MycoData

Oyster Mushroom · 2024 · Preprint · journal metadata

SIRT2-mediated deacetylation of Glutathione transferase alleviates oxidative damage and increases heat tolerance of Pleurotus ostreatus

Abstract High-temperature stress (HS) is the most important environmental factor that affects crop growth. It seriously threatens agricultural production.

Shiitake · 2024 · Preprint · journal metadata

The Two Sexually Compatible Monokaryons from a Heterokaryotic Lentinula edodes Strain Respond Differently to Heat Stress

A comprehensive understanding of the mechanisms underlying how Lentinula edodes handles heat stress (HS) is crucial for the development of superior HS-resistant strains. However, the mechanism by which the two sexually compatible haploid nuclei respond to heat stress remains largely unknown..

Cordyceps · 2022 · Journal Article · Andrologia

Cordycepin, a major bioactive component of Cordyceps militaris, ameliorates diabetes-induced testicular damage through the Sirt1/Foxo3a pathway.

Diabetes-induced male dysfunction is considered as a worldwide challenge, and testicular damage mainly caused by oxidative stress is its most common manifestation. Cordycepin, a natural antioxidant, has been used in the treatment of diabetic complications..

Cordyceps · 2022 · Journal Article · Food & function

The polysaccharide-peptide complex from mushroom Cordyceps militaris ameliorates atherosclerosis by modulating the lncRNA-miRNA-mRNA axis.

An N-glycosidic polysaccharide-peptide complex CMPS-80 was obtained from the fruiting body of C. militaris.

Cordyceps · 2021 · Journal Article · International journal of biological macromolecules

Purification, characterization and anti-atherosclerotic effects of the polysaccharides from the fruiting body of Cordyceps militaris.

Hyperlipidemia is one major cause of atherosclerosis, which is a basic pathological change of cardiovascular diseases. Polysaccharide is a water-soluble component with lipid-lowering effects.

Immune supportMetabolic healthGut & microbiomeLiver support

Cordyceps · 2021 · Research Article · Frontiers in molecular biosciences

The Cordyceps militaris-Derived Polysaccharide CM1 Alleviates Atherosclerosis in LDLR(-/-) Mice by Improving Hyperlipidemia.

Atherosclerotic cardiovascular disease has a high mortality worldwide. Our lab previously purified a polysaccharide designated as CM1 with (1→4)-β-D-Glcp and (1→2)-α-D-Manp glycosyls as the backbone..

OncologyEnergy & fatigueMetabolic healthRespiratory

Cordyceps · 2020 · Review · Sheng wu gong cheng xue bao = Chinese journal of biotechnology

[Advances in biosynthesis of cordycepin from Cordyceps militaris].

Cordycepin as the main active ingredient of Cordyceps militaris, a traditional medicinal fungus in China, has many physiological functions such as anti-cancer, anti-tumor and anti-virus activity. The most potential route for effective cordycepin production has been considered as liquid fermentation of C..

Cordyceps · 2020 · Review · Journal of ethnopharmacology

Can Cordyceps cicadae be used as an alternative to Cordyceps militaris and Cordyceps sinensis? - A review.

ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps cicadae (Mig.) Massee is one of the oldest and well-known traditional Chinese medicine (TCM), with its uses recorded as far back as the 5th century A.D. For centuries, C..

OncologyMetabolic health

King Oyster · 2020 · Review · International journal of biological macromolecules

Extraction, structure and bioactivities of the polysaccharides from Pleurotus eryngii: A review.

Pleurotus eryngii (also known as king trumpet mushroom or king oyster mushroom) is an edible mushroom cultivated widely in many regions of the world. Polysaccharides from P.

OncologyImmune supportMetabolic healthRespiratory

Reishi · 2020 · Review · International journal of biological macromolecules

Molecular mechanisms of bioactive polysaccharides from Ganoderma lucidum (Lingzhi), a review.

Ganoderma lucidum, commonly known as "Lingzhi" in Chinese, are well-known medicinal mushrooms. Lingzhi has been used in traditional Chinese herbal medicines for more than two thousand years.

OncologyImmune supportCognition & nervesMetabolic health

Lion's Mane · 2019 · Review · Critical reviews in food science and nutrition

Recent developments in Hericium erinaceus polysaccharides: extraction, purification, structural characteristics and biological activities.

Hericium erinaceus (H. erinaceus), an edible mushroom with medicinal value, has a long history of usage in China and other oriental countries.

OncologyImmune supportMetabolic healthRespiratory

Maitake · 2019 · Review · Progress in molecular biology and translational science

The biological activities of the antitumor drug Grifola frondosa polysaccharide.

Grifola frondosa, a polypore fungus that grows at the base of trees, is an edible and medicinal mushroom with a large fruiting body characterized by overlapping caps..

OncologyImmune supportCognition & nervesMetabolic health

Lion's Mane · 2019 · Review · International journal of molecular sciences

Therapeutic Potential of Hericium erinaceus for Depressive Disorder.

Depression is a common and severe neuropsychiatric disorder that is one of the leading causes of global disease burden. Although various anti-depressants are currently available, their efficacies are barely adequate and many have side effects..

Mesima · 2016 · Review · Fitoterapia

Traditional uses, fermentation, phytochemistry and pharmacology of Phellinus linteus: A review.

Medicinal mushroom Phellinus linteus ("Sanghuang" in Chinese, ) is a famous fungus which is widely used in China, Korea, and other Asian countries. As a traditional Chinese medicine with a 2000-year long history, medicinal applications of Phellinus linteus mainly include treating hemorrhage, hemostasis and diseases….

Cognition & nervesMetabolic healthGut & microbiomeLiver support

Yellow Morel · 2026 · Journal Article · Food Research International

A novel Fucose-specific lectin from Morchella esculenta modulates gut-liver Axis to alleviate non-alcoholic fatty liver disease

Morchella esculenta is an underexplored source of lectins with diverse bioactivities. In this study, a novel fucose-specific lectin (MEP5) was isolated from M.

Cognition & nervesMetabolic healthGut & microbiomeLiver support

Yellow Morel · 2026 · Journal Article · Food research international (Ottawa, Ont.)

A novel Fucose-specific lectin from Morchella esculenta modulates gut-liver Axis to alleviate non-alcoholic fatty liver disease.

Morchella esculenta is an underexplored source of lectins with diverse bioactivities. In this study, a novel fucose-specific lectin (MEP5) was isolated from M.

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Almond Mushroom · 2026 · Journal Article · Animal feed science and technology

Astragalus polysaccharide and Agaricus Blazei polysaccharides improve growth performance, meat quality and health status of lambs via rescheduling the rumen microbiota

Since the banning of antibiotics, the use of green feed additives has become crucial for the healthy farming of mutton sheep. Astragalus polysaccharides (APS) and Agaricus Blazei polysaccharides (ABP) exhibit various functions such as antioxidation, immunomodulation, and meat quality improvement..

Energy & fatigueMetabolic health

Oyster Mushroom · 2026 · Journal Article · Biometals: an international journal on the role of metal ions in biology, biochemistry, and medicine

Bioaccumulation and nutritional impact of fluoride in Pleurotus ostreatus and Pleurotus djamor with human health risk assessment.

Pleurotus species are nutritionally rich fungi, yet their potential to bioaccumulate environmental fluoride (F⁻) necessitates careful scientific evaluation further..

Oyster Mushroom · 2026 · Journal Article · Bioresource technology

Bioactive metabolites in Hypsizygus marmoreus spent substrate enhanced Pleurotus ostreatus growth.

The rapid accumulation of spent mushroom substrate (SMS) presents a critical environmental challenge globally, but efficient and cost-effective recycling approaches remain limited..

Reishi · 2026 · Research Article · Foods (Basel, Switzerland)

Comparative Analysis of Physicochemical Properties, Antioxidant and Enzyme Inhibitory Activities of Sporoderm-Broken Ganoderma lucidum Spore Powders from Different Regions in China.

Ganoderma lucidum spore powder is widely recognized as a high-grade Ganoderma product and is extensively consumed as a functional food and dietary supplement in China. To compare quality differences, nine batches of sporoderm-broken G..

Energy & fatigueMetabolic health

Lion's Mane · 2026 · Research Article · Frontiers in fungal biology

Comparative proteomic analysis reveals the effects of different light spectra on protein expression in Hericium erinaceus mycelium.

INTRODUCTION: Light represents a major environmental factor influencing the growth, developmental programming, and metabolic regulation of Hericium erinaceus. Different wavelengths differentially affect mycelial development, stress responses, and protein expression, highlighting the complexity of fungal….

Snow Fungus · 2026 · Journal Article · Food chemistry

Correlation analysis of monosaccharide composition and in vitro antioxidant and hypoglycemic activities of Tremella fuciformis spore polysaccharides.

Tremella fuciformis polysaccharides have diverse bioactivities and beneficial physicochemical properties, enabling broad use in pharmaceuticals and food. This study analyzed intracellular and extracellular polysaccharides (IPs and EPs) from three T..

Snow Fungus · 2026 · Journal Article · Journal of the science of food and agriculture

Deep eutectic solvent extraction of Tremella fuciformis polysaccharide and the extract's antioxidant activity

BACKGROUND: No study has, until now, examined the deep eutectic solvent (DES) extraction of Tremella fuciformis polysaccharide (TFP). In this study, a DES composed of choline chloride and citric acid (1:1 molar ratio) was prepared for TFP extraction..

Snow Fungus · 2026 · Journal Article · Journal of the science of food and agriculture

Deep eutectic solvent extraction of Tremella fuciformis polysaccharide and the extract's antioxidant activity.

Oyster Mushroom · 2026 · Journal Article · Journal of agricultural and food chemistry

Discovery and Functional Characterization of a β-Glucosidase from Pleurotus ostreatus for the Biocatalytic Conversion of Mogroside V into Mogroside IV and Siamenoside I.

Mogroside IV (MG-IV) and Siamenoside I (MG-SI) are key components responsible for the characteristic sweetness and flavor of Siraitia grosvenorii. However, their naturally low abundance limits both flavor enhancement and large-scale industrial application..

Energy & fatigueMetabolic healthGut & microbiome

Oyster Mushroom · 2026 · Research Article · Animal science journal = Nihon chikusan Gakkaiho

Effect of Supplemented Spent Mushroom Substrate (Pleurotus ostreatus) on Growth Performance, Nutrient Digestibility, Nitrogen Balance, and Blood Metabolites of Goats.

This study evaluated the effects of Pleurotus ostreatus spent mushroom substrate (SMS), supplemented with 4% urea and 18% molasses, as a partial replacement for Napier grass..

Snow Fungus · 2026 · Research Article · Journal of fungi (Basel, Switzerland)

Effects of Cultivation Substrate Differences on Quality Formation and Polysaccharide Composition Characteristics of Tremella fuciformis.

Cultivation substrate critically affects the quality of Tremella fuciformis. Five substrates, including cottonseed hulls (MZKs), Machilus pauhoi Kanehira sawdust (BNM), lotus seed hulls (LZKs), Corethrodendron scoparium sawdust (HB), and palm fiber (ZL), were evaluated for their effects on agronomic traits,….

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Reishi · 2026 · Research Article · Animals: an open access journal from MDPI

Effects of Enzyme-Microbe Co-Fermented Ganoderma lucidum Spent Substrate on Growth Performance, Apparent Nutrient Digestibility, Organ Indices, and Gut Microbiota in Yellow-Feathered Broilers.

The effects of dietary supplementation of enzyme-microbe co-fermented Ganoderma lucidum spent substrate (EFGLS) on growth performance, apparent nutrient digestibility, organ indices, and cecal microbiota in yellow-feathered broilers are investigated..

Metabolic healthSkin & hydration

Enoki · 2026 · Research Article · Foods (Basel, Switzerland)

Effects of Various Drying Techniques on the Quality Attributes and Metabolite Profiles of Flammulina velutipes (Fruiting Body) Based on Non-Target Metabolomics.

Flammulina velutipes (Golden Needle Mushroom, F. velutipes) undergoes rapid postharvest deterioration characterized by browning and decay.

Snow Fungus · 2026 · Journal Article · World journal of microbiology & biotechnology

Engineering a high-efficiency expression system in Tremella fuciformis using novel promoters and optimized transformation conditions.

The development of a high-efficiency expression system is crucial for advancing the molecular breeding and synthetic biology of Tremella fuciformis. Here, the system is reported through the identification of potent endogenous promoters and the systematic optimization of an Agrobacterium tumefaciens-mediated….

Immune supportEnergy & fatigueMetabolic health

Reishi · 2026 · Research Article · Microorganisms

Enhanced Exopolysaccharide Production in Bidirectional Liquid Fermentation of Ganoderma lucidum Using Clinacanthus nutans (Burm. f.) Lindau.

This study explored the enhancement of exopolysaccharide (EPS) production by Ganoderma lucidum through bidirectional liquid fermentation, employing Clinacanthus nutans (Burm. f.) Lindau leaves as a medicinal substrate.

Immune supportCognition & nervesMetabolic healthGut & microbiome

Lion's Mane · 2026 · Journal Article · Journal of food science

Exploring the Prebiotic Effects of Composite Fungal Polysaccharides From Hericium erinaceus and Lyophyllum decastes on Gut Microbiota and Metabolism.

Fungal polysaccharides have attracted considerable scholarly interest due to their potential as prebiotics, with the ability to modulate gut microbiota and enhance host health..

Reishi · 2026 · Research Article · Microbial cell factories

Functional characterization of HMG_9 and C2H2.07 as positive regulators of ganoderic acid biosynthesis in Ganoderma lucidum.

BACKGROUND: Ganoderic acids (GAs) are high-value lanostane-type triterpenoids produced by Ganoderma lucidum (G. lucidum) and are responsible for its diverse pharmacological activities.

OncologyImmune supportEnergy & fatigueMetabolic health

Reishi · 2026 · Journal Article · Cancer letters

Ganoderma lucidum polysaccharide ameliorates cancer cachexia with enhanced efficacy in aged group by reprogramming arginine metabolism to modulate Treg formation.

Cancer cachexia is a syndrome characterized by profound weight loss, muscle wasting, and metabolic disturbance in cancer patients. Cancer-associated cachexia represents significant biological and clinical challenges that profoundly affect human health..

Immune supportMetabolic healthGut & microbiome

Reishi · 2026 · Journal Article · Journal of agricultural and food chemistry

Ganoderma lucidum Polysaccharides Alleviate High-Fat Diet-Induced Obesity by Promoting Lipolysis and Inhibiting Inflammation through Lactobacillus johnsonii-Butyrate Axis.

Ganoderma lucidum polysaccharides (GLPs) exert antiobesity effects that are linked to gut-microbiota modulation, yet the underlying mechanisms remain elusive. Here, we show that GLPs raise the fecal butyrate level, which in turn inhibits high-fat diet (HFD)-induced weight gain, fat accumulation, adipocyte hypertrophy,….

Immune supportMetabolic healthGut & microbiomeLiver support

Reishi · 2026 · Journal Article · Journal of ethnopharmacology

Ganoderma lucidum polysaccharides alleviate non-alcoholic fatty liver disease by modulating gut microbiota against TLR4/NF-κB/MAPK pathway and activating AMPK pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (Leyss. ex Fr.) Karst has been a revered traditional Chinese medicinal herb, widely used in folk medicine to treat various metabolic diseases due to its remarkable bioactivities.

Immune supportMetabolic healthGut & microbiomeLiver support

Reishi · 2026 · Research Article · International journal of molecular medicine

Ganoderma lucidum polysaccharides improve liver metabolic disorders by modulating gut microbiota of ovariectomized mice.

The morbidity of cardiovascular disease in postmenopausal patients increases due to the lack of estrogen protection. One of the most common conditions is hyperlipidemia characterized by abnormally elevated low‑density lipoprotein cholesterol (LDL‑C) and total cholesterol (TC)..

Cognition & nervesMetabolic health

Reishi · 2026 · Research Article · Foods (Basel, Switzerland)

Ganoderma lucidum Triterpenoids Suppress Adipogenesis and Obesity via PRKCQ Activation: An Integrated In Vivo, In Vitro, and Systems Pharmacology Study.

Ganoderma lucidum triterpenoids (GLTs) exhibit potential anti-obesity activity. However, their mechanism remains unclear.

Zhu Ling · 2026 · Research Article · Journal of fungi (Basel, Switzerland)

Genetic-Geographic-Chemical Framework of Polyporus umbellatus Reveals Lineage-Specific Chemotypes for Elite Medicinal Line Breeding.

Polyporus umbellatus is a valuable fungus with both dietary and medicinal applications. However, heterogeneous germplasm and chemical variability constrain its sustainable use.

Maitake · 2026 · Journal Article · Journal of the science of food and agriculture

Grifola frondosa polysaccharide ameliorates adenine-induced CKD by inhibiting TGF-β1/Smad signaling pathway in mice.

BACKGROUND: Chronic kidney disease (CKD) is pathologically characterized by oxidative stress, inflammation, and renal fibrosis, yet effective therapeutic interventions for this condition remains limited. Grifola frondosa polysaccharide (GFP), an active component derived from the edible and medicinal mushroom G..

Metabolic healthGut & microbiome

Lion's Mane · 2026 · Research Article · Food science & nutrition

Hericium erinaceus Extracts Exert Gastroprotective Effects Through Modulation of the Gut Microbiota and Metabolites.

Hericium erinaceus (H. erinaceus) is a traditional edible and medicinal fungus with a long history of use in gastrointestinal protection.

Shiitake · 2026 · Research Article · Journal of fungi (Basel, Switzerland)

Identification of Candidate Genes Associated with the Pileus-Deficient Phenotype in Lentinula edodes Through Comparative Genomic and Transcriptomic Analyses.

This study aimed to elucidate the molecular mechanisms underlying phenotypic divergence between two Lentinula edodes strains, Le_L and Le_S, which exhibit distinct fruiting body morphologies..

Reishi · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Impact of Ganoderma lucidum fermentation and micro-pressure pulping on the structure, metabolism, and bioactivity of sugarcane bagasse.

Sugarcane bagasse (SB) is a typical lignocellulosic agricultural by-product with limited nutritional utilization due to its compact structure. This study investigated the effects of Ganoderma lucidum fermentation (GF) and micro-pressure pulping (MP) on the structural characteristics, metabolic profiles, and….

OncologyImmune supportMetabolic healthSkin & hydration

Reishi · 2026 · Research Article · Molecules (Basel, Switzerland)

In Vitro and In Vivo Evaluation of the Skincare Bioactivity of β-1,3;1,6-Glucans-Rich Ganoderma lucidum Polysaccharides.

Extracted from Ganoderma lucidum mycelium, the developed β-1,3;1,6-glucan rich polysaccharides have the potential to be used during the industrial production of health food products due to their inhibition of metabolic syndrome, immunomodulatory and antitumor activities and other health benefits..

Immune supportMetabolic healthGut & microbiomeLiver support

Chaga · 2026 · Research Article · Foods (Basel, Switzerland)

Inonotus obliquus Polysaccharides Prevent High-Fat Diet-Induced Obesity in Mice Related to Reshaping Gut Microbiota.

Obesity development is linked to disturbances in the gut microbiota. Inonotus obliquus polysaccharides (IOPs) have potential therapeutic efficacy in alleviating metabolic disorders.

Cordyceps · 2026 · Journal Article · Food chemistry

Integrated metabolomics to systematically monitor quality indicators and metabolic dynamics in stored Ophiocordyceps sinensis.

Ophiocordyceps sinensis, a highly valued medicinal fungus, requires proper storage to maintain its commercial quality. To elucidate the underlying mechanisms of O.

OncologyMetabolic healthGut & microbiome

Reishi · 2026 · Journal Article · International journal of biological macromolecules

Intestinal epithelial protection and gut microbiota modulation by Ganoderma lucidum proteoglycan are associated with its hypoglycemic potential in type 2 diabetes.

The interplay between gut microbiota, oxidative stress, and intestinal barrier integrity is increasingly recognized as a driving force in the progression of type 2 diabetes mellitus..

Reishi · 2026 · Research Article · BMC plant biology

Metabolomics analysis functional metabolites shaped by Ganoderma lucidum fermentation of daylily.

Edible fungi fermentation is an effective strategy for enhancing the functional value of traditional foods, while postbiotics offer multiple health benefits, primarily produced through heating..

Lion's Mane · 2026 · Journal Article · International journal of biological macromolecules

Metabolomics study on Hericium erinaceus polysaccharides in intervening ethanol induced gastric ulcer in mice.

Based on previous evidence indicating the gastroprotective potential of Hericium erinaceus polysaccharides (HEP), this study aimed to evaluate their protective effects against ethanol-induced gastric ulcers in mice and characterize the associated serum metabolic changes using an untargeted metabolomics approach..