MycoData

Cordyceps militaris is a crude dietary therapeutic mushroom with high nutritional and medicinal values. Mushroom-derived polysaccharides have been found to possess antihyperglycemic and antihyperlipidemic activities..

Immune supportMetabolic healthLiver support

High relevance

King Oyster · 2018 · Journal Article · International journal of medicinal mushrooms

Structural Characterization of Polysaccharides of a Productive Strain of the Culinary-Medicinal King Oyster Mushroom, Pleurotus eryngii (Agaricomycetes), from Italy.

A preliminary biological investigation of the dry basidiomata of strain C-142-c of Pleurotus eryngii has shown significant antioxidant activity. Two different polysaccharides (PEPS-A1 and PEPS-A2) were isolated from the cultivated edible mushroom, P.

OncologyImmune support

High relevance

Cordyceps · 2018 · Journal Article · Food & function

Structural elucidation and immunostimulatory activity of a new polysaccharide from Cordyceps militaris.

A new polysaccharide (CMPB90-1) was isolated from cultured Cordyceps militaris by alkaline extraction. The chemical structure of CMPB90-1 was determined by analysis of physicochemical and spectral data..

OncologyImmune support

High relevance

Agarikon · 2018 · Journal Article · Carbohydrate polymers

Structure characterization of the mannofucogalactan isolated from fruit bodies of Quinine conk Fomitopsis officinalis.

The mannofucogalactan as a major component of water extract was obtained from fruit bodies of Fomitopsis officinalis by extraction with boiling water followed by deproteination, decoloration, and purification using anion-exchange chromatography and size exclusion chromatography..

Immune support

High relevance

Cordyceps · 2018 · Journal Article · Molecular biotechnology

Targeted Gene Deletion in Cordyceps militaris Using the Split-Marker Approach.

The macrofungus Cordyceps militaris contains many kinds of bioactive ingredients that are regulated by functional genes, but the functions of many genes in C. militaris are still unknown..

High relevance

Lion's Mane · 2018 · Research Article · International journal of molecular sciences

The Cyanthin Diterpenoid and Sesterterpene Constituents of Hericium erinaceus Mycelium Ameliorate Alzheimer's Disease-Related Pathologies in APP/PS1 Transgenic Mice.

Hericium erinaceus was used in traditional Chinese medicine for physiologically beneficial medicines. Recently, it has become a candidate in causing positive brain health-related activities.

Cognition & nervesMetabolic health

High relevance

Shiitake · 2018 · Journal Article · International journal of food science & technology

The effect and mechanism of ultrasonic treatment on the postharvest texture of shiitake mushrooms (Lentinula edodes)

Fresh shiitake mushrooms (Lentinula edodes) are prone to texture softening and quality decline during storage. We investigated the effects of prestorage ultrasonic treatment on the textural changes of the mushrooms during storage..

Metabolic health

High relevance

Shiitake · 2018 · Journal Article · Journal of wood science

The effects of chemical components and particle size on the mechanical properties of binderless boards made from oak (Quercus spp.) logs degraded by shiitake fungi (Lentinula edodes)

Binderless boards are composite boards that rely on self-bonding mechanisms for inter-fibre bonding. Quercus acutissima and Quercus serrata logs degraded by Lentinula edodes (shiitake fungi) were used in this study to investigate whether physical and chemical changes induced by shiitake fungi can enhance board….

High relevance

Lion's Mane · 2018 · Research Article · Molecules (Basel, Switzerland)

The Prebiotic Activity of Simulated Gastric and Intestinal Digesta of Polysaccharides from the Hericium erinaceus.

Hericium erinaceus (HE) is a well-known edible and medicinal fungus widely grown in Asian countries. Polysaccharides from the Hericium erinaceus (HEP) are major biological macromolecules..

Immune supportGut & microbiome

High relevance

King Oyster · 2018 · Journal Article · Fitoterapia

Three bisabolane-type sesquiterpenes from edible mushroom Pleurotus eryngii.

Three bisabolane-type sesquiterpenes (1-3) were isolated from the fruiting bodies of king trumpet mushrooms (Pleurotus eryngii), together with a known compound (4). All isolated compounds were evaluated for their inhibitory effects on nitric oxide (NO) production..

High relevance

King Oyster · 2018 · Journal Article · Chemosphere

Transcriptome analysis reveals the role of nitric oxide in Pleurotus eryngii responses to Cd2+ stress.

Pleurotus eryngii is widely cultivated in China. However, our understanding of its transcriptional response to heavy metal stress and the underlying mechanism of nitric oxide (NO) in enhancing its tolerance to heavy metals is limited..

Metabolic health

High relevance

Reishi · 2018 · Journal Article · International journal of medicinal mushrooms

Triterpenes and Soluble Polysaccharide Changes in Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), During Fruiting Growth.

We analyzed the changes in triterpenes and soluble polysaccharides in Ganoderma lucidum strain G0119 during 4 growth phases in 3 regions of the fruiting bodies using reversed-phase high-performance liquid chromatography, and we also analyzed the soluble polysaccharides using high-performance size-exclusion….

Immune supportEnergy & fatigue

High relevance

Lion's Mane · 2018 · Research Article · International journal of molecular sciences

Two New Cyathane Diterpenoids from Mycelial Cultures of the Medicinal Mushroom Hericium erinaceus and the Rare Species, Hericium flagellum.

Basidiomycetes of the genus Hericium are among the most praised medicinal and edible mushrooms, which are known to produce secondary metabolites with the potential to treat neurodegenerative diseases..

Cognition & nerves

High relevance

King Oyster · 2018 · Journal Article · Water science and technology: a journal of the International Association on Water Pollution Research

Utilization of Pleurotus eryngii biosorbent as an environmental bioremedy for the decontamination of trace cadmium(II) ions from water system.

In many parts of the world, cadmium metal concentration in drinking water is higher than some international guideline values. To reduce its level below the safety limit, a sustainable and environmental friendly approach is crucial..

Energy & fatigue

High relevance

Shiitake · 2017 · Journal Article · Journal of food biochemistry

1H NMR‐based metabolic investigation of the effect of Lentinula edodes‐derived polysaccharides on aged mice

Few comprehensive metabolic profiles of Lentinula edodes‐derived polysaccharides on mammalians have been reported to date. In previous studies, a novel heteropolysaccharide, named L2, obtained from L.

Immune supportEnergy & fatigueMetabolic health

High relevance

King Oyster · 2017 · Journal Article · Journal of medicinal food

A 4-Nitroquinoleneoxide-Induced Pleurotus eryngii Mutant Variety Increases Pin1 Expression in Rat Brain.

To develop Pleurotus eryngii varieties with improved medicinal qualities, protoplasts of P. eryngii were mutagenized using 4-nitroquinoleneoxide.

Cognition & nervesLiver support

High relevance

Cordyceps · 2017 · Journal Article · Natural product research

A new ribonucleotide from Cordyceps militaris.

One new ribonucleotide, 5'-(3''-deoxy-β-D-ribofuranosyl)-3'-deoxyadenosine (1), and 14 known compounds (2-15) were isolated from an ethanol extract of Cordyceps militaris..

Immune support

High relevance

Cordyceps · 2017 · Journal Article · International journal of medicinal mushrooms

A Novel Technique for Rejuvenation of Degenerated Caterpillar Medicinal Mushroom, Cordyceps militaris (Ascomycetes), a Valued Traditional Chinese Medicine.

Cordyceps militaris has been used in traditional Chinese medicine for many years, but its frequent degeneration during continuous maintenance in culture can lead to substantial commercial losses. In this study, a degenerated strain of C..

High relevance

Lion's Mane · 2017 · Journal Article · International journal of medicinal mushrooms

A Polysaccharide Isolated from Mycelia of the Lion's Mane Medicinal Mushroom Hericium erinaceus (Agaricomycetes) Induced Apoptosis in Precancerous Human Gastric Cells.

Hericium erinaceus is typically used in traditional Chinese medicine for mucosal protection, healing of gastric ulcers, and treatment of gastritis. We purified from the cultured mycelia of H..

OncologyImmune support

High relevance

Enoki · 2017 · Journal Article · Bioscience, biotechnology, and biochemistry

A protease/peptidase from culture medium of Flammulina velutipes that acts on arabinogalactan-protein.

Arabinogalactan-proteins (AGPs) are highly diverse plant proteoglycans found on the plant cell surface. AGPs have large arabinogalactan (AG) moieties attached to a core-protein rich in hydroxyproline (Hyp)..

High relevance

King Oyster · 2017 · Journal Article · International immunopharmacology

Activity-guided isolation and structural identification of immunomodulating substances from Pleurotus eryngii byproducts.

A two-step extraction process was used to investigate the bioactive substances from the byproducts of the fungus Pleurotus eryngii. Methanol extraction followed by extraction using different polar solvents coupled with silica column chromatography was carried out to separate the bioactive components..

OncologyImmune support

High relevance

King Oyster · 2017 · Journal Article · Carbohydrate polymers

Anti-hyperlipidemic and antioxidant effects of alkali-extractable mycelia polysaccharides by Pleurotus eryngii var. tuolensis.

In this study, we noted that the Al-MPS from Pleurotus eryngii var. tuolensis provoked pharmacological effects on blood lipid profiles and oxidative stress.

Immune supportMetabolic healthLiver support

High relevance

Cordyceps · 2017 · Research Article · Food science and biotechnology

Anti-inflammatory effect of the extract from fermented Asterina pectinifera with Cordyceps militaris mycelia in LPS-induced RAW264.7 macrophages.

In our previous work, Asterina pectinifera was fermented with Cordyceps militaris mycelia to improve its bioactivities and was reported to have strong antioxidant activities. The aim of the current study was to investigate its anti-inflammatory effect and mechanisms of action..

Immune supportEnergy & fatigue

High relevance

Lion's Mane · 2017 · Journal Article · Journal of natural medicines

Anti-obesity activity of Yamabushitake (Hericium erinaceus) powder in ovariectomized mice, and its potentially active compounds.

Hericium erinaceus (H. erinaceus) improves the symptoms of menopause.

Cognition & nervesMetabolic health

High relevance

Shiitake · 2017 · Journal Article · Journal of food processing and preservation

Anti‐Inflammatory and Antioxidant Properties of Pulsed Light Irradiated Lentinula edodes

Intense pulsed light irradiation is used in food decontamination and in production of mushrooms with high level of ergocalciferol. Lentinula edodes (Berk.) Pegler, shiitake, was freeze‐dried and milled into powder and irradiated with 20, 40 and 60 pulses of pulsed light at a distance of 6 cm and the irradiation energy….

OncologyImmune supportEnergy & fatigue

High relevance

Cordyceps · 2017 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Anticancer Efficacy of Cordyceps militaris Ethanol Extract in a Xenografted Leukemia Model.

Cordyceps militaris is used widely as a traditional medicine in East Asia. Although a few studies have attempted to elucidate the anticancer activities of C.

OncologyImmune support

High relevance

Almond Mushroom · 2017 · Research Article · Oxidative medicine and cellular longevity

Antigenotoxic Properties of Agaricus blazei against Hydrogen Peroxide in Human Peripheral Blood Cells.

The ability of Agaricus blazei mushroom in its dried and powdered mycelial form was evaluated for its antigenotoxic properties for the first time. Antigenotoxic effects in human peripheral blood cells against H2O2-induced DNA damage were examined in pretreatment and posttreatment protocol by comet assay..

High relevance

King Oyster · 2017 · Research Article · BMC complementary and alternative medicine

Antihyperlipidaemic and hepatoprotective activities of acidic and enzymatic hydrolysis exopolysaccharides from Pleurotus eryngii SI-04.

BACKGROUND: Hyperlipidaemia is the major risk factor contributing to the development and progression of atherosclerosis, fatty liver and cerebrovascular disease. Pleurotus eryngii (P..

Immune supportMetabolic healthLiver support

High relevance

Niu-Chang-Chih · 2017 · Research Article · PloS one

Antimelanogenic, Antioxidant and Antiproliferative Effects of Antrodia camphorata Fruiting Bodies on B16-F0 Melanoma Cells.

Antrodia camphorata is a fungus that is endemic to Taiwan, and its fruiting body has been used as a folk medicine for the prevention or treatment of diverse diseases..

OncologySkin & hydration

High relevance

King Oyster · 2017 · Journal Article · International journal of biological macromolecules

Antioxidant and anti-hyperlipidemic effects of mycelia zinc polysaccharides by Pleurotus eryngii var. tuoliensis.

The aims of this work were designed to investigate the hepatoprotective and antioxidant effects of acidic- and alkali-extractable mycelia zinc polysaccharides (AcMZPS, AlMZPS) from Pleurotus eryngii var. tuoliensis on high-fat-high-cholesterol emulsion-induced hyperlipidemic mice..

Immune supportMetabolic healthLiver support

High relevance

King Oyster · 2017 · Journal Article · International journal of biological macromolecules

Antioxidant, antitumor and immunostimulatory activities of the polypeptide from Pleurotus eryngii mycelium.

The objective of this study was to investigate the antioxidant, antitumor and immunological activities of the polypeptide from Pleurotus eryngii mycelium (PEMP). The ability of the polypeptide to stimulate Ana-1 macrophages to englobe neutral red, secrete NO, H2O2, TNF-α, and IL-6, increase TLR2 and TLR4 expression….

OncologyImmune supportSkin & hydrationRespiratory

High relevance

Maitake · 2017 · Journal Article · Nutrition and cancer

Antitumoral Effects of D-Fraction from Grifola Frondosa (Maitake) Mushroom in Breast Cancer.

D-Fraction is protein-bound β-1,6 and β-1,3 glucans (proteoglucan) extracted from the edible and medicinal mushroom Grifola frondosa (Maitake). The antitumoral effect of D-Fraction has long been exclusively attributed to their immunostimulatory capacity..

OncologyImmune supportRespiratory

High relevance

Niu-Chang-Chih · 2017 · Journal Article · Environmental toxicology

Antrodia camphorata attenuates cigarette smoke-induced ROS production, DNA damage, apoptosis, and inflammation in vascular smooth muscle cells, and atherosclerosis in ApoE-deficient mice.

Cigarette smoke exposure activates several cellular mechanisms predisposing to atherosclerosis, including oxidative stress, dyslipidemia, and vascular inflammation..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Shiitake · 2017 · Research Article · Frontiers in microbiology

Association Mapping Reveals Genetic Loci Associated with Important Agronomic Traits in Lentinula edodes, Shiitake Mushroom.

Association mapping is a robust approach for the detection of quantitative trait loci (QTLs). Here, by genotyping 297 genome-wide molecular markers of 89 Lentinula edodes cultivars in China, the genetic diversity, population structure and genetic loci associated with 11 agronomic traits were examined..

High relevance

Oyster Mushroom · 2017 · Journal Article · World journal of microbiology & biotechnology

Bioactive compounds and antioxidant activity exhibit high intraspecific variability in Pleurotus ostreatus mushrooms and correlate well with cultivation performance parameters.

Experimental data related with oyster mushroom production and nutritional properties usually derive from the examination of only one strain, and hence their representativeness/usefulness is questionable..

Energy & fatigue

High relevance

Cordyceps · 2017 · Journal Article · International journal of biological macromolecules

Biochemical characterization of a novel fibrinolytic enzyme from Cordyceps militaris.

A fibrinolytic enzyme was produced by the medicinal mushroom, Cordyceps militaris using submerged fermentation. The enzyme was purified from culture supernatant by hydrophobic interaction, ion exchange and gel filtration chromatographies..

High relevance

Turkey Tail · 2017 · Research Article · Materials (Basel, Switzerland)

Biological Degradation of Chinese Fir with Trametes Versicolor (L.) Lloyd.

Chinese fir (Cunninghamia lanceolata (Lamb.) Hook.) has been an important afforestation species in northeast China. It has obvious defects of buckling and cracking easily, which are caused by its chemical components..

Gut & microbiomeSkin & hydration

High relevance

King Oyster · 2017 · Research Article · PloS one

Bioremediation of aflatoxin B1-contaminated maize by king oyster mushroom (Pleurotus eryngii).

Aflatoxin B1 (AFB1) is the most harmful mycotoxin that occurs as natural contaminant of agricultural commodities, particularly maize. Practical solutions for detoxification of contaminated staples and reduction of agricultural wastes are scarce..

High relevance

Cordyceps · 2017 · Journal Article · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Broad-spectrum immunoaffinity cleanup for the determination of aflatoxins B1, B2, G1, G2, M1, M2 in Ophiocordyceps sinensis and its pharmaceutical preparations by ultra performance liquid chromatography tandem mass spectrometry.

An ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the simultaneous determination of aflatoxins B1, B2, G1, G2, M1 and M2 (AFB1, AFB2, AFG1, AFG2, AFM1 and AFM2) in Ophiocordyceps sinensis and its pharmaceutical preparations..

Immune supportEnergy & fatigue

High relevance

Maitake · 2017 · Journal Article · Bioscience, biotechnology, and biochemistry

CE-MS-based metabolomics reveals the metabolic profile of maitake mushroom (Grifola frondosa) strains with different cultivation characteristics.

Maitake mushroom (Grifola frondosa [Dicks.] Gray) is generally cultured using the sawdust of broadleaf trees. The maitake strain Gf433 has high production efficiency, with high-quality of fruiting bodies even when 30% of the birch sawdust on the basal substrate is replaced with conifer sawdust..

Metabolic health

High relevance

Enoki · 2017 · Journal Article · Journal of food science

Characteristics and Rheological Properties of Polysaccharide Nanoparticles from Edible Mushrooms (Flammulina velutipes).

Nanotechnology has become relevant in the food-related industries, and edible mushrooms can be a potential raw material for providing satisfied edible nanomaterial..

Immune support

High relevance

King Oyster · 2017 · Journal Article · European journal of plant pathology

Characterization and pathogenicity of Cladobotryum mycophilum in Spanish Pleurotus eryngii mushroom crops and its sensitivity to fungicides

In 2010, symptoms of cobweb disease were observed on cultivated Pleurotus eryngii crops in Spain. Based on morphological and genetic analyses, the causal agent of cobweb was identified as Cladobotryum mycophilum.

High relevance

King Oyster · 2017 · Research Article · The plant pathology journal

Characterization of the rcsA Gene from Pantoea sp. Strain PPE7 and Its Influence on Extracellular Polysaccharide Production and Virulence on Pleurotus eryngii.

RcsA is a positive activator of extracellular polysaccharide (EPS) synthesis in the Enterobacteriaceae. The rcsA gene of the soft rot pathogen Pantoea sp.

Immune support

High relevance

King Oyster · 2017 · Journal Article · International journal of food properties

Chemical properties of vacuum-fried Pleurotus eryngii during storage and characterization of brown pigment

In this study, changes in the color value, 5-hydroxymethylfurfural (5-HMF), free amino acid (FAA), reducing sugar, peroxide value (PV) and malondialdehyde (MDA) in vacuum-fried Pleurotus eryngii products were investigated. The FAA and reducing sugar decreased, whereas 5-HMF, PV and MDA increased during storage..

High relevance

Cordyceps · 2017 · Research Article · BMC genomics

Chromosome level assembly and secondary metabolite potential of the parasitic fungus Cordyceps militaris.

BACKGROUND: Cordyceps militaris is an insect pathogenic fungus that is prized for its use in traditional medicine. This and other entomopathogenic fungi are understudied sources for the discovery of new bioactive molecules..

High relevance

Cordyceps · 2017 · Research Article · Oncotarget

Cordycepin and a preparation from Cordyceps militaris inhibit malignant transformation and proliferation by decreasing EGFR and IL-17RA signaling in a murine oral cancer model.

Cordyceps militaris (CM) and its active ingredient cordycepin have been reported to inhibit tumor growth, but the mechanisms are not fully understood. This study used a mouse model for oral cancer and a cell line, 4NAOC-1 derived from the model to study the mechanisms..

OncologyImmune support

High relevance

Cordyceps · 2017 · Journal Article · Journal of ethnopharmacology

Cordycepin-enriched WIB-801C from Cordyceps militaris improves functional recovery by attenuating blood-spinal cord barrier disruption after spinal cord injury.

ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps militaris is an ingredient of traditional Chinese medicine and have been widely used for inflammatory diseases and cancer. Cordycepin is one of the major bioactive components of Cordyceps militaris, and has been known to have anti-inflammatory and anti-oxidant effects..

OncologyImmune supportCognition & nerves

High relevance

Cordyceps · 2017 · Research Article · Heliyon

Cordyceps militaris improves the survival of Dahl salt-sensitive hypertensive rats possibly via influences of mitochondria and autophagy functions.

The genus Cordyceps and its specific ingredient, cordycepin, have attracted much attention for multiple health benefits and expectations for lifespan extension. We analyzed whether Cordyceps militaris (CM), which contains large amounts of cordycepin, can extend the survival of Dahl salt-sensitive rats, whose survival….

Immune supportCognition & nervesEnergy & fatigueMetabolic health

High relevance

Cordyceps · 2017 · Research Article · Journal of dietary supplements

Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation.

To determine the effects of a mushroom blend containing Cordyceps militaris on high-intensity exercise after 1 and 3 weeks of supplementation. Twenty-eight individuals (Mean ± standard deviation [SD]; Age = 22.7 ± 4.1 yrs; Height = 175.4 ± 8.7 cm; Weight = 71.6 ± 12.0 kg) participated in this randomized, repeated….

Energy & fatigueMetabolic health

High relevance

Cordyceps · 2017 · Journal Article · Bioscience, biotechnology, and biochemistry

Cytotoxic compounds against cancer cells from Bombyx mori inoculated with Cordyceps militaris.

Two compounds, 3'-deoxyinosine and cordycepin, were isolated from Bombyx mori inoculated with Cordyceps militaris. In the bioassay examining cytotoxicity against cancer cells, both compounds showed toxicity against A549, PANC-1, and MCF-7 cancer cells..

Oncology