MycoData

Cordyceps militaris exo-polysaccharides (EPS) have been reported to possess many benefits, such as anti-tumor, anti-inflammatory and antioxidant activities. In this study, the production of EPS via cultivation in a bioreactor was investigated..

OncologyImmune supportMetabolic health

High relevance

Reishi · 2019 · Research Support, Non U.S. Gov'T · Progress in molecular biology and translational science

Ganoderma lucidum polysaccharide used for treating physical frailty in China.

Ganoderma lucidum is an edible medicinal mushroom known as "Lingzhi" in China and "Reishi or Manetake" in Japan. It is a highly prized vitality-enhancing herb for >2000 years.

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Wood Ear · 2019 · Evaluation Study · International journal of medicinal mushrooms

Hypoglycemic Effect of the Degraded Polysaccharides from the Wood Ear Medicinal Mushroom Auricularia auricula-judae (Agaricomycetes).

Auricularia auricula-judae is an important culinary-medicinal mushroom. The A.

Immune supportMetabolic healthSkin & hydration

High relevance

Chaga · 2019 · Research Support, Non U.S. Gov'T · PloS one

Inonotus obliquus attenuates histamine-induced microvascular inflammation.

Cell-to-cell communication is a key element of microvascular blood flow control, including rapidly carrying signals through the vascular endothelium in response to local stimuli. This cell-to-cell communication is negatively impacted during inflammation through the disruption of junctional integrity..

Immune supportEnergy & fatigue

High relevance

Cordyceps · 2019 · Comparative Study · MicrobiologyOpen

Metabolic comparison of aerial and submerged mycelia formed in the liquid surface culture of Cordyceps militaris.

An entomopathogenic fungus, Cordyceps sp. has been known to produce cordycepin which is a purine nucleoside antimetabolite and antibiotic with potential anticancer, antioxidant and anti-inflammatory activities..

OncologyImmune supportMetabolic health

High relevance

Oyster Mushroom · 2019 · Research Support, Non U.S. Gov'T · PloS one

Optimization of extraction of antioxidant polysaccharide from Pleurotus ostreatus (Jacq.) P. Kumm and its cytotoxic activity against murine lymphoid cancer cell line.

The purpose of this study was to optimize the extraction method for polysaccharide from the fruiting bodies of Pleurotus ostreatus (Jacq.) P. Kumm and to assess the antioxidant and cytotoxic potentials of polysaccharide.

OncologyImmune supportEnergy & fatigue

High relevance

Yellow Morel · 2019 · Research Support, Non U.S. Gov'T · Journal of food biochemistry

Polysaccharides production from soybean curd residue via Morchella esculenta.

To minimize the serious environmental pollution caused by food byproducts, soybean curd residue was used as the substrate to ferment polysaccharides by Morchella esculenta..

Immune supportMetabolic health

High relevance

Cordyceps · 2019 · Research Support, Non U.S. Gov'T · The Journal of biological chemistry

Structural basis for the specific cleavage of core-fucosylated N-glycans by endo-β-N-acetylglucosaminidase from the fungus Cordyceps militaris.

N-Linked glycans play important roles in various cellular and immunological events. Endo-β-N-acetylglucosaminidase (ENGase) can release or transglycosylate N-glycans and is a promising tool for the chemoenzymatic synthesis of glycoproteins with homogeneously modified glycans..

Immune supportCognition & nerves

High relevance

Maitake · 2018 · Research Support, Non U.S. Gov'T · Scientific reports

A polysaccharide-peptide with mercury clearance activity from dried fruiting bodies of maitake mushroom Grifola frondosa.

Mercury is considered to be "a global pollutant" and raises concern worldwide. Once mercury enters the body, it will be distributed all over the body but will accumulate in the brain, kidney and liver.

Immune supportCognition & nervesLiver support

High relevance

Cordyceps · 2018 · Research Support, Non U.S. Gov'T · Scientific reports

Characterization of novel endo-β-N-acetylglucosaminidases from Sphingobacterium species, Beauveria bassiana and Cordyceps militaris that specifically hydrolyze fucose-containing oligosaccharides and human IgG.

Endo-β-N-acetylglucosaminidase (ENGase) catalyzes hydrolysis of N-linked oligosaccharides. Although many ENGases have been characterized from various organisms, so far no fucose-containing oligosaccharides-specific ENGase has been identified in any organism..

Immune support

High relevance

Shiitake · 2018 · Research Support, Non U.S. Gov'T · PloS one

Identification and evaluation of reference genes for qRT-PCR studies in Lentinula edodes.

Lentinula edodes (shiitake mushroom) is a common edible mushroom with a number of potential therapeutic and nutritional applications. It contains various medically important molecules, such as polysaccharides, terpenoids, sterols, and lipids, were contained in this mushroom..

Immune support

High relevance

King Oyster · 2018 · Research Support, Non U.S. Gov'T · Proteomics

Impacts of Dietary Pleurotus eryngii Polysaccharide on Nutrient Digestion, Metabolism, and Immune Response of the Small Intestine and Colon-An iTRAQ-Based Proteomic Analysis.

Pleurotus eryngii polysaccharides have been shown to exert significant biological activities to the host. However, few studies have been conducted on its effects on gastrointestinal tract (GIT) health alteration..

Immune supportMetabolic healthGut & microbiome

High relevance

King Oyster · 2018 · Research Support, Non U.S. Gov'T · Scientific reports

The characteristic, antioxidative and multiple organ protective of acidic-extractable mycelium polysaccharides by Pleurotus eryngii var. tuoliensis on high-fat emulsion induced-hypertriglyceridemic mice.

The antioxidant and multiple organ protection effects of acid- extracted mycelia polysaccharides (Ac-MPS) from Pleurotus eryngii var. tuoliensis on HFE-induced hypertriglyceridemic mice were investigated..

Immune supportMetabolic healthLiver support

High relevance

Maitake · 2017 · Comparative Study · Molecular nutrition & food research

Oral administration of Grifola frondosa polysaccharides improves memory impairment in aged rats via antioxidant action.

SCOPE: Grifola frondosa is an edible/medicinal mushroom with great nutritional value and bioactivity. The present study was performed to evaluate the beneficial effect of polysaccharides isolated from Grifola frondosa on memory impairment in aged rats..

Immune supportCognition & nerves

High relevance

Cordyceps · 2017 · Research Support, Non U.S. Gov'T · Scientific reports

Soya-cerebroside, an extract of Cordyceps militaris, suppresses monocyte migration and prevents cartilage degradation in inflammatory animal models.

Pathophysiological events that modulate the progression of structural changes in osteoarthritis (OA) include the secretion of inflammatory molecules, such as proinflammatory cytokines..

Immune support

High relevance

Cordyceps · 2017 · Research Support, Non U.S. Gov'T · Scientific reports

Systems Pharmacology-based strategy to screen new adjuvant for hepatitis B vaccine from Traditional Chinese Medicine Ophiocordyceps sinensis.

Adjuvants are common component for many vaccines but there are still few licensed for human use due to low efficiency or side effects. The present work adopted Systems Pharmacology analysis as a new strategy to screen adjuvants from traditional Chinese medicine..

Immune supportLiver support

High relevance

Cordyceps · 2016 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Anti-inflammatory Cerebrosides from Cultivated Cordyceps militaris.

Cordyceps militaris (bei-chong-chaw, northern worm grass) is a precious and edible entomopathogenic fungus, which is widely used in traditional Chinese medicine (TCM) as a general booster for the nervous system, metabolism, and immunity. Saccharides, nucleosides, mannitol, and sterols were isolated from this fungus..

Immune support

High relevance

King Oyster · 2016 · Research Support, Non U.S. Gov'T · Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

Biodegradation of toxic chemicals by Pleurotus eryngii in submerged fermentation and solid-state fermentation.

BACKGROUND/PURPOSE: The toxic chemicals bisphenol A (BPA), bisphenol F (BPF), nonylphenol (NP), and tetrabromobisphenol A (TBBPA) are endocrine-disrupting chemicals that have consequently drawn much concern regarding their effect on the environment..

Immune supportEnergy & fatigue

High relevance

King Oyster · 2016 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Chemical characterization of Pleurotus eryngii polysaccharide and its tumor-inhibitory effects against human hepatoblastoma HepG-2 cells.

This study was designed to investigate the chemical characterization and antitumor effects of Pleurotus eryngii polysaccharides (PEP). The crude PEP was fractionated into two fractions, namely PEP-1 and PEP-2..

OncologyImmune supportMetabolic healthLiver support

High relevance

Cordyceps · 2016 · Research Support, Non U.S. Gov'T · Food & function

Cordyceps militaris fruit body extract ameliorates membranous glomerulonephritis by attenuating oxidative stress and renal inflammation via the NF-κB pathway.

Membranous glomerulonephritis (MGN) is a common pathogenesis of nephritic syndrome in adult patients. Nuclear factor kappa B (NF-κB) serves as the main transcription factor for the inflammatory response mediated nephropathy..

OncologyImmune supportMetabolic health

High relevance

Shiitake · 2016 · Research Support, Non U.S. Gov'T · Journal of medicinal food

Extracts from Lentinula edodes (Shiitake) Edible Mushrooms Enriched with Vitamin D Exert an Anti-Inflammatory Hepatoprotective Effect.

Vitamin D has been known for its anti-inflammatory properties. Extracts derived from Lentinula edodes (Shiitake) edible mushroom exert an anti-inflammatory effect..

Immune supportLiver supportSkin & hydration

High relevance

King Oyster · 2016 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Pleurotus eryngii Polysaccharide Promotes Pluripotent Reprogramming via Facilitating Epigenetic Modification.

Pleurotus eryngii is a medicinal/edible mushroom with great nutritional value and bioactivity. Its polysaccharide has recently been developed into an effective gene vector via cationic modification.

Immune supportLiver support

High relevance

Cordyceps · 2015 · Research Article · Pharmacognosy magazine

A direct protein kinase B-targeted anti-inflammatory activity of cordycepin from artificially cultured fruit body of Cordyceps militaris.

BACKGROUND: Cordyceps militaris is one of well-known medicinal mushrooms with anti-inflammatory, anti-cancer, anti-diabetic, and anti-obesity activities. OBJECTIVE: The objective of the following study is to isolate chemical components from the ethanol extract (Cm-EE) from Cordyceps militaris and to evaluate their….

OncologyImmune supportMetabolic health

High relevance

King Oyster · 2015 · Journal Article · Journal of food biochemistry

Antitumor and Immunomodulatory Activity of Pleurotus eryngii Extract

Pleurotus eryngii (P. eryngii), also known as the king oyster mushroom, contains many bioactive substances, including polysaccharides, lipids, peptides, sterols and triterpenoids.

OncologyImmune supportLiver supportRespiratory

High relevance

Niu-Chang-Chih · 2015 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Application of Antrodia camphorata Promotes Rat's Wound Healing In Vivo and Facilitates Fibroblast Cell Proliferation In Vitro.

Antrodia camphorata is a parasitic fungus from Taiwan, it has been documented to possess a variety of pharmacological and biological activities. The present study was undertaken to evaluate the potential of Antrodia camphorata ethanol extract to accelerate the rate of wound healing closure and histology of wound area….

Immune supportSkin & hydration

High relevance

King Oyster · 2015 · Journal Article · International journal of food science & technology

Effects of different carbon sources and C/N values on nonvolatile taste components of Pleurotus eryngii

Pleurotus eryngii, the second largest industrial cultivation mushroom in China, is usually cultivated on substrates mainly consisting of sawdust and corncob. In this study, experiments were performed to determine the effects of different carbon sources and C/N values on nonvolatile taste components of P.

Immune support

High relevance

King Oyster · 2015 · Journal Article · Journal of dairy science

Effects of Pleurotus eryngii polysaccharides on bacterial growth, texture properties, proteolytic capacity, and angiotensin-I-converting enzyme-inhibitory activities of fermented milk.

Pleurotus eryngii is one of the most favored oyster mushrooms and contains various beneficial bioactive compounds. Polysaccharide extracted from P.

Immune support

High relevance

Shiitake · 2015 · Research Article · PloS one

Lentinula edodes-derived polysaccharide alters the spatial structure of gut microbiota in mice.

Lentinula edodes-derived polysaccharides possess many therapeutic characteristics, including anti-tumor and immuno-modulation. The gut microbes play a critical role in modulation of immune function.

OncologyImmune supportGut & microbiome

High relevance

Shiitake · 2015 · Journal Article · Bioscience, biotechnology, and biochemistry

Preparation of Lentinula edodes polysaccharide-calcium complex and its immunoactivity.

Polysaccharide is a major bioactive component of mushrooms. In this study, for the first time, starting from a new Lentinula edodes polysaccharide L2, we prepared a novel L2-calcium complex and the process was optimized..

Immune support

High relevance

Maitake · 2015 · Journal Article · Journal of leukocyte biology

Soluble β-glucan from Grifola frondosa induces tumor regression in synergy with TLR9 agonist via dendritic cell-mediated immunity.

The maturation of dendritic cells into more-immunostimulatory dendritic cells by stimulation with different combinations of immunologic agents is expected to provide efficient, adoptive immunotherapy against cancer..

OncologyImmune support

High relevance

Mesima · 2015 · Journal Article · Food & function

Structural characterization and immunomodulatory effects of polysaccharides from Phellinus linteus and Phellinus igniarius on the IL-6/IL-10 cytokine balance of the mouse macrophage cell lines (RAW 264.7).

Phellinus linteus and igniarius (L.) Quel. have been used in traditional Asian medicine for over two centuries against a variety of diseases.

Immune supportCognition & nervesMetabolic health

High relevance

Cordyceps · 2014 · Journal Article · Izvestiia Akademii nauk. Seriia biologicheskaia

[Insecticidal and immunosuppressive effect of ascomycete Cordyceps militaris on the larvae of the Colorado potato beetle Leptinotarsa decemlineata].

The immunosuppressive and insecticidal activity of cultures of the entomopathogenic fungus Cordyceps militaris on the larvae of the Colorado potato beetle Leptinotarsa decemlineata has been established for the first time..

Immune support

High relevance

Cordyceps · 2014 · Journal Article · Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

[Study on monosaccharide composition of intracellular polysacchride and contents of cordycepin and cordyceps polysacchride produced by Cordyceps militaris induced by blue light].

OBJECTIVE: To study effects of blue light irradiation on monosaccharide composition of intracellular polysacchride and contents of cordycepin and cordyceps polysacchride of mycelium and sporocarp in Cordyceps militaris..

Immune support

High relevance

Mesima · 2014 · Journal Article · Journal of ethnopharmacology

Anti-inflammatory effect of Phellinus linteus grown on germinated brown rice on dextran sodium sulfate-induced acute colitis in mice and LPS-activated macrophages.

ETHNOPHARMACOLOGICAL RELEVANCE AND AIM OF THE STUDY: Phellinus linteus is a herb used in traditional Asian medicine to treat stomachache, inflammation, and tumors. Recent studies show that the extract of Phellinus linteus has anti-inflammatory and antitumor activities..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

King Oyster · 2014 · Journal Article · Food chemistry

Antioxidant and antibacterial activities of sulphated polysaccharides from Pleurotus eryngii and Streptococcus thermophilus ASCC 1275.

Polysaccharides from Pleurotus eryngii (PEPS) and exopolysaccharides from Streptococcus thermophilus ASCC 1275 (ST1275 EPS) were sulphated, and antioxidant and antibacterial activities of sulphated and crude polysaccharides were determined. Degree of sulphonation of PEPS and ST1275 EPS was 0.69 and 0.31, respectively..

Immune support

High relevance

King Oyster · 2014 · Journal Article · Journal of the science of food and agriculture

Antiproliferative and immunostimulatory activity of a protein from Pleurotus eryngii

BACKGROUND: Currently, the use of mushrooms as functional foods, nutraceuticals or phytopharmaceuticals source has risen. In contrast, the possible cellular cytotoxicity and immunostimulatory activity of Pleurotus eryngii (DC.

OncologyImmune supportLiver supportRespiratory

High relevance

Shiitake · 2014 · Journal Article · Mycoscience

Characterization of vitamin B12 compounds in the fruiting bodies of shiitake mushroom (Lentinula edodes) and bed logs after fruiting of the mushroom

This study determined the vitamin B12 content in commercially available dried fruiting bodies of shiitake mushroom, Lentinula edodes. The vitamin B12 contents in dried donko-type fruiting bodies with closed caps (5.61 ± 3.90 μg/100 g dry weight), did not significantly differ from those of dried koushin-type fruiting….

Immune support

High relevance

King Oyster · 2014 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Chemical composition, antioxidant and anti-inflammatory properties for ethanolic extracts from Pleurotus eryngii fruiting bodies harvested at different time

Pleurotus eryngii, a popular edible mushroom in Taiwan, is usually cultivated using sawdust medium packing bags through several procedures including culture medium confection, bagging and sterilization, spawn inoculation, fostering mycelia, full growth of mycelia, and inducing fruiting body formation..

Immune supportEnergy & fatigue

High relevance

Cordyceps · 2014 · Journal Article · Annals of parasitology

Cordyceps fungi as natural killers, new hopes for medicine and biological control factors.

The Cordyceps genus includes many species of fungi, most of which are endoparasitoids on arthropods.The distribution of these fungi is cosmopolitan, but many occur in regions such as Asia with a hot, humid climate. These pathogens of insect pests are promising candidates for use as biological control factors..

OncologyImmune support

High relevance

Maitake · 2014 · Research Article · Annals of translational medicine

Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts.

BACKGROUND: The role of glucan in stimulation of immune reactions has been studied for several decades. In this report, we focused on the effects of orally administered glucan Maitake and Shiitake on immune reactions..

Immune support

High relevance

Chaga · 2014 · Journal Article · International journal of medicinal mushrooms

Inhibitory effects of a polysaccharide extract from the Chaga medicinal mushroom, Inonotus obliquus (higher Basidiomycetes), on the proliferation of human neurogliocytoma cells.

This study aimed to investigate the inhibitory roles of a polysaccharide extract from Inonotus obliquus on U251 human neurogliocytoma cells cultured in vitro. After administering the polysaccharide extract from I..

OncologyImmune supportCognition & nerves

High relevance

King Oyster · 2014 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Pleurotus eryngii Ameliorates Lipopolysaccharide-Induced Lung Inflammation in Mice.

Pleurotus eryngii (P. eryngii) is consumed as a fresh cultivated mushroom worldwide and demonstrated to have multiple beneficial effects.

Immune supportRespiratory

High relevance

Lion's Mane · 2014 · Journal Article · Journal of agricultural and food chemistry

Vitamin B12[c-lactone], a biologically inactive corrinoid compound, occurs in cultured and dried lion's mane mushroom (Hericium erinaceus) fruiting bodies.

This study determined the vitamin B12 content of the edible medicinal mushroom Hericium erinaceus, lion's mane mushroom fruiting body, using a microbiological assay based on Lactobacillus delbrueckii ATCC 7830..

Immune supportGut & microbiome

High relevance

Almond Mushroom · 2013 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Anti-Inflammatory Activity of Water-Soluble Polysaccharide of Agaricus blazei Murill on Ovariectomized Osteopenic Rats.

In the present study, we investigated the anti-inflammatory activity of water-soluble polysaccharide of Agaricus blazei Murill (WSP-AbM) on ovariectomized osteopenic rats. The rats were administered orally WSP-AbM (200 mg/kg BW) for 8 weeks..

OncologyImmune supportEnergy & fatigue

High relevance

Maitake · 2013 · Journal Article · Food and agricultural immunology

Antioxidant and immunomodulatory effects of a α-glucan from fruit body of maitake (Grifola frondosa)

The antioxidant and immunomodulatory effect of an α-glucan (designated here as MT-α-glucan) from fruit body of Maitake mushroom (Grifola frondosa) on D-galactose (D-gal)-induced senescent mice model was evaluated..

Immune supportCognition & nervesMetabolic healthLiver support

High relevance

King Oyster · 2013 · Journal Article · Carbohydrate polymers

Antitumor activity of a polysaccharide from Pleurotus eryngii on mice bearing renal cancer.

One water-soluble polysaccharide (PEPw), with an average molecular weight of 2.5×10(4)Da, was isolated from the fruiting bodies of Pleurotus eryngii and subjected to composition analysis and evaluated for the antitumor and immunomodulatory activity..

OncologyImmune support

High relevance

Almond Mushroom · 2013 · Journal Article · Obesity (Silver Spring, Md.)

Dietary supplementation with Agaricus blazei murill extract prevents diet-induced obesity and insulin resistance in rats.

OBJECTIVE: Dietary supplement may potentially help to fight obesity and other metabolic disorders such as insulin-resistance and low-grade inflammation. The present study aimed to test whether supplementation with Agaricus blazei murill (ABM) extract could have an effect on diet-induced obesity in rats..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

High relevance

Almond Mushroom · 2013 · Journal Article · Clinical journal of gastroenterology

Drug-induced liver injury associated with Agaricus blazei Murill which is very similar to autoimmune hepatitis.

Agaricus blazei Murill (ABM) is one of the most popular complementary alternative medicines (CAM). We experienced a case of a 60-year-old woman with severe hepatitis associated with extract of ABM and extract of Ganoderma lucidum, and a case of a 75-year-old man with drug-induced liver injury (DILI) associated with….

OncologyImmune supportLiver supportRespiratory

High relevance

Maitake · 2013 · Journal Article · Journal of oleo science

Effect of Dietary Maitake (Grifola frondosa) Mushrooms on Plasma Cholesterol and Hepatic Gene Expression in Cholesterol-Fed Mice

To investigate the effects of dietary Grifola frondosa on cholesterol, normal mice were fed a diet containing 1% cholesterol (HC group) or 1% cholesterol and 10% freeze-dried G..

Immune supportMetabolic healthLiver support

High relevance

Chaga · 2013 · Journal Article · Food research international (Ottawa, Ont.)

Effect of different drying methods on physicochemical properties and antioxidant activities of polysaccharides extracted from mushroom Inonotus obliquus

Inonotus obliquus is a kind of mushroom which has long been used as a folk remedy for curing various diseases such as cancers, heart disease and diabetes in Russian and Eastern Europe. Polysaccharides are one of the main bioactive constituents of Inonotus obliquus with health functions..

OncologyImmune supportMetabolic health