MycoData

OncologyImmune supportLiver supportRespiratory

Niu-Chang-Chih · 2008 · Journal Article · Toxicology and applied pharmacology

In vivo immunomodulatory effects of Antrodia camphorata polysaccharides in a T1/T2 doubly transgenic mouse model for inhibiting infection of Schistosoma mansoni.

Antrodia camphorata (A. camphorata) is a fungus commonly used for treatment of viral hepatitis and cancer in Chinese folk medicine.

Chaga · 2008 · Journal Article · Anticancer research

Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase-3-dependent apoptosis.

BACKGROUND: To investigate the antitumor effect of Inonotus obliquus Pilat, the antiproliferative effect of lanostane triterpenoids from a chloroform extract of I. obliquus sclerotia against mouse leukemia P388 cells was assessed.

Mesima · 2008 · Journal Article · Chemical & pharmaceutical bulletin

Phellifuropyranone A: A New Furopyranone Compound Isolated from Fruit Bodies of Wild Phellinus linteus

A new furopyranone, phellifuropyranone A, was isolated from fruit bodies of wild Phellinus linteus as well as phelligridin G, and their chemical structures were determined by various spectroscopic methods including measurement of NMR spectra..

OncologyRespiratory

Mesima · 2008 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Phellinus linteus Extract Augments the Immune Response in Mitomycin C-Induced Immunodeficient Mice.

Phellinus linteus is a fungus distributed throughout Japan, Korea and China. Boiled water-soluble extracts from P.

Maitake · 2008 · Journal Article · New biotechnology

Solid-state cultivation of Grifola frondosa (Dicks: Fr) S.F. Gray biomass and immunostimulatory effects of fungal intra- and extracellular beta-polysaccharides.

Grifola frondosa strain GF3, was cultivated on solid-state substrate consisting of milled whole corn plant (Zea mays) and olive press cake supplemented with mineral additives and olive oil. Maintenance of the moisture content in the solid substrate is of crucial importance..

Zhu Ling · 2007 · Research Article · Mycobiology

Improvement of Ergone Production from Mycelial Culture of Polyporus umbellatus.

Ergone,a fungal metabolite derived from ergosterol,was previously isolated and identified from Polyporus umbellatus. Ergone is a major component of P.

OncologyImmune supportLiver support

Enoki · 2007 · Journal Article · Carbohydrate polymers

Purification, characterization and biological activity on hepatocytes of a polysaccharide from Flammulina velutipes mycelium

A water-soluble polysaccharide named as FVP2 has been isolated from Flammulina velutipes mycelium by hot water extraction, anion-exchange and gel-permeation chromatography..

OncologyImmune supportRespiratory

Mesima · 2007 · Journal Article · Journal of agricultural and food chemistry

Structural and biological study of carboxymethylated Phellinus linteus polysaccharides.

Polysaccharides isolated from Phellinus linteus were chemically modified by carboxymethylation, and the structural and physiological properties of the derivative were investigated. 13C NMR spectroscopy showed that the polysaccharides extracted from P.

Enoki · 2006 · Journal Article · Mycologia

An agglutinin with mitogenic and antiproliferative activities from the mushroom Flammulina velutipes.

A hemagglutinin with a molecular mass of 12 kDa was isolated from the fruiting bodies of the mushroom Flammulina velutipes. Its molecular mass is similar to that of the fungal immunomodulatory protein isolated from F..

Mesima · 2006 · Research Article · Mycobiology

Antitumor and Antioxidant Activities of the Extracts from Fruiting Body of Phellinus linteus.

Fruiting bodies of Phellinus linteus were extracted by hot water and alkali methods. Sugar contents of PL-H (hot water extract) and PL-A (alkali water extract) were 81.1%, 37.4% and protein contents were 6.2%, 21.8%, respectively..

Mesima · 2006 · Journal Article · Immunopharmacology and immunotoxicology

Effects of oral administration of Phellinus linteus on the production of Th1- and Th2-type cytokines in mice.

The mushroom Phellinus linteus (PL) has been shown to have antitumor and immunostimulatory effects. We hypothesized that the hot water extract of PL (WEPL) exerts its significant immunostimulatory effect by inducing production of the Th1-derived cytokine interferon-gamma (IFN-gamma) by T lymphocytes..

OncologyCognition & nervesEnergy & fatigueSkin & hydration

Maitake · 2006 · Journal Article · Journal of lipid research

Lysophosphatidylethanolamine in Grifola frondosa as a neurotrophic activator via activation of MAPK.

We found that Grifola frondosa extracts induced the activation of mitogen-activated protein kinase (MAPK) in cultured PC12 cells, a line of rat pheochromocytoma cells..

OncologyImmune supportRespiratory

Mesima · 2006 · Research Article · Mycobiology

Mycelial Extract of Phellinus linteus Induces Cell Death in A549 Lung Cancer Cells and Elevation of Nitric Oxide in Raw 264.7 Macrophage Cells.

In the present study, in order to investigate the anti-proliferative phenomenon of PLME, the effects of mycelial extract of Phellinus linteus (PLME) on the growth of human lung carcinoma cell line A549 was examined..

Maitake · 2006 · Journal Article · Journal of agricultural and food chemistry

o-Orsellinaldehyde from the submerged culture of the edible mushroom Grifola frondosa exhibits selective cytotoxic effect against Hep 3B cells through apoptosis.

The tumoricidal activity of a bioactive metabolite produced by submerged culture in a 2.1-L airlift fermentor of Grifola frondosa NTUS was investigated. After 14 days of cultivation, ethyl acetate extracts from the supernatant of culture broth (EES) were analyzed by cell viability assay..

OncologyRespiratory

Maitake · 2006 · Journal Article · International journal of biological macromolecules

Preparation of a chemically sulfated polysaccharide derived from Grifola frondosa and its potential biological activities.

This report describes the preparation, characterization and potential biological activities of a chemically sulfated polysaccharide (S-GAP-P), which was derived from water-insoluble polysaccharide of Grifola frondosa mycelia..

Niu-Chang-Chih · 2005 · Patent · journal metadata

A new extraction method and application of antrodia camphorata to reduce the damage from chemotherapy for cancer and enhance the erythropoiesis in bone marrow

We found a new extraction method and application of Antrodia camphorata in promoting and protecting the Erythropoiesis after the chemotherapy of cyclophosphamide..

OncologyGut & microbiome

OncologyGut & microbiomeLiver supportRespiratory

Mesima · 2005 · Comparative Study · Biological & pharmaceutical bulletin

Cambodian Phellinus linteus Inhibits Experimental Metastasis of Melanoma Cells in Mice via Regulation of Urokinase Type Plasminogen Activator

Phellinus linteus (PL) is a fungus mainly found in tropical America, Africa and Asian countries including Korea, Japan and China. PL has been traditionally used for the treatment of arthritis, liver damage and cancer..

OncologyImmune supportEnergy & fatigueMetabolic health

Chaga · 2005 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

In vivo and in vitro anti-inflammatory and anti-nociceptive effects of the methanol extract of Inonotus obliquus.

The mushroom Inonotus obliquus (Fr.) Pilát (Hymenochaetaceae), has been traditionally used for the treatment of gastrointestinal cancer, cardiovascular disease and diabetes in Russia, Poland and most of Baltic countries..

Niu-Chang-Chih · 2005 · Patent · journal metadata

Isolate of Antrodia camphorata, process for producing a culture of the same and product obtained thereby

The present invention relates a process for culturing isolates of Antrodia camphorata to provide a product useful in medical and nourishment fields. The present invention also relates to a novel isolate of Antrodia camphorata capable of growing in a suitable artificial medium, while exhibiting desired pharmacological….

Enoki · 2005 · Patent · journal metadata

MUSHROOM BROWN FLAMMULINA VELUTIPES (ENOKI MUSHROOM) CONTAINING HIGH CONTENT OF TREHALOSE AND VITAMIN

PURPOSE: A mushroom brown Flammulina velutipes (enoki mushroom) is provided, which mushroom contains the high content of trehalose and vitamin, and has improved anticancer activity, and improved productivity..

OncologyImmune supportLiver support

Niu-Chang-Chih · 2005 · Patent · journal metadata

Process for preparing antrodia camphorata polysaccharide and antrodia camphorata triterpene with micro-prorous adsorptive resin and its product

The present invention provides preparation process of antrodia camphorata polysaccharide and antrodia camphorata triterpene with adsorptive microporous resin and its product, and relates to chromatographic separation technology with adsorptive microporous resin and extraction of effective Chinese medicine component..

OncologyImmune supportEnergy & fatigue

Mesima · 2004 · Comparative Study · Journal of ethnopharmacology

Acidic polysaccharide isolated from Phellinus linteus enhances through the up-regulation of nitric oxide and tumor necrosis factor-alpha from peritoneal macrophages.

Medicinal mushrooms are increasingly used to treat a wide variety of disease processes. Aqueous extract from the fruiting body or mycelia of Phellinus linteus has been reported to produce antitumor and immunomodulatory activities in vivo and in vitro..

OncologyImmune supportGut & microbiomeRespiratory

Mesima · 2004 · Patent · journal metadata

ANTICANCER AGENT CONTAINING POLYSACCHARIDE AND MITOMYCIN C EXTRACTED FROM PHELLINUS LINTEUS

PURPOSE: Provided is an anticancer agent containing polysaccharide that is galactomannoglucan and mitomycin C extracted from Phellinus linteus. It is useful for treatment of stomach cancer, breast cancer, colorectal cancer, large intestine cancer and the like..

Mesima · 2004 · Patent · journal metadata

ANTICANCER FOOD USING KEUMSA SANGWHANG MUSHROOM(PHELLINUS LINTEUS) TO DISPLAY ANTI-CANCER ACTIVITY DERIVED FROM KEUMSA SANGWHANG MUSHROOM(PHELLINUS LINTEUS)

PURPOSE: Food using Keumsa Sangwhang mushroom(Phellinus linteus) is provided, which food has anti-cancer activity derived from Keumsa Sangwhang mushroom(Phellinus linteus), so that a consumer can easily use the anti-cancer activity of Keumsa Sangwhang mushroom(Phellinus linteus) by eating the food..

Mesima · 2004 · Patent · journal metadata

COMPOSITE ANTICANCER AGENT CONTAINING POLYSACCHARIDE AND ADRIAMYCIN EXTRACTED FORM PHELLINUS LINTEUS

PURPOSE: Provided is a composite anticancer agent containing polysaccharide and adriamycin extracted form Phellinus linteus, thereby reducing adverse side effects of cancer chemotherapy and consequently treating cancer without adverse side effects..

OncologyImmune supportLiver supportRespiratory

Chaga · 2004 · Patent · journal metadata

COMPOSITION COMPRISING EXTRACT OF INONOTUS OBLIQUUS HAVING IMMUNE-ENHANCING AND ANTICANCER ACTIVITIES

PURPOSE: Provided is a pharmaceutical composition comprising the extract of Inonotus obliquus which has immune-enhancing and anticancer activities. The extract of Inonotus obliquus is effectively used for health foods and medicaments for prevention and treatment of adult diseases, such as immunodeficiency diseases and….

Mesima · 2004 · Patent · journal metadata

COSMETIC COMPOSITION CONTAINING THE EXTRACT OF PHELLINUS LINTEUS MYCELIUM WHICH PREVENTS SKIN WRINKLES BY MOISTURIZING SKIN AND PROVIDES ANTIOXIDATION EFFECT FOR ANTI-AGING

PURPOSE: Provided is a cosmetic composition containing the extract of Phellinus linteus mycelium. The composition prevents skin wrinkles by moisturizing the skin and provides antioxidation effect for anti-aging.

OncologySkin & hydration

Mesima · 2004 · Patent · journal metadata

MICROORGANISM PHELLINUS LINTEUS PRODUCING A LARGE QUANTITY OF ANTICANCER POLYSACCHARIDES AND MASS PRODUCTION METHOD THEREOF

PURPOSE: A microorganism Phellinus linteus and a mass production method thereof are provided. The microorganism produces a large quantity of anticancer polysaccharides.

OncologyImmune supportMetabolic health

Mesima · 2004 · Patent · journal metadata

PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF DISEASES ASSOCIATED WITH ANGIOGENESIS, CONTAINING POLYSACCHARIDE EXTRACTED FROM PHELLINUS LINTEUS

PURPOSE: A pharmaceutical composition containing polysaccharide such as galactomannoglucan extracted from the mycelium of Phellinus linteus as an effective ingredient is provided. The composition can be used for treatment of arthritis, diabetic retinopathy, psoriasis, cancer or the like..

Mesima · 2004 · Patent · journal metadata

PROCESS FOR PREPARING MYCELIUM OF PHELLINUS LINTEUS USING PLANT OIL

PURPOSE: A process for preparing mycelium of Phellinus linteus using plant oil is provided, thereby mass-producing the mycelium of Phellinus linteus containing protein bounded polysaccharide having improved anticancer activity..

Mesima · 2004 · Patent · journal metadata

PRODUCTION OF DRINK FOR PREVENTING CANCER, CONTAINING EXTRACT OF PHELLINUS LINTEUS, ULMUS DAVIDIANA, THEAE FOLIUM, BAMBOO SALT AND TRICHOLOMA MATSUTAKE

PURPOSE: A method of preparing a drink using the extract of Phellinus linteus, Ulmus davidiana Planch., Theae folium, bamboo salt and Tricholoma matsutake is provided. A consumer easily and conveniently takes the drink and as drinking it for a long period of time, the consumer is prevented from cancer..

Mesima · 2004 · Patent · journal metadata

PRODUCTION OF FERMENTED SOYBEAN PASTE AND RED PEPPER PASTE USING MYCELIUM OF PHELLINUS LINTEUS

PURPOSE: A method of making fermented soybean paste and red pepper paste by culturing the mycelium of Phellinus linteus in steamed beans is provided. The fermented soybean paste and red pepper paste have synergistic action between pharmacological efficacy of Phellinus linteus and anticancer effect of the fermented….

OncologyImmune supportGut & microbiome

Mesima · 2004 · Research Support, Non U.S. Gov'T · Cancer letters

Protein-bound polysaccharide from Phellinus linteus induces G2/M phase arrest and apoptosis in SW480 human colon cancer cells.

The cytotoxic mechanism of protein-bound polysaccharide isolated from Phellinus linteus (PL, Mesima) has been investigated. PL inhibited the proliferation and colony formation of SW480 human colon cancer cells.

Mesima · 2003 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Anti-angiogenic, antioxidant and xanthine oxidase inhibition activities of the mushroom Phellinus linteus.

Fruiting bodies of Phellinus linteus were extracted with 70% ethanol at room temperature. The Phellinus linteus extract (PL) showed strong anti-angiogenic activity, which was detected using the chick embryo chorioallantoic membrane (CAM) assay..

Niu-Chang-Chih · 2002 · Patent · journal metadata

Isolate of Antrodia camphorata process for producing a culture of the same and product obtained thereby

OncologyImmune supportGut & microbiomeRespiratory

Turkey Tail · 2026 · Review · Chinese clinical oncology

Clinical evidence on a Coriolus versicolor-based vaginal gel for HPV-related cervical disease: a narrative review.

BACKGROUND AND OBJECTIVE: Human papillomavirus (HPV) infection is the most common sexually transmitted disease worldwide. Its persistence may lead to cervical dysplasia and, eventually, cervical cancer..

OncologyCognition & nerves

Almond Mushroom · 2026 · Clinical Trial Protocol · JMIR research protocols

Digital Attention Bias in Cancer Survivors Intervention for Adolescent and Young Adult Cancer Survivors: Protocol for a Pilot Randomized Controlled Trial.

BACKGROUND: Adolescent and young adult cancer survivors face a high burden of psychological late effects, with cancer-related anxiety being a prevalent mental health concern..

OncologyImmune supportMetabolic healthSkin & hydration

Reishi · 2026 · Preprint · journal metadata

In Vitro and In Vivo Evaluation of the Skin-Care Bioactivity of β-1,3; 1,6-Glucans-Rich Ganoderma lucidum Polysaccharides

Extracted from Ganoderma lucidum mycelium, the developed β-1,3;1,6-glucan rich polysaccharides have the potential for industrial production of health food products due to their inhibition of metabolic syndrome, immunomodulatory and anti-tumor activities and other health benefits..

OncologyImmune supportMetabolic healthGut & microbiome

Reishi · 2025 · Review · NPJ science of food

Application of edible fungi in gut microbiota regulation.

The human gut microbiota serves as a critical hub for host metabolic and immune regulation. Disruption of its homeostasis is closely associated with diseases such as Inflammatory Bowel Disease (IBD), metabolic syndrome, and colorectal cancer..

OncologyImmune supportCognition & nervesLiver support

Reishi · 2025 · Review · Journal of ethnopharmacology

Ganoderic acid A: an in-depth review of pharmacological effects and molecular docking analysis.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderic acid A (GAA, C30H44O7) is one of the most abundant and active components of Ganoderic acids (GAs). GAs are highly oxidized tetracyclic triterpenoid compounds mainly derived from Ganoderma lucidum (Curtis) P.

OncologyMetabolic healthLiver supportSkin & hydration

Reishi · 2025 · Review · Frontiers in cellular and infection microbiology

Ganodermataceae-current status, research, and development in Lower Mekong Basin.

The family Ganodermataceae encompasses several genera, including the widely studied Ganoderma, which is prominent in traditional medicine for its therapeutic properties..

OncologyImmune supportLiver support

Almond Mushroom · 2024 · Review · Journal of agricultural and food chemistry

Chemical Structures, Biological Activities, and Biosynthetic Analysis of Secondary Metabolites from Agaricus Mushrooms: A Review.

Agaricus mushrooms are an important genus in the Agaricaceae family, belonging to the order Agaricales of the class Basidiomycota. Among them, Agaricus bisporus is a common mushroom for mass consumption, which is not only nutritious but also possesses significant medicinal properties such as anticancer, antibacterial,….

OncologyImmune supportCognition & nervesMetabolic health

King Oyster · 2024 · Preprint · journal metadata

Olive mill solid waste induces beneficial mushroom-specialized metabolite diversity revealed by computational metabolomics strategies

Introduction Mushrooms contain besides proteins a diverse pallet of specialized metabolites bioactive in either beneficial or harmful manner. Therefore, mushrooms have been exploited by humans for centuries for dietary or medical purposes..

Oyster Mushroom · 2023 · Journal Article · International journal of medicinal mushrooms

Antimicrobial, Antioxidant, Cytotoxicity and DNA Protective Properties of the Pink Oyster Mushroom, Pleurotus djamor (Agaricomycetes).

In this study, pink oyster mushroom Pleurotus djamor was cultivated using wheat straw (WS), quinoa stalk (QS), and their mixtures (WS-QS (1:1)) as substrate and evaluated in terms of antimicrobial, antioxidant, cytotoxicity, and DNA protective effects..

Cordyceps · 2023 · Journal Article · Phytochemistry

Bifusicoumarins A-D: Cytotoxic 3S-dihydroisocoumarins from the entomopathogenic fungus Cordyceps bifusispora (NBRC 108997).

Cordyceps is a genus of ascomycete fungi with some of them being edible and/or having a long tradition in Chinese medicine. The chemical characterization of a solvent extract of the entomopathogenic fungus Cordyceps bifusispora afforded four undescribed coumarins, bifusicoumarin A-D (1-4), along with previously….

Reishi · 2023 · Journal Article · International journal of medicinal mushrooms

Chemical Components of Volatile Oil Extracted from the Fermentation Broth of Ganoderma lingzhi (Agaricomycetes) Coupled with Its Antitumor and Antioxidant Activities In Vitro.

Volatile oil extracted from fermentation broth of Ganoderma lingzhi by hydrodistillation was analyzed based on gas chromatography-mass spectrometry (GC-MS). Its antitumor activity was tested on K562, SW620, A549, HepG2 cells in vitro..

OncologyImmune supportMetabolic healthRespiratory

Cordyceps · 2023 · Journal Article · Journal of natural medicines

Cordythiazole A, the first member of thiazole alkaloids from Chinese cordyceps, with α-glucosidase inhibitory activity.

Chinese cordyceps, also known as Dong-Chong-Xia-Cao, is widely recognized as a famous precious tonic herb, and used as traditional Chinese medicine for centuries..

OncologyCognition & nervesLiver support

Cordyceps · 2023 · Research Article · Cellular and molecular bioengineering

Enhancing Neurological Competence of Nanoencapsulated Cordyceps/Turmeric Extracts in Human Neuroblastoma SH-SY5Y Cells.

INTRODUCTION: Neurological diseases, including Alzheimer's, Parkinson's diseases, and brain cancers, are reportedly caused by genetic aberration and cellular malfunction..