MycoData
Medicinal fungi research database
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Oncology
Cancer, tumor biology, chemotherapy support, and oncology adjunct literature.
Species records
Species record
Oyster Mushroom
Pleurotus ostreatus
- Studies
- 1,947
- Avg relevance
- 53
- Latest
- 2026
Species record
Reishi · Lingzhi
Ganoderma lucidum
- Studies
- 1,830
- Avg relevance
- 60
- Latest
- 2026
Species record
Turkey Tail · Yun Zhi
Trametes versicolor
- Studies
- 1,828
- Avg relevance
- 41
- Latest
- 2026
Species record
Shiitake · Hua Gu
Lentinula edodes
- Studies
- 1,766
- Avg relevance
- 60
- Latest
- 2026
Species record
Cordyceps · Scarlet Club
Cordyceps militaris
- Studies
- 1,635
- Avg relevance
- 67
- Latest
- 2026
Species record
Cordyceps · Caterpillar Fungus
Ophiocordyceps sinensis
- Studies
- 1,576
- Avg relevance
- 59
- Latest
- 2026
Species record
Almond Mushroom · ABM
Agaricus blazei
- Studies
- 1,441
- Avg relevance
- 54
- Latest
- 2026
Species record
Enoki · Winter Mushroom
Flammulina velutipes
- Studies
- 1,403
- Avg relevance
- 47
- Latest
- 2026
Species record
King Oyster · Eryngii
Pleurotus eryngii
- Studies
- 1,278
- Avg relevance
- 60
- Latest
- 2026
Species record
Maitake · Hen of the Woods
Grifola frondosa
- Studies
- 1,276
- Avg relevance
- 48
- Latest
- 2026
Species record
Snow Fungus · Silver Ear
Tremella fuciformis
- Studies
- 1,052
- Avg relevance
- 29
- Latest
- 2026
Species record
Lion's Mane · Yamabushitake
Hericium erinaceus
- Studies
- 862
- Avg relevance
- 67
- Latest
- 2026
Species record
Chaga
Inonotus obliquus
- Studies
- 738
- Avg relevance
- 65
- Latest
- 2026
Species record
Mesima · Sanghwang
Phellinus linteus
- Studies
- 722
- Avg relevance
- 58
- Latest
- 2026
Species record
Niu-Chang-Chih
Antrodia camphorata
- Studies
- 496
- Avg relevance
- 63
- Latest
- 2026
Species record
Nameko · Nametake
Pholiota microspora
- Studies
- 421
- Avg relevance
- 29
- Latest
- 2026
Species record
Yellow Morel
Morchella esculenta
- Studies
- 392
- Avg relevance
- 42
- Latest
- 2026
Species record
Zhu Ling · Umbrella Polypore
Polyporus umbellatus
- Studies
- 263
- Avg relevance
- 55
- Latest
- 2026
Species record
Wood Ear · Kikurage
Auricularia auricula-judae
- Studies
- 254
- Avg relevance
- 51
- Latest
- 2026
Species record
Agarikon · Quinine Conk
Fomitopsis officinalis
- Studies
- 47
- Avg relevance
- 55
- Latest
- 2026
Articles
4,056 results
Showing 1,501–1,550 of 4,056
Chaga · 1998 · Journal Article · Bollettino chimico farmaceutico
The effect of aqueous extracts from Inonotus obliquus on the mitotic index and enzyme activities.
The effect of aqueous extract from Inonotus obliquus on the mitotic index and some enzyme activities in human cervical uteri tumour cells HeLa S3 in vitro was evaluated. It was concluded that Inonotus extract inhibited the growth of tumour cells..
Maitake · 1997 · Journal Article · Immunopharmacology and immunotoxicology
Effects of Lentinus edodes, Grifola frondosa and Pleurotus ostreatus administration on cancer outbreak, and activities of macrophages and lymphocytes in mice treated with a carcinogen, N-butyl-N-butanolnitrosoamine.
ICR mice were treated with a carcinogen, N-butyl-N'-butanolnitrosoamine BBN), every day for 8 consecutive weeks and the effects of oral administration of edible mushrooms on the induction of urinary bladder carcinoma and on the activities of macrophages and lymphocytes were studied..
Chaga · 1996 · Journal Article · Bollettino chimico farmaceutico
Antimitotic activity of aqueous extracts of Inonotus obliquus.
The cytotoxic effect of two aqueous extracts of Inonotus obliquus on human cervical uteri cancer cells (Hela S3) in vitro was evaluated. It was concluded that Inonotus extracts at a concentration of 10 micrograms/ml to 2000 micrograms/ml inhibited cancer cells growth..
Enoki · 1995 · Journal Article · Shanghai Nongye Xuebao
Optimum seeking of superior selected Flammulina velutipes strain FV_(8812) for deep fermentation
The second reported patient with simultaneous metastatic epidermoid carcinoma and chronic myelogenous leukemia is described. The difficulty of differentiating the leukemia from a leukemoid reaction is discussed..
Zhu Ling · 1994 · Journal Article · The American journal of Chinese medicine
Combined effects of chuling (Polyporus umbellatus) extract and mitomycin C on experimental liver cancer.
Chuling (Polyporus umbellatus), one of the commonly used Chinese medical herbs, was combined with mitomycin C and then studied against intrahepatic implantation of sarcoma 180 tumor cells in mice..
Maitake · 1994 · Journal Article · Bioscience, biotechnology, and biochemistry
Fractionation and Antitumor Activity of Polysaccharides from Grifola frondosa Mycelium.
We developed a method for the fractionation and purification of antitumor polysaccharides, considered to be a type of immuno-potentiator or BRM (biological response modifier), from the mycelium of liquid cultured Grifola frondosa..
Zhu Ling · 1992 · Journal Article · Chemical & pharmaceutical bulletin
Studies on constituents of fruit body of Polyporus umbellatus and their cytotoxic activity.
From the crude drug Chorei, the fruit body of Polyporus umbellatus, seven new components named polyporusterone A, B, C, D, E, F and G, were isolated and their structures were determined on the basis of the spectral data. These compounds showed cytotoxic action on leukemia 1210 cell proliferation..
Maitake · 1990 · Journal Article · Biochimica et biophysica acta
Isolation and characterization of a lectin from Grifola frondosa fruiting bodies.
An N-acetylgalactosamine-specific lectin (GFL) was isolated from Grifola frondosa fruiting bodies by affinity chromatographies on acid-treated Sepharose CL-4B and then GalNAc-Toyopearl. The isolated lectin agglutinated all types of erythrocytes equally..
Maitake · 1989 · Journal Article · Chemical & pharmaceutical bulletin
Antitumor and Immunomodulating Activities of a β-Glucan Obtained from Liquid-Cultured Grifola frondosa
The effects of the beta-1,3-glucan, LELFD, obtained from liquid-cultured mycelium of Grifola frondosa, on the growth of syngeneic tumors and immune responses in mice were examined..
Maitake · 1989 · Journal Article · Chemical & pharmaceutical bulletin
Physicochemical Properties and Antitumor Activities of Chemically Modified Derivatives of Antitumor Glucan "Grifolan LE" from Grifola frondosa
Antitumor glucan, grifolan LE (GRN LE), from Grifola frondosa was chemically modified to examine the structure-function relationship of the products. Modification by periodate, borohydride and acid hydrolysis of side chains of GRN LE did not alter properties such as helical conformation and antitumor activity of GRN….
Maitake · 1987 · Journal Article · Journal of pharmacobio-dynamics
Host-mediated antitumor effect of grifolan NMF-5N, a polysaccharide obtained from Grifola frondosa.
The antitumor mechanism of grifolan NMF-5N, a beta-1,3-glucan obtained from mycelia of Grifola frondosa, was examined. Grifolan NMF-5N did not show direct cytocidal effect on cultured tumor cells..
Maitake · 1986 · Journal Article · Journal of pharmacobio-dynamics
ANTITUMOR ACTIVITY OF A β-1, 3-GLUCAN OBTAINED FROM LIQUID CULTURED MYCELIUM OF GRIFOLA FRONDOSA
The antitumor activity of a branched beta-1,3-glucan "grifolan LE" purified from liquid cultures of Grifola frondosa (Ohno et al. Chem.
Maitake · 1985 · Journal Article · Journal of pharmacobio-dynamics
Effect of a polysaccharide fraction from Grifola frondosa on immune response in mice.
The biological and immunomodulating activities of polysaccharide fraction (GF-1), an antitumor poysaccharide fraction from cultured fruiting bodies of Grifola frondosa, was examined in mice. GF-1 showed no cytocidal effect on culturing tumor cells..
Maitake · 1984 · Journal Article · Journal of pharmacobio-dynamics
Antitumor activity of a polysaccharide fraction extracted from cultured fruiting bodies of Grifola frondosa.
Antitumor activity of a polysaccharide fraction (GF-1) extracted from cultured fruiting bodies of a fungus, Grifola frondosa, was examined on allogeneic and syngeneic tumors in mice..
Enoki · 1983 · Journal Article · Journal of pharmacobio-dynamics
AUGMENTATION OF HOST'S IMMUNITY BY COMBINED CRYODESTRUCTION OF SARCOMA 180 AND ADMINISTRATION OF PROTEIN-BOUND POLYSACCHARIDE, EA6, ISOLATED FROM FLAMMULINA VELUTIPES (CURT.ex FR.) SING.IN ICR MICE
Augmentation of the host's immunity by combined in situ freeze-destruction of the tumor (cryosurgery) and administration of the antitumor active protein-bound polysaccharide, EA6, isolated from a hot water extract of an edible mushroom, Flammulina velutipes (Curt..
Enoki · 1983 · Journal Article · Journal of pharmacobio-dynamics
INTENSIFICATION OF ANTITUMOR-IMMUNITY BY PROTEINBOUND POLYSACCHARIDE, EA6, DERIVED FROM FLAMMULINA VELUTIPES (CURT.ex FR.) SING. COMBINED WITH MURINE LEUKEMIA L1210 VACCINE IN ANIMAL EXPERIMENTS
The antitumor effect of protein-bound polysaccharide, EA6, derived from fruit bodies of Flammulina velutipes (Curt. ex Fr.) Sing., when combined with a vaccine treatment was studied by the challenge test in BDF1 mice and L1210 murine leukemia system..
Enoki · 1982 · Journal Article · Journal of pharmacobio-dynamics
AUGMENTATION OF ANTITUMOR ACTIVITY BY COMBINED CRYODESTRUCTION OF SARCOMA 180 AND PROTEIN-BOUND POLYSACCHARIDE, EA6, ISOLATED FROM FLAMMULINA VELUTIPES (CURT. EX FR.) SING. IN ICR MICE
Augmentation of antitumor activity by combined in situ freeze-destruction of tumor (cryosurgery) and administration of antitumor active substances isolated from a hot water extract of an edible mushroom, Flammulina velutipes (Curt. ex Fr.) SING., was investigated in sarcoma 180 bearing ICR mice..
Cordyceps · 2026 · Research Article · Pharmaceutics
A Green Self-Assembled Nanoplatform of 10-Hydroxycamptothecin and Cordyceps Polysaccharides for Dual Anti-Tumor Efficacy Through Apoptosis and Immune Modulation.
Background: Melanoma is one of the most dangerous types of skin cancer, with its global incidence having surged in recent years. There exists an urgent clinical need for novel therapeutic strategies that combine high efficacy, low toxicity, and multiple mechanisms of action..
Cordyceps · 2026 · Journal Article · Phytotherapy research: PTR
Bioactive Sphingolipids of Cordyceps sinensis Modulate Tumor Immunity Through the SphK1-Mediated Cer/S1P Axis.
Cordyceps sinensis is a traditional medicinal fungus known for its immunomodulatory properties. Its bioactive sphingolipids (SPLs) exhibit antitumor potential, though their mechanisms remain poorly understood.
Cordyceps · 2026 · Research Article · Scientific reports
Cordyceps sinensis enhances the efficacy of anti-PD-1 immunotherapy in Lewis lung adenocarcinoma.
Lung cancer, primarily non-small cell lung cancer (NSCLC), causes the highest cancer-related mortality. Although PD-1/PD-L1 inhibitors have improved survival in advanced NSCLC, they can cause immune-related adverse events.
Cordyceps · 2026 · Journal Article · Journal of toxicology and environmental health. Part A
In vitro anti-inflammatory activity of ethyl acetate extract and nicotinic acid from Cordyceps neovolkiana DL0004 in RAW 264.7 macrophages.
The aim of this study was to investigate the anti-inflammatory properties of the ethyl acetate extract (EA) of Cordyceps neovolkiana DL0004, a native fungal species recently isolated in Vietnam and its purified compound, nicotinic acid (NCA), using in vitro assays..
Cordyceps · 2026 · Research Article · Biomolecules
New Pyridinone Alkaloid and Polyketide from the Cordyceps-Colonizing Fungus Pseudogymnoascus roseus.
One new pyridinone alkaloid pseudogymnone A (1) and one new tricyclic polyketide penijanthinone C (2), together with six known compounds, harzianic acid (3), 3-methyl-2-(2-nonenyl)-4(1H)-quinolinone (4), emodic acid (5), alaternin (6), violaceol-I (7), and violaceol-II (8), were obtained from the Cordyceps-colonizing….
Cordyceps · 2025 · Research Article · ACS omega
The Effect of Cordyceps sinensis Polysaccharide Combined with Cisplatin on LLC1 Lung Cancer.
Although cisplatin (DDP) is commonly used in the clinical treatment of lung cancer, the associated side effects remained serious. Chinese medicine can be used to increase the sensitivity of the body to antitumor drugs while reducing their adverse effects..
Cordyceps · 2024 · Journal Article · Archives of microbiology
A rho-type GTPase activating protein affects the growth and development of Cordyceps cicadae.
Cordyceps cicadae is recognized for its medicinal properties, attributed to bioactive constituents like polysaccharides and adenosine, which have been shown to improve kidney and liver functions and possess anti-tumor properties..
Cordyceps · 2024 · Research Article · Chinese medicine
Cordyceps sinensis relieves non-small cell lung cancer by inhibiting the MAPK pathway.
OBJECTIVE: To determine the pharmacodynamic mechanism underlying Cordyceps sinensis relief in a murine model of non-small cell lung cancer (NSCLC). METHODS: We created a murine model of NSCLC and studied the potential molecular mechanism by which C..
Oyster Mushroom · 2024 · Journal Article · Food & function
Novel approach for ameliorating high-fat diet-induced syndromes via probiotic-fermented oyster mushroom: from metabolites and microbiota to regulation mechanisms.
The potential effects of probiotics on lowering lipid accumulation and alleviating gut microbiota perturbation have been extensively substantiated, but whether Lactobacillus rhamnoses-fermented oyster mushroom (FOM) could more pronouncedly attenuate obesity remains unclear..
Cordyceps · 2024 · Research Article · Frontiers in microbiology
Roles of CcDFR and CcOMT9 in the cyanidin biosynthesis and development of Cordyceps cicadae.
INTRODUCTION: Cordyceps cicadae is a traditional Chinese medicinal fungus known for its rich production of bioactive substances, particularly cyanidin, an anthocyanin commonly found in plants with notable anti-inflammatory, anti-tumor, antiviral, and antibacterial properties..
Cordyceps · 2024 · Journal Article · The Journal of pharmacy and pharmacology
Wild Cordyceps proteins reinforce intestinal epithelial barrier through MAPK/NF-κB pathway in MRL/lpr mice.
OBJECTIVES: The effects of wild Cordyceps proteins (WCPs) on the gut microbiota and the immune system of MRL/lpr mice were studied. METHODS: The effects of WCP on serum metabolic indexes (total triglyceride, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol) content was….
Maitake · 2019 · Journal Article · International immunopharmacology
Maturation of dendritic cells by maitake α-glucan enhances anti-cancer effect of dendritic cell vaccination.
Dendritic cells (DCs) play a primary role in antigen presentation to CD4+ and CD8+ T cells and induce acquired immune response against cancer cells. Therefore, determining positive modulators of DC activation to improve therapeutic approaches for cancer immunotherapy is greatly needed..
Maitake · 2018 · Research Article · Oncotarget
Antitumoral and antimetastatic activity of Maitake D-Fraction in triple-negative breast cancer cells.
Triple-negative breast cancer (TNBC) is associated with poor prognosis, high local recurrence rate and high rate of metastasis compared with other breast cancer subtypes. In addition, TNBC lacks a targeted therapy.
Maitake · 2017 · Research Article · PloS one
Antitumor activity of orally administered maitake α-glucan by stimulating antitumor immune response in murine tumor.
Maitake α-glucan, YM-2A, isolated from Grifola frondosa, has been characterized as a highly α-1,6-branched α-1,4 glucan. YM-2A has been shown to possess an anti-virus effect in mice; however, it does not directly inhibit growth of the virus in vitro, indicating that the anti-virus effect of YM-2A might be associated….
Shiitake · 2026 · Review · Colloids and surfaces. B, Biointerfaces
Comprehensive mechanisms and advanced delivery strategies of lentinan in antitumor therapy: A review.
Lentinan (LNT) is a bioactive polysaccharide derived from shiitake mushrooms (Lentinula edodes). It exhibits a unique triple-helix structure and specific glycosidic bonds, which confer exceptional water solubility and gel-forming properties..
King Oyster · 2025 · Review · International journal of molecular sciences
Medicinal Mushrooms in Colon Cancer Therapy: Mechanisms of Action of Bioactive Compounds and Therapeutic Potential.
Colon cancer is the second leading cause of cancer-related deaths in the world. This is commonly observed among older adults, and the occurrence of colon cancer is mainly influenced by unhealthy lifestyle factors..
Cordyceps · 2025 · Review · International journal of medicinal mushrooms
The Role of Medicinal Mushrooms in Cancer Treatment: Bioactive Compounds and Therapeutic Potential.
In recent years, research on the therapeutic potential of mushroom species has notably expanded, and the effects of these organisms on cancer treatment have come to the forefront..
Oyster Mushroom · 2024 · Preprint · journal metadata
In vitro anti-influenza virus (H1N1) activity of eleven species of Korean medicinal mushrooms
Abstract Background: Oseltamivir is the most commonly used antiviral drug for the treatment and prevention of influenza. However, there are growing concerns about its use due to the risk of psychiatric side effects..
Cordyceps · 2024 · Review · Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
The role and mechanisms of cordycepin in inhibiting cancer cells.
With the escalating incidence and mortality rates of cancer, there is an ever-growing emphasis on the research of anticancer drugs. Cordycepin, the primary nucleoside antibiotic isolated from Cordyceps militaris, has emerged as a remarkable agent for cancer prevention and treatment..
Reishi · 2023 · Abstract · Journal of animal science
202 Functional Properties of Ganoderma Lucidum (GL) Supplementation in Canine Nutrition
Metadata-grounded summary: This abstract indexes research on Ganoderma lucidum in Journal of animal science in 2023. MycoData maps the paper to oncology, immune support, metabolic health, liver support based on its title, species context, article metadata, and study classification..
Oyster Mushroom · 2023 · Published Erratum · AMB Express
Correction: Anti-tumor effect of polysaccharide from Pleurotus ostreatus on H22 mouse Hepatoma ascites in-vivo and hepatocellular carcinoma in-vitro model.
Metadata-grounded summary: This published erratum indexes research on Pleurotus ostreatus in AMB Express in 2023. MycoData maps the paper to oncology, immune support, liver support based on its title, species context, article metadata, and study classification..
Maitake · 2022 · Published Erratum · International journal of molecular medicine
[Corrigendum] Grifola frondosa polysaccharides induce breast cancer cell apoptosis via the mitochondrial-dependent apoptotic pathway.
Subsequently to the publication of the above paper, an interested reader drew to the authors' attention that, in Fig. 3B on p.
Niu-Chang-Chih · 2022 · Research Support, Non U.S. Gov'T · Aging
Antrodia Camphorata Polysaccharide activates autophagy and regulates NLRP3 degradation to improve liver injury-related inflammatory response.
This study illustrated the liver protection mechanism of ACP from the perspective of autophagy activation. ACP suppressed the inflammatory injury of KCs, and decreased the cell apoptosis rate..
Niu-Chang-Chih · 2022 · Abstract · Current developments in nutrition
Antrodia Camphorata Supplement in the Early Life Inhibits Intestinal Tumorigenesis Later in Young Adult APC1638N Mice
Abstract Objectives Colorectal cancer (CRC) is a critical burden in the U.S. with a temporal increase in incidence in young adults.
Niu-Chang-Chih · 2022 · Research Support, Non U.S. Gov'T · Microbiology spectrum
Sexual Crossing, Chromosome-Level Genome Sequences, and Comparative Genomic Analyses for the Medicinal Mushroom Taiwanofungus Camphoratus (Syn. Antrodia Cinnamomea, Antrodia Camphorata).
Taiwanofungus camphoratus mushrooms are a complementary and alternative medicine for hangovers, cancer, hypertension, obesity, diabetes, and inflammation. Though Taiwanofungus camphoratus has attracted considerable biotechnological and pharmacological attention, neither classical genetic nor genomic approaches have….
Reishi · 2021 · Published Erratum · Frontiers in chemistry
Erratum: Meroterpenoids From Ganoderma lucidum Mushrooms and Their Biological Roles in Insulin Resistance and Triple-Negative Breast Cancer.
[This corrects the article DOI: 10.3389/fchem.2021.772740.]..
Lion's Mane · 2021 · Retraction Notice · Journal of translational medicine
Retraction Note to: Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade.
Metadata-grounded summary: This retraction notice indexes research on Hericium erinaceus in Journal of translational medicine in 2021. MycoData maps the paper to oncology, cognition & nerves based on its title, species context, article metadata, and study classification..
Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · Bioorganic & medicinal chemistry letters
A new cerebroside from the fruiting bodies of Hericium erinaceus and its applicability to cancer treatment.
A new cerebroside, cerebroside E (1) was isolated from the fruiting bodies of Hericium erinaceus (Hericiaceae). The structure of 1 was elucidated by a combination of extensive spectroscopic analyses, including extensive 2D NMR, HR-MS, and chemical reactions..
Mesima · 2015 · Research Support, Non U.S. Gov'T · Carbohydrate polymers
A novel polysaccharide from mycelia of cultured Phellinus linteus displays antitumor activity through apoptosis.
Two novel polysaccharides termed PLPS-1 and PLPS-2 were isolated from mycelia of cultured Phellinus linteus by hot water extraction, purified by DEAE-52 cellulose and Sephadex G-100 column chromatography, and structurally characterized by FTIR and NMR spectroscopy, GC-MS, periodate oxidation/Smith degradation, and….
Maitake · 2015 · Research Support, Non U.S. Gov'T · Carbohydrate polymers
Antitumor and immunomodulatory activity of a water-soluble polysaccharide from Grifola frondosa.
Grifola frondosa has long been known and respected as a medically important fungus. This study investigated the characterization, antitumor and immunomodulatory activity of a polysaccharide named GP11 purified from G.
Niu-Chang-Chih · 2015 · Research Support, Non U.S. Gov'T · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association
Antroquinonol from Antrodia Camphorata suppresses breast tumor migration/invasion through inhibiting ERK-AP-1- and AKT-NF-κB-dependent MMP-9 and epithelial-mesenchymal transition expressions.
Antroquinonol (ANQ) is an ubiquinon derivative isolated from the mycelium of Antrodia camphorata. However, the effect of ANQ on breast cancer treatment is unknown..
Niu-Chang-Chih · 2015 · Research Support, Non U.S. Gov'T · PloS one
Apoptosis of Hepatocellular Carcinoma Cells Induced by Nanoencapsulated Polysaccharides Extracted from Antrodia Camphorata.
Antrodia camphorata is a well-known medicinal mushroom in Taiwan and has been studied for decades, especially with focus on anti-cancer activity. Polysaccharides are the major bioactive compounds reported with anti-cancer activity, but the debates on how they target cells still remain..
Snow Fungus · 2015 · Comparative Study · The American journal of Chinese medicine
Comparison of Immunomodulatory and Anticancer Activities in Different Strains of Tremella fuciformis Berk.
Tremella fuciformis Berk (TF) is a common edible and medicinal mushroom, and has long been used in food and in Chinese medicine. It possesses anticancer, anti-inflammation, anti-oxidative, and neuroprotective abilities..