MycoData

Enoki · 2018 · Research Support, Non U.S. Gov'T · Scientific reports

Structural elucidation of a polysaccharide from Flammulina velutipes and its immunomodulation activities on mouse B lymphocytes.

A novel polysaccharide FVPB2 was purified from fruiting bodies of Flammulina velutipes. Its structure was elucidated by monosaccharide composition and methylation analyses, UV-Visible and FTIR spectroscopy as well as NMR..

Snow Fungus · 2017 · Brief Report · Mycobiology

An Improved Total RNA Extraction Method for White Jelly Mushroom Tremella fuciformis Rich in Polysaccharides.

An improved method for extracting high quality and quantity RNA from a jelly mushroom and a dimorphic fungus-Tremella fuciformis which is especially rich in polysaccharides, is described. RNA was extracted from T.

Immune supportMetabolic healthLiver support

Lion's Mane · 2017 · Research Support, Non U.S. Gov'T · Scientific reports

Antihyperglycaemic and organic protective effects on pancreas, liver and kidney by polysaccharides from Hericium erinaceus SG-02 in streptozotocin-induced diabetic mice.

The present work was designed to investigate the antihyperglycaemic and protective effects of two Hericium erinaceus intracellular polysaccharide (HIPS) purified fractions (HIPS1 and HIPS2) from mycelia of H. erinaceus SG-02 on pancreas, liver and kidney in streptozotocin (STZ)-induced diabetic mice..

Shiitake · 2017 · Comparative Study · Journal of proteomics

Comparative secretomic analysis of lignocellulose degradation by Lentinula edodes grown on microcrystalline cellulose, lignosulfonate and glucose.

UNLABELLED: Lentinula edodes has the potential to degrade woody and nonwoody lignocellulosic biomass. However, the mechanism of lignocellulose degradation by L.

Immune supportEnergy & fatigueMetabolic health

Turkey Tail · 2017 · Research Support, Non U.S. Gov'T · Scientific reports

Proteomic analysis reveals large amounts of decomposition enzymes and major metabolic pathways involved in algicidal process of Trametes versicolor F21a.

A recent algicidal mode indicates that fungal mycelia can wrap and eliminate almost all co-cultivated algal cells within a short time span. However, the underlying molecular mechanism is rarely understood..

Immune supportGut & microbiome

Oyster Mushroom · 2017 · Journal Article · Applied microbiology and biotechnology

Valorization of spent oyster mushroom substrate and laccase recovery through successive solid state cultivation of Pleurotus, Ganoderma, and Lentinula strains.

Spent mushroom substrate (SMS) of Pleurotus ostreatus was supplemented with wheat bran and soybean flour in various proportions to obtain C/N ratios of 10, 20, and 30, and their effect was evaluated in successive cultivation of Pleurotus ostreatus, Pleurotus pulmonarius, Ganoderma adspersum, Ganoderma resinaceum, and….

OncologyImmune supportEnergy & fatigue

Niu-Chang-Chih · 2016 · Research Support, Non U.S. Gov'T · International immunopharmacology

4,7-Dimethoxy-5-methyl-1,3-benzodioxole from Antrodia camphorata inhibits LPS-induced inflammation via suppression of NF-κB and induction HO-1 in RAW264.7 cells.

Several benzenoid compounds have been isolated from Antrodia camphorata are known to have excellent anti-inflammatory activity. In this study, we investigated the anti-inflammatory potential of 4,7-dimethoxy-5-methyl-1,3-benzodioxole (DMB), one of the major benzenoid compounds isolated from the mycelia of A..

OncologyImmune supportMetabolic health

Maitake · 2016 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Anti-tumor and immunomodulatory activity of selenium (Se)-polysaccharide from Se-enriched Grifola frondosa.

A polysaccharide termed Se-GP11 was extracted and purified from Se-enriched Grifola frondosa in our previous study. This study investigated the characterization, anti-tumor and immunomodulatory activity of Se-GP11..

Enoki · 2016 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Antioxidative and renoprotective effects of residue polysaccharides from Flammulina velutipes.

Three extractable polysaccharides including Ac-RPS, Al-RPS and En-RPS were extracted from the residue of Flammulina velutipes and their antioxidative and renoprotective effects on STZ-induced mice were investigated..

Mesima · 2016 · Comparative Study · Journal of food and drug analysis

Comparing the functional components, SOD-like activities, antimutagenicity, and nutrient compositions of Phellinus igniarius and Phellinus linteus mushrooms.

Many species of the genus Phellinus possess beneficial properties, including antioxidant, immune-enhancing, and antimutagenic effects. Phenolic compounds and polysaccharides are two kinds of bioactive compounds; however, few studies have compared the differences between Phellinus igniarius and Phellinus linteus in….

Snow Fungus · 2016 · Research Support, Non U.S. Gov'T · Journal of microbiology (Seoul, Korea)

Comparing the sugar profiles and primary structures of alkali-extracted water-soluble polysaccharides in cell wall between the yeast and mycelial phases from Tremella fuciformis.

To gain insights into dimorphism, cell wall polysaccharides from Tremella fuciformis strains were obtained from alkali-extracted water-soluble fractions PTF-M38 (from the mycelial form), PTF-Y3 and PTF-Y8 (from the yeast form) of T. fuciformis strains were used to gain some insights into dimorphism study..

Immune supportEnergy & fatigueGut & microbiome

Almond Mushroom · 2016 · Research Support, Non U.S. Gov'T · PloS one

Effect of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™, on Symptoms, Fatigue and Quality of Life in Patients with Ulcerative Colitis in a Randomized Single-Blinded Placebo Controlled Study.

BACKGROUND: Ingestion of AndoSan™, based on the mushroom Agaricus blazei Murill, has previously been shown to exhibit anti-inflammatory effects because of reduction of pro-inflammatory cytokines in healthy individuals and patients with ulcerative colitis..

OncologyImmune supportEnergy & fatigue

Lion's Mane · 2016 · Research Support, Non U.S. Gov'T · Oxidative medicine and cellular longevity

Hericium erinaceus Inhibits TNF-α-Induced Angiogenesis and ROS Generation through Suppression of MMP-9/NF-κB Signaling and Activation of Nrf2-Mediated Antioxidant Genes in Human EA.hy926 Endothelial Cells.

Hericium erinaceus (HE) is an edible mushroom that has been shown to exhibit anticancer and anti-inflammatory activities. We investigated the antiangiogenic and antioxidant potentials of ethanol extracts of HE in human endothelial (EA.hy926) cells upon tumor necrosis factor-α- (TNF-α-) stimulation (10 ng/mL)..

OncologyImmune supportCognition & nerves

Lion's Mane · 2016 · Retracted Publication · Journal of translational medicine

Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade.

BACKGROUND: Hericium erinaceus is an edible mushroom; its various pharmacological effects which have been investigated. This study aimed to demonstrate whether efficacy of oral administration of H..

Shiitake · 2016 · Clinical Study · Alternative therapies in health and medicine

Improvement of QOL and Immunological Function With Lentinula Edodes Mycelia in Patients Undergoing Cancer Immunotherapy: An Open Pilot Study.

Context • Combined treatment with an extract of Lentinula edodes mycelia (LEM) and chemotherapy has been reported to improve quality of life (QOL) and immunological function in cancer patients. However, those effects have not been elucidated for patients receiving cancer immunotherapy..

Chaga · 2016 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Investigation of three lignin complexes with antioxidant and immunological capacities from Inonotus obliquus.

Mushroom Inonotus obliquus (I. obliquus), a folk medicine, has been widely used to treat several human malicious tumors since 16th century.

Mesima · 2016 · Research Support, Non U.S. Gov'T · Journal of bioscience and bioengineering

Modulation of T cell response by Phellinus linteus.

Phellinus linteus, a species of mushroom, has been shown to contribute to health benefits, such as anti-inflammatory activity and immunomodulatory efficacy. The aim of this study was to analyze the most effective constituents of P..

Enoki · 2016 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Purification, characterization and antioxidant activity of polysaccharides from Flammulina velutipes residue.

In this study, we isolated polysaccharides from Flammulina velutipes residue (FVRP) using microwave-assisted extraction and then purified the polysaccharides by column chromatography to yield FVRP-1, FVRP-2 and FVRP-3..

Mesima · 2016 · Research Support, Non U.S. Gov'T · Journal of microbiology (Seoul, Korea)

Species identity of Phellinus linteus (sanghuang) extensively used as a medicinal mushroom in Korea.

Sanghuang is a medicinal mushroom that has gained particular attention in Korea. It has been extensively studied for the past few decades as a natural immune booster and cancer suppressor..

Immune supportRespiratory

Maitake · 2016 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Structural characterization and antiviral activity of a novel heteropolysaccharide isolated from Grifola frondosa against enterovirus 71.

A novel heteropolysaccharide from Grifola frondosa mycelia was extracted and purified using DEAE Sephadex A-50 and Sephadex G-200 chromatography. Fourier transform infrared (FT-IR) spectroscopy and nuclear magnetic resonance ((1)H NMR and (13)C NMR) spectroscopy were used to decipher the structure of the purified G..

Zhu Ling · 2016 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Structure elucidation and antioxidant activity of a novel polysaccharide from Polyporus umbellatus sclerotia.

A novel water-soluble polysaccharide PUP60S2, with a molecular weight of 1.44×10(4)Da, was obtained from the sclerotia of Polyporus umbellatus by hot water extraction, ethanol precipitation, anion-exchange and size-exclusion chromatography. PUP60S2 was a polysaccharide comprised of about 22.3% glucuronic acid..

Lion's Mane · 2016 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Structure elucidation of a bioactive polysaccharide from fruiting bodies of Hericium erinaceus in different maturation stages.

HPB-3, a heteropolysaccharide, with a mean molecular weight of 1.5×10(4)Da, was obtained from the maturating-stage IV, V and VI fruiting body of Hericium erinaceus, exhibited higher macrophages stimulation activities, was able to upregulate the functional events mediated by activated macrophages, such as production of….

Snow Fungus · 2016 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Structure, physical property and antioxidant activity of catechin grafted Tremella fuciformis polysaccharide.

In this study, structural characterization, physical property and antioxidant activity of catechin grafted Tremella fuciformis polysaccharide (catechin-g-TPS) were investigated. Crude polysaccharides were isolated from the fruit bodies of T..

Mesima · 2016 · Research Support, Non U.S. Gov'T · Ultrasonics sonochemistry

Ultrasonic effects on the degradation kinetics, preliminary characterization and antioxidant activities of polysaccharides from Phellinus linteus mycelia.

In this study, a high-molecular-weight polysaccharide PL-N isolated from the alkaline extract of Phellinus linteus mycelia was degraded by ultrasound. Results showed that ultrasound treatment at different ultrasonic intensities decreased the intrinsic viscosity and molecular weight of PL-N, as well as narrowed the….

Immune supportMetabolic healthGut & microbiomeLiver support

Shiitake · 2016 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Water-Soluble Compounds from Lentinula edodes Influencing the HMG-CoA Reductase Activity and the Expression of Genes Involved in the Cholesterol Metabolism.

A water extract from Lentinula edodes (LWE) showed HMG-CoA reductase inhibitory activity but contained no statins. NMR indicated the presence of water-soluble α- and β-glucans and fucomannogalactans..

Immune supportEnergy & fatigue

Lion's Mane · 2015 · Research Article · Experimental and therapeutic medicine

Anti-fatigue activities of polysaccharides extracted from Hericium erinaceus.

Hericium erinaceus (HEP) is a notable medicinal fungus grown in China and other oriental countries. Polysaccharides from HEP have recently attracted considerable attention due to their numerous physiological activities.

OncologyImmune supportLiver supportRespiratory

Shiitake · 2015 · Journal Article · Biochemical and biophysical research communications

Anti-HCV effect of Lentinula edodes mycelia solid culture extracts and low-molecular-weight lignin.

Lentinula edodes mycelia solid culture extract (MSCE) contains several bioactive molecules, including some polyphenolic compounds, which exert immunomodulatory, antitumor, and hepatoprotective effects..

Maitake · 2015 · Journal Article · Food research international (Ottawa, Ont.)

Biological potential of extracts of the wild edible Basidiomycete mushroom Grifola frondosa

Partially purified polysaccharides (FP) and hot alkali extract (FNa) obtained from fruiting bodies of the wild basidiomycete Grifola frondosa were examined for their antimicrobial, antioxidant and cytotoxic activity..

Maitake · 2015 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Changes in some nutritional components of soymilk during fermentation by the culinary and medicinal mushroom Grifola frondosa

Soymilk was fermented by Grifola frondosa and the changes in the contents of polysaccharide, oligosaccharide, crude protein, B-vitamins, free amino acids and isoflavones were analyzed. Polysaccharide and free amino acids were increased by the fermentation of G.

Maitake · 2015 · Journal Article · International journal of food science & technology

Effect of the main ingredients of Rhizoma gastrodiae on mycelial biomass and exopolysaccharide productions by submerged culture of Grifola frondosa

Various concentrations of the main ingredients of Rhizoma gastrodiae including gastrodin (GA) and p‐hydroxybenzyl alcohol (HA) as well as p‐hydroxylbenzaldehyde (HBA) were separately added into the cultural medium of Grifola frondosa in submerged culture..

Immune supportEnergy & fatigueMetabolic healthSkin & hydration

Yellow Morel · 2015 · Journal Article · International journal of food properties

Isolation, Purification, and Characterization of Polysaccharides from Wide Morchella esculenta (L.) Pers

A new polysaccharide (MEP-1) was isolated from fruit body of wide Morchella esculenta (L.) Pers with a stepwise procedure of hot water extraction, removal of the protein, dialysis against water, DEAE-Cellulose A52 and Sephadex G-100 columns..

Immune supportGut & microbiome

Shiitake · 2015 · Journal Article · Food & function

Lentinula edodes-derived polysaccharide enhances systemic and mucosal immunity by spatial modulation of intestinal gene expression in mice.

Mushroom polysaccharides have been reported to possess significant biological activities. However, their molecular mechanisms are not fully elucidated.

OncologyImmune supportEnergy & fatigueGut & microbiome

Maitake · 2015 · Clinical Trial, Phase II · Cancer immunology, immunotherapy: CII

Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study.

BACKGROUND: Myelodysplastic syndromes (MDS) are characterized by ineffective erythropoiesis with dysplastic bone marrow leading to peripheral cytopenia, risk of infection, and progression to acute myelogenous leukemia..

Immune supportLiver support

Snow Fungus · 2015 · Journal Article · Biotechnology letters

Oral vaccination of mice with Tremella fuciformis yeast-like conidium cells expressing HBsAg

Tremella fuciformis yeast-like conidium (YLC) cells were transformed by co-cultivation with Agrobacterium cells harboring the hepatitis B surface antigen (HBsAg) gene construct under the control of the CaMV35S promoter. Integration of HBsAg DNA into the YLC genome was confirmed by PCR and dot-blot hybridization..

Immune supportLiver support

Lion's Mane · 2015 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Protective Effect of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice.

We investigated the effects of Hericium erinaceus (HEM) on liver injury induced by acute alcohol administration in mice. Mice received ethanol (5 g/kg BW) by gavage every 12 hrs for a total of 3 doses.

Enoki · 2015 · Research Article · Journal of food and drug analysis

Separation and speciation analysis of zinc from Flammulina velutipes.

Orthogonal experiment was applied to optimize the water extraction parameters of zinc from Flammulina velutipes, and then the extracts were separated by membrane filter (0.45 μm) and D101 macroporous resin..

Lion's Mane · 2015 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Sequential extraction of Hericium erinaceus using green solvents

Hericium erinaceus was processed to obtain soluble fractions using a sequence of stages consisting on: microwave hydrogravity (400 W), supercritical CO2 extraction (20 MPa, 40 °C, 10% ethanol) and the remaining raffinates were subjected either to enzyme assisted extraction (3% protease + cellulase + pectinase, 50 °C,….

OncologyImmune supportEnergy & fatigueMetabolic health

Mesima · 2015 · Journal Article · Journal of investigative medicine: the official publication of the American Federation for Clinical Research

The Effects of Phellinus linteus Polysaccharide Extracts on Cholesterol Efflux in Oxidized Low-Density Lipoprotein-Loaded THP-1 Macrophages.

The removal of excess cellular cholesterol is critical for maintaining cellular cholesterol homeostasis. Phellinus linteus polysaccharide extracts (PLPEs) is an immunomudulatory agent with a molecular weight of 153 kd..

Mesima · 2014 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Chemical characterization of the medicinal mushroom Phellinus linteus (Berkeley & Curtis) Teng and contribution of different fractions to its bioactivity

Mushrooms are widely appreciated for their organoleptic qualities, being also recognized as good sources of bioactive compounds that provide antioxidant, antimicrobial and cytotoxic activities..

Enoki · 2014 · Journal Article · Molecular biology reports

Cloning and analysis of a functional promoter of fungal immunomodulatory protein from Flammulina velutipes.

Fugal immunomodulatory protein from Flammulina velutipes (FIP-fve) belongs to FIPs family, which has precious pharmaceutical value. To understand the regulatory mechanism of FIP-fve expression, we have cloned a 900 bp genomic DNA fragment from the transcriptional start site of the FIP-fve gene using genomic walker….

OncologyImmune supportRespiratory

Mesima · 2014 · Research Article · Immune network

Phellinus linteus Extract Exerts Anti-asthmatic Effects by Suppressing NF-κB and p38 MAPK Activity in an OVA-induced Mouse Model of Asthma.

Phellinus linteus has been used as a traditional herbal medicine in Asian countries and is known to have anti-tumor, immunomodulatory, anti-inflammatory, and anti-allergic activities. However, the protective effects of P.

Immune supportMetabolic healthLiver support

Chaga · 2014 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Protective Effect of Polysaccharides from Inonotus obliquus on Streptozotocin-Induced Diabetic Symptoms and Their Potential Mechanisms in Rats.

The present study aimed to evaluate the therapeutic effects of polysaccharides from Inonotus obliquus (PIO) on streptozotocin- (STZ-) induced diabetic symptoms and their potential mechanisms..

Immune supportLiver support

Chaga · 2013 · Research Article · Molecules (Basel, Switzerland)

Anti-oxidant and anti-inflammatory activities of Inonotus obliquus and germinated brown rice extracts.

Inonotus obliquus (IO) is parasitic mushroom that grows on birch and other trees in Russia, Korea, Europe and United States. However, IO is not readily available for consumption due to its high cost and difficult growth..

OncologyImmune supportEnergy & fatigueGut & microbiome

Niu-Chang-Chih · 2013 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Ethanol Extract of Antrodia camphorata Grown on Germinated Brown Rice Suppresses Inflammatory Responses in Mice with Acute DSS-Induced Colitis.

The anti-inflammatory activity of Antrodia camphorata (AC) grown on germinated brown rice (CBR) extract was evaluated in vitro and in vivo. CBR suppressed the release of nitric oxide (NO) and prostaglandin (PG) E2 from lipopolysaccharide-(LPS-)stimulated RAW264.7 cells..

Lion's Mane · 2013 · Journal Article · International journal of biological macromolecules

Evaluation of in vivo antioxidant activity of Hericium erinaceus polysaccharides.

Hericium erinaceus polysaccharide (HEP) is a traditional Chinese medicine. In the present study, chemical composition and antioxidant activity of HEP was investigated..

Enoki · 2013 · Research Article · International journal of molecular sciences

High-Yield Production in Escherichia coli of Fungal Immunomodulatory Protein Isolated from Flammulina velutipes and Its Bioactivity Assay in Vivo.

A fungal immunomodulatory protein isolated from Flammulina velutipes (FIP-fve) has structural similarity to the variable region of the immunoglobulin heavy chain..

OncologyImmune supportEnergy & fatigueLiver support

Yellow Morel · 2013 · Journal Article · Biotechnology letters

Induction of apoptosis in HepG2 cells by polysaccharide MEP-II from the fermentation broth of Morchella esculenta

A novel polysaccharide, MEP-II, isolated from the fermentation broth of Morchella esculenta inhibited the proliferation of human hepatoma cell line (HepG2) through an apoptotic pathway..

Turkey Tail · 2013 · Journal Article · New biotechnology

Influence of treatment conditions on the oxidation of micropollutants by Trametes versicolor laccase.

Many organic compounds present at low concentrations in municipal wastewater, such as various pharmaceuticals and biocides, are recalcitrant in conventional wastewater treatment plants (WWTPs). To improve their biodegradation, oxidoreductase enzymes such as laccases were tested..