MycoData

Niu-Chang-Chih · 2013 · Research Article · International journal of molecular sciences

New Anti-Inflammatory Aromatic Components from Antrodia camphorata.

Three new benzenoids, 3-isopropenyl-2-methoxy-6-methyl-4,5-methylenedioxy- phenol (1), 2-hydroxy-4,4'-dimethoxy-3,3'-dimethyl-5,6,5',6'-bimethylenedioxybiphenyl (2), 4,4'-dihydroxy-3,3'-dimethoxy-2,2'-dimethyl-5,6,5',6'-bimethylenedioxybiphenyl (3), together with two known benzenoids, 2,3,6-trimethoxy-5-methylphenol….

Yellow Morel · 2013 · Journal Article · Industrial crops and products

Optimization of fermentation conditions for crude polysaccharides by Morchella esculenta using soybean curd residue

In this study, orthogonal experimental design and response surface methodology were employed to optimize the fermentation conditions for crude polysaccharides (MPS) production from the strain Morchella esculenta (M. esculenta) by soybean curd residue (SCR)..

Maitake · 2013 · Research Article · Pharmacognosy magazine

Optimization of subcritical water extraction of polysaccharides from Grifola frondosa using response surface methodology.

BACKGROUND: This research is among the few that has been conducted on the feasibility of subcritical water extraction (SWE) as a rapid and efficient extraction tool for polysaccharides..

OncologyImmune supportEnergy & fatigue

Mesima · 2013 · Research Article · Chinese medicine

Phellinus linteus polysaccharide extracts increase the mitochondrial membrane potential and cause apoptotic death of THP-1 monocytes.

BACKGROUND: The differentiation resp. death of human monocytic THP-1 cells induced by polysaccharide extracts of the medicinal mushrooms Phellinus linteus, Agaricus bisporus and Agaricus brasiliensis have been studied..

Turkey Tail · 2012 · Journal Article · Subtropical Plant Science

Antioxidative activities and chemical characterization of polysaccharide extracts from the widely used mushrooms Ganoderma applanatum, Ganoderma lucidum, Lentinus edodes and Trametes versicolor

Antioxidant activities of polysaccharide extracts of four of the most widely known mushrooms often used in medicinal applications as well as in tea and food, namely Ganoderma applanatum, Ganoderma lucidum, Lentinus edodes and Trametes versicolor, were studied. G.

Enoki · 2012 · Journal Article · Carbohydrate polymers

Bioactivity of the crude polysaccharides from fermented soybean curd residue by Flammulina velutipes.

The solid-state fermentation, reusing soybean curd residue (SCR) as a solid substrate, was conducted for producing polysaccharides by Flammulina velutipes (F. velutipes).

OncologyImmune supportEnergy & fatigueGut & microbiome

Niu-Chang-Chih · 2012 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Inhibition of Cell Growth and Induction of Apoptosis by Antrodia camphorata in HER-2/neu-Overexpressing Breast Cancer Cells through the Induction of ROS, Depletion of HER-2/neu, and Disruption of the PI3K/Akt Signaling Pathway.

Previously, we demonstrated that a submerged fermentation culture of Antrodia camphorata (AC) promotes cell-cycle arrest and apoptosis in human estrogen receptor-positive/negative breast cancer cells. However, whether AC is effective against HER-2/neu-overexpressing breast cancers has not been thoroughly elucidated..

Turkey Tail · 2012 · Research Article · ISRN oncology

Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer.

Introduction. Orally administered preparations from the Trametes versicolor (Tv) mushroom have been hypothesized to improve immune response in women with breast cancer after standard chemotherapy and radiotherapy.

OncologyImmune supportEnergy & fatigueLiver support

Niu-Chang-Chih · 2012 · Journal Article · Food chemistry

Protective effect of antrosterol from Antrodia camphorata submerged whole broth against carbon tetrachloride-induced acute liver injury in mice

The hepatoprotective potential of antrosterol (ergostatrien-3Î²-ol, ST1) from Antrodia camphorata (AC) against carbon tetrachloride (CClâ)-induced liver damage was evaluated in preventive models in mice..

Immune supportMetabolic healthLiver support

Mesima · 2012 · Research Article · Chinese medicine

Protective effect of Phellinus linteus polysaccharide extracts against thioacetamide-induced liver fibrosis in rats: a proteomics analysis.

BACKGROUND: The hepatoprotective potential of Phellinus linteus polysaccharide (PLP) extracts has been described. However, the molecular mechanism of PLP for the inhibition of liver fibrosis is unclear..

Enoki · 2012 · Journal Article · Carbohydrate polymers

Purification and structural investigation of a water-soluble polysaccharide from Flammulina velutipes

A novel water-soluble heteropolysaccharide FVP60-B was extracted from the fruiting bodies of Flammulina velutipes with boiling water and purified by Sephacryl S-300 and S-400, which molecular weight was estimated to be 1.3×10⁴Da by HPLC..

OncologyImmune supportCognition & nervesSkin & hydration

Enoki · 2012 · Journal Article · Carbohydrate polymers

Purification, characterization and anti-proliferation activity of polysaccharides from Flammulina velutipes

A polysaccharide was isolated from Flammulina velutipes (FVP) using ultrasonic-assisted extraction, and then further purified by DEAE cellulose-52 chromatography and Sephadex G-100 size-exclusion chromatography to afford FVP-1 and FVP-2..

Maitake · 2012 · Journal Article · Journal of leukocyte biology

Soluble β-glucan from Grifola frondosa induces proliferation and Dectin-1/Syk signaling in resident macrophages via the GM-CSF autocrine pathway.

MD-Fraction, a highly purified, soluble β-(1,3) (1,6)-glucan obtained from Grifola frondosa (an oriental edible mushroom), has been reported to inhibit tumor growth by modulating host immunity..

Immune supportEnergy & fatigueMetabolic health

Lion's Mane · 2012 · Journal Article · Carbohydrate polymers

Structure of a water-soluble heteropolysaccharide from fruiting bodies of Hericium erinaceus

A new heteropolysaccharide (HEPF4), with a molecular weight of 2.03×10⁴Da as determined by high-performance liquid chromatography (HPLC), was obtained from the fruiting bodies of Hericium erinaceus. It is composed of 3-O-methylrhamnose, l-fucose, d-galactose and d-glucose in the ratio of 0.12:1.00:3.27:0.28..

Yellow Morel · 2012 · Journal Article · International journal of food sciences and nutrition

Utilization of chicken feather hydrolysate as a novel fermentation substrate for production of exopolysaccharide and mycelial biomass from edible mushroom Morchella esculenta.

This study was performed to investigate the usability of chicken feather hydrolysate (Chicken feather peptone (CFP)) as substrate for mycelial biomass and extracellular polysaccharides (EPS) production from edible mushroom Morchella esculenta..

Mesima · 2011 · Journal Article · Food chemistry

Antioxidative and immunomodulating activities of polysaccharide extracts of the medicinal mushrooms Agaricus bisporus, Agaricus brasiliensis, Ganoderma lucidum and Phellinus linteus

Partially purified polysaccharides were obtained from four medicinal mushroom species, Agaricus bisporus, Agaricus brasiliensis, Phellinus linteus and Ganoderma lucidum by hot water extraction, followed by ethanol precipitation..

Chaga · 2011 · Journal Article · Food chemistry

Comparative antioxidative characteristics of polysaccharide-enriched extracts from natural sclerotia and cultured mycelia in submerged fermentation of Inonotus obliquus

The potential antioxidant property of polysaccharide-enriched extracts from the natural fungal sclerotia and the cultured mycelia in submerged fermentation of Inonotus obliquus was evaluated using three antioxidant assays..

Wood Ear · 2011 · Research Article · Toxicological research

Comparative Antitumor Activity of Different Solvent Fractions from an Auricularia auricula-judae Ethanol Extract in P388D1 and Sarcoma 180 Cells.

The objective of this study was to evaluate and compare the antitumor activity of different solvent fractions (ethanol, dichloromethane, ethyl acetate, butanol and water) of the Auricularia auricula-judae 70% ethanol extract on the P388D1 macrophage and sarcoma 180 cells..

OncologyImmune supportEnergy & fatigueGut & microbiome

Lion's Mane · 2011 · Journal Article · Journal of agricultural and food chemistry

Composition and mechanism of antitumor effects of Hericium erinaceus mushroom extracts in tumor-bearing mice.

We investigated antitumor effects of the following four extracts of freeze-dried Hericium erinaceus mushrooms in Balb/c mice intracutaneously transplanted on the backs with CT-26 colon cancer cells: HWE, hot water extraction by boiling in water for 3 h; MWE, microwaving in 50% ethanol/water at 60 W for 3 min; and ACE….

Chaga · 2011 · Research Article · Molecules and cells

Immunostimulating activity by polysaccharides isolated from fruiting body of Inonotus obliquus.

In this study, we investigated the immunostimulating activity of polysaccharides isolated from fruiting body of Inonotus obliquus (PFIO). Additionally, the signaling pathway of PFIO-mediated macrophage activation was investigated in RAW264.7 macrophage cells..

Maitake · 2011 · Research Article · Brazilian journal of microbiology: [publication of the Brazilian Society for Microbiology]

Lignin degradation, ligninolytic enzymes activities and exopolysaccharide production by Grifola frondosa strains cultivated on oak sawdust.

Fourteen strains of Grifola frondosa (Dicks.) S. F.

Immune supportCognition & nerves

Enoki · 2011 · Journal Article · Food research international (Ottawa, Ont.)

Optimization of ultrasonic extraction of Flammulina velutipes polysaccharides and evaluation of its acetylcholinesterase inhibitory activity

Polysaccharide was testified to be the main component of Flammulina velutipes for inhibiting AChE activity in our preliminary study. Therefore, response surface methodology, based on Box–Behnken design, was used to optimize the ultrasonic extraction conditions of F.

OncologyImmune supportLiver support

Mesima · 2011 · Journal Article · Journal of ethnopharmacology

Orally administered mycelial culture of Phellinus linteus exhibits antitumor effects in hepatoma cell-bearing mice.

AIM OF THE STUDY: The aim of this study was to evaluate the anticancer effect of a mycelial culture from Phellinus linteus PL-7 (MCPL-7) and to elucidate its potential mechanism in vivo. MATERIALS AND METHODS: SCID CB-17 mice received a transplant of Hep3B cells followed by daily MCPL-7 administrations for 8 weeks..

Maitake · 2011 · Journal Article · International journal of biological macromolecules

Physical characteristics and antioxidant effect of polysaccharides extracted by boiling water and enzymolysis from Grifola frondosa.

Grifola frondosa has been widely consumed in China and other Asian countries. Recent studies on G.

OncologyImmune supportRespiratory

Maitake · 2011 · Journal Article · World journal of microbiology & biotechnology

Production of exopolysaccharides by submerged mycelial culture of Grifola frondosa TFRI1073 and their antioxidant and antiproliferative activities

The exopolysaccharide (EPS) extract of a newly screened Grifola frondosa TFRI1073 was evaluated antioxidant activity, including superoxide anion scavenging activity and reducing power, and the antiproliferative activities by using lung (A549 cells) and breast (MDA-MD-231 cells) cancer cell line..

Maitake · 2010 · Journal Article · Mycoscience

Effect of a hot water-soluble extraction from Grifola frondosa on the viability of a human monocyte cell line exposed to mitomycin C

The effects of a hot water-soluble extract of Grifola frondosa on the viability of multiple immune cell lines were examined in vitro. The extract and the 1000-cut extract, a low molecular weight fraction, improved the viability of a human monocyte cell line, THP-1, treated by the anticancer drug mitomycin C..

Immune supportEnergy & fatigue

Enoki · 2010 · Journal Article · Journal of agricultural and food chemistry

Effects of ergothioneine from mushrooms (Flammulina velutipes) on melanosis and lipid oxidation of kuruma shrimp (Marsupenaeus japonicus).

The antimelanosic and antioxidative properties of a hot water extract prepared from the fruiting body of the edible mushroom (Flammulina velutipes) were evaluated by dietary supplementation in Kuruma shrimp (Marsupenaeus japonicus) for possible aquaculture application..

OncologyImmune supportLiver support

Lion's Mane · 2010 · Journal Article · Cancer letters

Hericium erinaceus enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells.

It has been demonstrated that the Hericium erinaceus (HE) mushroom, which primarily consists of polysaccharides, possesses anti-tumor activities. However, the mechanisms by which HE inhibits human hepatocellular carcinoma growth remain unknown..

OncologyImmune supportEnergy & fatigueMetabolic health

Mesima · 2010 · Journal Article · Archives of pharmacal research

Hispidin produced from Phellinus linteus protects pancreatic beta-cells from damage by hydrogen peroxide.

Phellinus linteus, which is a traditional medicinal mushroom used in Asian countries for the treatment of various diseases, has attracted a lot of attention due to its antioxidant, anti-inflammatory, anti-mutagenicity, and cell-mediated immunity properties in addition to its ability to inhibit tumor growth and….

Niu-Chang-Chih · 2010 · Journal Article · Food chemistry

Inhibitory effect of Antrodia camphorata constituents on the Helicobacter pylori-associated gastric inflammation

Helicobacter pylori infection plays a crucial role in the pathogenesis of peptic ulcer, and gastric cancer. Among the 13 chemical constituents isolated from fruiting bodies of Antrodia camphorata, methyl antcinate B (4), antcins K (10) and A (12) displayed potential anti-H..

Yellow Morel · 2010 · Journal Article · Carbohydrate polymers

Optimization for the production of exopolysaccharides from Morchella esculenta SO-02 in submerged culture and its antioxidant activities in vitro

The aims of this work were to optimize the conditions for exopolysaccharides (EPS) production by Morchella esculenta SO-02 in submerged culture, and to evaluate the antioxidant activities of EPS in vitro..

Chaga · 2010 · Journal Article · International journal of biological macromolecules

Optimization of ultrasonic/microwave assisted extraction (UMAE) of polysaccharides from Inonotus obliquus and evaluation of its anti-tumor activities.

Recently, the use of ultrasonic and microwave has attracted considerable interest as an alternative approach to the traditional extraction methods. In this paper, in order to maximize the yield and purity of polysaccharides from Inonotus obliquus, response surface methodology (RSM) was employed to optimize the….

Niu-Chang-Chih · 2010 · Journal Article · Bioorganic & medicinal chemistry

Structure and functions of gamma-dodecalactone isolated from Antrodia camphorata for NK cell activation.

The preserved fungal species Antrodia camphorata has diverse health-promoting effects and has been popularly used in East Asia as a traditional herb. We isolated a volatile compound from the culture medium of A.

OncologyImmune supportMetabolic healthGut & microbiome

Mesima · 2009 · Research Article · Mycobiology

Antitumor Effects and Immunomodulating Activities of Phellinus linteus Extract in a CT-26 Cell-Injected Colon Cancer Mouse Model.

The antitumor effects of Phellinus linteus extract (Keumsa Linteusan) were investigated in a CT-26 cell-injected colon cancer mouse model. When administered orally (250~1,000 mg/kg body weight), Keumsa Linteusan significantly inhibited the growth of solid colon cancer..

OncologyImmune supportGut & microbiome

Maitake · 2009 · Journal Article · Journal of agricultural and food chemistry

Characterization and antitumor effect of a novel polysaccharide from Grifola frondosa.

A novel polysaccharide, MZF, with a molecular mass of 23 kDa was isolated from Grifola frondosa. Results from methylation and (1)H NMR led to the conclusion that MZF is a heteropolysaccharide consisting of -->6)-alpha-D-Galp-(1--> (36.2%), -->3)-alpha-L-Fucp-(1--> (14.5%), -->6)-alpha-D-Manp-(1--> (9.4%),….

OncologyImmune supportGut & microbiome

Chaga · 2009 · Journal Article · Journal of bioscience and bioengineering

Comparative study of antioxidant activity and antiproliferative effect of hot water and ethanol extracts from the mushroom Inonotus obliquus.

The medicinal mushroom Inonotus obliquus is a traditional and widely used multi-functional fungus. Hot water (50 degrees C, 70 degrees C, and 80 degrees C) and ethanol crude extracts of I..

Niu-Chang-Chih · 2009 · Journal Article · Food chemistry

Immunostimulatory effect of Antrodia camphorata extract on functional maturation of dendritic cells

Dendritic cells (DCs) are now recognised as the most potent professional antigen presenting cells (APCs) involved in initiating primary immune responses. The medicinal mushroom Antrodia camphorata (AC) is one of the most popular chemopreventive mushrooms in Taiwan..

Lion's Mane · 2009 · Journal Article · Journal of microbiology and biotechnology

Study of macrophage activation and structural characteristics of purified polysaccharides from the fruiting body of Hericium erinaceus.

Most, if not all, Basidiomycetes mushrooms have biologically active polysaccharides showing potent antitumor activity with immunomodulating properties. These polysaccharides have various chemical compositions and belong primarily to the beta-glucan group..

Lion's Mane · 2009 · Journal Article · Carbohydrate polymers

Study on macrophage activation and structural characteristics of purified polysaccharides from the liquid culture broth of Hericium erinaceus

Recently, a number of bioactive molecules, including antitumor agents, have been identified in various higher basidiomycetes mushrooms. Polysaccharides are the best known and most potent mushroom derived substances that display immuno-pharmacological properties..

Immune supportMetabolic healthGut & microbiome

Turkey Tail · 2008 · Journal Article · Wood Sci Technol

Effects of propiconazole on extra-cellular enzymes involved in nutrient mobilization during Trametes versicolor wood colonization

The effects of propiconazole on extra-cellular enzyme levels in Trametes versicolor have been investigated during wood colonization and degradation. The working hypothesis was that the biocide could alter metabolic pathways, which could lead to an alteration of extra-cellular enzyme production..

OncologyImmune supportLiver supportRespiratory

Niu-Chang-Chih · 2008 · Journal Article · Toxicology and applied pharmacology

In vivo immunomodulatory effects of Antrodia camphorata polysaccharides in a T1/T2 doubly transgenic mouse model for inhibiting infection of Schistosoma mansoni.

Antrodia camphorata (A. camphorata) is a fungus commonly used for treatment of viral hepatitis and cancer in Chinese folk medicine.

Mesima · 2008 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Phellinus linteus Extract Augments the Immune Response in Mitomycin C-Induced Immunodeficient Mice.

Phellinus linteus is a fungus distributed throughout Japan, Korea and China. Boiled water-soluble extracts from P.

Enoki · 2008 · Journal Article · Hybridoma (2005)

Preparation and characterization of monoclonal antibodies against a polysaccharide from Flammulina velutipes mycelium.

Antigen was synthesized for the preparation of monoclonal antibodies (MAbs) against FVP2, a polysaccharide from Flammulina velutipes. FVP2 was coupled to bovine serum albumin (BSA) by 1-cyano-4-dimethyl-aminopyridinium tetrafluoroborate (CDAP) to produce a neoglycoprotein with the degree of substitution (DS;….

Maitake · 2008 · Journal Article · New biotechnology

Solid-state cultivation of Grifola frondosa (Dicks: Fr) S.F. Gray biomass and immunostimulatory effects of fungal intra- and extracellular beta-polysaccharides.

Grifola frondosa strain GF3, was cultivated on solid-state substrate consisting of milled whole corn plant (Zea mays) and olive press cake supplemented with mineral additives and olive oil. Maintenance of the moisture content in the solid substrate is of crucial importance..

Immune supportEnergy & fatigue

Maitake · 2007 · Journal Article · Se pu = Chinese journal of chromatography

[Behaviors of beta-glucan from Grifola frondosa in high performance gel permeation chromatography].

The high performance gel permeation chromatographic (HPGPC) behaviors of four beta-1, 3/1, 6-glucans (GF1, GF2, GF3, GF4) with different protein contents and one alpha-1, 4/1, 6-glucan (P100) from Grifola frondosa were examined with different concentrations of NaCl solution and pH values..

Enoki · 2007 · Journal Article · Journal of food engineering

Kinetics of winter mushrooms (Flammulina velutipes) microstructure and quality changes during thermal processing

Winter mushrooms have become a popular traditional foodstuff with high nutritive value. Winter mushrooms (Flammulina velutipes) were subjected to thermal treatments to 70, 80, 90 and 100 °C for 1, 2, 3, 5 and 10 min.

Immune supportEnergy & fatigue

Niu-Chang-Chih · 2007 · Journal Article · Acta pharmacologica Sinica

Modulation of inflammation-related genes of polysaccharides fractionated from mycelia of medicinal basidiomycete Antrodia camphorata.

AIM: To investigate the effect of water soluble-ethanol precipitation fraction (AC-1) and alkaline extraction-isoelectric precipitation fraction (AC-2) from Antrodia camphorata (Polyporaceae, Aphyllophorales) on lipopolysaccharide (LPS)-induced gene activation in mouse macrophages..

OncologyImmune supportLiver support

Enoki · 2007 · Journal Article · Carbohydrate polymers

Purification, characterization and biological activity on hepatocytes of a polysaccharide from Flammulina velutipes mycelium

A water-soluble polysaccharide named as FVP2 has been isolated from Flammulina velutipes mycelium by hot water extraction, anion-exchange and gel-permeation chromatography..