MycoData

Hericium erinaceus, a well known edible mushroom, has numerous biological activities. Especially hericenones and erinacines isolated from its fruiting body stimulate nerve growth factor (NGF) synthesis, which expects H.

Cognition & nerves

High relevance

Shiitake · 2026 · Research Article · Foods (Basel, Switzerland)

A Conjoint Analysis of Consumer Preferences on Shiitake Mushrooms: A Case Study of the Republic of Korea.

Shiitake mushrooms (Lentinula edodes) are widely consumed as a key health food in the Republic of Korea. However, they face declining production value and consumption, necessitating a shift from production-focused research to an understanding of consumer demand..

High relevance

Maitake · 2026 · Journal Article · Journal of complementary & integrative medicine

Black maitake induces apoptosis and enhances the efficacy of standard chemotherapy in 2D and 3D U-87 MG glioblastoma cell models.

OBJECTIVES: Glioblastoma is an aggressive primary brain tumor marked by rapid growth, invasiveness, poor prognosis, and an over 90 % tumor recurrence rate. Current radiation and chemotherapy treatments are limited by non-selectivity and toxicity, creating a need for safer complementary treatments..

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Shiitake · 2026 · Journal Article · New biotechnology

Mechanical properties and water absorption of shiitake mushroom-based films with natural rubber latex.

Mechanical properties and water absorption were determined of films produced from powdered Lentinula edodes (shiitake) mushrooms with and without the addition of natural rubber latex using 80:20, 60:40, and 40:60 (w/w) mushroom-latex ratios..

High relevance

Nameko · 2026 · Journal Article · Fungal biology

Proteomic insights into Pholiota nameko mycelial response to wood-based substrates.

Pholiota microspora (Berk.) Sacc., commonly known as "nameko," is an edible mushroom widely cultivated in East Asia for both culinary and medicinal purposes. This study aimed to investigate how substrate composition influences the expression of lignocellulolytic enzymes in Pholiota nameko using label-free quantitative….

Energy & fatigue

High relevance

Shiitake · 2025 · Journal Article · Natural product research

A novel method for detecting conformation-dependent β-glucans-single, double, and triple-helical from Shiitake mushroom.

This pioneering study explores the structural intricacies of therapeutic β-glucan in Shiitake (Lentinula edodes), i.e. Lentinan (LNT).

Immune support

High relevance

Cordyceps · 2025 · Journal Article · Journal of medicinal food

Anti-Diabetic Activity of Cordyceps-Fermented Edible Insects by the Promotion of Glucose Absorption.

Insects are considered important food resources for future diet due to diverse nutrients and pharmacological effects. Fermentation is an important strategy of food processing with various beneficial effects such as increasing nutrients, promoting bioavailability, and reducing anti-nutrients..

Metabolic health

High relevance

Chaga · 2025 · Research Article · The Journal of veterinary medical science

Anticancer potentials of chaga and notoginseng against dog bladder cancer organoids.

Muscle-invasive bladder cancer (MIBC) is a common form of BC in dogs. Adjuvant chemotherapy administration is commonly applied in MIBC cases, but patients sometimes experience treatment failure and recurrence..

OncologyEnergy & fatigue

High relevance

Reishi · 2025 · Research Article · RSC advances

Encapsulation of progesterone in reishi mushroom composite for optimized hormone replacement and targeted anticancer therapy.

Conventional hormone replacement therapy (HRT) and hormone-dependent cancer treatments face significant challenges, including poor bioavailability, rapid metabolism, and adverse side effects of progesterone, as well as limited targeting efficiency and systemic toxicity..

Oncology

High relevance

Shiitake · 2025 · Journal Article · Journal of basic microbiology

Establishing an Interactive Sequence Database for Shiitake Cultivar Identification.

Shiitake mushrooms (Lentinula edodes) hold significant cultural and economic value, particularly in Asia where they are extensively cultivated. The diversification of shiitake cultivars, driven by the need to adapt to various climatic conditions and cultivation methods, has resulted in over 200 distinct cultivars..

High relevance

Lion's Mane · 2025 · Research Article · Foods (Basel, Switzerland)

Functional and Nutritional Properties of Lion's Mane Mushrooms in Oat-Based Desserts for Dysphagia and Healthy Ageing.

Hericium erinaceus (Lion's Mane mushroom) is a medicinal species recognised for its neuroprotective and antioxidant properties. This study investigated its potential as a functional ingredient in oat milk-based desserts formulated for individuals with dysphagia..

Cognition & nervesLiver support

High relevance

Reishi · 2025 · Research Article · RSC advances

Innovative eco-sustainable reishi mushroom-based adsorbents for progesterone removal and agricultural sustainability.

The pervasive presence of endocrine-disrupting chemicals (EDCs), particularly progesterone, in aquatic ecosystems poses significant ecological and human health risks, necessitating the development of sustainable and efficient removal strategies..

High relevance

Chaga · 2025 · Research Article · International journal of molecular sciences

INO10, a Chaga Mushroom Extract, Alleviates Alzheimer's Disease-Related Pathology and Cognitive Deficits in 3xTg-AD Mice.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive impairment with amyloid-β (Aβ) accumulation, tau hyperphosphorylation, and neuroinflammation. Among these pathological features, microglial activation is hallmark of neuroinflammation..

Immune supportCognition & nerves

High relevance

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Integrated Amino Acid Profiling and 4D-DIA Proteomics Reveal Protein Quality Divergence and Metabolic Adaptation in Cordyceps Species.

To explore the differences in protein quality among classic medicinal entomopathogenic fungi and to evaluate their metabolic adaptability, we analyzed the amino acid composition and proteomic characteristics of Cordyceps sinensis (CS), Cordyceps militaris (CM), and Cordyceps cicadae (CC)..

Energy & fatigueMetabolic healthLiver support

High relevance

Shiitake · 2025 · Journal Article · Food chemistry

Integrated peptidomics and in-silico approach for elucidation of the flavour generating peptides in enzymatically hydrolysed shiitake mushroom extracts.

Shiitake mushroom (Lentinula edodes) is the world's second most cultivated edible fungus valued for its delicious taste and unique flavour. Abundant in proteins, nucleotides, and fatty acids, it represents a promising raw material for flavour enhancement and product development.

Cognition & nerves

High relevance

Enoki · 2025 · Journal Article · Food Chemistry

Metabolic remodeling during fructification of enoki mushroom

This study investigated the patterns of change and differences in metabolites between white and golden enoki (Flammulina velutipes) mycelium and across stages of fruit-body growth of golden enoki, which was cultured under controlled conditions..

Metabolic health

High relevance

Enoki · 2025 · Journal Article · Food chemistry

Metabolic remodeling during fructification of enoki mushroom.

Metabolic health

High relevance

Cordyceps · 2025 · Research Article · Scientific reports

Quantitative detection of β-glucans in Cordyceps species using a validated Congo red assay.

β-Glucan is extensively utilized in the food industry for its functional benefits, including blood glucose and lipid regulation, enhanced food texture, and a prolonged shelf life..

OncologyImmune supportMetabolic healthSkin & hydration

High relevance

Shiitake · 2025 · Research Article · PloS one

Sustainable memristors from shiitake mycelium for high-frequency bioelectronics.

Neuromorphic computing, inspired by the structure of the brain, offers advantages in parallel processing, memory storage, and energy efficiency. However, current semiconductor-based neuromorphic chips require rare-earth materials and costly fabrication processes, whereas neural organoids need complex bioreactor….

Cognition & nervesEnergy & fatigueSkin & hydration

High relevance

Shiitake · 2025 · Journal Article · Journal of applied microbiology

Warm-tolerant shiitake cultivation on alternative subtropical substrates.

AIMS: We aim to evaluate the productivity of shiitake strains under warm cultivation temperatures using alternative substrates from neotropical tree species, addressing the challenges of global warming and substrate availability..

High relevance

Shiitake · 2024 · Journal Article · Journal of food composition and analysis

Comparative analysis of substrate components, nutritive value, ergosterol distribution, and vitamin D2 enrichment in shiitake mushrooms cultivated on wood substrates

This study investigated shiitake [Lentinula edodes (Berk.)] mushrooms cultivated on seven hardwood and two softwood substrates for production, compositional changes, nutritive value, and ergosterol conversion to vitamin D₂ content..

High relevance

Oyster Mushroom · 2024 · Research Article · Mycology

Fabrication of mycelium (oyster mushroom)-based composites derived from spent coffee grounds with pineapple fibre reinforcement.

Mycelium-based composites (MBCs) are eco-friendly materials made by combining mushroom mycelia with lignocellulosic biomass, offering diverse applications such as packaging and construction..

High relevance

Reishi · 2024 · Research Article · Journal of biomaterials and nanobiotechnology

Rapid Green Synthesis of Silver Nanoparticles by Reishi and Their Antibacterial Activity and Mechanisms.

Nanotechnology is a rapidly growing field in biomedical engineering with references to efficiency, safety, and cost-effective approaches. Herein, the objective of this study was to examine an innovative approach to rapidly synthesis silver nanoparticles from an aqueous extract of medicinal mushroom Ganoderma lucidum….

Respiratory

High relevance

Lion's Mane · 2023 · Randomized Controlled Trial · Nutrients

Acute Effects of Naturally Occurring Guayusa Tea and Nordic Lion's Mane Extracts on Cognitive Performance.

The aim of this study was to assess the effects of guayusa extract and Nordic Lion's Mane (LM) on cognition. Using a randomized, double-blind, placebo-controlled, crossover design, we examined the effects of a single dose of 650 mg guayusa extract (AMT: AmaTea® Max) vs.

Cognition & nervesEnergy & fatigueMetabolic health

High relevance

Chaga · 2023 · Review · Frontiers in pharmacology

Chaga mushroom: a super-fungus with countless facets and untapped potential.

Inonotus obliquus (Chaga mushroom) is an inexpensive fungus with a broad range of traditional and medicinal applications. These applications include therapy for breast, cervix, and skin cancers, as well as treating diabetes..

OncologyImmune supportMetabolic healthSkin & hydration

High relevance

Almond Mushroom · 2023 · Randomized Controlled Trial · Scandinavian journal of psychology

Cognitive behavioral therapy (CBT) plus attention bias modification (ABM) reduces anxiety sensitivity and depressive symptoms in panic disorder: A pilot randomized trial.

BACKGROUND: Cognitive bias theories propose that reducing threat hypervigilance in mental disorders can augment cognitive behavioral therapy (CBT) outcomes. However, no studies have tested whether adding attention bias modification (ABM) can effectively enhance CBT's effects on anxiety sensitivity (AS),….

Cognition & nervesSkin & hydration

High relevance

Snow Fungus · 2023 · Randomized Controlled Trial · Nutrients

Effectiveness of Fish Roe, Snow Fungus, and Yeast Supplementation for Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

The brain is one of the most critical organs in the human body, regulating functions such as thinking, memory, learning, and perception. Studies have indicated that fish roe, snow fungus, and yeast may have the potential to modulate cognitive, memory, and emotional functions..

Cognition & nervesEnergy & fatigue

High relevance

Almond Mushroom · 2023 · Randomized Controlled Trial · Journal of affective disorders

The long-term effects of ABM on symptom severity in patients with recurrent depression: A randomized sham-controlled trial.

BACKGROUND: The present study reports on long-term outcomes of ABM over one year in self-reported and clinician-rated depression symptoms, anxiety symptoms, and relapse rates..

Cognition & nerves

High relevance

Cordyceps · 2022 · Review Article · Molecules (Basel, Switzerland)

Effect of Cordyceps spp. and Cordycepin on Functions of Bones and Teeth and Related Processes: A Review.

Cordyceps spp. (belonging to the Ascomycota group) are entomopathogenic mushrooms that have traditionally been used in ethnomedicine in Asian countries such as China, Japan, Korea, and India.

High relevance

Shiitake · 2022 · Research Article · Animals: an open access journal from MDPI

Effect of Lentinula edodes on Morphological and Biochemical Blood Parameters of Horses.

Shiitake mushrooms have been highly regarded as possessing enormous nutritive and medicinal values. No clinical studies have yet investigated the effect of shitake supplementation on the health of horses..

Immune supportMetabolic health

High relevance

Maitake · 2022 · Randomized Controlled Trial · Acta biochimica Polonica

Effect of Maitake D-fraction in advanced laryngeal and pharyngeal cancers during concurrent chemoradiotherapy: A randomized clinical trial.

BACKGROUND: Concurrent chemo-radiotherapy (CCRT) is an ideal treatment for advanced head and neck squamous cell carcinoma (HNSCC). The performance of CCRT induces severe toxicities in HNSCC patients and decreases the quality of life (QOL)..

OncologyImmune supportEnergy & fatigue

High relevance

Cordyceps · 2021 · Randomized Controlled Trial · Zhonghua nan ke xue = National journal of andrology

[Cordyceps sinensis combined with Jujing Pills for male infertility].

OBJECTIVE: To observe the clinical effect and safety of Cordyceps sinensis (CS) combined with Jujing Pills (JJP) in the treatment of male infertility. METHODS: We randomly divided 90 male infertility patients into three groups of an equal number and treated them with JJP tid 5g once, CS bid 1g once and CS+JJP,….

High relevance

Shiitake · 2021 · Randomized Controlled Trial · International journal of medicinal mushrooms

Effects of Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Bars on Lipid and Antioxidant Profiles in Individuals with Borderline High Cholesterol: A Double-Blind Randomized Clinical Trial.

Shiitake (Lentinus edodes) is a culinary-medicinal mushroom that has low lipid content and is rich in protein, fiber, minerals, vitamins, antioxidant compounds, and β-glucans. We assessed the effects of L..

Metabolic healthSkin & hydration

High relevance

Reishi · 2021 · Research Article · Foods (Basel, Switzerland)

Study of the Lipolysis Effect of Nanoliposome-Encapsulated Ganoderma lucidum Protein Hydrolysates on Adipocyte Cells Using Proteomics Approach.

Excessive lipid accumulation is a serious condition. Therefore, we aimed at developing safe strategies using natural hypolipidemic products.

Metabolic health

High relevance

Maitake · 2019 · Meta-Analysis · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Meta-analysis on effect of Grifola frondosa polysaccharide in regulating in vivo immunoregulatory function on animal disease models].

The study aimed to explore the in vivo immunoregulatory function of Grifola frondosa polysaccharide( GFP) on animal disease models. Databases of PubMed,Embase,Web of Scinece,CNKI,CBM and Wan Fang Data were searched from the date of their establishment to February 2018..

Immune support

High relevance

Chaga · 2023 · English Abstract · Voprosy virusologii

[Antiviral activity of basidial fungus Inonotus obliquus aqueous extract against SARS-CоV-2 virus (Coronaviridae: Betacoronavirus: Sarbecovirus) in vivo in BALB/c mice model].

INTRODUCTION: The COVID-19 pandemic combined with seasonal epidemics of respiratory viral diseases requires targeted antiviral prophylaxis with restorative and immunostimulant drugs. The compounds of natural origin are low-toxic, but active against several viruses at the same time..

Immune supportRespiratory

High relevance

Chaga · 2023 · English Abstract · Voprosy virusologii

[Screening of antiviral activity of samples from chaga Inonotus obliquus and humic acid from brown coal on Vero cell culture against ectromelia virus (Poxviridae: Orthopoxvirus; ECTV)].

INTRODUCTION: The mouse-specific orthopoxvirus, ectromelia virus, is one of the best models that can be used to study key issues of pathogenesis, prevention, and treatment of smallpox, and to develop measures to increase virulence, transmissibility, or the ability to overcome vaccine immunity..

OncologyImmune supportRespiratory

High relevance

Almond Mushroom · 2023 · English Abstract · Zhongguo shi yan xue ye xue za zhi

[Study on the Mechanism of Multi-Drug Resistance of Agaricus Blazei Extract FA-2-b-β Mediated Wnt Signaling Pathway to Reverse Acute T Lymphoblastic Leukemia].

OBJECTIVE: To investigate the mechanism of drug reversing resistance of Agaricus blazei extract FA-2-b-β on T cell acute lymphoblastic leukemia (T-ALL) cell lines..

OncologyImmune supportEnergy & fatigue

High relevance

Cordyceps · 2023 · Research Support, Non U.S. Gov'T · PloS one

Altered GC- and AT-biased genotypes of Ophiocordyceps sinensis in the stromal fertile portions and ascospores of natural Cordyceps sinensis.

OBJECTIVE: To examine multiple genotypes of Ophiocordyceps sinensis in a semi-quantitative manner in the stromal fertile portion (SFP) densely covered with numerous ascocarps and ascospores of natural Cordyceps sinensis and to outline the dynamic alterations of the coexisting O..

High relevance

Turkey Tail · 2023 · Research Support, Non U.S. Gov'T · Scientific reports

Anti-Toxoplasma gondii activity of Trametes versicolor (Turkey tail) mushroom extract.

Toxoplasma gondii (T. gondii) infection continues to rise globally in humans and animals with high socioeconomic and public health challenges.

OncologyEnergy & fatigue

High relevance

Lion's Mane · 2023 · Research Support, Non U.S. Gov'T · Scientific reports

Commercial scale production of Yamabushitake mushroom (Hericium erinaceus (Bull.) Pers. 1797) using rubber and bamboo sawdust substrates in tropical regions.

Yamabushitake (Hericium erinaceus) is one of the most sought out mushrooms that is widely used for both direct consumption and medicinal purposes. While its demand increases worldwide, cultivation of the mushroom is limited to temperate areas and its production in tropical regions has never been explored..

High relevance

Oyster Mushroom · 2023 · Comparative Study · Food science and technology international = Ciencia y tecnologia de los alimentos internacional

Comparison of modelling approaches for the prediction of kinetic growth parameters of Pseudomonas spp. in oyster mushroom (Pleurotus ostreatus).

In predictive microbiology, primary and secondary models can be used to predict microbial growth, usually in a two-step modelling approach. The inverse dynamic modelling approach is an alternative method to direct modelling methods, in which the primary and secondary models are fitted simultaneously from….

High relevance

Reishi · 2023 · Research Support, Non U.S. Gov'T · Scientific reports

Comparison of the dried properties of Ganoderma lucidum produced by the convective dryer and infrared dryer.

Ganoderma lucidum is a promising medicine with a high amount of antioxidants and calcium. The selection of appropriate drying process methods in food science has a chief role to reach the best final characteristics..

Energy & fatigue

High relevance

Shiitake · 2023 · Research Support, Non U.S. Gov'T · FEMS microbiology letters

Development of a gene-targeting system using CRISPR/Cas9 and utilization of pyrG as a novel selectable marker in Lentinula edodes.

First, we attempted to recombine the Shiitake (Lentinula edodes) pyrG (ura3) gene homologously by introducing a donor vector containing a carboxin resistance gene (lecbxR) flanked by homologous sequences of pyrG into protoplasts of the fungus..

High relevance

Reishi · 2023 · Comparative Study · International journal of medicinal mushrooms

Differential Analysis of Korean and Chinese Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Spore Powder by Infrared Spectroscopy with Stoichiometry.

To investigate the differences between Korean Ganoderma lucidum spore powder (KP), broken-spo-roderm KP (BSKP), Chinese traditional G. lucidum spore powder (CP), and broken-sporoderm CP (BSCP), they were identified by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), second….

Immune support

High relevance

Cordyceps · 2023 · Research Support, Non U.S. Gov'T · PloS one

Differential coexistence of multiple genotypes of Ophiocordyceps sinensis in the stromata, ascocarps and ascospores of natural Cordyceps sinensis.

OBJECTIVE: To examine the differential occurrence of Ophiocordyceps sinensis genotypes in the stroma, stromal fertile portion (SFP) densely covered with numerous ascocarps, and ascospores of natural Cordyceps sinensis. METHODS: Immature and mature C.

High relevance

Oyster Mushroom · 2023 · Research Support, Non U.S. Gov'T · FEMS microbiology letters

Double-gene targeting with preassembled Cas9 ribonucleoprotein for safe genome editing in the edible mushroom Pleurotus ostreatus.

CRISPR/Cas9 has potential for efficient molecular breeding. Recently, a foreign-DNA-free gene-targeting technology was established by introducing a preassembled Cas9 ribonucleoprotein (RNP) complex into the oyster mushroom Pleurotus ostreatus..

High relevance

Cordyceps · 2023 · Research Support, Non U.S. Gov'T · FEMS microbiology letters

Efficient disruption of CmHk1 using CRISPR/Cas9 ribonucleoprotein delivery in Cordyceps militaris.

Cordyceps militaris, an entomopathogenic ascomycete, produces edible medicinal mushrooms known to have medicinal and therapeutic functions. To develop the genetic transformation system in C.

Liver support

High relevance

Yellow Morel · 2023 · Research Support, Non U.S. Gov'T · Scientific reports

Elucidating the molecular mechanisms underlying anti-inflammatory effects of Morchella esculenta in the arachidonic acid metabolic pathway by network pharmacology and molecular docking.

Morchella esculenta is an edible fungus with a uniquely delicious flavor and remarkable benefits for health. Herein, the molecular mechanism underlying the anti-inflammatory effects of Morchella esculenta was elucidated using molecular docking and network pharmacology..

Immune supportCognition & nervesMetabolic health

High relevance

Cordyceps · 2023 · Research Support, Non U.S. Gov'T · Scientific reports

First report of emerging fungal pathogens of Cordyceps militaris in Vietnam.

Cultivation of Cordyceps militaris, a valuable medicinal and edible fungus, has dramatically increased in Vietnam since 2010. During industrial production, parasitic white molds were found to infect the mycelia and fruiting bodies of C.