MycoData

This invention is intended to discover a fraction having strong anti-influenza virus activity via M[phi] activation in the Grifola frondosa extract or an active substance distributed therein to develop a simple and effective production method and to use such fraction for food and beverage products, pharmaceutical….

Respiratory

High relevance

Niu-Chang-Chih · 2010 · Patent · journal metadata

NEW COMPOUNDS ISOLATED FROM EXTRACT OF ANTRODIA CAMPHORATA

The present invention relates to a novel compound and use thereof, in particular to Antroquinonol B and Antroquinonol C isolated from Antrodia camphorata extracts which can effectively inhibit the growth of cancer cells..

OncologyLiver supportRespiratory

High relevance

Chaga · 2010 · Research Support, Non U.S. Gov'T · Acta poloniae pharmaceutica

Separation of an aqueous extract Inonotus obliquus (Chaga). A novel look at the efficiency of its influence on proliferation of A549 human lung carcinoma cells.

Aqueous extract of Inonotus obliquus was hydrolyzed in dilute hydrochloric acid. The products were extracted applying organic solvents, and separated chromatographically on a silica gel-packed column.

OncologyRespiratory

High relevance

Niu-Chang-Chih · 2009 · Patent · journal metadata

AN ANTRODIA CAMPHORATA CYCLOHEXENONE COMPOUND USED FOR INHIBITING HEPATITIS B VIRUS

Antrodia camphoratacyclohexenone compounds which is effective in inhibiting hepatitis B virus, in particular 4-hydroxy-2,3-dimethoxy-6-methy-5 [3,7,11-trimethy-dodeca-2,6,10-trienyl]-cyclohex-2-enone isolated from an extract of Antrodia camphorata..

OncologyLiver supportRespiratory

High relevance

Maitake · 2009 · Patent · journal metadata

Grifola frondosa-origin substance having antiinfluenza virus activity and method of producing the same

This invention is intended to discover a fraction having strong anti-influenza virus activity via M Phi activation in the Grifola frondosa extract or an active substance distributed therein to develop a simple and effective production method and to use such fraction for food and beverage products, pharmaceutical….

Respiratory

High relevance

Maitake · 2009 · Patent · journal metadata

GRIFOLA FRONDOSA-ORIGIN SUBSTANCE HAVING ANTIINFLUENZA VIRUS ACTIVITY AND METHOD OF PRODUCING THE SAME

This invention is intended to discover a fraction having strong anti-influenza virus activity via MÕ activation in the Grifola frondosa extract or an active substance distributed therein to develop a simple and effective production method and to use such fraction for food and beverage products, pharmaceutical….

Respiratory

High relevance

Niu-Chang-Chih · 2009 · Patent · journal metadata

INHIBITION OF HEPATITIS B VIRUS BY CYCLOHEXENONE COMPOUNDS FROM ANTRODIA CAMPHORATA

A cyclohexenone compound, and a pharmaceutical composition containing the cyclohexenone compound are provided to treat the HBV-induced disease by suppressing the reproduction and secretion of HBV..

Liver supportRespiratory

High relevance

Niu-Chang-Chih · 2008 · Patent · journal metadata

Compounds from Antrodia camphorata

OncologyLiver supportRespiratory

High relevance

Niu-Chang-Chih · 2008 · Patent · journal metadata

NOVEL COMPOUNDS FROM ANTRODIA CAMPHORATA

OncologyLiver supportRespiratory

High relevance

King Oyster · 2007 · Research Support, Non U.S. Gov'T · Biotechnology letters

Isolation and characterization of a novel mycovirus, PeSV, in Pleurotus eryngii and the development of a diagnostic system for it.

A novel mycovirus was isolated from a cultivated edible mushroom, Pleurotus eryngii, with severe epidemic symptoms. Purification of the virus was carried out by a sequential procedure of polyethylene glycol precipitation, differential centrifugation, and equilibrium centrifugation in a CsCl gradient..

Gut & microbiomeRespiratory

High relevance

Mesima · 2007 · Patent · journal metadata

MAKGEOLLI WITH PHELLINUS LINTEUS AND METHOD FOR MANUFACTURING THEREOF

Unrefined rice wine(makgeolli) with Phellinus linteus and a method for manufacturing thereof are provided to confer health-improving effects such as activating function of internal organs including heart, liver, spleen, lung, kidney and stomach, and detoxification on the unrefined rice wine(makgeolli)..

Liver supportRespiratory

High relevance

Chaga · 2007 · Research Support, Non U.S. Gov'T · Bioorganic & medicinal chemistry

Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus.

Two new lanostane-type triterpenoids, inonotsuoxides A (1) and B (2) along with three known lanostane-type triterpenoids, inotodiol (3), trametenolic acid (4), and lanosterol (5), were isolated from the sclerotia of Inonotus obliquus (Pers.: Fr.) (Japanese name: Kabanoanakake) (Russian name: Chaga)..

OncologySkin & hydrationRespiratory

High relevance

Mesima · 2006 · Research Support, Non U.S. Gov'T · Biological & pharmaceutical bulletin

Inhibition of Anaphylaxis-Like Reaction and Mast Cell Activation by Water Extract from the Fruiting Body of Phellinus linteus

Mast cell-mediated anaphylactic reaction is involved in many allergic diseases such as asthma and allergic rhinitis. Phellinus linteus has been used as a traditional herb medicine in oriental countries and is known to have anti-tumor, immunomodulatory, anti-inflammatory, and anti-allergic activities..

OncologyImmune supportRespiratory

High relevance

Niu-Chang-Chih · 2006 · Patent · journal metadata

Liver cancer resistant Antrodia camphorata and preparation method thererof

The invention discloses an Antrodia camphorata capsule for resisting hepatic carcinoma, which comprises the following constituents (by weight portions): Antrodia camphorate mycelium fermentation extract 20-100, protein-free maize starch or medicinal starch gum 200-480..

OncologyLiver supportRespiratory

High relevance

Niu-Chang-Chih · 2006 · Research Support, Non U.S. Gov'T · Proteomics

Proteomic analysis of the effect of Antrodia camphorata extract on human lung cancer A549 cell.

Antrodia camphorata (niu-chang-chih) is a fungus native to Taiwan that is believed to be effective in preventing diseases. This study demonstrates that 0.2-2% v/v ethanol extracts of A..

OncologyEnergy & fatigueRespiratory

High relevance

King Oyster · 2003 · Journal Article · The Journal of the Japanese Respiratory Society

Hypersensitivity Pneumonitis Induced by Pleurotus Eryngii Spores-A Case Report

Metadata-grounded summary: This journal article indexes research on Pleurotus eryngii in The Journal of the Japanese Respiratory Society in 2003. MycoData maps the paper to respiratory based on its title, species context, article metadata, and study classification..

Respiratory

High relevance

Niu-Chang-Chih · 2023 · Journal Article · Fish Pathology

Enhancement of Non-specific Immune Responses in Giant Grouper Epinephelus lanceolatus via Dietary Administration of Antrodia camphorata Extract (ACE) and Protection Against Grouper Iridovirus Infection

Metadata-grounded summary: This journal article indexes research on Antrodia camphorata in Fish Pathology in 2023. MycoData maps the paper to immune support, respiratory based on its title, species context, article metadata, and study classification..

Immune supportRespiratory

High relevance

Cordyceps · 2023 · Preprint · journal metadata

Mechanism of alleviating acute lung injury in mice from serum metabolomics analysis of Cordyceps fumosorosea

Abstract Introduction Mechanism of alleviating acute lung injury in mice from serum metabolomics analysis of Cordyceps fumosorose a Aims This study investigated the potential anti-inflammatory effects of Cordyceps fumosorosea mycelia on lung health, with a focus on acute lung injury in mice..

Immune supportMetabolic healthRespiratory

High relevance

Maitake · 2023 · Preprint · journal metadata

Pharmacokinetic Parameters and Tissular Biodistribution of 1,3 β-glucans From Maitake Pro4x in Balbc Mice.

The objective of this study was to examine the pharmacokinetic parameters of 1,3-beta-glucans from Maitake Pro4X in BALBc mice through oral and intravenous (IV) administration..

Immune supportGut & microbiomeLiver supportRespiratory

High relevance

Almond Mushroom · 2022 · Preprint · journal metadata

COVID-19 Submodel for the NC MInD ABM Overview, Design Concepts, and Details Protocol

This Overview, Design Concepts, and Details (ODD) Protocol is an ODD extension to an agent-based model (ABM) framework built for the North Carolina Modeling Infectious Diseases Program (NC MInD). The model, NC MInD ABM, can be used as a base model for various infectious disease simulations..

Respiratory

High relevance

Shiitake · 2022 · Research Article · Infection and drug resistance

In vitro Anti SARS-CoV-2 Activity and Docking Analysis of Pleurotus ostreatus, Lentinula edodes and Agaricus bisporus Edible Mushrooms.

BACKGROUND: Fungi are rich source of biologically active metabolites aimed for the improvement of human health through the prevention of various diseases, including infections and inflammatory disorders..

OncologyImmune supportEnergy & fatigueRespiratory

High relevance

Almond Mushroom · 2021 · Preprint · journal metadata

A hybrid PDE–ABM model for viral dynamics with application to SARS–CoV–2 and influenza

We propose a hybrid partial differential equation – agent-based (PDE–ABM) model to describe the spatio-temporal viral dynamics in a cell population. The virus concentration is considered as a continuous variable and virus movement is modelled by diffusion, while changes in the states of cells (i.e..

Respiratory

High relevance

Cordyceps · 2021 · Preprint · journal metadata

Molecular Characterization of a Novel Alternavirus Infecting the Entomopathogenic Fungus Cordyceps Chanhua

Abstract In this study, a novel double-stranded RNA (dsRNA) mycovirus, named Cordyceps chanhua alternavirus 1 (CcAV1), was detected in the entomogenous fungus Cordyceps chanhua from China..

Respiratory

High relevance

Agarikon · 2020 · Research Support, Non U.S. Gov'T · Scientific reports

Medicinal potential of mycelium and fruiting bodies of an arboreal mushroom Fomitopsis officinalis in therapy of lifestyle diseases.

Fomitopsis officinalis is a medicinal mushroom used in traditional European eighteenth and nineteenth century folk medicine. Fruiting bodies of F.

OncologyRespiratory

High relevance

Niu-Chang-Chih · 2019 · Research Support, Non U.S. Gov'T · Journal of cellular physiology

Antrodia camphorata inhibits epithelial-to-mesenchymal transition by targeting multiple pathways in triple-negative breast cancers.

Antrodia camphorata (AC) exhibits potential for engendering cell-cycle arrest as well as prompting apoptosis and metastasis inhibition in triple-negative breast cancer (TNBC) cells..

OncologyRespiratory

High relevance

Niu-Chang-Chih · 2018 · Research Support, Non U.S. Gov'T · Cytokine

Analogous corticosteroids, 9A and EK100, derived from solid-state-cultured mycelium of Antrodia camphorata inhibit proinflammatory cytokine expression in macrophages.

Antrodia camphorata mycelium is used in traditional Chinese medicine in Taiwan. The wild-type mycelium is rare and expensive, so a solid-state-cultured mycelium of A.

Immune supportRespiratory

High relevance

Shiitake · 2018 · Research Support, Non U.S. Gov'T · Virus research

Genetic variation and phylogenetic analyses reveal transmission clues of Lentinula edodes partitivirus 1 (LePV1) from the Chinese L. edodes core collection.

Lentinula edodes partitivirus 1 (LePV1), a new mycovirus possibly responsible for serious morphological deformities during L. edodes cultivation, is widespread in the Chinese L.

Respiratory

High relevance

Chaga · 2018 · Research Support, Non U.S. Gov'T · Molecular and cellular probes

Immunopotentiating effect of Inonotus obliquus fermentation products administered at vaccination in chickens.

Vaccination is an important approach for the control of avian viral diseases. The aim of this study was to evaluate the immune-potentiating effect of oral administration of Inonotus obliquus fermentation products (IOFP) at vaccination in chickens..

Immune supportRespiratory

High relevance

Zhu Ling · 2017 · Research Support, Non U.S. Gov'T · Scientific reports

SWATH label-free proteomics analyses revealed the roles of oxidative stress and antioxidant defensing system in sclerotia formation of Polyporus umbellatus.

Understanding the initiation and maturing mechanisms is important for rational manipulating sclerotia differentiation and growth from hypha of Polyporus umbellatus. Proteomes in P.

Respiratory

High relevance

Turkey Tail · 2016 · Research Support, Non U.S. Gov'T · Scientific reports

Discovery of novel xylosides in co-culture of basidiomycetes Trametes versicolor and Ganoderma applanatum by integrated metabolomics and bioinformatics.

Transcriptomic analysis of cultured fungi suggests that many genes for secondary metabolite synthesis are presumably silent under standard laboratory condition. In order to investigate the expression of silent genes in symbiotic systems, 136 fungi-fungi symbiotic systems were built up by co-culturing seventeen….

Respiratory

High relevance

Maitake · 2016 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Structural characterization and antiviral activity of a novel heteropolysaccharide isolated from Grifola frondosa against enterovirus 71.

A novel heteropolysaccharide from Grifola frondosa mycelia was extracted and purified using DEAE Sephadex A-50 and Sephadex G-200 chromatography. Fourier transform infrared (FT-IR) spectroscopy and nuclear magnetic resonance ((1)H NMR and (13)C NMR) spectroscopy were used to decipher the structure of the purified G..

Immune supportRespiratory

High relevance

Shiitake · 2015 · Journal Article · Biochemical and biophysical research communications

Anti-HCV effect of Lentinula edodes mycelia solid culture extracts and low-molecular-weight lignin.

Lentinula edodes mycelia solid culture extract (MSCE) contains several bioactive molecules, including some polyphenolic compounds, which exert immunomodulatory, antitumor, and hepatoprotective effects..

OncologyImmune supportLiver supportRespiratory

High relevance

Mesima · 2015 · Research Article · Journal of clinical medicine research

Potent Anticancer Effects of Bioactive Mushroom Extracts (Phellinus linteus) on a Variety of Human Cancer Cells.

BACKGROUND: Although several therapeutic options are currently available for patients with various cancers, the outcomes are often disappointing and a more effective modality needs to be promptly established..

OncologyCognition & nervesLiver supportRespiratory

High relevance

Mesima · 2014 · Research Article · Immune network

Phellinus linteus Extract Exerts Anti-asthmatic Effects by Suppressing NF-κB and p38 MAPK Activity in an OVA-induced Mouse Model of Asthma.

Phellinus linteus has been used as a traditional herbal medicine in Asian countries and is known to have anti-tumor, immunomodulatory, anti-inflammatory, and anti-allergic activities. However, the protective effects of P.

OncologyImmune supportRespiratory

High relevance

Chaga · 2011 · Journal Article · Bulletin of experimental biology and medicine

Antiviral activity of Inonotus obliquus fungus extract towards infection caused by hepatitis C virus in cell cultures.

Fractions of Inonotus obliquus fungus water extract exhibited a virucidal effect towards hepatitis C virus: it 100-fold reduced its infective properties within 10 min..

Liver supportRespiratory

High relevance

Maitake · 2011 · Journal Article · World journal of microbiology & biotechnology

Production of exopolysaccharides by submerged mycelial culture of Grifola frondosa TFRI1073 and their antioxidant and antiproliferative activities

The exopolysaccharide (EPS) extract of a newly screened Grifola frondosa TFRI1073 was evaluated antioxidant activity, including superoxide anion scavenging activity and reducing power, and the antiproliferative activities by using lung (A549 cells) and breast (MDA-MD-231 cells) cancer cell line..

OncologyImmune supportRespiratory

High relevance

Niu-Chang-Chih · 2008 · Journal Article · Toxicology and applied pharmacology

In vivo immunomodulatory effects of Antrodia camphorata polysaccharides in a T1/T2 doubly transgenic mouse model for inhibiting infection of Schistosoma mansoni.

Antrodia camphorata (A. camphorata) is a fungus commonly used for treatment of viral hepatitis and cancer in Chinese folk medicine.

OncologyImmune supportLiver supportRespiratory

High relevance

Mesima · 2008 · Journal Article · Chemical & pharmaceutical bulletin

Phellifuropyranone A: A New Furopyranone Compound Isolated from Fruit Bodies of Wild Phellinus linteus

A new furopyranone, phellifuropyranone A, was isolated from fruit bodies of wild Phellinus linteus as well as phelligridin G, and their chemical structures were determined by various spectroscopic methods including measurement of NMR spectra..

OncologyRespiratory

High relevance

Maitake · 2007 · Journal Article · Antiviral research

Isolation, identification and function of a novel anti-HSV-1 protein from Grifola frondosa.

A novel antiviral protein was purified from an extract of Grifola frondosa fruiting bodies using a procedure that included 40% ammonium sulfate precipitation and DEAE-cellulose ion exchange chromatography, and designated GFAHP..

Gut & microbiomeRespiratory

High relevance

Mesima · 2007 · Journal Article · Journal of agricultural and food chemistry

Structural and biological study of carboxymethylated Phellinus linteus polysaccharides.

Polysaccharides isolated from Phellinus linteus were chemically modified by carboxymethylation, and the structural and physiological properties of the derivative were investigated. 13C NMR spectroscopy showed that the polysaccharides extracted from P.

OncologyImmune supportRespiratory

High relevance

Mesima · 2006 · Research Article · Mycobiology

Mycelial Extract of Phellinus linteus Induces Cell Death in A549 Lung Cancer Cells and Elevation of Nitric Oxide in Raw 264.7 Macrophage Cells.

In the present study, in order to investigate the anti-proliferative phenomenon of PLME, the effects of mycelial extract of Phellinus linteus (PLME) on the growth of human lung carcinoma cell line A549 was examined..

OncologyImmune supportRespiratory

High relevance

Maitake · 2006 · Journal Article · Journal of agricultural and food chemistry

o-Orsellinaldehyde from the submerged culture of the edible mushroom Grifola frondosa exhibits selective cytotoxic effect against Hep 3B cells through apoptosis.

The tumoricidal activity of a bioactive metabolite produced by submerged culture in a 2.1-L airlift fermentor of Grifola frondosa NTUS was investigated. After 14 days of cultivation, ethyl acetate extracts from the supernatant of culture broth (EES) were analyzed by cell viability assay..

OncologyRespiratory

High relevance

Mesima · 2005 · Comparative Study · Biological & pharmaceutical bulletin

Cambodian Phellinus linteus Inhibits Experimental Metastasis of Melanoma Cells in Mice via Regulation of Urokinase Type Plasminogen Activator

Phellinus linteus (PL) is a fungus mainly found in tropical America, Africa and Asian countries including Korea, Japan and China. PL has been traditionally used for the treatment of arthritis, liver damage and cancer..

OncologyGut & microbiomeLiver supportRespiratory

High relevance

Mesima · 2004 · Patent · journal metadata

ANTICANCER AGENT CONTAINING POLYSACCHARIDE AND MITOMYCIN C EXTRACTED FROM PHELLINUS LINTEUS

PURPOSE: Provided is an anticancer agent containing polysaccharide that is galactomannoglucan and mitomycin C extracted from Phellinus linteus. It is useful for treatment of stomach cancer, breast cancer, colorectal cancer, large intestine cancer and the like..

OncologyImmune supportGut & microbiomeRespiratory

High relevance

Chaga · 2004 · Patent · journal metadata

COMPOSITION COMPRISING EXTRACT OF INONOTUS OBLIQUUS HAVING IMMUNE-ENHANCING AND ANTICANCER ACTIVITIES

PURPOSE: Provided is a pharmaceutical composition comprising the extract of Inonotus obliquus which has immune-enhancing and anticancer activities. The extract of Inonotus obliquus is effectively used for health foods and medicaments for prevention and treatment of adult diseases, such as immunodeficiency diseases and….

OncologyImmune supportLiver supportRespiratory

High relevance

Maitake · 2004 · Case Reports · Internal medicine (Tokyo, Japan)

Successful Treatment of Hypersensitivity Pneumonitis Caused by Grifola frondosa (Maitake) Mushroom Using a HFA-BDP Extra-fine Aerosol

We successfully treated a patient with occupational hypersensitivity pneumonitis (HP) caused by Grifola frondosa (Maitake) mushroom spore with an extra-fine aerosol corticosteroid; beclomethasone dipropionate (BDP) dissolved in hydrofluoroalkane-134a (HFA)..

Respiratory

High relevance

King Oyster · 2003 · Research Support, Non U.S. Gov'T · Wei sheng wu xue bao = Acta microbiologica Sinica

[Screening of proteins anti-tobacco mosaic virus in Pleurotus eryngii].

Proteins were obtained by ion-exchange chromatography and gel filtration from the dry sample of Pleurotus eryngii. In terms of detection on local lesion host, these components were confirmed to be anti-TMV and their inhibition rates reach more than 70%, or even 99%..

Respiratory

Medium relevance

Turkey Tail · 2026 · Review · Chinese clinical oncology

Clinical evidence on a Coriolus versicolor-based vaginal gel for HPV-related cervical disease: a narrative review.

BACKGROUND AND OBJECTIVE: Human papillomavirus (HPV) infection is the most common sexually transmitted disease worldwide. Its persistence may lead to cervical dysplasia and, eventually, cervical cancer..

OncologyImmune supportGut & microbiomeRespiratory

Medium relevance

Reishi · 2026 · Clinical Trial Protocol · JMIR research protocols

Effectiveness and Safety of a Supplement Containing a Pharmacologically Active Basidiomycete Mushroom for Chronic Fatigue and Post-COVID-19 Fatigue Syndrome: Protocol for a Randomized Controlled Trial.

BACKGROUND: Chronic fatigue syndrome, or myalgic encephalomyelitis, is characterized by persistent, unexplained exhaustion unalleviated by rest, with a pathophysiology distinct from underlying medical conditions..

Immune supportCognition & nervesEnergy & fatigueRespiratory

Medium relevance

Oyster Mushroom · 2025 · Randomized Controlled Trial · Scientific reports

Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma.

The aim of this study was to evaluate the effects of pleuran (β-glucan isolated from Pleurotus ostreatus) on asthma control and respiratory morbidity in children on conventional GINA-based asthma treatment who had partially controlled perennial asthma..

Respiratory