MycoData

Advanced oxidation of benzene, toluene, ethylbenzene, and o-, m-, and p-xylene (BTEX) by the extracellular hydroxyl radicals (*OH) generated by the white-rot fungus Trametes versicolor is for the first time demonstrated..

Medium relevance

Enoki · 2010 · Research Support, Non U.S. Gov'T · Bioscience, biotechnology, and biochemistry

Agrobacterium tumefaciens-Mediated Transformation of the Vegetative Dikaryotic Mycelium of the Cultivated Mushroom Flammulina velutipes

Agrobacterium tumefaciens was used to transform the vegetative dikaryotic mycelium of Flammulina velutipes using a hygromycin B resistance gene as selectable marker. The gene coding for urogen III methyltransferase (cob) was introduced into F.

Medium relevance

Mesima · 2010 · Research Support, Non U.S. Gov'T · Journal of medicinal food

An extract of Phellinus linteus grown on germinated brown rice inhibits inflammation markers in RAW264.7 macrophages by suppressing inflammatory cytokines, chemokines, and mediators and up-regulating antioxidant activity.

The immunomodulatory activity of an organic extract of Phellinus linteus grown on slightly germinated brown rice (PBR) was previously demonstrated. Here, we investigated the possible anti-inflammatory activity of the PBR extract by analyzing its effect on the expression of macrophage-derived cytokines, chemokines, and….

OncologyImmune supportEnergy & fatigueGut & microbiome

Medium relevance

Chaga · 2010 · Research Support, Non U.S. Gov'T · Phytochemistry

An unusual lanostane-type triterpenoid, spiroinonotsuoxodiol, and other triterpenoids from Inonotus obliquus.

An unusual lanostane-type triterpenoid, spiroinonotsuoxodiol (1), and two lanostane-type triterpenoids, inonotsudiol A (2) and inonotsuoxodiol A (3), were isolated from the sclerotia of Inonotus obliquus..

Medium relevance

Niu-Chang-Chih · 2010 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Analgesic effects and the mechanisms of anti-inflammation of ergostatrien-3beta-ol from Antrodia camphorata submerged whole broth in mice.

Ergostatrien-3beta-ol (ST1), an active and major ingredient from Antrodia camphorata (AC) submerged whole broth was evaluated for the analgesic and anti-inflammatory effects..

OncologyImmune supportLiver support

Medium relevance

Enoki · 2010 · Research Support, Non U.S. Gov'T · Bioresource technology

Antioxidative activities of hydrophilic extracts prepared from the fruiting body and spent culture medium of Flammulina velutipes.

Antioxidative properties of hydrophilic extracts prepared from the fruiting body and spent culture medium of Flammulina velutipes were evaluated by monitoring the total reducing power ability (RPA) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity (RSA), together with antioxidative activities….

Energy & fatigue

Medium relevance

Niu-Chang-Chih · 2010 · Research Support, Non U.S. Gov'T · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association

Antrodia camphorata suppresses lipopolysaccharide-induced nuclear factor-kappaB activation in transgenic mice evaluated by bioluminescence imaging.

In an earlier study, we found that Antrodia camphorata inhibited the production of lipopolysaccharide (LPS)-induced cytokines, inducible nitric oxide synthase, and cyclooxygenase-2 by blocking nuclear factor-kappaB (NF-kappaB) activation in cultured RAW 264.7 macrophages..

OncologyImmune supportEnergy & fatigueGut & microbiome

Medium relevance

Chaga · 2010 · Research Support, Non U.S. Gov'T · Natural product research

Beneficial effects of the ethanol extract from the dry matter of a culture broth of Inonotus obliquus in submerged culture on the antioxidant defence system and regeneration of pancreatic beta-cells in experimental diabetes in mice.

The antihyperglycaemic and antilipidperoxidative effects of the ethanol extract from the dry matter of a culture broth (DMCB) of Inonotus obliquus were investigated in alloxan-induced diabetic mice and the possible mechanism of action was also discussed..

Metabolic healthLiver support

Medium relevance

Maitake · 2010 · Research Support, Non U.S. Gov'T · Journal of medicinal food

Bioaccumulation and bioavailability of copper and zinc on mineral-enriched mycelium of Grifola frondosa.

Grifola frondosa is an edible and medicinal mushroom. The bioaccumulation and potential biovailability of Cu and Zn were studied to obtain mycelium with potential properties as a food dietary supplement..

Gut & microbiomeSkin & hydration

Medium relevance

Maitake · 2010 · Research Support, Non U.S. Gov'T · Archives of pharmacal research

Biological activities of Fructus arctii fermented with the basidiomycete Grifola frondosa.

Fructus arctii extract containing phenolic glycosides was cultured with Grifola frondosa mycelia to produce β-glucosidase and its biological activities were studied. This β-glucosidase converted the glycosides (arctiin and caffeic acid derivatives) into aglycones (arctigenin and caffeic acid)..

Energy & fatigueSkin & hydration

Medium relevance

Snow Fungus · 2010 · Research Support, Non U.S. Gov'T · Applied microbiology and biotechnology

Biosorption of Cd, Cu, Pb, and Zn from aqueous solutions by the fruiting bodies of jelly fungi (Tremella fuciformis and Auricularia polytricha).

In this study, dried and humid fruiting bodies of Tremella fuciformis and Auricularia polytricha were examined as cost-effective biosorbents in treatment of heavy metals (Cd(2+), Cu(2+), Pb(2+), and Zn(2+)) in aqueous solution. The humid T..

Medium relevance

Enoki · 2010 · Patent · journal metadata

CARBOXIN RESISTANCE GENE FOR FLAMMULINA VELUTIPES

The present invention pertains to a polynucleotide sequence expressed in Flammulina velutipes against carboxin and the proteins encoded thereby. Also provided is the expression vector and host cell comprising the polynucleotides of the invention..

Medium relevance

Enoki · 2010 · Patent · journal metadata

CARBOXIN RESISTANCE GENE FOR FLAMMULINA VELUTIPES

Medium relevance

Turkey Tail · 2010 · Research Support, Non U.S. Gov'T · Fungal genetics and biology: FG & B

Changes in oxidative enzyme activity during interspecific mycelial interactions involving the white-rot fungus Trametes versicolor.

Interspecific fungal antagonism leads to biochemical changes in competing mycelia, including up-regulation of oxidative enzymes. Laccase, manganese peroxidase (MnP), manganese-repressed peroxidase (MRP) and lignin peroxidase (LiP) gene expression and enzyme activity were compared during agar interactions between….

Medium relevance

Enoki · 2010 · Research Support, Non U.S. Gov'T · Virology journal

Characterization of a mycovirus associated with the brown discoloration of edible mushroom, Flammulina velutipes.

BACKGROUND: A mycovirus previously identified in brown discolored fruiting bodies of the cultivated mushroom Flammulina velutipes was characterized. We tentatively named the virus the F.

Respiratory

Medium relevance

Mesima · 2010 · Patent · journal metadata

COMPOSITION CONTAINING EXTRACTS OF FUSCOPORIA OBLIQUA, GANODERMA LUCIDUM AND PHELLINUS LINTEUS FOR PROMOTING THE PROLIFERATION OF HEMATOPOIETIC STEM CELLS

The present invention relates to a composition containing mushroom extracts for promoting the proliferation of hematopoietic stem cells, and more specifically to a composition having a proliferation-promotive effect on hematopoietic stem cells, wherein the composition contains active ingredients composed of extracts….

OncologyImmune support

Medium relevance

Niu-Chang-Chih · 2010 · Patent · journal metadata

Compound from Antrodia camphorata and the use thereof

The present invention relates to novel compounds from Antrodia camphorata and the use thereof..

Medium relevance

Turkey Tail · 2010 · Comparative Study · Artificial cells, blood substitutes, and immobilization biotechnology

Construction and comparison of Trametes versicolor laccase biosensors capable of detecting xenobiotics.

Amperometric biosensors using laccase from Trametes versicolor as a bioelement were developed for 2,4-dichloro phenoxy acetic acid (2,4-D). Laccase enzyme was immobilized by gelatin and glutaraldehyde onto a Clark oxygen probe and screen printed electrodes (SPEs)..

Energy & fatigue

Medium relevance

Zhu Ling · 2010 · Research Support, Non U.S. Gov'T · Planta medica

Cytotoxic steroids from Polyporus umbellatus.

The steroids ergone (1), (22E, 24R)-ergosta-7,22-dien-3β-ol (2), 5α,8α-epidioxy-(22E,24R) -ergosta-6,22-dien-3β-ol (3), ergosta-6,22-dien-3β,5α,6β-triol (4), and polyporusterone B (5) were isolated from Polyporus umbellatus by bioassay-guided approach. They showed potent anticancer activity against HepG2 cells..

Oncology

Medium relevance

Turkey Tail · 2010 · Research Support, Non U.S. Gov'T · Bioresource technology

Degradation of naproxen and carbamazepine in spiked sludge by slurry and solid-phase Trametes versicolor systems.

Growth and activity of the white-rot fungus Trametes versicolor on sewage sludge were assessed in bioslurry and solid-phase systems. Bioslurry cultures with different loads of sludge (10%, 25% and 38%, w/v) were performed..

Medium relevance

Turkey Tail · 2010 · Research Support, Non U.S. Gov'T · Journal of hazardous materials

Degradation of the drug sodium diclofenac by Trametes versicolor pellets and identification of some intermediates by NMR.

Degradation of diclofenac sodium, a nonsteroidal anti-inflammatory drug widely found in the aquatic environment, was assessed using the white-rot fungus Trametes versicolor. Almost complete diclofenac removal (> or = 94%) occurred the first hour with T..

Immune support

Medium relevance

Enoki · 2010 · Research Support, Non U.S. Gov'T · Journal of bioscience and bioengineering

Development and characterization of simple sequence repeat (SSR) markers for the mushroom Flammulina velutipes.

Ten polymorphic SSR markers of Flammulina velutipes were developed and characterized with FIASCO methods. The polymorphism information content (PIC) ranged from 0.13 to 0.69.

Medium relevance

Enoki · 2010 · Research Support, Non U.S. Gov'T · Bioscience, biotechnology, and biochemistry

Development of a Gene Transfer System for the Mycelia of Flammulina velutipes Fv-1 Strain

To develop a gene transformation method for Flammulina velutipes, we constructed a vector with hph gene under control of the trp1 gene promoter. The vector was integrated into protoplast derived from mycelia by the calcium-polyethylene glycol method, as it has not been reported for F.

Medium relevance

Niu-Chang-Chih · 2010 · Research Support, Non U.S. Gov'T · Journal of pharmaceutical and biomedical analysis

Development of a LC-MS/MS method for the determination of antrodin B and antrodin C from Antrodia camphorata extract in rat plasma for pharmacokinetic study.

A selective and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of antrodin B and antrodin C in rat plasma..

Medium relevance

Wood Ear · 2010 · Brief Report · Mycobiology

Development of Detection Methods for Cellulolytic Activity of Auricularia auricula-judae.

To obtain basic information on the detection of cellulolytic activity in Auricularia auricula-judae, the influences of dye reagent, pH, and temperature were assessed..

Immune support

Medium relevance

Wood Ear · 2010 · Research Support, Non U.S. Gov'T · Applied microbiology and biotechnology

DyP-like peroxidases of the jelly fungus Auricularia auricula-judae oxidize nonphenolic lignin model compounds and high-redox potential dyes.

The jelly fungus Auricularia auricula-judae produced an enzyme with manganese-independent peroxidase activity during growth on beech wood (approximately 300 U l(-1)). The same enzymatic activity was detected and produced at larger scale in agitated cultures comprising of liquid, plant-based media (e.g..

Medium relevance

Niu-Chang-Chih · 2010 · Patent · journal metadata

ETHANOL EXTRACT OF ANTRODIA CAMPHORATA FOR INDUCING APOPTOSIS AND PREPARATION METHOD THEREOF

A preparation method for an ethanol extract of the fruiting body of Antrodia camphorata (EEAC) is provided. The preparation method includes steps of: (a) providing the fruiting body of A.

Oncology

Medium relevance

Mesima · 2010 · Research Support, Non U.S. Gov'T · International immunopharmacology

Evaluation of antidiabetic activity of polysaccharide isolated from Phellinus linteus in non-obese diabetic mouse.

Polysaccharide (PLP) isolated from Phellinus linteus inhibits tumor growth and metastasis by enhancing immune functions of macrophages, dendritic cells, NK cells, T cells, and B cells. Here, we report that PLP can inhibit the development of autoimmune diabetes in non-obese diabetic (NOD) mice..

OncologyImmune supportMetabolic health

Medium relevance

Yellow Morel · 2010 · Research Support, Non U.S. Gov'T · Bioresource technology

Extraction optimization and in vivo antioxidant activities of exopolysaccharide by Morchella esculenta SO-01.

Response surface methodology was used to optimize extraction parameters for Morchella esculenta SO-01 exopolysaccharide (EPS) produced during submerged culture. The optimum conditions for EPS extraction were predicted to be, concentration at 84.07 degrees C, precipitation for 22.19 h and pH 8.44, and EPS production….

Immune supportLiver support

Medium relevance

Niu-Chang-Chih · 2010 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Fruiting body of Niuchangchih (Antrodia camphorata) protects livers against chronic alcohol consumption damage.

An alcoholic fatty liver disease was induced by drinking water containing 20% (w/w) alcohol. Therapeutic groups were orally administrated dosages of 0.25 g silymarin/kg body weight (BW) and a low dosage of Niuchangchih (Antrodia camphorata) (0.025 g/kg BW) and a high dosage of Niuchangchih (0.1 g/kg BW) per day..

Metabolic healthLiver support

Medium relevance

Maitake · 2010 · Patent · journal metadata

Grifola frondosa extract and composition containing the same for promoting the production of hyaluronic acid (hyaluronan)

To provide a Grifola frondosa extract which more effectively promotes the production of hyaluronic acid (hyaluronan) and a composition containing the same. A G.

Skin & hydration

Medium relevance

Maitake · 2010 · Research Support, Non U.S. Gov'T · Experimental & molecular medicine

Grifola frondosa water extract alleviates intestinal inflammation by suppressing TNF-alpha production and its signaling.

TNF-alpha is a major cytokine involved in inflammatory bowel disease (IBD). In this study, water extract of Grifola frondosa (GFW) was evaluated for its protective effects against colon inflammation through the modulation of TNF-alpha action..

OncologyImmune supportEnergy & fatigueGut & microbiome

Medium relevance

Enoki · 2010 · Brief Report · Mycobiology

Highly Efficient Electroporation-mediated Transformation into Edible Mushroom Flammulina velutipes.

In this study, we developed an efficient electroporation-mediated transformation system featuring Flammulina velutipes. The flammutoxin (ftx) gene of F.

Medium relevance

Enoki · 2010 · Research Support, Non U.S. Gov'T · Bioscience, biotechnology, and biochemistry

Improvement of the Transformation Efficiency of Flammulina velutipes Fv-1 Using the Glyceraldehyde-3-phosphate Dehydrogenase Gene Promoter

To improve the expression level of heterologous genes in Flammulina velutipes Fv-1, we constructed new vectors having glyceraldehydes-3-phosphate dehydrogenase (gpd) gene promoter to control the expression of target genes..

Medium relevance

Turkey Tail · 2010 · Research Support, Non U.S. Gov'T · Applied biochemistry and biotechnology

Induction of an oxalate decarboxylase in the filamentous fungus Trametes versicolor by addition of inorganic acids.

In order to improve yields and to reduce the cost of oxalate decarboxylase (OxDC, EC 4.1.1.2), the induction of OxDC in the white-rot fungus Trametes versicolor was studied in this work. OxDC was induced by addition of inorganic acids including hydrochloric acid, sulfuric acid, and phosphoric acid to culture media..

Medium relevance

Turkey Tail · 2010 · Research Support, Non U.S. Gov'T · Journal of hazardous materials

Influence of iron and copper nanoparticle powder on the production of lignocellulose degrading enzymes in the fungus Trametes versicolor.

White rot fungi are one of the key group of microorganisms that help to enrich the soil via degradation of wood. In the current communication, influence of iron and copper nanoparticles on the production of lignocellulolytic enzymes by Trametes versicolor have been investigated..

Medium relevance

Mesima · 2010 · Research Support, Non U.S. Gov'T · Natural product communications

Inhibition of protein tyrosine phosphatase 1beta by hispidin derivatives isolated from the fruiting body of Phellinus linteus.

Protein tyrosine phosphatase 1beta (PTP1beta) acts as a negative regulator of insulin signaling. Selective inhibition of PTP1beta has served as a potential drug target for the treatment of type 2 diabetes mellitus..

Metabolic health

Medium relevance

Lion's Mane · 2010 · Research Support, Non U.S. Gov'T · Phytomedicine: international journal of phytotherapy and phytopharmacology

Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation.

Platelet aggregation in the blood vessel causes thrombosis. Therefore, inhibitors of platelet aggregation promise to be preventive or therapeutic agents of various vascular diseases, including myocardial infarction and stroke..

Cognition & nervesSkin & hydration

Medium relevance

Turkey Tail · 2010 · Research Support, Non U.S. Gov'T · Environmental toxicology and chemistry

Insights into the development of fungal biomarkers for metal ecotoxicity assessment: case of Trametes versicolor exposed to copper.

The relationship between the physiological state of fungi and the response of their functional system to metals is not known, limiting the use of fungal enzymes as tools for assessing metal ecotoxicity in terrestrial ecosystems..

Medium relevance

Turkey Tail · 2010 · Research Support, Non U.S. Gov'T · Bioprocess and biosystems engineering

Mathematical model for Trametes versicolor growth in submerged cultivation.

Trametes versicolor is a white-rot fungus known as a producer of extracellular enzymes such as laccase, manganese-peroxidase, and lignin-peroxidase. The production of these enzymes requires detailed knowledge of the growth characteristics and physiology of the fungus.

Metabolic health

Medium relevance

Niu-Chang-Chih · 2010 · Research Support, Non U.S. Gov'T · Chemical research in toxicology

Methyl antcinate A from Antrodia camphorata induces apoptosis in human liver cancer cells through oxidant-mediated cofilin- and Bax-triggered mitochondrial pathway.

We investigated the effects of antcin A, antcin C, and methyl antcinate A (MAA) isolated from Antrodia camphorata on the proliferation of human liver cancer cell lines Huh7, HepG2, and Hep3B and the normal cell rat hepatocytes..

OncologyEnergy & fatigueLiver support

Medium relevance

Turkey Tail · 2010 · Research Support, Non U.S. Gov'T · Journal of hazardous materials

Naproxen degradation test to monitor Trametes versicolor activity in solid-state bioremediation processes.

The white-rot fungus Trametes versicolor has been studied as a potential agent for the removal of environmental pollutants. For long-time solid-phase bioremediation systems a test is required to monitor the metabolic status of T.

Immune supportMetabolic health

Medium relevance

Niu-Chang-Chih · 2010 · Patent · journal metadata

Novel Mixture and Compounds from Mycelia of Antrodia Camphorata and Use Thereof

The present invention relates to a compound derived from mycelium of Antrodia camphorata. The present invention also relates to the composition or mycelium comprising the compounds of the invention.

Metabolic health

Medium relevance

Chaga · 2010 · Research Support, Non U.S. Gov'T · Journal of microbiology and biotechnology

Optimization of hydroxyl radical scavenging activity of exo-polysaccharides from Inonotus obliquus in submerged fermentation using response surface methodology.

The objectives of this study were to investigate the effect of fermentation medium on the hydroxyl radical scavenging activity of exo-polysaccharides from Inonotus obliquus by response surface methodology. A two-level fractional factorial design was used to evaluate the effect of different components of medium..

Immune supportMetabolic health

Medium relevance

Turkey Tail · 2010 · Research Support, Non U.S. Gov'T · Bioresource technology

Optimization of removal conditions of copper ions from aqueous solutions by Trametes versicolor.

A multi-step response surface methodology was successfully applied to optimize the biosorption conditions for the maximum removal of Cu(II) ions from aqueous solutions using Trametes versicolor fungi as a biosorbent..

Medium relevance

Turkey Tail · 2010 · Research Support, Non U.S. Gov'T · Water research

Oxidation of atenolol, propranolol, carbamazepine and clofibric acid by a biological Fenton-like system mediated by the white-rot fungus Trametes versicolor.

Biological advanced oxidation of the pharmaceuticals clofibric acid (CA), carbamazepine (CBZP), atenolol (ATL) and propranolol (PPL) is reported for the first time..

Medium relevance

Mesima · 2010 · Research Support, Non U.S. Gov'T · PloS one

Phellinus linteus extract sensitizes advanced prostate cancer cells to apoptosis in athymic nude mice.

Phellinus linteus (PL) mushroom possesses anti-tumor property. We previously reported that the treatment with PL caused cultured human prostate cancer cells to undergo apoptosis..

OncologyImmune support

Medium relevance

Chaga · 2010 · Research Support, Non U.S. Gov'T · Journal of the science of food and agriculture

Phytochemical characteristics and hypoglycaemic activity of fraction from mushroom Inonotus obliquus.

BACKGROUND: Inonotus obliquus is a medicinal mushroom that has been used as an effective agent to treat various diseases such as diabetes, tuberculosis and cancer. In order to elucidate the active fraction and its constituents, the effects of ethyl acetate fraction from I..

OncologyMetabolic healthLiver support

Medium relevance

Maitake · 2010 · Research Support, Non U.S. Gov'T · Acta biochimica et biophysica Sinica

Prokaryotic expression, purification, and polyclonal antibody production of a hydrophobin from Grifola frondosa.

Hydrophobins are small fungal proteins that self-assemble spontaneously at hydrophilic-hydrophobic interfaces and change the polar nature of the surfaces to which they attach. A new hydrophobin gene hgfI was identified recently from the edible mushroom Grifola frondosa..

Immune support

Medium relevance

Niu-Chang-Chih · 2010 · Research Support, Non U.S. Gov'T · Cancer immunology, immunotherapy: CII

Promoting effect of Antrodia camphorata as an immunomodulating adjuvant on the antitumor efficacy of HER-2/neu DNA vaccine.

It is well known that DNA vaccines induce protective humoral and cell-mediated immune responses in several animal models. Antrodia camphorata (AC) is a unique basidiomycete fungus of the Polyporaceae family that only grows on the aromatic tree Cinnamomum kanehirai Hayata (Lauraceae) endemic to Taiwan..

OncologyImmune support