MycoData
Medicinal fungi research database
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Immune support
Immune modulation, polysaccharides, beta-glucans, and host-response studies.
Species records
Species record
Oyster Mushroom
Pleurotus ostreatus
- Studies
- 1,947
- Avg relevance
- 53
- Latest
- 2026
Species record
Reishi · Lingzhi
Ganoderma lucidum
- Studies
- 1,830
- Avg relevance
- 60
- Latest
- 2026
Species record
Turkey Tail · Yun Zhi
Trametes versicolor
- Studies
- 1,828
- Avg relevance
- 41
- Latest
- 2026
Species record
Shiitake · Hua Gu
Lentinula edodes
- Studies
- 1,766
- Avg relevance
- 60
- Latest
- 2026
Species record
Cordyceps · Scarlet Club
Cordyceps militaris
- Studies
- 1,635
- Avg relevance
- 67
- Latest
- 2026
Species record
Cordyceps · Caterpillar Fungus
Ophiocordyceps sinensis
- Studies
- 1,576
- Avg relevance
- 59
- Latest
- 2026
Species record
Almond Mushroom · ABM
Agaricus blazei
- Studies
- 1,441
- Avg relevance
- 54
- Latest
- 2026
Species record
Enoki · Winter Mushroom
Flammulina velutipes
- Studies
- 1,403
- Avg relevance
- 47
- Latest
- 2026
Species record
King Oyster · Eryngii
Pleurotus eryngii
- Studies
- 1,278
- Avg relevance
- 60
- Latest
- 2026
Species record
Maitake · Hen of the Woods
Grifola frondosa
- Studies
- 1,276
- Avg relevance
- 48
- Latest
- 2026
Species record
Snow Fungus · Silver Ear
Tremella fuciformis
- Studies
- 1,052
- Avg relevance
- 29
- Latest
- 2026
Species record
Lion's Mane · Yamabushitake
Hericium erinaceus
- Studies
- 862
- Avg relevance
- 67
- Latest
- 2026
Species record
Chaga
Inonotus obliquus
- Studies
- 738
- Avg relevance
- 65
- Latest
- 2026
Species record
Mesima · Sanghwang
Phellinus linteus
- Studies
- 722
- Avg relevance
- 58
- Latest
- 2026
Species record
Niu-Chang-Chih
Antrodia camphorata
- Studies
- 496
- Avg relevance
- 63
- Latest
- 2026
Species record
Nameko · Nametake
Pholiota microspora
- Studies
- 421
- Avg relevance
- 29
- Latest
- 2026
Species record
Yellow Morel
Morchella esculenta
- Studies
- 392
- Avg relevance
- 42
- Latest
- 2026
Species record
Zhu Ling · Umbrella Polypore
Polyporus umbellatus
- Studies
- 263
- Avg relevance
- 55
- Latest
- 2026
Species record
Wood Ear · Kikurage
Auricularia auricula-judae
- Studies
- 254
- Avg relevance
- 51
- Latest
- 2026
Species record
Agarikon · Quinine Conk
Fomitopsis officinalis
- Studies
- 47
- Avg relevance
- 55
- Latest
- 2026
Articles
7,168 results
Showing 1,901–1,950 of 7,168
Lion's Mane · 2013 · Research Article · Evidence-based complementary and alternative medicine: eCAM
Gastroprotective Effects of Lion's Mane Mushroom Hericium erinaceus (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer in Rats.
Hericium erinaceus is a famous tonic in oriental medicine. The gastroprotective effects of aqueous extract of H.
King Oyster · 2013 · Journal Article · Archives of microbiology
Medium optimization, molecular characterization, and bioactivity of exopolysaccharides from Pleurotus eryngii.
An optimal medium for exopolysaccharides (EPS) production was obtained through one-factor-at-a-time method and response surface methodology. Under optimal culture medium, the maximum EPS concentration in shake flask was 5.16 g/l..
Maitake · 2013 · Journal Article · International journal of cancer
Oral administration of soluble β-glucans extracted from Grifola frondosa induces systemic antitumor immune response and decreases immunosuppression in tumor-bearing mice.
Maitake D (MD)-Fraction is a highly purified soluble β-glucan derived from Grifola frondosa (an oriental edible mushroom). Intraperitoneal (i.p.) injection of MD-Fraction has been reported to inhibit tumor growth via enhancement of the host immune system..
Turkey Tail · 2013 · Journal Article · Plant foods for human nutrition (Dordrecht, Netherlands)
Trametes versicolor extract modifies human fecal microbiota composition in vitro.
Trametes versicolor is a mushroom used as a traditional Chinese medicine (Yun-zhi) for a wide array of seemingly disparate conditions. We hypothesized that many of its multiple purported activities could be mediated through stimulation of beneficial mutualist components of the microbiota..
Shiitake · 2012 · Journal Article · Biological & pharmaceutical bulletin
Direct Cytotoxicity of Lentinula edodes Mycelia Extract on Human Hepatocellular Carcinoma Cell Line
Lentinula edodes mycelia (L.E.M.) is a dried powder extracted from shiitake mushrooms (Lentinula edodes). We previously demonstrated that it has immunomodulatory effects.
Chaga · 2012 · Journal Article · Aquaculture
Effect of Inonotus obliquus enriched diet on hematology, immune response, and disease protection in kelp grouper, Epinephelus bruneus against Vibrio harveyi
The aim of the present study was to determine the changes in the hematological and immunological response in kelp grouper Epinephelus bruneus against Vibrio harveyi infection after fed with 0%, 0.1%, 1.0%, and 2.0% Chaga mushroom, Inonotus obliquus extract enriched diet..
Maitake · 2012 · Journal Article · International journal of medicinal mushrooms
Immunomodulating activities of cultivated maitake medicinal mushroom Grifola frondosa (Dicks.: Fr.) S.F. Gray (higher Basidiomycetes) on peripheral blood mononuclear cells.
Grifola frondosa is a culinary-medicinal mushroom that contains several physiologically active compounds, of which polysaccharides, specifically β-glucans, are known to possess immunomodulating properties..
King Oyster · 2012 · Journal Article · International journal of biological macromolecules
Optimization of extracellular glucan production from Pleurotus eryngii and its impact on angiogenesis.
Pleurotus eryngii, an edible mushroom with therapeutic potential was optimized using response surface methodology of four-factor Box-Behnken design for maximum mycelial biomass and extracellular glucan (EPS) production..
Almond Mushroom · 2011 · Journal Article · International journal of oncology
Agaricus blazei Murill enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells by NFκB-mediated increase of intracellular doxorubicin accumulation.
It has been demonstrated that the Agaricus blazei Murill (ABM) mushroom, which primarily consists of polysaccharides, possesses anti-tumor activities. However, the mechanisms by which ABM inhibits human hepatocellular carcinoma growth remain unknown..
Wood Ear · 2011 · Research Article · Toxicological research
Anti-inflammatory Activity of Dichloromethane Extract of Auricularia auricula-judae in RAW264.7 Cells.
The present study investigated the anti-inflammatory effects of dichloromethane extract of Auricularia auricula-judae. Dichloromethane extract of Auricularia auricula-judae inhibited Lipopolysaccharide (LPS) -induced nitric oxide (NO) production significantly in a dose-dependent manner in the concentration ≥10 μg/ml….
Chaga · 2011 · Journal Article · International journal of medicinal mushrooms
Anticancer effects of fraction isolated from fruiting bodies of Chaga medicinal mushroom, Inonotus obliquus (Pers.:Fr.) Pilát (Aphyllophoromycetideae): in vitro studies.
The medicinal mushroom Chaga, Inonotus obliquus (Pers.:Fr.) Pilát (Hymenochaetaceae), has been used in folk medicine in Russia, Poland, and most of the Baltic countries, as a cleansing and disinfecting measure, and as decoctions for stomach diseases, intestinal worms, liver and heart ailments, and cancer treatment..
Yellow Morel · 2011 · Journal Article · Journal of food processing and preservation
Biomass and exopolysaccharide production by morchella esculenta in submerged culture using the extract from waste loquat (eriobotrya japonica l.) kernels
Detoxified loquat kernel extract (DLKE) and neutralized loquat kernel extract (LKE) prepared from waste loquat kernels were used as main carbon sources in the submerged and solid cultures of Morchella esculenta..
Almond Mushroom · 2011 · Journal Article · In vivo (Athens, Greece)
Effect of Agaricus blazei Murrill extract on HT-29 human colon cancer cells in SCID mice in vivo.
Agaricus blazei Murrill (ABM) popularly known as 'Cogumelo do Sol' in Brazil, or 'Himematsutake' in Japan, is a mushroom native to Brazil and widely cultivated in Japan for its medicinal uses and is now considered one of the most important edible and culinary-medicinal biotechnological species..
Maitake · 2011 · Journal Article · Carbohydrate polymers
Effect of the degree of oxidation on the physicochemical and biological properties of Grifola frondosa polysaccharides
Polysaccharide extracted from Grifola frondosa was subjected to 2,2,6,6-tetramethyl-1-piperidine oxoammonium ion (TEMPO)-mediated oxidation of which effects on the structural and biological properties of the polysaccharide were investigated as a function of degree of oxidation..
King Oyster · 2011 · Journal Article · Food Hydrocolloids
Effect of the degree of sulfation on the physicochemical and biological properties of Pleurotus eryngii polysaccharides
Polysaccharides extracted from Pleurotus eryngii were chemically modified by sulfation and the effects on the structural and biological properties of the polysaccharides were investigated as a function of the degree of sulfation. ¹³C NMR spectroscopy demonstrated that polysaccharides from P..
Chaga · 2011 · Journal Article · Chinese journal of integrative medicine
Effects of inotodiol extracts from inonotus obliquus on proliferation cycle and apoptotic gene of human lung adenocarcinoma cell line A549.
OBJECTIVE: To observe the proliferation inhibition, apoptosis, and cell proliferation cycle of human lung carcinoma cell line A549 treated with Inotodiol extracts from Inonotus obliquus and explore the possibility of Inotodiol extracts from Inonotus obliquus as a new tumor chemopreventive drug..
Maitake · 2011 · Research Article · North American journal of medical sciences
Immune enhancing effects of WB365, a novel combination of Ashwagandha (Withania somnifera) and Maitake (Grifola frondosa) extracts.
BACKGROUND: Stress has been found to significantly reduce the abilities of the immune system to fight infections. One of the ways to overcome the defects of the immune system is the strengthening of the defense reactions by nutrition..
Yellow Morel · 2011 · Journal Article · Journal of the science of food and agriculture
Isolation, partial characterisation and immunomodulatory activities of polysaccharide from Morchella esculenta
BACKGROUND: Polysaccharides extracted from fungi or algae have shown a variety of medical activities, and the exploitation of polysaccharides for application in pharmacy has been very promising..
Almond Mushroom · 2011 · Research Article · Evidence-based complementary and alternative medicine: eCAM
Phase I Clinical Study of the Dietary Supplement, Agaricus blazei Murill, in Cancer Patients in Remission.
Although many cancer patients use complementary and alternative medicine, including Agaricus blazei Murill (ABM), safety is not yet well understood. Cancer survivors took 1.8, 3.6, or 5.4 g ABM granulated powder (Kyowa Wellness Co., Ltd., Tokyo, Japan) per day orally for 6 months..
Lion's Mane · 2011 · Journal Article · Journal of food biochemistry
Structural elucidation of a neutral water‐soluble α‐d‐glucan from the fungus of hericium erinaceus
A new α‐D‐glucan (HEPF5), with a molecular weight of 4.23 × 105 Da as determined by high‐performance liquid chromatography, was isolated from the water extract of the fruiting bodies of Hericium erinaceus..
Maitake · 2010 · Research Article · Cancer immunology, immunotherapy: CII
A polysaccharide extracted from Grifola frondosa enhances the anti-tumor activity of bone marrow-derived dendritic cell-based immunotherapy against murine colon cancer.
We previously isolated the novel heteropolysaccharide maitake Z-fraction (MZF) from the maitake mushroom (Grifola frondosa), and demonstrated that MZF significantly inhibited tumor growth by inducing cell-mediated immunity..
Almond Mushroom · 2010 · Journal Article · Cytokine
An extract based on the medicinal mushroom Agaricus blazei Murill stimulates monocyte-derived dendritic cells to cytokine and chemokine production in vitro.
The edible mushroom Agaricus blazei Murill (AbM), which has been used in traditional medicine against a range of diseases and possess immunomodulating properties, probably due to its high content of beta-glucans..
Almond Mushroom · 2010 · Journal Article · International journal of biological macromolecules
Chemical analysis of Agaricus blazei polysaccharides and effect of the polysaccharides on IL-1beta mRNA expression in skin of burn wound-treated rats.
Agaricus blazei polysaccharides were analyzed by GC-MS. Results indicated that the polysaccharides contained glucose (93.87%), mannose (3.54%), and arabinose (2.25%).
Chaga · 2010 · Journal Article · Journal of food biochemistry
Glycosidase inhibitory activity and antioxidant properties of a polysaccharide from the mushroom inonotus obliquus
A water-soluble polysaccharide from Inonotus obliquus (IOPS) was isolated from the mushroom Inonotus obliquus (Fr.) Pilat. The chemical compositions, molecular weight and inhibitory activities on glycosidase and antioxidant properties of IOPS were investigated..
Maitake · 2010 · Journal Article · Journal of medicinal food
Potential antitumor activity of a low-molecular-weight protein fraction from Grifola frondosa through enhancement of cytokine production.
Edible mushrooms contain an abundance of immune-enhancing nutritients. Some of these compounds, referred to as biological response modifiers (BRMs), have been used in biological therapies for cancer treatment..
Maitake · 2010 · Journal Article · Journal of food biochemistry
Preparation and anticoagulation activity of a chemically sulfated polysaccharide (s-gfb) obtained from grifola frondosa
The aim of this study was mainly to determine anticoagulant activity of a chemically sulfated polysaccharide (S-GFB), which was derived from water-insoluble polysaccharide of Grifola frondosa mycelia..
Enoki · 2010 · Journal Article · The American journal of Chinese medicine
Purification, characterization and immuno-modulating properties of polysaccharides isolated from Flammulina velutipes mycelium.
To investigate the immuno-modulating activity of Flammulina velutipes mycelium, three different Flammulina velutipes polysaccharides (FVPs) were isolated by fractionation using gel filtration and were identified as the immunomodulators of murine peritoneal macrophages..
Mesima · 2009 · Research Article · Mycobiology
Anti-cancer Activities of Ginseng Extract Fermented with Phellinus linteus.
In the present study, the anti-cancer effects of ginseng fermented with Phellinus linteus (GFPL) extract were examined through in vitro and in vivo assays. GFPL was produced by co-cultivating ginseng and Phellinus linteus together..
King Oyster · 2009 · Journal Article · Carbohydrate polymers
Glucans from fruit bodies of cultivated mushrooms Pleurotus ostreatus and Pleurotus eryngii: Structure and potential prebiotic activity
Cultivated oyster mushrooms (genus Pleurotus) are interesting as a source of biologically active glucans. Partially, β-glucan from Pleurotus sp.
Niu-Chang-Chih · 2008 · Journal Article · Journal of ethnopharmacology
Immunomodulatory effect of Antrodia camphorata mycelia and culture filtrate.
AIM OF THE STUDY: Antrodia camphorata, a precious folkloric medicinal mushroom, has been used to treat tumorigenic diseases in Taiwan. This study was to investigate the innate immunity augmentation effects of different fractions prepared from hot water extracts of submerged cultured Antrodia camphorata (AC)..
Enoki · 2008 · Journal Article · Bioscience, biotechnology, and biochemistry
Purification and Characterization of a Novel Exo-β-1,3-1,6-glucanase from the Fruiting Body of the Edible Mushroom Enoki (Flammulina velutipes)
To elucidate the role of beta-glucanases in the cell-wall degradation involved in morphogenesis, an exo-beta-1,3-1,6-glucanase (FvBGL1) was purified from fruiting bodies of the edible mushroom Enoki (Flammulina velutipes), and its enzymatic properties were studied..
Mesima · 2008 · Research Article · Mycobiology
Submerged Culture of Phellinus linteus for Mass Production of Polysaccharides.
In order to increase the mycelial production of Phellinus linteus, which exhibits potent anticancer activity, some ingredients of the medium used to culture P. linteus were investigated..
Snow Fungus · 2007 · Research Article · International journal of molecular sciences
Modification of Low Molecular Weight Polysaccharides from Tremella Fuciformis and Their Antioxidant Activity in Vitro
Metadata-grounded summary: This research article indexes research on Tremella fuciformis in International journal of molecular sciences in 2007. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..
King Oyster · 2006 · Journal Article · Carbohydrate polymers
A β-glucan from the fruit bodies of edible mushrooms Pleurotus eryngii and Pleurotus ostreatoroseus
The glucans of basidiomycetes are an important class of polysaccharides with potential biological activities. In this work, the β-glucans were isolated from the fruiting bodies of edible mushrooms, Pleurotus eryngii and Pleurotus ostreatoroseus, via extraction with hot water, and then fractionation by freeze-thawing..
Cordyceps · 2024 · Meta-Analysis · Journal of ethnopharmacology
Adjuvant treatment with Cordyceps sinensis for lung cancer: A systematic review and meta-analysis of randomized controlled trials.
ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps sinensis (CS) is a fungus parasitic on lepidopteran larvae which is often used to treat lung diseases and regulate immune function. AIM OF THE STUDY: This review aimed to evaluate the efficacy of CS in the adjuvant treatment of lung cancer..
Reishi · 2023 · English Abstract · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
[Lean strategy for data mining and continuous improvement of Chinese pharmaceutical process: a case study of sporoderm-removal Ganoderma lucidum spore powder].
In the digital transformation of Chinese pharmaceutical industry, how to efficiently govern and analyze industrial data and excavate the valuable information contained therein to guide the production of drug products has always been a research hotspot and application difficulty..
Lion's Mane · 2023 · Comparative Study · International journal of biological macromolecules
A comparison of study on intestinal barrier protection of polysaccharides from Hericium erinaceus before and after fermentation.
The intestinal barrier protects the host from harmful substances. This paper investigated two polysaccharides extracted from the Hericium erinaceus before and after fermentation (HEP and FHEP).
Almond Mushroom · 2023 · Research Support, Non U.S. Gov'T · Molecular nutrition & food research
Agaricus blazei Murrill Polysaccharide Attenuates Periodontitis via H2 S/NRF2 Axis-Boosted Appropriate Level of Autophagy in PDLCs.
SCOPE: Periodontitis is one of the most prevalent chronic inflammatory diseases with impaired autophagy. Agaricus blazei Murrill polysaccharide (ABMP) shows beneficial effects in various inflammatory diseases..
Reishi · 2023 · Research Support, Non U.S. Gov'T · Scientific reports
Amelioration of CCl4-induced oxidative stress and hepatotoxicity by Ganoderma lucidum in long evans rats.
Liver disease is a serious health problem affecting people worldwide at an alarming rate. The present study aimed to investigate the protective effects of Ganoderma lucidum against CCl4-induced liver toxicity in rats..
Enoki · 2023 · Research Support, Non U.S. Gov'T · The Journal of nutritional biochemistry
Auricularia polytricha and Flammulina velutipes reduce liver injury in DSS-induced Inflammatory Bowel Disease by improving inflammation, oxidative stress, and apoptosis through the regulation of TLR4/NF-κB signaling pathways.
Auricularia polytricha and Flammulina velutipes are two dietary mushrooms mostly consumed in China and known for their traditional use on gastric ulceration and to boost bowel movement..
Reishi · 2023 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)
Effects of drying methods on bioactive components of Ganoderma lucidum fermented whole wheat in products & in vitro digestive model.
The content of bioactive components is the key to determining the quality of Ganoderma lucidum fermented whole wheat (GW) products, and drying is a necessary link in the initial processing of GW, which will affect the bioactivity and quality of GW..
Reishi · 2023 · Research Support, Non U.S. Gov'T · Experimental gerontology
Ganoderma lucidum polysaccharides ameliorates D-galactose-induced aging salivary secretion disorders by upregulating the rhythm and aquaporins.
Longer-term deterioration in saliva secretion has been observed to occur in response to aging. The functional deterioration of the salivary gland damages swallowing and chewing abilities and consequently reduces life quality of the elderly..
Lion's Mane · 2023 · Research Support, Non U.S. Gov'T · Molecular nutrition & food research
Hericium erinaceus mycelium-Derived Polysaccharide Alleviates Ulcerative Colitis and Modulates Gut Microbiota in Cynomolgus Monkeys.
SCOPE: Ulcerative colitis (UC) is rapidly increasing worldwide but prolong use of available corticosteroids treatment is associated with numerous adverse effects. There is the urgent need to develop novel therapeutic options..
Reishi · 2023 · Research Support, Non U.S. Gov'T · Journal of materials chemistry. B
Improving nanochemoimmunotherapy efficacy by boosting "eat-me" signaling and downregulating "don't-eat-me" signaling with Ganoderma lucidum polysaccharide-based drug delivery.
To address the challenges posed by low immunogenicity and immune checkpoints during cancer treatment, we propose an alternative strategy that combines immunogenic cell death (ICD) effects with CD47/SIRPα blockade to reactivate phagocytosis of tumor cells by macrophages with polysaccharide-based drug delivery..
Chaga · 2023 · Research Support, Non U.S. Gov'T · FEMS microbiology letters
Inonotus obliquus sclerotia epidermis were different from internal tissues in compound composition, antioxidant activity, and associated fungi.
Inonotus obliquus is a medicinal fungus with potential for use in various health applications. To better utilize this fungus, this study focused on epidermis and internal tissues of five sclerotia from different regions in Jilin, Inner Mongolia, and Heilongjiang, examining their polyphenols, polysaccharides,….
Reishi · 2023 · Research Support, Non U.S. Gov'T · Aging
Ling Zhi-8, a fungal immunomodulatory protein in Ganoderma lucidum, alleviates CPT-11-induced intestinal injury via restoring claudin-1 expression.
CPT-11 (Irinotecan) remains an important chemotherapeutic agent against various solid tumors nowadays. Potential adverse effects, especially gastrointestinal toxicities, are the main limiting factor for its clinical utility..
Enoki · 2023 · Research Support, Non U.S. Gov'T · mSystems
Longitudinal Study of the Effects of Flammulina velutipes Stipe Wastes on the Cecal Microbiota of Laying Hens.
Because antibiotics have been phased out of use in poultry feed, measures to improve intestinal health have been sought. Dietary fiber may be beneficial to intestinal health by modulating gut microbial composition, but the exact changes it induces remain unclear..
Reishi · 2023 · Research Support, Non U.S. Gov'T · Organic letters
One-Pot Assembly of the Highly Branched Tetradecasaccharide from Ganoderma lucidum Glycan GLSWA-1 with Immune-Enhancing Activities.
The highly branched tetradecasaccharide repeating unit and shorter sequences of GLSWA-1 with immune-enhancing activities from Ganoderma lucidum have been prepared via a one-pot glycan assembly strategy..
Oyster Mushroom · 2023 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)
Preparation, structural characterization and neuroprotective effects to against H2O2-induced oxidative damage in PC12 cells of polysaccharides from Pleurotus ostreatus.
Pleurotus ostreatus is one of the most common edible and medicinal fungi in life, and its polysaccharide has been a hot research topic in recent years. In this paper, a new intracellular polysaccharide component named P.
Reishi · 2023 · Research Support, Non U.S. Gov'T · Microbiology spectrum
PRMT5 regulates the polysaccharide content by controlling the splicing of thaumatin-like protein in Ganoderma lucidum.
PRMT5 contributes to secondary metabolite biosynthesis in Ganoderma lucidum. However, the mechanism through which PRMT5 regulates the biosynthesis of secondary metabolites remains unclear.