MycoData

Mesima · 2010 · Patent · journal metadata

COMPOSITION CONTAINING EXTRACTS OF FUSCOPORIA OBLIQUA, GANODERMA LUCIDUM AND PHELLINUS LINTEUS FOR PROMOTING THE PROLIFERATION OF HEMATOPOIETIC STEM CELLS

The present invention relates to a composition containing mushroom extracts for promoting the proliferation of hematopoietic stem cells, and more specifically to a composition having a proliferation-promotive effect on hematopoietic stem cells, wherein the composition contains active ingredients composed of extracts….

Zhu Ling · 2010 · Research Support, Non U.S. Gov'T · Planta medica

Cytotoxic steroids from Polyporus umbellatus.

The steroids ergone (1), (22E, 24R)-ergosta-7,22-dien-3β-ol (2), 5α,8α-epidioxy-(22E,24R) -ergosta-6,22-dien-3β-ol (3), ergosta-6,22-dien-3β,5α,6β-triol (4), and polyporusterone B (5) were isolated from Polyporus umbellatus by bioassay-guided approach. They showed potent anticancer activity against HepG2 cells..

Niu-Chang-Chih · 2010 · Patent · journal metadata

ETHANOL EXTRACT OF ANTRODIA CAMPHORATA FOR INDUCING APOPTOSIS AND PREPARATION METHOD THEREOF

A preparation method for an ethanol extract of the fruiting body of Antrodia camphorata (EEAC) is provided. The preparation method includes steps of: (a) providing the fruiting body of A.

Mesima · 2010 · Research Support, Non U.S. Gov'T · International immunopharmacology

Evaluation of antidiabetic activity of polysaccharide isolated from Phellinus linteus in non-obese diabetic mouse.

Polysaccharide (PLP) isolated from Phellinus linteus inhibits tumor growth and metastasis by enhancing immune functions of macrophages, dendritic cells, NK cells, T cells, and B cells. Here, we report that PLP can inhibit the development of autoimmune diabetes in non-obese diabetic (NOD) mice..

OncologyImmune supportEnergy & fatigueGut & microbiome

Maitake · 2010 · Research Support, Non U.S. Gov'T · Experimental & molecular medicine

Grifola frondosa water extract alleviates intestinal inflammation by suppressing TNF-alpha production and its signaling.

TNF-alpha is a major cytokine involved in inflammatory bowel disease (IBD). In this study, water extract of Grifola frondosa (GFW) was evaluated for its protective effects against colon inflammation through the modulation of TNF-alpha action..

OncologyEnergy & fatigueLiver support

Niu-Chang-Chih · 2010 · Research Support, Non U.S. Gov'T · Chemical research in toxicology

Methyl antcinate A from Antrodia camphorata induces apoptosis in human liver cancer cells through oxidant-mediated cofilin- and Bax-triggered mitochondrial pathway.

We investigated the effects of antcin A, antcin C, and methyl antcinate A (MAA) isolated from Antrodia camphorata on the proliferation of human liver cancer cell lines Huh7, HepG2, and Hep3B and the normal cell rat hepatocytes..

Mesima · 2010 · Research Support, Non U.S. Gov'T · PloS one

Phellinus linteus extract sensitizes advanced prostate cancer cells to apoptosis in athymic nude mice.

Phellinus linteus (PL) mushroom possesses anti-tumor property. We previously reported that the treatment with PL caused cultured human prostate cancer cells to undergo apoptosis..

OncologyMetabolic healthLiver support

Chaga · 2010 · Research Support, Non U.S. Gov'T · Journal of the science of food and agriculture

Phytochemical characteristics and hypoglycaemic activity of fraction from mushroom Inonotus obliquus.

BACKGROUND: Inonotus obliquus is a medicinal mushroom that has been used as an effective agent to treat various diseases such as diabetes, tuberculosis and cancer. In order to elucidate the active fraction and its constituents, the effects of ethyl acetate fraction from I..

Niu-Chang-Chih · 2010 · Research Support, Non U.S. Gov'T · Cancer immunology, immunotherapy: CII

Promoting effect of Antrodia camphorata as an immunomodulating adjuvant on the antitumor efficacy of HER-2/neu DNA vaccine.

It is well known that DNA vaccines induce protective humoral and cell-mediated immune responses in several animal models. Antrodia camphorata (AC) is a unique basidiomycete fungus of the Polyporaceae family that only grows on the aromatic tree Cinnamomum kanehirai Hayata (Lauraceae) endemic to Taiwan..

OncologyImmune supportGut & microbiome

Mesima · 2010 · Research Support, Non U.S. Gov'T · Phytotherapy research: PTR

The ethyl acetate extract of Phellinus linteus grown on germinated brown rice induces G0/G1 cell cycle arrest and apoptosis in human colon carcinoma HT29 cells.

It is well known that Phellinus linteus has a variety of biological functions, such as antitumor and immunomodulating activities. In our previous studies, we developed a P..

Niu-Chang-Chih · 2010 · Patent · journal metadata

WATER EXTRACT OF ANTRODIA CAMPHORATA FOR IMMUNOSTIMULATORY EFFECT AND PREPARATION METHOD THEREOF

A preparation method for a water extract of the fruiting body of Antrodia camphorata (ACW) is provided. The method includes steps of: (a) providing the fruiting body and (b) boiling the fruiting body in water to obtain the water extract.

Enoki · 2009 · English Abstract · Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

[Effect of Flammulina velutipes polysaccharides on production of cytokines by murine immunocytes and serum levels of cytokines in tumor-bearing mice].

OBJECTIVE: To study the effect of Flammulina velutipes polysaccharides (FVP) on the production of tumor necrosis factor alpha (TNF-alpha), interferon-gamma (INF-gamma) and interleukin 2 (IL-2) by murine immunocytes..

OncologyEnergy & fatigueSkin & hydration

Niu-Chang-Chih · 2009 · Research Support, Non U.S. Gov'T · International heart journal

A novel inhibitory effect of Antrodia camphorata extract on vascular smooth muscle cell migration and neointima formation in mice.

Antrodia camphorata (AC) is a well-known traditional Chinese medicine that has been shown to inhibit proliferation and migration of cancer cells. We examined whether AC could inhibit rat aortic smooth muscle cell (RASMC) proliferation and migration and evaluated its effect on neointima formation in mouse carotid….

Niu-Chang-Chih · 2009 · Research Support, Non U.S. Gov'T · Archives of toxicology

Active extracts of wild fruiting bodies of Antrodia camphorata (EEAC) induce leukemia HL 60 cells apoptosis partially through histone hypoacetylation and synergistically promote anticancer effect of trichostatin A.

The endemic species of Antrodia camphorate (AC) is a promising chemotherapeutic drug for cancer. We found that the ethanol extract from wild fruiting bodies of Antrodia camphorata (EEAC) could induce HL 60 cells apoptosis via histone hypoacetylation, up-regulation of histone deacetyltransferase 1 (HDAC 1), and….

Maitake · 2009 · Research Support, Non U.S. Gov'T · Carbohydrate research

An unambiguous structural elucidation of a 1,3-beta-D-glucan obtained from liquid-cultured Grifola frondosa by solution NMR experiments.

Grifolan LE (GRN-LE), a purified beta-D-glucan, which is obtained from liquid-cultured Grifola frondosa, exhibits various biological activities, including antitumor effects. Significant progress has been made in the study of these effects..

Niu-Chang-Chih · 2009 · Research Support, Non U.S. Gov'T · Electrophoresis

Cyclodextrin-modified capillary electrophoresis for achiral and chiral separation of ergostane and lanostane compounds extracted from the fruiting body of Antrodia camphorata.

A CD-modified capillary electrophoretic method has been developed for achiral and chiral analysis of seven bioactive compounds isolated from the fruiting body of Antrodia camphorata..

Niu-Chang-Chih · 2009 · Research Support, Non U.S. Gov'T · Cancer letters

Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells.

Five lanostane (2, 3, 4, 6 and 8) and three ergostane-type (1, 5 and 7) triterpenes isolated from the fruiting bodies of Antrodia camphorata were evaluated for their in vitro cytotoxic data against various cancer cell types..

OncologyGut & microbiome

Niu-Chang-Chih · 2009 · Research Support, Non U.S. Gov'T · The Chinese journal of physiology

Effects of Antrodia camphorata extracts on the viability, apoptosis, [Ca2+]i, and MAPKs phosphorylation of OC2 human oral cancer cells.

The effect of Antrodia camphorata (AC) on human oral cancer cells has not been explored. This study examined the effect of AC on the viability, apoptosis, mitogen-activated protein kinases (MAPKs) phosphorylation and Ca2+ regulation of OC2 human oral cancer cells..

Niu-Chang-Chih · 2009 · Research Support, Non U.S. Gov'T · Planta medica

New constituents with iNOS inhibitory activity from mycelium of Antrodia camphorata.

In continuing our investigation on the bioactive constituents of mycelium of Antrodia camphorata, antroquinonol B (1), 4-acetyl-antroquinonol B (2), 2,3-(methylenedioxy)-6-methylbenzene-1,4-diol (3) and 2,4-dimethoxy-6-methylbenzene-1,3-diol (4) along with antrodin D (5) were isolated by the guidance of an inducible….

OncologyLiver supportRespiratory

Niu-Chang-Chih · 2009 · Patent · journal metadata

Novel compounds from antrodia camphorata

Antroquinonol B (X=OH) and Antroquinonol C (X=OMe) are described. They can be isolated from Antrodia camphorata extracts and may inhibit the growth of cancer cells (e.g.

Turkey Tail · 2009 · Research Support, U.S. Gov'T, Non P.H.S. · Bioresource technology

Oxidation of anthracene by immobilized laccase from Trametes versicolor.

The laccase of Trametes versicolor was immobilized on the functionalized nanoparticles SBA-15 with the average diameter less than 10 nm. Laccase mediated oxidations of anthracene (ANT) were investigated in the presence of two mediators, 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS)….

Niu-Chang-Chih · 2009 · Patent · journal metadata

Protein ACA1 of antrodia camphorata

A new protein, named ACA1, has been isolated and purified from the medical fungi Antrodia camphorata using the technique of anion-exchange chromatography. ACA1, a glycoprotein with a molecular mass of 29 kDa, has a pI value of pH 5.3 and contains 118 amino acids in its peptide moiety..

Niu-Chang-Chih · 2009 · Research Support, Non U.S. Gov'T · ChemMedChem

Rapid evaluation of Antrodia camphorata natural products and derivatives in tumourigenic liver progenitor cells with a novel cell proliferation assay.

We report the syntheses of five natural product maleimide and maleic anhydrides from the mushroom Antrodia camphorata. The ability of these compounds to affect proliferation in non-tumourigenic and tumourigenic liver progenitor cell lines was monitored by the Cellscreen system, a novel and nondestructive….

Niu-Chang-Chih · 2009 · Research Support, Non U.S. Gov'T · The American journal of Chinese medicine

The augmented anti-tumor effects of Antrodia camphorata co-fermented with Chinese medicinal herb in human hepatoma cells.

Antrodia camphorata, unique fungal specie, has been used as a folk medicine in Taiwan for many years. The purpose of this study was to compare the extracts from the solid-state culture of A..

Niu-Chang-Chih · 2008 · Patent · journal metadata

4-hydroxy-2,3-disubstituted-cyclohex-2-en-1-on-5-yl isoprenoids, extractable from Antrodia camphorata, as anti-tumour & cardiovascular agents, & antioxidant

Compounds of formula (1): '''wherein: X and Y are O or S R' are independently H or C1-13 linear alkyl and n is 1-12 can be isolated and purified from an extract of Antrodia camphorata, and used to inhibit the growth of cancer cells (such as breast cancer, hepatic cancer and prostate cancer), to prevent heart disease….

Niu-Chang-Chih · 2008 · Research Support, Non U.S. Gov'T · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association

Antrodia camphorata inhibits proliferation of human breast cancer cells in vitro and in vivo.

Antrodia camphorata (A. camphorata) has been shown to induce apoptosis in cultured human breast cancer cells (MDA-MB-231).

Niu-Chang-Chih · 2008 · Research Support, Non U.S. Gov'T · The Chinese journal of physiology

Effects of antrodia camphorata on viability, apoptosis, and [Ca2+]i in PC3 human prostate cancer cells.

Antrodia camphorata (AC) has been used as a health supplement in Asia to control different cancers; however, the cellular mechanisms of its effects are unclear. The effect of AC on cultured human prostate cancer cells (PC3) has not been explored..

Maitake · 2008 · Patent · journal metadata

Grifola frondosa beta-dextran freeze-dried powder for injection

The invention relates to a freeze-dried powder for injection which is prepared by Beta-glucan that is extracted and separated by using Grifola frondosa mycelium and has the structure shown in the attached figure I and a preparation method thereof, which pertains to the technical field of medical preparations..

OncologyImmune supportEnergy & fatigueLiver support

Chaga · 2008 · Research Support, Non U.S. Gov'T · Current microbiology

Identification of Inonotus obliquus and analysis of antioxidation and antitumor activities of polysaccharides.

Inonotus obliquus, a wild wood-decay fungus which grows on Betula trees in cool climates, has a variety of biological activities that the scientific community is paying more and more attention to. However, the research work is moving at a snail's pace..

Chaga · 2008 · Research Support, Non U.S. Gov'T · European journal of medicinal chemistry

Lanostane-type triterpenoids from the sclerotia of Inonotus obliquus possessing anti-tumor promoting activity.

Two new lanostane-type triterpenoids, 1 and 2 besides two known lanostane-type triterpenoids, 3 and 4 were isolated from the sclerotia of Inonotus obliquus. Their structures were determined to be lanosta-8,23E-diene-3beta,22R,25-triol (1) and lanosta-7:9(11),23E-triene-3beta,22R,25-triol (2) by spectral data..

OncologySkin & hydration

OncologyEnergy & fatigueLiver support

Niu-Chang-Chih · 2008 · Patent · journal metadata

NOVEL CYCLOHEXENONE COMPOUNDS FROM ANTRODIA CAMPHORATA AND APPLICATION THEREOF

A cyclohexenone compound is provided to suppress the growth of cancer cells such as breast cancer, liver cancer, and prostatic cancer, and to ensure antioxidant activities..

OncologyImmune supportLiver supportRespiratory

Niu-Chang-Chih · 2008 · Research Support, Non U.S. Gov'T · International immunopharmacology

Polysaccharides from Antrodia camphorata mycelia extracts possess immunomodulatory activity and inhibits infection of Schistosoma mansoni.

Antrodia camphorata (AC) is a commonly used fungus in folk medicine for the treatment of viral hepatitis and cancer. AC polysaccharides (AC-PS) are reported to possess anti-inflammatory, anti-hepatitis B virus, and anticancer activities..

Turkey Tail · 2008 · Research Support, Non U.S. Gov'T · Journal of the Society for Integrative Oncology

Trametes versicolor mushroom immune therapy in breast cancer.

Data from multiple epidemiologic and clinical studies on immune effects of conventional cancer treatment and the clinical benefits of polysaccharide immune therapy suggest that immune function has a role in breast cancer prevention..

Niu-Chang-Chih · 2007 · Research Support, Non U.S. Gov'T · Planta medica

A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata.

Antroquinonol ( 1), an ubiquinone derivative, was isolated from the solid-state fermented mycelium of Antrodia camphorata (Polyporaceae, Aphyllophorales), a parasitic fungus indigenous to Taiwan. The structure of compound 1 was elucidated by the analysis of their spectroscopic data..

Niu-Chang-Chih · 2007 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Antrodia camphorata extract induces replicative senescence in superficial TCC, and inhibits the absolute migration capability in invasive bladder carcinoma cells.

The Antrodia camphorata crude extract (ACCE), an extract obtained from a precious traditional Chinese folkloric herbal medicine Zhan-Ku (a camphor tree mushroom) since the 18th century, has showed rather significant inhibitory effects on the growth and proliferation of the transitional cell carcinomas (TCC) cell lines….

OncologyImmune supportEnergy & fatigue

Chaga · 2007 · Research Support, Non U.S. Gov'T · Journal of medicinal food

Ethanol extract of Inonotus obliquus inhibits lipopolysaccharide-induced inflammation in RAW 264.7 macrophage cells.

Inonotus obliquus (Pers.:Fr.) Pil. is a white rot fungus that belongs to the family Hymenochaetaceae of Basidiomycetes.

OncologyImmune supportGut & microbiome

Niu-Chang-Chih · 2007 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Evaluation of the anti-inflammatory and anti-proliferation tumoral cells activities of Antrodia camphorata, Cordyceps sinensis, and Cinnamomum osmophloeum bark extracts.

The extracts of chloroform (1) and methanol (2) from Antrodia camphorata (AC), and chloroform (3) and n-butanol (4) fractions of methanol extract from Cordyceps sinensis (CS), and hexane (5), ethyl acetate (6), and methanol (7) from Cinnamomum osmophloeum bark (CO) were evaluated for their anti-inflammatory as well as….

OncologyImmune supportEnergy & fatigueLiver support

Maitake · 2007 · Research Support, Non U.S. Gov'T · Toxicology in vitro: an international journal published in association with BIBRA

Induction of apoptosis in SGC-7901 cells by polysaccharide-peptide GFPS1b from the cultured mycelia of Grifola frondosa GF9801.

The biological function of GFPPS1b, a novel polysaccharide-peptide isolated from cultured mycelia of Grifola frondosa GF9801, was well investigated. GFPS1b has anti-tumor activity and can significantly inhibit the proliferation of SGC-7901 cells, whereas slightly influences the growth of human normal liver cell line….

Niu-Chang-Chih · 2007 · Research Support, Non U.S. Gov'T · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association

Inhibition of cyclooxygenase-2 and induction of apoptosis in estrogen-nonresponsive breast cancer cells by Antrodia camphorata.

The objective of this study was to investigate the fermented culture broth of Antrodia camphorata (A. camphorata) to induce apoptosis and inhibit cyclooxygenase-2 (COX-2) in estrogen-nonresponsive (MDA-MB-231) human breast cancer cells.

OncologyEnergy & fatigue

OncologyImmune supportRespiratory

Mesima · 2007 · Research Support, Non U.S. Gov'T · Molecular carcinogenesis

Modulation of lung cancer growth arrest and apoptosis by Phellinus Linteus.

The Phellinus Linteus (PL) mushroom has been shown to possess anti-tumor properties. Through influencing lymphocytes, PL indirectly augments the host's immune system against cancer cells.

Niu-Chang-Chih · 2007 · Patent · journal metadata

New protein (ACA1) of antrodia camphorata

OncologyImmune supportRespiratory

Mesima · 2007 · Research Support, Non U.S. Gov'T · British journal of cancer

Phellinus linteus activates different pathways to induce apoptosis in prostate cancer cells.

It is known that polysaccharides extracted from the Phellinus linteus (PL) mushroom possess antitumour activity. We previously have demonstrated that high doses of PL render murine or human lung cancer cells susceptible to apoptosis..

OncologyEnergy & fatigueLiver support

Mesima · 2007 · Research Support, Non U.S. Gov'T · Phytotherapy research: PTR

Protective effects of Phellinus linteus extract against iron overload-mediated oxidative stress in cultured rat hepatocytes.

Phellinus linteus (PL) mushroom has been reported to possess antioxidant activity. The present study was designed to investigate whether an ethanol extract obtained from PL might ameliorate oxidative stress and enhance antioxidant enzyme activities in primary rat hepatocytes, which were overloaded with iron using….

Maitake · 2007 · Research Support, Non U.S. Gov'T · Bioresource technology

Structural analysis of anti-tumor heteropolysaccharide GFPS1b from the cultured mycelia of Grifola frondosa GF9801.

A 21-kDa heteropolysaccharide, coded as GFPS1b, was obtained from the cultured mycelia of Grifola frondosa GF9801 by hot-water extraction, ethanol precipitation, and fractioned by DEAE Sepharose Fast-flow, followed by the purification with Sephadex G-100 column chromatography using an AKTA purifier..

Niu-Chang-Chih · 2007 · Research Support, Non U.S. Gov'T · Nutrition and cancer

Unique formosan mushroom Antrodia camphorata differentially inhibits androgen-responsive LNCaP and -independent PC-3 prostate cancer cells.

Antrodia camphorata (AC), a precious and unique folkloric medicinal mushroom enriched in polyphenolics, isoflavonoids, triterpenoids, and polysaccharides, has been diversely used in Formosa (Taiwan) since the 18th century..

Mesima · 2006 · Research Support, Non U.S. Gov'T · International immunopharmacology

Acidic polysaccharide from Phellinus linteus inhibits melanoma cell metastasis by blocking cell adhesion and invasion.

The acidic polysaccharide (PL) from Phellinus linteus is an immunostimulator that has therapeutic activity against cancers. Here, we show that PL markedly inhibits melanoma cell metastasis in mice, and report that PL directly inhibits cancer cell adhesion to and invasion through the extracellular matrix, but that it….

Chaga · 2006 · Research Support, Non U.S. Gov'T · Life sciences

Anti-cancer effect and structural characterization of endo-polysaccharide from cultivated mycelia of Inonotus obliquus.

The endo-polysaccharide extracted from mycelia of Inonotus obliquus (Pers.:Fr.) Pil. (Hymenochaetaceae) is a specific activator of B cells and macrophages.

OncologyLiver supportRespiratory

Niu-Chang-Chih · 2006 · Patent · journal metadata

Antrodia camphorata mycelium fermented extract and application thereof

The invention discloses an Antrodia camphorate mycelium fermentation extract abstracted by ethanol, wherein the Antrodia camphorata bacterial strain Ac001 was preserved in the China General Microbiological Culture Collection Center with a docket number of CGMCC No.1460..