MycoData

Tasty components in Lentinula edodes pileus and stipe at different growth stages were studied. Mannitol, trehalose, arabitol, and glucose were the main soluble polyols and sugars, whereas succinic acid, malic acid, and citric acid were the main organic acids..

Metabolic health

High relevance

Niu-Chang-Chih · 2015 · Journal Article · Fitoterapia

Anti-cancer agents derived from solid-state fermented Antrodia camphorata mycelium.

Three new ubiquinone derivatives, antrocamol LT1, antrocamol LT2, and antrocamol LT3, along with two known compounds, were isolated from Antrodia camphorata (Polyporaceae) mycelium. The structures of these compounds were established on the basis of extensive 1D and 2D NMR spectroscopic analyses..

Oncology

High relevance

Lion's Mane · 2015 · Research Article · Experimental and therapeutic medicine

Anti-fatigue activities of polysaccharides extracted from Hericium erinaceus.

Hericium erinaceus (HEP) is a notable medicinal fungus grown in China and other oriental countries. Polysaccharides from HEP have recently attracted considerable attention due to their numerous physiological activities.

Immune supportEnergy & fatigue

High relevance

Shiitake · 2015 · Journal Article · Biochemical and biophysical research communications

Anti-HCV effect of Lentinula edodes mycelia solid culture extracts and low-molecular-weight lignin.

Lentinula edodes mycelia solid culture extract (MSCE) contains several bioactive molecules, including some polyphenolic compounds, which exert immunomodulatory, antitumor, and hepatoprotective effects..

OncologyImmune supportLiver supportRespiratory

High relevance

Niu-Chang-Chih · 2015 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Antrodia camphorata Potentiates Neuroprotection against Cerebral Ischemia in Rats via Downregulation of iNOS/HO-1/Bax and Activated Caspase-3 and Inhibition of Hydroxyl Radical Formation.

Antrodia camphorata (A. camphorata) is a fungus generally used in Chinese folk medicine for treatment of viral hepatitis and cancer.

OncologyCognition & nervesEnergy & fatigueLiver support

High relevance

Turkey Tail · 2015 · Journal Article · Chemosphere

Biodegradation of polycyclic aromatic hydrocarbons (PAHs) by laccase from Trametes versicolor covalently immobilized on amino-functionalized SBA-15.

A covalent immobilization method based on glutaraldehyde and amino-functionalized SBA-15 supports has been successfully applied to covalently and stably immobilize laccase from Trametes versicolor..

High relevance

Maitake · 2015 · Journal Article · Food research international (Ottawa, Ont.)

Biological potential of extracts of the wild edible Basidiomycete mushroom Grifola frondosa

Partially purified polysaccharides (FP) and hot alkali extract (FNa) obtained from fruiting bodies of the wild basidiomycete Grifola frondosa were examined for their antimicrobial, antioxidant and cytotoxic activity..

OncologyImmune support

High relevance

Maitake · 2015 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Changes in some nutritional components of soymilk during fermentation by the culinary and medicinal mushroom Grifola frondosa

Soymilk was fermented by Grifola frondosa and the changes in the contents of polysaccharide, oligosaccharide, crude protein, B-vitamins, free amino acids and isoflavones were analyzed. Polysaccharide and free amino acids were increased by the fermentation of G.

Immune support

High relevance

Turkey Tail · 2015 · Journal Article · Artificial cells, nanomedicine, and biotechnology

Characterization and immobilization of Trametes versicolor laccase on magnetic chitosan-clay composite beads for phenol removal.

Laccase from Trametes versicolor was immobilized on magnetic chitosan-clay composite beads by glutaraldehyde crosslinking. The physical, chemical, and biochemical properties of the immobilized laccase and its application in phenol removal were comprehensively investigated..

High relevance

Mesima · 2015 · Research Article · Mycobiology

Chemical Constituents of the Culture Broth of Phellinus linteus and Their Antioxidant Activity.

The medicinal fungus Phellinus linteus, in the family Hymenochaetaceae, has been used as a traditional medicine for the treatment of various diseases. In this study, the chemical constituents of the culture broth of P.

Energy & fatigue

High relevance

Enoki · 2015 · Journal Article · Bioscience, biotechnology, and biochemistry

Cloning and characterization of a novel O-methyltransferase from Flammulina velutipes that catalyzes methylation of pyrocatechol and pyrogallol structures in polyphenols.

A novel O-methyltransferase gene was isolated from Flammulina velutipes. The isolated full-length cDNA was composed of a 690-nucleotide open reading frame encoding 230 amino acids..

High relevance

Maitake · 2015 · Journal Article · Mycoscience

Development of a transformation system for the edible mushroom Grifola frondosa: Demonstrating heterologous gene expression and RNAi-mediated gene silencing

Grifola frondosa is a well-known edible mushroom that is industrially produced year-round under artificial cultivation. To improve the productivity and quality of cultivated mushrooms, transcriptomic and genomic data for G.

High relevance

Lion's Mane · 2015 · Journal Article · International journal of food science & technology

Development of fermented Hericium erinaceus juice with high content of L‐glutamine and L‐glutamic acid

Fermented plant beverages (FPB) with a high content of desirable principle components are served as functional foods from several years. Hericium erinaceus is famous for its antimicrobial, antioxidant, antihypertensive and antidiabetic nature.

Metabolic health

High relevance

Chaga · 2015 · Journal Article · Applied biochemistry and biotechnology

Effect of Light Wavelengths and Coherence on Growth, Enzymes Activity, and Melanin Accumulation of Liquid-Cultured Inonotus obliquus (Ach.:Pers.) Pilát.

To investigate effects of light wavelengths and coherence on growth of liquid-cultured Inonotus obliquus mycelia, melanin accumulation and enzymes activity, culture condition as light of different wavelengths and coherence were studied..

Skin & hydration

High relevance

Maitake · 2015 · Journal Article · International journal of food science & technology

Effect of the main ingredients of Rhizoma gastrodiae on mycelial biomass and exopolysaccharide productions by submerged culture of Grifola frondosa

Various concentrations of the main ingredients of Rhizoma gastrodiae including gastrodin (GA) and p‐hydroxybenzyl alcohol (HA) as well as p‐hydroxylbenzaldehyde (HBA) were separately added into the cultural medium of Grifola frondosa in submerged culture..

Immune support

High relevance

Lion's Mane · 2015 · Journal Article · Archives of physiology and biochemistry

Enhancement of the neuroprotective activity of Hericium erinaceus mycelium co-cultivated with Allium sativum extract.

This study investigated the neuroprotective effects of Hericium erinaceus mycelium enriched with garlic extract (HGE) on rat pheochromocytoma nerve cells (PC12). The survival rates of the PC12 nerve cells and the neurite-bearing cells after the addition of HGE were estimated as 3.5 × 10(3) viable cells/ml and 2.3 ×….

Cognition & nerves

High relevance

Shiitake · 2015 · Journal Article · Journal of basic microbiology

Evaluating genetic diversity and constructing core collections of Chinese Lentinula edodes cultivars using ISSR and SRAP markers.

Genetic diversity among 89 Chinese Lentinula edodes cultivars was analyzed by inter-simple sequence repeat (ISSR) and sequence-related amplified polymorphism (SRAP) markers. A 123 out of 126 ISSR loci (97.62%) and 108 out of 129 SRAP loci (83.73%) were polymorphic between two or more strains..

High relevance

Enoki · 2015 · Journal Article · Plant disease

First Report of Acrostalagmus luteo-albus Causing Red Rust of Needle Mushroom (Flammulina velutipes) in China.

Needle mushroom (Flammulina velutipes) is an edible and medicinal mushroom with annual production yields for China exceeding 2 million metric tons. Hebei province is one of the biggest producers of needle mushrooms in China..

Gut & microbiome

High relevance

Shiitake · 2015 · Journal Article · AMB Express

Grouping of multicopper oxidases in Lentinula edodes by sequence similarities and expression patterns.

The edible white rot fungus Lentinula edodes possesses a variety of lignin degrading enzymes such as manganese peroxidases and laccases. Laccases belong to the multicopper oxidases, which have a wide range of catalytic activities including polyphenol degradation and synthesis, lignin degradation, and melanin….

Skin & hydration

High relevance

Shiitake · 2015 · Journal Article · Brazilian journal of biology = Revista brasleira de biologia

Influence of nitrogen sources on the enzymatic activity and grown by Lentinula edodes in biomass Eucalyptus benthamii.

Lignocellulose is the most abundant environmental component and a renewable organic resource in soil. There are some filamentous fungi which developed the ability to break down and use cellulose, hemicellulose and lignin as an energy source..

Energy & fatigue

High relevance

Shiitake · 2015 · Journal Article · Mycobiology

Isolation and Characterization of Monokaryotic Strains of Lentinula edodes Showing Higher Fruiting Rate and Better Fruiting Body Production.

The effects of monokaryotic strains on fruiting body formation of Lentinula edodes were examined through mating and cultivation of the mated dikaryotic mycelia in sawdust medium. To accomplish this, monokaryotic strains of L..

Energy & fatigue

High relevance

Yellow Morel · 2015 · Journal Article · International journal of food properties

Isolation, Purification, and Characterization of Polysaccharides from Wide Morchella esculenta (L.) Pers

A new polysaccharide (MEP-1) was isolated from fruit body of wide Morchella esculenta (L.) Pers with a stepwise procedure of hot water extraction, removal of the protein, dialysis against water, DEAE-Cellulose A52 and Sephadex G-100 columns..

Immune supportEnergy & fatigueMetabolic healthSkin & hydration

High relevance

Zhu Ling · 2015 · Journal Article · Journal of medicinal food

Khz (fusion product of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis in human colon carcinoma HCT116 cells, accompanied by an increase in reactive oxygen species, activation of caspase 3, and increased intracellular Ca²⁺.

Khz (a fusion mycelium of Ganoderma lucidum and Polyporus umbellatus mycelia) is isolated from ganoderic acid and P. umbellatus and it exerts antiproliferative effects against malignant cells.

OncologyEnergy & fatigueGut & microbiome

High relevance

Shiitake · 2015 · Journal Article · Food & function

Lentinula edodes-derived polysaccharide enhances systemic and mucosal immunity by spatial modulation of intestinal gene expression in mice.

Mushroom polysaccharides have been reported to possess significant biological activities. However, their molecular mechanisms are not fully elucidated.

Immune supportGut & microbiome

High relevance

Maitake · 2015 · Clinical Trial, Phase II · Cancer immunology, immunotherapy: CII

Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study.

BACKGROUND: Myelodysplastic syndromes (MDS) are characterized by ineffective erythropoiesis with dysplastic bone marrow leading to peripheral cytopenia, risk of infection, and progression to acute myelogenous leukemia..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Snow Fungus · 2015 · Journal Article · Biotechnology letters

Oral vaccination of mice with Tremella fuciformis yeast-like conidium cells expressing HBsAg

Tremella fuciformis yeast-like conidium (YLC) cells were transformed by co-cultivation with Agrobacterium cells harboring the hepatitis B surface antigen (HBsAg) gene construct under the control of the CaMV35S promoter. Integration of HBsAg DNA into the YLC genome was confirmed by PCR and dot-blot hybridization..

Immune supportLiver support

High relevance

Maitake · 2015 · Journal Article · Mycoscience

Overexpression of a putative transcription factor Gf.CRZ1 affects the expression of oxalate-degrading genes and causes morphological defects during mycelium formation in Grifola frondosa

Grifola frondosa is commercially produced year-round in large-scale facilities. However, the molecular mechanisms of fruiting body differentiation remain elusive, and understanding these mechanisms at the molecular genetic level is therefore important for improving the cultivation of this economically important….

Gut & microbiome

High relevance

Mesima · 2015 · Research Article · Journal of clinical medicine research

Potent Anticancer Effects of Bioactive Mushroom Extracts (Phellinus linteus) on a Variety of Human Cancer Cells.

BACKGROUND: Although several therapeutic options are currently available for patients with various cancers, the outcomes are often disappointing and a more effective modality needs to be promptly established..

OncologyCognition & nervesLiver supportRespiratory

High relevance

Turkey Tail · 2015 · Journal Article · Biotechnology letters

Production, purification and biochemical characterization of two laccase isoforms produced by Trametes versicolor grown on oak sawdust

Two laccase isoforms (lcc1 and lcc2) produced by Trametes versicolor, grown on oak sawdust under solid-state fermentation conditions, were purified and characterized. The two isoforms showed significant biochemical differences.

High relevance

Lion's Mane · 2015 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced Diabetic Neuropathic Pain in Rats.

We investigated the effects of Hericium erinaceus (HEE) on alloxan induced diabetic neuropathic pain in laboratory rats. Alloxan induced diabetic rats were administered orally HEE..

Cognition & nervesMetabolic health

High relevance

Lion's Mane · 2015 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Protective Effect of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice.

We investigated the effects of Hericium erinaceus (HEM) on liver injury induced by acute alcohol administration in mice. Mice received ethanol (5 g/kg BW) by gavage every 12 hrs for a total of 3 doses.

Immune supportLiver support

High relevance

Enoki · 2015 · Research Article · Journal of food and drug analysis

Separation and speciation analysis of zinc from Flammulina velutipes.

Orthogonal experiment was applied to optimize the water extraction parameters of zinc from Flammulina velutipes, and then the extracts were separated by membrane filter (0.45 μm) and D101 macroporous resin..

Immune support

High relevance

Lion's Mane · 2015 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Sequential extraction of Hericium erinaceus using green solvents

Hericium erinaceus was processed to obtain soluble fractions using a sequence of stages consisting on: microwave hydrogravity (400 W), supercritical CO2 extraction (20 MPa, 40 °C, 10% ethanol) and the remaining raffinates were subjected either to enzyme assisted extraction (3% protease + cellulase + pectinase, 50 °C,….

Immune support

High relevance

Niu-Chang-Chih · 2015 · Journal Article · Archives of pharmacal research

Simultaneous determination of 19 fatty acids in Antrodia camphorata by derivatized GC-MS and evaluation of antioxidant activity of Antrodia camphorata crude oil.

To analyze the components of the fatty oil extracted from Antrodia camphorata fungus powder and to evaluate the antioxidant activity of A. camphorata crude oil.

High relevance

Mesima · 2015 · Journal Article · Journal of investigative medicine: the official publication of the American Federation for Clinical Research

The Effects of Phellinus linteus Polysaccharide Extracts on Cholesterol Efflux in Oxidized Low-Density Lipoprotein-Loaded THP-1 Macrophages.

The removal of excess cellular cholesterol is critical for maintaining cellular cholesterol homeostasis. Phellinus linteus polysaccharide extracts (PLPEs) is an immunomudulatory agent with a molecular weight of 153 kd..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Wood Ear · 2015 · Journal Article · Archives of biochemistry and biophysics

The toolbox of Auricularia auricula-judae dye-decolorizing peroxidase - Identification of three new potential substrate-interaction sites.

Dye-decolorizing peroxidases (DyPs) such as AauDyPI from the fungus Auricularia auricula-judae are able to oxidize substrates of different kinds and sizes. A crystal structure of an AauDyPI-imidazole complex gives insight into the binding patterns of organic molecules within the heme cavity of a DyP..

High relevance

Chaga · 2015 · Journal Article · Fitoterapia

Triterpenoids from Inonotus obliquus and their antitumor activities.

Three new lanostane-type triterpenes, inonotusanes A-C (1-3), and a new naturally occurring one, 3β-hydroxy-25,26,27-trinorlanosta-8,22E-dien-24-oic acid (4), together with sixteen known triterpenoids (5-20), including 13 lanostane derivatives, 2 lupanes and 1 oleanane-type triterpene were isolated from the sclerotia….

Oncology

High relevance

Lion's Mane · 2015 · Research Article · Mycobiology

Water Extract from Spent Mushroom Substrate of Hericium erinaceus Suppresses Bacterial Wilt Disease of Tomato.

Culture filtrates of six different edible mushroom species were screened for antimicrobial activity against tomato wilt bacteria Ralstonia solanacearum B3. Hericium erinaceus, Lentinula edodes (Sanjo 701), Grifola frondosa, and Hypsizygus marmoreus showed antibacterial activity against the bacteria..

High relevance

Turkey Tail · 2014 · Research Article · SpringerPlus

Bioconversion of xylose, hexoses and biomass to ethanol by a new isolate of the white rot basidiomycete Trametes versicolor.

Second-generation bioethanol production requires the development of economically feasible and sustainable processes that use renewable lignocellulosic biomass as a starting material..

Metabolic health

High relevance

Turkey Tail · 2014 · Research Article · SpringerPlus

Biogenic silver nanoparticles associated with silver chloride nanoparticles (Ag@AgCl) produced by laccase from Trametes versicolor.

In the present study, semi-purified laccase from Trametes versicolor was applied for the synthesis of silver nanoparticles, and the properties of the produced nanoparticles were characterized. All of the analyses of the spectra indicated silver nanoparticle formation..

High relevance

Mesima · 2014 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Chemical characterization of the medicinal mushroom Phellinus linteus (Berkeley & Curtis) Teng and contribution of different fractions to its bioactivity

Mushrooms are widely appreciated for their organoleptic qualities, being also recognized as good sources of bioactive compounds that provide antioxidant, antimicrobial and cytotoxic activities..

OncologyImmune support

High relevance

Enoki · 2014 · Journal Article · Molecular biology reports

Cloning and analysis of a functional promoter of fungal immunomodulatory protein from Flammulina velutipes.

Fugal immunomodulatory protein from Flammulina velutipes (FIP-fve) belongs to FIPs family, which has precious pharmaceutical value. To understand the regulatory mechanism of FIP-fve expression, we have cloned a 900 bp genomic DNA fragment from the transcriptional start site of the FIP-fve gene using genomic walker….

Immune support

High relevance

Lion's Mane · 2014 · Journal Article · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association

Evaluation of the toxicological safety of erinacine A-enriched Hericium erinaceus in a 28-day oral feeding study in Sprague-Dawley rats.

Natural products have attained great importance as they are believed to be the new alternative medicines for conventional therapy. As numerous studies have proved the tremendous medicinal values of Hericium erinaceus, it is necessary to take into account its safety as well as its risk for the recipient..

Cognition & nervesMetabolic health

High relevance

Lion's Mane · 2014 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Feasibility of using Hericium erinaceus as the substrate for vinegar fermentation

In this study we investigated the production of vinegar using a Hericium erinaceus fermentation. After 9 days of alcoholic fermentation, the alcohol contents reached 16% with all concentrations (1.25%, 2.5% and 5.0%) of H.

High relevance

Enoki · 2014 · Research Article · Mycobiology

Genome-Wide Identification and Characterization of Novel Laccase Genes in the White-Rot Fungus Flammulina velutipes.

The aim of this study was to identify and characterize new Flammulina velutipes laccases from its whole-genome sequence. Of the 15 putative laccase genes detected in the F..

High relevance

Lion's Mane · 2014 · Research Article · Toxicology reports

Genotoxicity profile of erinacine A-enriched Hericium erinaceus mycelium.

Hericium erinaceus (H. erinaceus) has a long history of usage in traditional Chinese medicine for the treatment of gastric disorders.

Cognition & nervesGut & microbiome

High relevance

Maitake · 2014 · Journal Article · Mycoscience

Heat shock protein 9 mRNA expression increases during fruiting body differentiation in Grifola frondosa and other edible mushrooms

We isolated a homolog of Schizosaccharomyces pombe HSP9 from Grifola frondosa and designated it Gf.HSP9. The Gf.HSP9 gene consisted of four exons and three introns and encoded 84 amino acid residues..

High relevance

Lion's Mane · 2014 · Journal Article · Biological & pharmaceutical bulletin

Mutagenesis of the Novel Hericium erinaceus Ribonuclease, RNase He1, Reveals Critical Responsible Residues for Enzyme Stability and Activity

Here, we determined the sequence of a cDNA encoding a guanylic acid-specific ribonuclease (RNase He1) from Hericium erinaceus that exhibits high sequence identity (59%) with RNase Po1, an enzyme with anti-cancer activity and which is found in Pleurotus ostreatus..

Oncology

High relevance

Mesima · 2014 · Research Article · Immune network

Phellinus linteus Extract Exerts Anti-asthmatic Effects by Suppressing NF-κB and p38 MAPK Activity in an OVA-induced Mouse Model of Asthma.

Phellinus linteus has been used as a traditional herbal medicine in Asian countries and is known to have anti-tumor, immunomodulatory, anti-inflammatory, and anti-allergic activities. However, the protective effects of P.

OncologyImmune supportRespiratory

High relevance

Chaga · 2014 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Protective Effect of Polysaccharides from Inonotus obliquus on Streptozotocin-Induced Diabetic Symptoms and Their Potential Mechanisms in Rats.

The present study aimed to evaluate the therapeutic effects of polysaccharides from Inonotus obliquus (PIO) on streptozotocin- (STZ-) induced diabetic symptoms and their potential mechanisms..

Immune supportMetabolic healthLiver support