MycoData

Mushroom polysaccharides are increasingly being utilized to treat a wide variety of diseases. Aqueous extracts from the Phellinus linteus have been reported to have anti-tumor and immunomodulatory properties.

OncologyImmune support

Medium relevance

Mesima · 2003 · Research Support, Non U.S. Gov'T · Biochemical and biophysical research communications

Acidic polysaccharides isolated from Phellinus linteus induce phenotypic and functional maturation of murine dendritic cells.

Acidic polysaccharides (PL) isolated from Phellinus linteus are known to stimulate the proliferation of T lymphocytes and humoral immune functions to act as a polyclonal activator of B cells, and to inhibit tumor growth and metastasis..

OncologyImmune support

Medium relevance

Mesima · 2003 · Research Support, Non U.S. Gov'T · Biological & pharmaceutical bulletin

Alleviation of Experimental Septic Shock in Mice by Acidic Polysaccharide Isolated from the Medicinal Mushroom Phellinus linteus

This study reports that acidic polysaccharide (PL) isolated from Phellinus linteus alleviated the septic shock induced by high dose lipopolysaccharide (LPS) injection in mice..

OncologyImmune support

Medium relevance

Niu-Chang-Chih · 2003 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Antioxidative and hepatoprotective effects of Antrodia camphorata extract.

Antrodia camphorata (A. camphorata) is well-known in Taiwan as a traditional Chinese medicine.

Cognition & nervesLiver support

Medium relevance

Mesima · 2003 · Comparative Study · Biotechnology letters

Extracts of Phellinus linteus grown on germinated brown rice suppress liver damage induced by carbon tetrachloride in rats.

Extracts of Phellinus linteus (EPB), grown on germinated brown rice, protected rats from liver injury induced by carbon tetrachloride (CCl4). Peroxidation products in the liver were decreased to 10% by EPB..

Liver support

Medium relevance

Lion's Mane · 2003 · Research Support, Non U.S. Gov'T · Bioscience, biotechnology, and biochemistry

Hypolipidemic Effect of an Exo-biopolymer Produced from a Submerged Mycelial Culture of Hericium erinaceus

The hypolipidemic effect of an exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceus was investigated in dietary-induced hyperlipidemic rats. Hypolipidemic effects were proportionally increased with the increasing concentration of the exo-biopolymer for oral administration..

Metabolic healthLiver support

Medium relevance

Niu-Chang-Chih · 2003 · Patent · journal metadata

Liver-caring medicine containing antrodia camphorata

The present invention relates to a liver-caring medicine that cures alcohol-induced liver cancer and contains active ingredients from the fruiting body and the mycelium of Antrodia Camphorata or Antrodia Cinnamomea, which is a kind of mushroom that only grows inside a unique plant in Taiwan, a Cinnamomum kanehirae….

OncologyLiver support

Medium relevance

Mesima · 2003 · Research Support, Non U.S. Gov'T · Biological & pharmaceutical bulletin

Oral Administration of Proteoglycan Isolated from Phellinus linteus in the Prevention and Treatment of Collagen-Induced Arthritis in Mice

To examine whether oral administration of proteoglycan derived from Phellinus linteus, which is known as the medicinal mushroom, can prevent or treat collagen-induced arthritis (CIA) in mice as experimental model of autoimmune disease..

Immune supportSkin & hydration

Medium relevance

Niu-Chang-Chih · 2003 · Patent · journal metadata

Preparation and compositions for antrodia camphorata mycelium biologically active material

The present invention relates to biologically active material, containing mainly polysaccharides, from the solution culturing for mycelium of Antrodia camphorata, a kind of mushroom that only grows inside a unique Taiwanese plant called Cinnamomum kanehirae tree, being able to improve immunity and resist tumors and….

OncologyImmune support

Medium relevance

Niu-Chang-Chih · 2003 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Protective effects of fermented filtrate from Antrodia camphorata in submerged culture against CCl4-induced hepatic toxicity in rats.

The protective effects and the possible mechanisms of dry matter of fermented filtrate (DMF) from Antrodia camphorata in submerged culture (ACSC) on H(2)O(2)-induced cytotoxicity in HepG2 and carbon tetrachloride (CCl(4))-induced hepatotoxicity in Sprague-Dawley rats were investigated..

OncologyMetabolic healthLiver support

Medium relevance

Mesima · 2003 · Research Support, Non U.S. Gov'T · International immunopharmacology

Proteoglycan isolated from Phellinus linteus activates murine B lymphocytes via protein kinase C and protein tyrosine kinase.

Medicinal mushrooms are increasingly used to treat a wide variety of disease processes. Aqueous extract from the fruiting body or mycelia of Phellinus linteus has been reported to produce antitumor and immunomodulatory activities in vivo and in vitro.

OncologyImmune supportEnergy & fatigue

Medium relevance

Mesima · 2003 · Research Support, Non U.S. Gov'T · Bioresource technology

Purification and characterization of acidic proteo-heteroglycan from the fruiting body of Phellinus linteus (Berk. & M.A. Curtis) Teng.

Phellinus linteus is a well-known oriental medicinal fungus that has various biological activities such as stimulation of humoral and cell mediated immunity, anti-mutagenicity activity, and anti-cancer activity. The process of isolating and purifying a water-soluble glycan from P..

OncologyImmune supportMetabolic health

Medium relevance

Maitake · 2003 · Patent · journal metadata

Use of grifola frondosa fungus extracts

Methods for treating skin by contacting the skin with an extract of Grifola frondosa are described, along with skin-care and hair-care compositions containing such extracts and processes for preparing such extracts..

Skin & hydration

Medium relevance

Maitake · 2003 · Patent · journal metadata

USE OF GRIFOLA FRONDOSA FUNGUS EXTRACTS

The invention relates to the use of grifola frondosa fungus extracts in cosmetic and/or dermatological skin care agents..

Skin & hydration

Medium relevance

Chaga · 2002 · Comparative Study · Prikladnaia biokhimiia i mikrobiologiia

[Physicochemical properties of melanins produced by Inonotus obliquus("chagi") in the nature and the cultivated fungus].

Physicochemical properties of pigments isolated from the naturally occurring sterile form of Inonotus obliquus (Fr.) Pil. known as Chagi and comprising the major constituent of the medicine befungin were compared with those of melanins synthesized by this fungus in the culture in order to develop a new medicine..

Skin & hydration

Medium relevance

Enoki · 2002 · Research Support, Non U.S. Gov'T · Protein science: a publication of the Protein Society

Active site geometry of oxalate decarboxylase from Flammulina velutipes: Role of histidine-coordinated manganese in substrate recognition.

Oxalate decarboxylase (OXDC) from the wood-rotting fungus Flammulina velutipes, which catalyzes the conversion of oxalate to formic acid and CO(2) in a single-step reaction, is a duplicated double-domain germin family enzyme. It has agricultural as well as therapeutic importance..

Cognition & nerves

Medium relevance

Niu-Chang-Chih · 2002 · Comparative Study · Journal of agricultural and food chemistry

Antioxidant properties of Antrodia camphorata in submerged culture.

The biologically active compounds, antioxidant activities, and free radical scavenging effects of dry matter of cultural medium (DMCM), filtrate (DMF), and different solvent extracts of mycelia from Antrodia camphorata in submerged culture (ACSC) were investigated..

Immune support

Medium relevance

Niu-Chang-Chih · 2002 · Comparative Study · FEMS microbiology letters

Antrodia camphorata polysaccharides exhibit anti-hepatitis B virus effects.

Polysaccharides were extracted from fruiting bodies and cultured mycelia from five Antrodia camphorata strains. Polysaccharide profiles of the five strains, as determined by high-performance anion-exchange chromatography, showed varying yields and composition of neutral sugars.

OncologyImmune supportEnergy & fatigueMetabolic health

Medium relevance

Enoki · 2002 · Research Support, Non U.S. Gov'T · The Biochemical journal

Cloning and characterization of the 5'-flanking region of the oxalate decarboxylase gene from Flammulina velutipes.

The oxalate-degrading enzyme, oxalate decarboxylase (OXDC), was purified and characterized from Flammulina velutipes, a basidiomycetous fungus [Mehta and Datta (1991) J. Biol.

Medium relevance

Maitake · 2002 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Cyclooxygenase inhibitory and antioxidant compounds from the mycelia of the edible mushroom Grifola frondosa.

The bioassay-guided isolation and purification of the hexane extract of the cultured mycelia of Grifola frondosa led to the characterization of a fatty acid fraction and three compounds, ergosterol (1), ergostra-4,6,8(14),22-tetraen-3-one (2), and 1-oleoyl-2-linoleoyl-3-palmitoylglycerol (3)..

Energy & fatigue

Medium relevance

Niu-Chang-Chih · 2002 · Patent · journal metadata

Isolate of antrodia camphorata, process for producing a culture of the same and product obtained thereby

The present invention relates a process for culturing isolates of Antrodia camphorata to provide a product useful in medical and nourishment fields. The present invention also relates to a novel isolate of Antrodia camphorata capable of growing in a suitable artificial medium, while exhibiting desired pharmacological….

Oncology

Medium relevance

Niu-Chang-Chih · 2002 · Patent · journal metadata

Isolate of Antrodia camphorata, process for producing a culture of the same and product obtained thereby

Oncology

Medium relevance

Yellow Morel · 2002 · Research Support, U.S. Gov'T, Non P.H.S. · Journal of agricultural and food chemistry

Isolation of a galactomannan that enhances macrophage activation from the edible fungus Morchella esculenta.

The edible mushroom Morchella esculenta is among the most highly prized and morphologically recognizable fungi in the world. We describe the isolation from a polar extract of M.

Immune support

Medium relevance

Mesima · 2002 · Patent · journal metadata

METHOD FOR ARTIFICIAL CULTIVATION OF SPARASSIS AND PHELLINUS LINTEUS USING LOG

PURPOSE: A method for cultivating mushrooms such as Sparassis Cripsa Wulfen Fr. and Phellinus linteus by changing the temperature during cultivation is provided.

Medium relevance

Niu-Chang-Chih · 2002 · Research Support, Non U.S. Gov'T · Life sciences

Protection of oxidative damage by aqueous extract from Antrodia camphorata mycelia in normal human erythrocytes.

Antrodia camphorata (A. camphorata) is well known in Taiwan as a traditional Chinese medicine.

Oncology

Medium relevance

Mesima · 2002 · Research Support, Non U.S. Gov'T · Carcinogenesis

The roles of ERK1/2 and p38 MAP kinases in the preventive mechanisms of mushroom Phellinus linteus against the inhibition of gap junctional intercellular communication by hydrogen peroxide.

Modulation of gap junctional intercellular communication (GJIC) is a known cellular event associated with tumor promotion. The present study was undertaken to test the potential preventive effect of mushroom Phellinus linteus extract (PL) on the inhibition of GJIC, induced by hydrogen peroxide (H(2)O(2)), in WB-F344….

OncologyLiver support

Medium relevance

Maitake · 2002 · Patent · journal metadata

USE OF GRIFOLA FRONDOSA FUNGUS EXTRACTS

The invention relates to the use of grifola frondosa fungus extracts in cosmetic and/or dermatological skin care agents..

Skin & hydration

Medium relevance

Enoki · 2001 · Comparative Study · Current genetics

A gene encoding a hydrophobin, fvh1, is specifically expressed after the induction of fruiting in the edible mushroom Flammulina velutipes.

A cDNA clone of the gene fvh1 was previously isolated from a preprimordial cDNA library made from the basidiomycete Flammulina velutipes. Sequence analysis showed that fvh1 encoded for a hydrophobin, a small fungal protein usually secreted by filamentous fungi..

Medium relevance

Enoki · 2001 · Research Support, Non U.S. Gov'T · Journal of natural products

Antimicrobial cuparene-type sesquiterpenes, enokipodins C and D, from a mycelial culture of Flammulina velutipes.

Two new cuparene-type sesquiterpenes, enokipodins C (1) and D (2), were isolated from culture medium of an edible mushroom, Flammulina velutipes, along with enokipodins A (3) and B (4). The structures of 1 and 2 were determined using spectroscopic methods (HRMS, (1)H and (13)C, and 2D NMR)..

Medium relevance

Mesima · 2001 · Patent · journal metadata

NOVEL USE OF POLYSACCHARIDE FROM PHELLINUS LINTEUS FOR TREATING DIABETES MELLITUS

The present invention relates to a novel use of polysaccharides (PL) from Phellinus linteus for treating diabetes mellitus, which provides medicine or food comprising polysaccharide as active components..

Immune supportMetabolic health

Medium relevance

Maitake · 2001 · Research Support, Non U.S. Gov'T · Acta crystallographica. Section D, Biological crystallography

Structure of a new 'aspzincin' metalloendopeptidase from Grifola frondosa: implications for the catalytic mechanism and substrate specificity based on several different crystal forms.

Crystal structures of a peptidyl-Lys metalloendopeptidase (MEP) from the edible mushroom Grifola frondosa (GfMEP) were solved in four crystal forms. This represents the first structure of the new family 'aspzincins' with a novel active-site architecture..

Medium relevance

Chaga · 2000 · English Abstract · Prikladnaia biokhimiia i mikrobiologiia

[Melanin complex of the fungus Inonotus obliquus].

The fungus Inonotus obliquus (Pers.) Pil. synthesised high-molecular-weight phenolic pigments that were assigned to melanins according to their physicochemical properties.

Skin & hydration

Medium relevance

Enoki · 2000 · Research Support, Non U.S. Gov'T · FEMS microbiology letters

Basidiomycetous fungus Flammulina velutipes harbors two linear mitochondrial plasmids encoding DNA and RNA polymerases.

Basidiomycetous fungus Flammulina velutipes R15 strain had two linear plasmids in its mitochondria designated pFV1 and pFV2. They were double-stranded DNAs, whose sizes were 8.3 and 8.9 kb, respectively..

Cognition & nervesEnergy & fatigue

Medium relevance

Enoki · 2000 · Research Support, Non U.S. Gov'T · FEMS microbiology letters

Cloning and sequencing analysis of Trp1 gene of Flammulina velutipes.

The genomic TRP1 gene from basidiomycete Flammulina velutipes was cloned by complementation of yeast Saccharomyces cerevisiae trp1 mutation. Sequencing analysis revealed that the TRP1 gene encoded a single protein consisting of three catalytic functional domains; glutamine amidotransferase, indole-3-glycerol phosphate….

Medium relevance

Enoki · 2000 · Research Support, Non U.S. Gov'T · Biochimica et biophysica acta

Flammutoxin, a cytolysin from the edible mushroom Flammulina velutipes, forms two different types of voltage-gated channels in lipid bilayer membranes.

Flammutoxin, a 31-kDa cardiotoxic and cytolytic protein from the edible mushroom Flammulina velutipes, has been shown to assemble into a pore-forming annular oligomer with outer and inner diameters of 10 and 5 nm on the target cells [Tomita et al., Biochem. J.

Metabolic health

Medium relevance

Enoki · 2000 · Research Support, Non U.S. Gov'T · Phytochemistry

Highly oxidized cuparene-type sesquiterpenes from a mycelial culture of Flammulina velutipes.

Cuparene-type sesquiterpenes were isolated from a culture broth of Flammulina velutipes (Curt.:Fr.) Sing. Using spectroscopic methods (HR-MS, 1H and 13C NMR, and 2D NMR, spectroscopy), their structures were determined to be 2,3,4,5-tetrahydro-2,7-dihydroxy-5,8,10,10-tetramethyl-2,5-methano-1- benzoxepin and….

Medium relevance

Mesima · 1999 · Patent · journal metadata

HEALTH BEVERAGE CONTAINING THE EXTRACT OF i(PHELLINUS LINTEUS)

According to the present invention, a health beverage containing the extract of i(Phellinus linteus) as main ingredient and manufacturing method thereof are disclosed and regular drinking of these beverages can reduce the incidence rate of cancers..

Oncology

Medium relevance

Enoki · 1998 · Research Support, Non U.S. Gov'T · The Biochemical journal

Assembly of flammutoxin, a cytolytic protein from the edible mushroom Flammulina velutipes, into a pore-forming ring-shaped oligomer on the target cell.

Flammutoxin has been previously isolated as a cardiotoxic and cytolytic polypeptide of 22 or 32 kDa from the fruiting bodies of the edible mushroom Flammulina velutipes. In the present study, we purified flammutoxin as a single haemolytic protein of 31 kDa and studied the mode of its cytolytic action..

Immune support

Medium relevance

Maitake · 1998 · Research Support, Non U.S. Gov'T · Journal of biochemistry

Kinetic characterization of lysine-specific metalloendopeptidases from Grifola frondosa and Pleurotus ostreatus fruiting bodies.

Two zinc-metalloendopeptidases, GFMEP (accession number P81054) and POMEP (accession number P81055), from the fruiting bodies of two edible mushrooms, Grifola frondosa and Pleurotus ostreatus, respectively, specifically hydrolyze peptidyl-lysine bonds (-X-Lys-) in polypeptides..

Medium relevance

Maitake · 1997 · Research Support, Non U.S. Gov'T · The Journal of biological chemistry

Amino acid sequences of metalloendopeptidases specific for acyl-lysine bonds from Grifola frondosa and Pleurotus ostreatus fruiting bodies.

The complete amino acid sequences of two lysine-specific zinc metalloendopeptidases (EC 3.4.24), Grifola frondosa metalloendopeptidase (GFMEP) and Pleurotus ostreatus metalloendopeptidase (POMEP), from the fruiting bodies of these two edible mushrooms have been established based on the sequence information of the….

Gut & microbiome

Medium relevance

Snow Fungus · 1997 · Research Support, Non U.S. Gov'T · Planta medica

Characterization and cytokine-stimulating activities of acidic heteroglycans from Tremella fuciformis.

Four acidic heteroglycans, T2a-T2d, were isolated from the body of Tremella fuciformis Berk. They contained 1.9%-2.9% of acetyl groups and were composed of mannose (Man), glucuronic acid (GlcA), and small amounts of xylose (Xyl), glucose (Glc), and fucose (Fuc)..

OncologyImmune supportMetabolic health

Medium relevance

Enoki · 1997 · Research Support, Non U.S. Gov'T · Journal of the Formosan Medical Association = Taiwan yi zhi

Molecular cloning and expression of a fungal immunomodulatory protein, FIP-fve, from Flammulina velutipes.

FIP-fve, a fungal immunomodulatory protein, was isolated from the fruiting bodies of the edible mushroom, Flammulina velutipes. FIP-fve was shown to stimulate blast-forming activity of human peripheral blood lymphocytes and gene expression of interleukin-2, interferon-gamma and tumor necrosis factor-alpha..

OncologyImmune support

Medium relevance

Enoki · 1997 · Research Support, Non U.S. Gov'T · Immunopharmacology

The isolation and characterization of an immunomodulatory and anti-tumor polysaccharide preparation from Flammulina velutipes.

Alkaline-soluble antitumor polysaccharide was prepared from the cell wall of the mushroom Flammulina velutipes. The backbones) of the polysaccharide is mainly composed of beta-(1-->3)-D-linked glucose and its molecular weight was estimated to be about 200 kD..

OncologyImmune supportMetabolic health

Medium relevance

Enoki · 1996 · Research Support, Non U.S. Gov'T · European journal of cell biology

Cellular graviperception in the basidiomycete Flammulina velutipes--can the nuclei serve as fungal statoliths?

In search for the cellular mechanisms of graviperception in basidiomycete fruit bodies, nuclear and vacuole motility was investigated in the fungus, Flammulina velutipes. In this organism, hyphal nuclei are closely linked with the actin cytoskeleton, which is involved in gravity perception..

Medium relevance

Snow Fungus · 1996 · Research Support, Non U.S. Gov'T · Carbohydrate research

Characterisation of acidic heteroglycans from Tremella fuciformis Berk with cytokine stimulating activity.

Four kinds of acidic heteroglycan, T3a-T3d, were isolated from the body of the fungus Tremella fuciformis Berk. The molecular weights of T3a-T3d were 550, 420, 55, and 48 kDa, respectively..

OncologyImmune support

Medium relevance

Snow Fungus · 1996 · Research Support, Non U.S. Gov'T · Planta medica

Characterization and cytokine stimulating activities of heteroglycans from Tremella fuciformis.

Three heteroglycans, T1a, T1b, and T1c, have been isolated from the body of Tremella fuciformis Berk. They are composed of mannose (Man), xylose (Xyl), glucose (Glc), fucose (Fuc), and glucuronic acid (GlcA)..

OncologyImmune supportMetabolic health

Medium relevance

Mesima · 1996 · Research Support, Non U.S. Gov'T · Chemical & pharmaceutical bulletin

Characterization of carbohydrate-peptide linkage of acidic heteroglycopeptide with immuno-stimulating activity from mycelium of Phellinus linteus.

The carbohydrate-peptide linkage in acidic heteroglycopeptide from Phellinus linteus was characterized. Amino acid analysis showed large amounts of serine and threonine.

Immune support

Medium relevance

Enoki · 1996 · Comparative Study · Advances in space research: the official journal of the Committee on Space Research (COSPAR)

Gravimorphogenesis and ultrastructure of the fungus Flammulina velutipes grown in space, on clinostats and under hyper-g conditions.

The D-2-mission provided the facilities to cultivate the higher basidomycete Flammulina velutipes (Agaricales) in space for about 8 days. Gravimorphogenesis of developing fruiting body primordia in weightlessness was documented in comparison to cultures incubated on a 1xg reference centrifuge in space..

Medium relevance

Mesima · 1996 · Research Support, Non U.S. Gov'T · International journal of immunopharmacology

Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom Phellinus linteus.

Polysaccharide was purified from mycelial culture of Phellinus linteus (PL) and its effect on immunocompetence of normal splenocytes was observed. Overall in vitro immune function was enhanced by addition of PL into culture of mouse spleen lymphocyte and i.p..

OncologyImmune support

Medium relevance

Enoki · 1995 · Research Support, Non U.S. Gov'T · European journal of biochemistry

A new fungal immunomodulatory protein, FIP-fve isolated from the edible mushroom, Flammulina velutipes and its complete amino acid sequence.

A new fungal immunomodulatory protein (FIP-fve) has been isolated and purified from the edible golden needle mushroom (Flammulina velutipes). The apparent molecular mass of FIP-fve determined by SDS/PAGE agrees well with the value of 12704 Da calculated from its amino acid composition and sequence..

Immune support