MycoData

Grifola frondosa is commercially produced year-round in large-scale facilities. However, the molecular mechanisms of fruiting body differentiation remain elusive, and understanding these mechanisms at the molecular genetic level is therefore important for improving the cultivation of this economically important….

Gut & microbiome

High relevance

Lion's Mane · 2014 · Research Article · Toxicology reports

Genotoxicity profile of erinacine A-enriched Hericium erinaceus mycelium.

Hericium erinaceus (H. erinaceus) has a long history of usage in traditional Chinese medicine for the treatment of gastric disorders.

Cognition & nervesGut & microbiome

High relevance

Niu-Chang-Chih · 2013 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Ethanol Extract of Antrodia camphorata Grown on Germinated Brown Rice Suppresses Inflammatory Responses in Mice with Acute DSS-Induced Colitis.

The anti-inflammatory activity of Antrodia camphorata (AC) grown on germinated brown rice (CBR) extract was evaluated in vitro and in vivo. CBR suppressed the release of nitric oxide (NO) and prostaglandin (PG) E2 from lipopolysaccharide-(LPS-)stimulated RAW264.7 cells..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Mesima · 2013 · Research Article · Journal of ginseng research

The bioavailability of red ginseng extract fermented by Phellinus linteus.

For the improvement of ginsenoside bioavailability, the ginsenosides of fermented red ginseng by Phellinus linteus (FRG) were examined with respect to bioavailability and physiological activity..

Gut & microbiomeSkin & hydration

High relevance

Enoki · 2012 · Journal Article · Animal science journal =

Effects of fermented mushroom (Flammulina velutipes) by‐product diets on growth performance and carcass traits in growing‐fattening Berkshire pigs

This study was conducted to investigate effects of fermented mushroom (Flammulina velutipes) by‐product diets on the growth performance and carcass traits in growing‐fattening Berkshire pigs..

Energy & fatigueMetabolic healthGut & microbiome

High relevance

Niu-Chang-Chih · 2012 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Inhibition of Cell Growth and Induction of Apoptosis by Antrodia camphorata in HER-2/neu-Overexpressing Breast Cancer Cells through the Induction of ROS, Depletion of HER-2/neu, and Disruption of the PI3K/Akt Signaling Pathway.

Previously, we demonstrated that a submerged fermentation culture of Antrodia camphorata (AC) promotes cell-cycle arrest and apoptosis in human estrogen receptor-positive/negative breast cancer cells. However, whether AC is effective against HER-2/neu-overexpressing breast cancers has not been thoroughly elucidated..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Lion's Mane · 2011 · Journal Article · Journal of agricultural and food chemistry

Composition and mechanism of antitumor effects of Hericium erinaceus mushroom extracts in tumor-bearing mice.

We investigated antitumor effects of the following four extracts of freeze-dried Hericium erinaceus mushrooms in Balb/c mice intracutaneously transplanted on the backs with CT-26 colon cancer cells: HWE, hot water extraction by boiling in water for 3 h; MWE, microwaving in 50% ethanol/water at 60 W for 3 min; and ACE….

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Mesima · 2009 · Journal Article · Food chemistry

Antioxidant properties of solid-state fermented adlay and rice by Phellinus linteus

Phellinus linteus (Berkeley & Curtis) Teng (Hymenochaetaceae) was inoculated into cooked grains, and new products were formed after the colonisation of fungal mycelia..

Gut & microbiome

High relevance

Mesima · 2009 · Research Article · Mycobiology

Antitumor Effects and Immunomodulating Activities of Phellinus linteus Extract in a CT-26 Cell-Injected Colon Cancer Mouse Model.

The antitumor effects of Phellinus linteus extract (Keumsa Linteusan) were investigated in a CT-26 cell-injected colon cancer mouse model. When administered orally (250~1,000 mg/kg body weight), Keumsa Linteusan significantly inhibited the growth of solid colon cancer..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Maitake · 2009 · Journal Article · Journal of agricultural and food chemistry

Characterization and antitumor effect of a novel polysaccharide from Grifola frondosa.

A novel polysaccharide, MZF, with a molecular mass of 23 kDa was isolated from Grifola frondosa. Results from methylation and (1)H NMR led to the conclusion that MZF is a heteropolysaccharide consisting of -->6)-alpha-D-Galp-(1--> (36.2%), -->3)-alpha-L-Fucp-(1--> (14.5%), -->6)-alpha-D-Manp-(1--> (9.4%),….

OncologyImmune supportGut & microbiome

High relevance

Chaga · 2009 · Journal Article · Journal of bioscience and bioengineering

Comparative study of antioxidant activity and antiproliferative effect of hot water and ethanol extracts from the mushroom Inonotus obliquus.

The medicinal mushroom Inonotus obliquus is a traditional and widely used multi-functional fungus. Hot water (50 degrees C, 70 degrees C, and 80 degrees C) and ethanol crude extracts of I..

OncologyImmune supportGut & microbiome

High relevance

Turkey Tail · 2009 · Journal Article · Wood Sci Technol

Effect of heat treatment on extracellular enzymatic activities involved in beech wood degradation by Trametes versicolor

Effect of heat treatment on extracellular enzymes involved in wood degradation by Trametes versicolor was investigated. Heat-treated and untreated beech blocks were exposed to T.

Gut & microbiome

High relevance

Turkey Tail · 2009 · Journal Article · Chemosphere

Interactions of Trametes versicolor, Coriolopsis rigida and the arbuscular mycorrhizal fungus Glomus deserticola on the copper tolerance of Eucalyptus globulus.

The presence of high levels of Cu in soil decreases the shoot and root dry weights of Eucalyptus globulus. However, higher plant tolerance of Cu has been observed in the presence of the arbuscular mycorrhizal (AM) fungus Glomus deserticola.

Metabolic healthGut & microbiome

High relevance

Mesima · 2008 · Journal Article · Fitoterapia

Composition and proposed structure of a water-soluble glycan from the Keumsa Sangwhang Mushroom (Phellinus linteus).

Phellinus linteus is a mushroom which has been prized in Korea for its medicinal properties since ancient times. A glycan preparation from this source has shown promise in experimental anti-tumour and metastasis studies, but the glycan has not been well characterized..

OncologyMetabolic healthGut & microbiome

High relevance

Mesima · 2008 · Research Article · Mycobiology

Cultural Characteristics and Log-Mediated Cultivation of the Medicinal Mushroom, Phellinus linteus.

The optimal conditions for mycelial growth of Phellinus linteus ATCC 26710 were determined to be a log length of 20 cm, temperature of 30℃ and pH of 6.0. Mycelial growth was excellent on the mushroom complete medium, and was optimal when sucrose, mannose and glucose were supplied as carbon sources..

Metabolic healthGut & microbiome

High relevance

Turkey Tail · 2008 · Journal Article · Wood Sci Technol

Effects of propiconazole on extra-cellular enzymes involved in nutrient mobilization during Trametes versicolor wood colonization

The effects of propiconazole on extra-cellular enzyme levels in Trametes versicolor have been investigated during wood colonization and degradation. The working hypothesis was that the biocide could alter metabolic pathways, which could lead to an alteration of extra-cellular enzyme production..

Immune supportMetabolic healthGut & microbiome

High relevance

Maitake · 2007 · Journal Article · Antiviral research

Isolation, identification and function of a novel anti-HSV-1 protein from Grifola frondosa.

A novel antiviral protein was purified from an extract of Grifola frondosa fruiting bodies using a procedure that included 40% ammonium sulfate precipitation and DEAE-cellulose ion exchange chromatography, and designated GFAHP..

Gut & microbiomeRespiratory

High relevance

Maitake · 2006 · Journal Article · World journal of microbiology & biotechnology

Effect of Nutritional Parameters on Laccase Production by the Culinary and Medicinal Mushroom, Grifola frondosa

Extracellular laccase in cultures of Grifola frondosa grown in liquid culture on a defined medium was first detectable in the early/middle stages of primary growth, and enzyme activity continued to increase even after fungal biomass production had peaked..

Gut & microbiome

High relevance

Niu-Chang-Chih · 2005 · Patent · journal metadata

A new extraction method and application of antrodia camphorata to reduce the damage from chemotherapy for cancer and enhance the erythropoiesis in bone marrow

We found a new extraction method and application of Antrodia camphorata in promoting and protecting the Erythropoiesis after the chemotherapy of cyclophosphamide..

OncologyGut & microbiome

High relevance

Mesima · 2005 · Comparative Study · Biological & pharmaceutical bulletin

Cambodian Phellinus linteus Inhibits Experimental Metastasis of Melanoma Cells in Mice via Regulation of Urokinase Type Plasminogen Activator

Phellinus linteus (PL) is a fungus mainly found in tropical America, Africa and Asian countries including Korea, Japan and China. PL has been traditionally used for the treatment of arthritis, liver damage and cancer..

OncologyGut & microbiomeLiver supportRespiratory

High relevance

Maitake · 2004 · Research Support, Non U.S. Gov'T · Yi chuan = Hereditas

[A method for preparation of genomic DNA from Grifola frondosa and construction of a genomic library].

Grifola frondosa, is a valuable medicinal fungus. High quality total genomic DNA is difficult to prepare due to its high polysaccharide content.

Immune supportGut & microbiome

High relevance

Mesima · 2004 · Patent · journal metadata

ANTICANCER AGENT CONTAINING POLYSACCHARIDE AND MITOMYCIN C EXTRACTED FROM PHELLINUS LINTEUS

PURPOSE: Provided is an anticancer agent containing polysaccharide that is galactomannoglucan and mitomycin C extracted from Phellinus linteus. It is useful for treatment of stomach cancer, breast cancer, colorectal cancer, large intestine cancer and the like..

OncologyImmune supportGut & microbiomeRespiratory

High relevance

Mesima · 2004 · Patent · journal metadata

EXTRACTION METHOD OF BETA-GLUCAN FROM PHELLINUS LINTEUS THROUGH CELL DESTRUCTION BY SUPERSONIC WAVE AND ENZYME FERMENTATION METHOD, THEREBY IMPROVING EXTRACTION EFFICIENCY OF BETA-GLUCAN AND OTHER USEFUL COMPONENTS

PURPOSE: An extraction method of beta-glucan from Phellinus linteus through cell destruction and enzyme fermentation method is provided, thereby improving extraction efficiency of beta-glucan and other useful components by making condition to easily digest a substrate by protease and cellulase..

Immune supportGut & microbiome

High relevance

Mesima · 2004 · Research Support, Non U.S. Gov'T · Cancer letters

Protein-bound polysaccharide from Phellinus linteus induces G2/M phase arrest and apoptosis in SW480 human colon cancer cells.

The cytotoxic mechanism of protein-bound polysaccharide isolated from Phellinus linteus (PL, Mesima) has been investigated. PL inhibited the proliferation and colony formation of SW480 human colon cancer cells.

OncologyImmune supportGut & microbiome

High relevance

Mesima · 2001 · Patent · journal metadata

MICROORGANISM PHELLINUS LINTEUS HAVING ANTIOXIDATION ACTIVITY

PURPOSE: A microorganism Phellinus linteus having an antioxidation activity is provided, which can be used as probiotics, beverage or food additives or adjuvants..

Gut & microbiome

Medium relevance

Turkey Tail · 2026 · Review · Chinese clinical oncology

Clinical evidence on a Coriolus versicolor-based vaginal gel for HPV-related cervical disease: a narrative review.

BACKGROUND AND OBJECTIVE: Human papillomavirus (HPV) infection is the most common sexually transmitted disease worldwide. Its persistence may lead to cervical dysplasia and, eventually, cervical cancer..

OncologyImmune supportGut & microbiomeRespiratory

Medium relevance

Reishi · 2025 · Review · NPJ science of food

Application of edible fungi in gut microbiota regulation.

The human gut microbiota serves as a critical hub for host metabolic and immune regulation. Disruption of its homeostasis is closely associated with diseases such as Inflammatory Bowel Disease (IBD), metabolic syndrome, and colorectal cancer..

OncologyImmune supportMetabolic healthGut & microbiome

Medium relevance

Cordyceps · 2025 · Research Support, Non U.S. Gov'T · Molecular nutrition & food research

Cordyceps-Fermented Chinese Jujube Ameliorates Oxidative Stress and Restores Gut Microbiome in Alcohol-Induced Liver Injury in Mice.

This research investigated the influence of Chinese jujube fermented with Cordyceps kyushuensis extracts on mice with alcohol-induced liver injury (ALI). Our findings highlighted the antioxidant properties of these extracts through various assays and demonstrated potential biochemical effects in ALI mice..

Immune supportMetabolic healthGut & microbiomeLiver support

Medium relevance

King Oyster · 2025 · Comparative Study · Molecules (Basel, Switzerland)

Hydrolytic Enzymes in the Secretome of the Mushrooms P. eryngii and P. ostreatus: A Comparison Between the Two Species.

The fungi belonging to the genus Pleurotus can be cultivated in different substrates and represent excellent producers of several extracellular enzymes. In this study, we analyzed eleven hydrolytic enzymes of the P.

Gut & microbiome

Medium relevance

Lion's Mane · 2025 · Review · Molecules (Basel, Switzerland)

Macromycete Edible Fungi as a Functional Poultry Feed Additive: Influence on Health, Welfare, Eggs, and Meat Quality-Review.

Over the years, macromycete fungi have been used as a source of food, part of religious rites and rituals, and as a medicinal remedy. Species with strong health-promoting potential include Hericium erinaceus, Cordyceps militaris, Ganoderma lucidum, Pleurotus ostreatus, Flammulina velutipes, and Inonotus obliquus..

Immune supportCognition & nervesMetabolic healthGut & microbiome

Medium relevance

Shiitake · 2025 · Research Support, U.S. Gov'T, Non P.H.S. · The Journal of nutrition

Shiitake Mushroom as a Wholefood Supplementation in a Western Diet Modulates the Gut Microbiome, Serotonergic System, and Wnt Signaling to Promote Gut Health in Mice.

BACKGROUND: A Western-style diet (WD), typically high in fat and low in fiber and certain micronutrients, has been linked to a range of chronic diseases through its impact on gut health. Mushrooms exhibit a distinct nutritional profile that complements the deficiencies commonly associated with a WD..

Metabolic healthGut & microbiome

Medium relevance

Shiitake · 2025 · Preprint · journal metadata

Valorization of mushroom by-products for sustainability: exploring antioxidant and prebiotic properties

Agaricus bisporus (white button mushroom), Pleurotus ostreatus (oyster mushroom), and Lentinula edodes (shiitake mushroom) are the most cultivated mushrooms in the Spanish region of Castilla-La Mancha..

Immune supportMetabolic healthGut & microbiome

Medium relevance

Reishi · 2023 · Journal Article · Archives of microbiology

Application of Miscanthus substrates in the cultivation of Ganoderma lingzhi.

Ganoderma lingzhi is a traditional Chinese medicine that has been used to improve health and longevity for thousands of years. It is usually cultivated on hardwood log- or sawdust-based formulations.

Immune supportGut & microbiome

Medium relevance

Reishi · 2023 · Journal Article · Wiadomosci lekarskie (Warsaw, Poland: 1960)

EFFECT OF DRY EXTRACT FROM REISHI MUSHROOMS ON THE STATE OF ANTIOXIDANT SYSTEM IN RATS WITH DMH-INDUCED COLON CARCINOGENESIS.

OBJECTIVE: The aim: To study pro- and antioxidant systems indicators in rats with chemically induced colon carcinogenesis on the background of the reishi mushrooms dry extract use. PATIENTS AND METHODS: Materials and methods: The study was performed on 120 white male rats..

Metabolic healthGut & microbiomeLiver support

Medium relevance

Reishi · 2023 · Research Article · Antioxidants (Basel, Switzerland)

The Addition of Reishi and Lion's Mane Mushroom Powder to Pasta Influences the Content of Bioactive Compounds and the Antioxidant, Potential Anti-Inflammatory, and Anticancer Properties of Pasta.

The influence of a 2.5% and 5% addition of dried Reishi and Lion's Mane mushrooms on the content of bioactive compounds and some pro-health properties of pasta was studied..

OncologyImmune supportEnergy & fatigueGut & microbiome

Medium relevance

Cordyceps · 2022 · Journal Article · The American journal of Chinese medicine

Cordyceps Improves Obesity and its Related Inflammation via Modulation of Enterococcus cecorum Abundance and Bile Acid Metabolism.

Dysbiotic gut microbiota has been identified as a primary mediator of inherent inflammation that underlies the pathogenesis of obesity. Cordyceps comprises the larval body and the stroma of Cordyceps sinensis (BerK.) Sacc.

Immune supportMetabolic healthGut & microbiomeLiver support

Medium relevance

Cordyceps · 2022 · Research Article · Frontiers in chemistry

In situ Chemical Profiling and Imaging of Cultured and Natural Cordyceps sinensis by TOF-SIMS.

Time-of-flight secondary ion mass spectrometry (TOF-SIMS) is a sensitive surface analytical technology, which can simultaneously acquire diverse chemical components and their precise locations on the surfaces of samples without any requirements for chemical damage pretreatments or additional matrices..

Gut & microbiome

Medium relevance

Shiitake · 2022 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Shiitake mycelium fermentation improves digestibility, nutritional value, flavor and functionality of plant proteins.

Plant proteins can serve as inexpensive and environmentally friendly meat-replacements. However, poor taste characteristics and relatively low nutritional value prevent their full acceptance as meat substitutes.

Energy & fatigueGut & microbiome

Medium relevance

Cordyceps · 2022 · Research Article · Insects

Study of Pathogenesis Using Fluorescent Strain of Cordyceps farinosa Revealed Infection of Thitarodes armoricanus Larvae via Digestive Tract.

Cordyceps farinosa is often utilized as a biocontrol agent because of its wide host range, strong lethality, and safety for mammals. Artificial rearing of Thitarodes armoricanus larvae is a prerequisite for the artificial cultivation of Chinese cordyceps, and C..

Gut & microbiome

Medium relevance

Shiitake · 2021 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Effects of fermentation with different microbial species on the umami taste of Shiitake mushroom (Lentinus edodes)

To explore the effects of fermentation on the umami taste substances of shiitake mushrooms (Lentinus edodes), the umami substances of fermented shiitake mushrooms using different microorganism species were investigated..

Gut & microbiome

Medium relevance

Enoki · 2021 · Journal Article · Food chemistry

No mutagenicity and oral toxicity of winter mushroom powder treated with atmospheric non-thermal plasma.

This study aimed to evaluate the mutagenicity and oral acute toxicity of winter mushroom powder (PW) treated by atmospheric non-thermal plasma (ANP). Winter mushroom powder without plasma treatment (CW) containing an equivalent amount of sodium nitrite as PW was used as a control..

Metabolic healthGut & microbiome

Medium relevance

Oyster Mushroom · 2021 · Journal Article · Environmental science and pollution research international

Two birds with one stone: oyster mushroom mediated bimetallic Au-Pt nanoparticles for agro-waste management and anticancer activity.

Agriculture has the most significant contribution in fulfilling the basic human need, sustaining life, and strengthening the economy of any country. To feed the exploding population of the world, there has been a quantum jump in the production of agricultural commodities, which has led to the production of a….

OncologyEnergy & fatigueGut & microbiomeSkin & hydration

Medium relevance

Shiitake · 2019 · Case Reports · Gastroenterology report

Two cases of small bowel obstruction due to a shiitake mushroom.

The shiitake mushroom (Lentinula edodes), known as Xiang-gu in China, has been an important component of Asian cuisine for hundreds of years. Although not easily digestible, there are few reports of them causing bowel obstruction..

Gut & microbiome

Medium relevance

Maitake · 2009 · Journal Article · International immunopharmacology

Maitake beta-glucan enhances granulopoiesis and mobilization of granulocytes by increasing G-CSF production and modulating CXCR4/SDF-1 expression.

Previous studies have presented that Maitake beta-glucan (MD-Fraction) extracted from the fruit body of Grifola frondosa has an anti-tumor effect by activating the immune system..

OncologyImmune supportGut & microbiome

Medium relevance

Shiitake · 2026 · Journal Article · Environmental microbiology

Edible Fungi Are a Hidden Source of Carbon Monoxide and Carbon Dioxide.

This study provides the first clear evidence that edible mushrooms, such as Lentinula edodes (shiitake), Pleurotus ostreatus and Pleurotus eryngii, can generate carbon monoxide (CO) as part of their metabolic activity-independent of bacteria, illumination or oxygen limitation..

Energy & fatigueMetabolic healthGut & microbiome

Medium relevance

Shiitake · 2026 · Research Article · Food chemistry: X

The effect of combining the enzymolysis of snail digestive enzyme and β-glucanase on the release of flavor in Lentinus edodes powder.

In this paper, the regulatory effect of combining the enzymolysis of snailase and β-glucanase on the flavor release of Lentinula edodes powder was analyzed. The flavor attributes and differences of volatiles before and after enzymatic hydrolysis were evaluated using gas chromatograph-ion mobility spectrometry,….

Gut & microbiome

Medium relevance

Cordyceps · 2025 · Research Article · Molecules (Basel, Switzerland)

Effect of Wheat Flour Substitution with Medicinal Mushroom Powder on Protein and Starch Digestibility and Functional Properties of Bread.

Medicinal mushrooms are recognised as a source of bioactive polysaccharides and proteins with potential health benefits. This study presents the first comparative evaluation of wheat bread fortified with powdered fruiting bodies of three medicinal mushroom species: Hericium erinaceus (Lion's Mane), Ganoderma lucidum….

Immune supportGut & microbiome

Medium relevance

Oyster Mushroom · 2025 · Journal Article · Journal of economic entomology

Mycelium as a beneficial dietary additive to support managed bumble bee development and colony growth.

Managed bumble bee (Hymenoptera: Apidae: Bombus impatiens (Cresson, 1863)) colonies are commercially reared and sold for crop pollination. The rearing process requires feeding honey bee (Hymenoptera: Apidae: Apis mellifera (Linnaeus, 1758))-collected multifloral pollen mixes to developing bumble bee colonies..

Gut & microbiome

Medium relevance

King Oyster · 2024 · Journal Article · Environmental technology

The liquid by-product of biogas production: characterisation and impact on soil fungi.

ABSTRACTA liquid digestate (LD) obtained from the anaerobic digestion of mixed organic waste was characterised and tested on the fungi Pleurotus eryngii, Irpex lacteus and Trametes versicolor..

Gut & microbiome

Medium relevance

Oyster Mushroom · 2024 · Research Article · Journal of Zhejiang University. Science. B

Unlocking the growth potential: harnessing the power of synbiotics to enhance cultivation of Pleurotus spp.

The oyster mushroom (Pleurotus spp.) is one of the most widely cultivated mushroom species globally. The present study investigated the effect of synbiotics on the growth and quality of Pleurotus ostreatus and Pleurotus pulmonarius..

Energy & fatigueGut & microbiome