MycoData

OncologyImmune supportEnergy & fatigue

Niu-Chang-Chih · 2012 · Research Support, Non U.S. Gov'T · The Journal of nutritional biochemistry

Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells.

Pancreatic cancer is a malignant neoplasm of the pancreas. A mutation and constitutive activation of K-ras occurs in more than 90% of pancreatic adenocarcinomas.

Enoki · 2012 · Patent · journal metadata

ASPARAGINASE FROM BASIDIOMYCETES

An asparaginase enzyme derived from the fungi Basidiomycete, in particular the Basidiomycete is Flammulina velutipes. A method for hydrolysing at least one of L-asparagine or L-glutamine.

OncologyMetabolic healthLiver supportRespiratory

Mesima · 2012 · Research Support, Non U.S. Gov'T · Oncology reports

BreastDefend™ prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer.

We have recently demonstrated that a natural dietary supplement BreastDefend (BD), which contains extracts from medicinal mushrooms (Coriolus versicolor, Ganoderma lucidum, Phellinus linteus), medicinal herbs (Scutellaria barbata, Astragalus membranaceus, Curcuma longa), and purified biologically active nutritional….

Enoki · 2012 · Research Support, Non U.S. Gov'T · Transgenic research

Characterization of an immunomodulatory Der p 2-FIP-fve fusion protein produced in transformed rice suspension cell culture.

Der p 2, a major allergen of Dermatophagoides pteronyssinus mites, is one of the most clinically relevant allergens to allergic patients worldwide. FIP-fve protein (Fve) from the golden needle mushroom (Flammulina velutipes) is an immunomodulatory protein with potential Th1-skewed adjuvant properties..

Immune supportMetabolic health

Enoki · 2012 · Research Support, Non U.S. Gov'T · Molecules (Basel, Switzerland)

Chemical characteristics and antioxidant properties of crude water soluble polysaccharides from four common edible mushrooms.

Four crude water soluble polysaccharides, CABP, CAAP, CFVP and CLDP, were isolated from common edible mushrooms, including Agaricus bisporus, Auricularia auricula, Flammulina velutipes and Lentinus edodes, and their chemical characteristics and antioxidant properties were determined..

Yellow Morel · 2012 · Comparative Study · International journal of medicinal mushrooms

Comparative study of contents of several bioactive components in fruiting bodies and mycelia of culinary-medicinal mushrooms.

Mushrooms have been consumed for thousands of years, and several bioactive components were found therein, including lovastatin, γ-aminobutyric acid (GABA) and ergothioneine..

Turkey Tail · 2012 · Evaluation Study · The Science of the total environment

Evaluation of fungal- and photo-degradation as potential treatments for the removal of sunscreens BP3 and BP1.

Photodecomposition might be regarded as one of the most important abiotic factors affecting the fate of UV absorbing compounds in the environment and photocatalysis has been suggested as an effective method to degrade organic pollutants..

Metabolic health

Turkey Tail · 2012 · Evaluation Study · Chemosphere

Evaluation of the antifungal effects of bio-oil prepared with lignocellulosic biomass using fast pyrolysis technology.

This study was performed to investigate the utility of bio-oil, produced via a fast pyrolysis process, as an antifungal agent against wood-rot fungi. Bio-oil solutions (25-100 wt.%) were prepared by diluting the bio-oil with EtOH..

Maitake · 2012 · Research Support, Non U.S. Gov'T · Protein expression and purification

Expression and characterization of hydrophobin HGFI fused with the cell-specific peptide TPS in Pichia pastoris.

The cell-specific peptide TPS (TPSLEQRTVYAK) has been proposed as a potential candidate for fabricating tissue engineering scaffolds based on its ability of binding to human endothelial progenitor cells (EPC) with high affinity and specificity..

Enoki · 2012 · Research Support, Non U.S. Gov'T · Scientific reports

Expression of a fungal sterol desaturase improves tomato drought tolerance, pathogen resistance and nutritional quality.

Crop genetic engineering mostly aims at improving environmental stress (biotic and abiotic) tolerance as well as nutritional quality. Empowering a single crop with multiple traits is highly demanding and requires manipulation of more than one gene..

Enoki · 2012 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

IFN-γ induction on carbohydrate binding module of fungal immunomodulatory protein in human peripheral mononuclear cells.

FIP-fve is a protein that is isolated from Flammulina velutipes. Its known immunomodulatory activities are elicitation of the production of type II interferon from human peripheral mononuclear cells (hPBMCs) and hemagglutination..

Niu-Chang-Chih · 2012 · Research Support, Non U.S. Gov'T · The American journal of Chinese medicine

Inhibition of Na(+)/K(+) -ATPase by antcins, unique steroid-like compounds in Antrodia camphorate.

The inhibition of Na(+)/K(+) -ATPase by versatile steroid-like compounds contributes to the putative therapeutic effects of many Chinese medicinal cardiac products via the same molecular mechanism triggered by cardiac glycosides..

Turkey Tail · 2012 · Evaluation Study · Enzyme and microbial technology

Laccase catalysed oxidation of syringic acid: calorimetric determination of kinetic parameters.

Isothermal titration calorimetry (ITC) was used to study the oxidation of syringic acid by laccases from two different sources: Galerina sp. HC1 and Trametes versicolor..

Immune supportMetabolic healthGut & microbiomeRespiratory

Maitake · 2012 · Research Support, Non U.S. Gov'T · Glycobiology

Mannose-specific lectin from the mushroom Hygrophorus russula.

A lectin was purified from the mushroom Hygrophorus russula by affinity chromatography on a Sephadex G-50 column and BioAssist S cation exchange chromatography and designated H. russula lectin (HRL)..

Enoki · 2012 · Research Support, Non U.S. Gov'T · Molecular biology reports

Molecular classification and phylogenetic relationships of selected edible Basidiomycetes species.

Morphological identification of edible mushrooms can sometimes prove troublesome, because phenotypic variation in fungi can be affected by substrate and environmental factors..

Maitake · 2012 · Research Support, Non U.S. Gov'T · Bioorganic & medicinal chemistry

Molybdophyllysin, a toxic metalloendopeptidase from the tropical toadstool, Chlorophyllum molybdites.

A toxic protein, dubbed molybdophyllysin, was isolated from the tropical toadstool Chlorophyllum molybdites by following its lethal effect in mice. Analysis of the protein using SDS-PAGE revealed a single 23-kDa band..

Immune supportMetabolic health

Turkey Tail · 2012 · Research Support, Non U.S. Gov'T · Bioresource technology

Optimization of dilute acid-based pretreatment and application of laccase on apple pomace.

The present study was aimed to optimize acid-based pretreatment of apple pomace in relation to acid concentration, temperature and reaction time using response surface method with glucose as response variable. In addition, laccase (EC..

Immune supportEnergy & fatigueMetabolic health

Maitake · 2012 · Patent · journal metadata

PRODUCT OF FUNCTIONAL HEALTH FOOD THAT ENHANCES ORGAN IMMUNITY

A functional health food product that enhances organ immunity and controls diabetes comprises active ingredients and auxiliary material. The active ingredients consist of the following: 5 to 10 parts of cordyceps militaris extracts, 35 to 50 parts of grifola frondosa extracts, 20 to 30 parts of lentinan, 5 to 10 parts….

Immune supportSkin & hydration

Snow Fungus · 2012 · Patent · journal metadata

SKIN WOUND DRESSING AND PREPARING METHOD THEREOF

A skin wound dressing is disclosed. The skin wound dressing comprises Tremella polysaccharide and alginate and is used to cover on a skin wound to accelerate wound healing.

Turkey Tail · 2012 · Research Support, Non U.S. Gov'T · Bioresource technology

Treatment of tetracycline antibiotics by laccase in the presence of 1-hydroxybenzotriazole.

Tetracycline antibiotics are widely used in human and veterinary medicine; however, residual amounts of these antibiotics in the environment are of concern since they could contribute to selection of resistant bacteria..

Turkey Tail · 2012 · Evaluation Study · Applied microbiology and biotechnology

Utilizing pigment-producing fungi to add commercial value to American beech (Fagus grandifolia).

American beech (Fagus grandifolia) is an abundant, underutilized tree in certain areas of North America, and methods to increase its market value are of considerable interest. This research utilized pigment-producing fungi to induce color in American beech to potentially establish its use as a decorative wood..

Mesima · 2011 · Research Support, Non U.S. Gov'T · Nutrition and cancer

A heat-stable extract from Mucuna stimulates the differentiation of bone marrow cells into dendritic cells and induces apoptosis in cancer cells.

Pine cone extract is known to induce differentiation of human mononuclear cells into dendritic cells (DCs) and also to induce apoptosis in human cancer cells. In the present study, we screened edible plants that contain components with biological activities similar to or more potent than those of pine cone extract..

OncologyImmune support

Wood Ear · 2011 · Research Support, Non U.S. Gov'T · Fungal genetics and biology: FG & B

A heme peroxidase of the ascomyceteous lichen Leptogium saturninum oxidizes high-redox potential substrates.

Lichens belonging to the order Peltigerales display strong activity of multi-copper oxidases (e.g. tyrosinase) as well as heme-containing peroxidases.

Energy & fatigueMetabolic health

Turkey Tail · 2011 · Comparative Study · Biosensors & bioelectronics

A highly efficient buckypaper-based electrode material for mediatorless laccase-catalyzed dioxygen reduction.

The redox enzyme laccase from Trametes versicolor efficiently catalyzes the oxygen reduction reaction (ORR) in mediatorless biofuel cell cathodes when adsorbed onto multi-walled carbon nanotubes (MWCNTs)..

Enoki · 2011 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

An antifungal protein from the culinary-medicinal beech mushroom, Hypsizygus marmoreus (Peck) Bigel. (Agaricomycetideae).

An antifungal protein (HM-af) was purified from the culinary-medicinal mushroom Hypsizygus marmoreus. The results of sodium dodecyl sulfate polyacrylamide gel electrophoresis and matrix-assisted laser desorption ionization time-of-flight mass spectrometry of HM-af indicated that its molecular mass was 9.5 kDa..

Immune supportLiver support

Mesima · 2011 · Other · Evidence-based complementary and alternative medicine: eCAM

Analgesic effects and the mechanisms of anti-inflammation of hispolon in mice.

Hispolon, an active ingredient in the fungi Phellinus linteus was evaluated with analgesic and anti-inflammatory effects. Treatment of male ICR mice with hispolon (10 and 20 mg/kg) significantly inhibited the numbers of acetic acid-induced writhing response..

Wood Ear · 2011 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Antioxidant properties of extracts of wild medicinal mushroom species from Croatia.

Antioxidant activity and total phenol (TP) content of methanol and water extracts of three wild Croatian mushroom species Auricularia auricula-judae (Bull.) Quél., Sarcoscypha austriaca (Sacc.) Boud., and Strobilurus esculentus (Wulfen) Singer were determined and compared with the values obtained for extracts of four….

OncologyEnergy & fatigueRespiratory

Niu-Chang-Chih · 2011 · Research Support, Non U.S. Gov'T · Mutation research

Antroquinonol inhibits NSCLC proliferation by altering PI3K/mTOR proteins and miRNA expression profiles.

Antroquinonol a derivative of Antrodia camphorata has been reported to have antitumor effects against various cancer cells. However, the effect of antroquinonol on cell signalling and survival pathways in non-small cell lung cancer (NSCLC) cells has not been fully demarcated..

Niu-Chang-Chih · 2011 · Research Support, Non U.S. Gov'T · Free radical biology & medicine

Antroquinonol reduces oxidative stress by enhancing the Nrf2 signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice.

Oxidative stress, inflammation, and fibrosis are involved in the development and progression of focal segmental glomerulosclerosis (FSGS), a common form of idiopathic nephrotic syndrome that represents a therapeutic challenge because it has a poor response to steroids..

Maitake · 2011 · Research Support, Non U.S. Gov'T · Biological trace element research

Determination of trace elements in three mushroom samples of basidiomycetes from Shandong, China.

We have determined the trace element composition of three mushrooms of Basidiomycetes, used in traditional Chinese medicine using atomic absorption spectrophotometer (AAS)..

Maitake · 2011 · Dissertation · journal metadata

Development of natural multifunctional cosmetic ingredients using biotechnological approach

Metadata-grounded summary: This dissertation indexes research on Grifola frondosa in 2011. MycoData maps the paper to skin & hydration based on its title, species context, article metadata, and study classification..

Skin & hydration

Zhu Ling · 2011 · Research Support, Non U.S. Gov'T · Biochimica et biophysica acta

Ergosta-4,6,8(14),22-tetraen-3-one induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.

BACKGROUND: Mushrooms have been used in Asia as traditional foods and medicines for a long time. Ergosta-4,6,8(14),22-tetraen-3-one (ergone) is one of the well-known bioactive steroids, which exists widely in various medicinal fungi such as Polyporus umbellatus, Russula cyanoxantha, and Cordyceps sinensis..

OncologyLiver support

Turkey Tail · 2011 · Evaluation Study · Journal of agricultural and food chemistry

Evaluation of the potential of fungal and plant laccases for active-packaging applications.

Laccases from Trametes versicolor (TvL), Myceliophthora thermophila (MtL), and Rhus vernicifera (RvL) were investigated with regard to their potential utilization as oxygen scavengers in active packages containing food susceptible to oxidation reactions..

Enoki · 2011 · Research Support, Non U.S. Gov'T · Molecular plant-microbe interactions: MPMI

Expression of an oxalate decarboxylase impairs the necrotic effect induced by Nep1-like protein (NLP) of Moniliophthora perniciosa in transgenic tobacco.

Oxalic acid (OA) and Nep1-like proteins (NLP) are recognized as elicitors of programmed cell death (PCD) in plants, which is crucial for the pathogenic success of necrotrophic plant pathogens and involves reactive oxygen species (ROS)..

Niu-Chang-Chih · 2011 · Research Support, Non U.S. Gov'T · Organic & biomolecular chemistry

First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents.

Naturally occurring antrocamphin A (1) is a potent anti-inflammatory compound from the edible fungus Antrodia camphorata (Taiwanofungus camphoratus), whose wild fruiting body is used as a valuable folk medicine in Taiwan. This study is the first total synthesis of antrocamphin A (1) and its analogs..

Lion's Mane · 2011 · Patent · journal metadata

FUNCTIONAL DUMPLING USING MILLSTONE AND THE MANUFACTURING METHOD THEREOF

PURPOSE: Functional dumplings, and a producing method thereof using a millstone are provided prevent the damage of micro-components including nutrients from ingredients..

Skin & hydration

Snow Fungus · 2011 · Patent · journal metadata

FUNGUS POLYOSE COMPOSITION WITH IMMUNITY ENHANCING EFFECT AND APPLICATION THEREOF

The present invention relates to a compound fungus polyose with the effect of enhancing immunity. The compound is prepared with raw material as follows: Lentinus edodes 8~100, Poria cocos 15~100, Dictyophora indusiata 10~200, Tremella fuciformis 15~80, Paecilomyces hepiali mycelium 2~50..

Niu-Chang-Chih · 2011 · Research Support, Non U.S. Gov'T · Journal of natural products

Is 2,3,4,5-tetramethoxybenzoyl chloride a natural product?

The title compound, which was reported to be a constituent of the fruiting body of the fungus Antrodia camphorata, has been synthesized. The reactivity and spectroscopic properties of the synthetic material do not match those of the natural product..

Enoki · 2011 · Patent · journal metadata

Methods for the administration of FV and related compositions

The present invention is generally directed to methods for the administration of compositions related to improved physical performance and post-exertion recovery, as well as the administered compositions..

Wood Ear · 2011 · Comparative Study · Food microbiology

Microbiological quality and safety of fresh cultivated and wild mushrooms commercialized in Spain.

402 samples of 22 species of cultivated and wild fresh mushrooms sold in retail markets and supermarkets in Zaragoza (Spain) were studied to quantify their microbial load (mesophilic aerobic microorganisms, Pseudomonas genus, Enterobacteriaceae, lactic acid bacteria, total and thermotolerant coliform bacteria,….

Immune supportSkin & hydration

Mesima · 2011 · Patent · journal metadata

MIXTURE EXTRACTS HAVING ANTI-OXIDATION ACTIVITY AND ANTI-INFLAMMATORY ACTIVITY AND COSMETIC COMPOSITION COMPRISING THE SAME

PURPOSE: A mixture extract of Carthamus tinctorius L., Triticum vulgare buds, Schizomepeta tenuifolia var. japonica, and Glycine soja is provided to ensure antioxidation and anti-inflammation and to relieve skin irritation..

Niu-Chang-Chih · 2011 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Monothiol glutaredoxin cDNA from Taiwanofungus camphorata: a novel CGFS-type glutaredoxin possessing glutathione reductase activity.

Glutaredoxins (Grxs) play important roles in the redox system via reduced glutathione as a reductant. A TcmonoGrx cDNA (1039 bp, EU158772) encoding a putative monothiol Grx was cloned from Taiwanofungus camphorata (formerly named Antrodia camphorata)..

Gut & microbiome

Energy & fatigueGut & microbiome

Wood Ear · 2011 · Research Support, Non U.S. Gov'T · FEMS microbiology ecology

Patterns of lignin degradation and oxidative enzyme secretion by different wood- and litter-colonizing basidiomycetes and ascomycetes grown on beech-wood.

The degradation of lignocellulose and the secretion of extracellular oxidoreductases were investigated in beech-wood (Fagus sylvatica) microcosms using 11 representative fungi of four different ecophysiological and taxonomic groups causing: (1) classic white rot of wood (e.g..

Maitake · 2011 · Research Support, Non U.S. Gov'T · RNA (New York, N.Y.)

Recurrent insertion of 5'-terminal nucleotides and loss of the branchpoint motif in lineages of group II introns inserted in mitochondrial preribosomal RNAs.

A survey of sequence databases revealed 10 instances of subgroup IIB1 mitochondrial ribosomal introns with 1 to 33 additional nucleotides inserted between the 5' exon and the consensus sequence at the intron 5' end..

Mesima · 2011 · Research Support, Non U.S. Gov'T · International journal of oncology

Suppression of growth and invasive behavior of human prostate cancer cells by ProstaCaid™: mechanism of activity.

Since the use of dietary supplements as alternative treatments or adjuvant therapies in cancer treatment is growing, a scientific verification of their biological activity and the detailed mechanisms of their action are necessary for the acceptance of dietary supplements in conventional cancer treatments..

OncologySkin & hydration

Mesima · 2011 · Patent · journal metadata

THE HEALTHY AND FUNTIONAL FOODS

PURPOSE: Health functional food and a producing method thereof are provided to use cudrania tricuspidata, ulmus davidiana planch, orostachys japonicus, and bong-hwang wild ginseng to produce the food..

Immune supportMetabolic health

Maitake · 2011 · Patent · journal metadata

UMAMI FOOD, AND METHOD FOR PRODUCING SAME

Provided is a food which takes on a rich umami flavor, and which is effective for the treatment and prevention of various immunological and inflammatory disorders, oxidative stress disorder, and metabolic syndrome. Also provided is a method for producing said food..

Turkey Tail · 2010 · English Abstract · Huan jing ke xue= Huanjing kexue

[Enhancement of laccase activity by combining white rot fungal strains].

The method of combining white rot fungal strains was used to enhance laccase activity, and the interaction mechanism between strains was also studied. The laccase activity of combined fungi of strain 55 (Trametes trogii) and strain m-6 (Trametes versicolor) were 24.13 and 4.07-fold higher than that of strain 55 and….