoxylomannan isolated from Ganoderma lucidum fruiting bodies.

A fucoxylomannan (FXM) was isolated from the mushroom Ganoderma lucidum through alkaline extraction followed by dialysis, freeze-thawing, and fractionation by Fehling's solution..

OncologyImmune supportGut & microbiome

High relevance

Lion's Mane · 2022 · Journal Article · International journal of medicinal mushrooms

Aqueous Extracts of Pleurotus ostreatus and Hericium erinaceus Protect against Ultraviolet A-Induced Damage in Human Dermal Fibroblasts.

Pleurotus ostreatus (PO) and Hericium erinaceus (HE) have been traditionally used to treat various diseases, owing to their antioxidant, antimicrobial, neuroprotective, and antitumor effects. However, few studies have been reported on their antiaging effects..

OncologyImmune supportCognition & nervesSkin & hydration

High relevance

Yellow Morel · 2022 · Journal Article · International journal of medicinal mushrooms

Bioactive Extract of Morel Mushroom, Morchella esculenta (Ascomycota) Attenuates Doxorubicin-Induced Oxidative Stress Leading to Myocardial Injury.

Doxorubicin (DOX) is an extensively used anticancer drug for chemotherapy. Cardiotoxicity induced by DOX is an impediment in its clinical use.

OncologyEnergy & fatigue

High relevance

Shiitake · 2022 · Research Article · BMC genomics

Chromosomal genome and population genetic analyses to reveal genetic architecture, breeding history and genes related to cadmium accumulation in Lentinula edodes.

BACKGROUND: Lentinula edodes (Berk.) is the second most productive mushroom in the world. It contains compounds effective for antiviral, antitumor, antioxidant and immune regulation.

OncologyImmune supportRespiratory

High relevance

Reishi · 2022 · Journal Article · International journal of medicinal mushrooms

Cytotoxicity of Medicinal Mushrooms Oudemansiella canarii and Ganoderma lucidum (Agaricomycetes) Against Hematologic Malignant Cells via Activation of Apoptosis-Related Markers.

Cancer is the second leading cause of death worldwide, and despite of the of the availability of the advanced chemical treatments, development of effective and safe alternatives derived from natural resources are still of high interest..

OncologyEnergy & fatigue

High relevance

Chaga · 2022 · Research Article · Nutrients

Effect of Inonotus obliquus Extract Supplementation on Endurance Exercise and Energy-Consuming Processes through Lipid Transport in Mice.

Inonotus obliquus (IO) is used as functional food to treat diabetes. This study investigated the effect of IO supplementation on body composition in relation to changes in energy expenditure and exercise performance..

OncologyEnergy & fatigueMetabolic health

High relevance

Reishi · 2022 · Journal Article · BioMed research international

Effects and Mechanism of Ganoderma lucidum Polysaccharides in the Treatment of Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats.

Ganoderma lucidum polysaccharides (GLP) have renal protection effect but there was no study on the diabetic nephropathy. This study was designed to investigate its effect and mechanism using a diabetic rat model induced by streptozotocin (50 mg/kg, i.p.)..

OncologyImmune supportMetabolic health

High relevance

Shiitake · 2022 · Research Article · Bioengineering (Basel, Switzerland)

Enhanced Effects of Iron on Mycelial Growth, Metabolism and In Vitro Antioxidant Activity of Polysaccharides from Lentinula edodes.

The polysaccharides found in Lentinula edodes have a variety of medicinal properties, such as anti-tumor and anti-viral effects, but their content in L. edodes sporophores is very low.

OncologyImmune supportMetabolic healthRespiratory

High relevance

Mesima · 2022 · Research Article · Journal of nanobiotechnology

Exosome-like nanovesicles derived from Phellinus linteus inhibit Mical2 expression through cross-kingdom regulation and inhibit ultraviolet-induced skin aging.

BACKGROUND: Phellinus linteus (PL), which is a typical medicinal fungus, has been shown to have antitumor and anti-inflammatory activities. However, studies on the effect of anti-photoaging are limited..

OncologyImmune supportSkin & hydration

High relevance

Reishi · 2022 · Research Article · American journal of cancer research

Ganoderma lucidum enhances carboplatin chemotherapy effect by inhibiting the DNA damage response pathway and stemness.

Inflammatory Breast Cancer (IBC) is a rare and aggressive type of breast cancer with a poor prognosis. Its management is challenging because of a lack of targeted therapies, increased metastatic potential, and high recurrence rates..

OncologyImmune support

High relevance

Reishi · 2022 · Journal Article · Translational andrology and urology

Ganoderma lucidum polysaccharide ameliorated diabetes mellitus-induced erectile dysfunction in rats by regulating fibrosis and the NOS/ERK/JNK pathway.

BACKGROUND: Diabetes mellitus-induced erectile dysfunction (DMED) is a frequent complication of diabetes mellitus (DM), with limited therapy at present. This study aimed to explore the role and mechanism of Ganoderma lucidum polysaccharide (GLP) on DMED..

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Reishi · 2022 · Journal Article · Acta biochimica Polonica

Ganoderma lucidum polysaccharide inhibits the proliferation of leukemic cells through apoptosis.

OBJECTIVE: To investigate the cytotoxic effect of polysaccharides derived from Ganoderma lucidum on T lymphocyte leukemia cells. METHODS: Water-soluble polysaccharides were extracted from the fruit bodies of G.

OncologyImmune supportSkin & hydration

High relevance

Lion's Mane · 2022 · Journal Article · International journal of biological macromolecules

Gastroprotective activity of polysaccharide from the fruiting body of Hericium erinaceus against acetic acid-induced gastric ulcer in rats and structure of one bioactive fraction.

This study aimed at investigating gastroprotective activity of Hericium erinaceus polysaccharide (HEP) and characterizing one of its bioactive fractions. Acetic acid-induced gastric ulcer (GU) rat model was used to evaluate the gastroprotective activity of HEP, while H2O2-induced injury GES-1 cell model was conducted….

OncologyImmune supportSkin & hydration

High relevance

Chaga · 2022 · Research Article · BMC genomics

Genome sequencing of Inonotus obliquus reveals insights into candidate genes involved in secondary metabolite biosynthesis.

BACKGROUND: Inonotus obliquus is an important edible and medicinal mushroom that was shown to have many pharmacological activities in preclinical trials, including anti-inflammatory, antitumor, immunomodulatory, and antioxidant effects..

OncologyImmune supportMetabolic health

High relevance

Cordyceps · 2022 · Research Article · Mycology

Glyceroglycolipids from the solid culture of Ophiocordyceps sinensis strain LY34 isolated from Tibet of China.

Ophiocordyceps sinensis is a well-known entomogenous fungus with its fruiting bodies or cultural mycelium as food and herbal medicines in Asia. While metabolites which could responsible for its potent pharmaceutical effects has long remained to be elucidated..

OncologyImmune support

High relevance

Maitake · 2022 · Research Article · Nutrients

Grifola frondosa Extract Containing Bioactive Components Blocks Skin Fibroblastic Inflammation and Cytotoxicity Caused by Endocrine Disrupting Chemical, Bisphenol A.

Grifola frondosa (GF), a species of Basidiomycotina, is widely distributed across Asia and has been used as an immunomodulatory, anti-bacterial, and anti-cancer agent..

OncologyImmune supportEnergy & fatigueSkin & hydration

High relevance

Lion's Mane · 2022 · Research Article · Nutrients

Hericium erinaceus Mycelium Ameliorates In Vivo Progression of Osteoarthritis.

Osteoarthritis (OA) is an age-related disorder that affects the joints and causes functional disability. Hericium erinaceus is a large edible mushroom with several known medicinal functions.

OncologyImmune support